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ONTOLOGY REPORT - ANNOTATIONS

Term:respiratory chain complex IV assembly
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Accession:GO:0008535 term browser browse the term
Definition:The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms.
Synonyms:exact_synonym: cytochrome c oxidase complex assembly
 broad_synonym: cytochrome c oxidase biogenesis

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respiratory chain complex IV assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102022268 protoheme IX farnesyltransferase, mitochondrial involved_in ISO (PMID:14607829) HGNC-UCL PMID:14607829 NCBI chrNW_004955467:3,294,200...3,415,778
Ensembl chrNW_004955467:3,292,018...3,415,778 		JBrowse link
G LOC102025739 mitochondrial inner membrane protein COX18 involved_in ISO (PMID:16911509) UniProt PMID:16911509 NCBI chrNW_004955447:382,631...390,399
Ensembl chrNW_004955447:382,679...390,037 		JBrowse link
G LOC102028200 cytochrome c oxidase assembly factor 6 homolog involved_in ISO (PMID:25959673), (PMID:26160915)
(PMID:24549041)		 UniProt PMID:24549041 PMID:25959673 PMID:26160915 NCBI chrNW_004955492:5,316,594...5,324,913 JBrowse link
G LOC106146232 protein SCO2 homolog, mitochondrial acts_upstream_of_or_within ISO (PMID:19837698) MGI PMID:19837698 NCBI chrNW_004955413:33,503,882...33,505,417 JBrowse link
G Slc25a46 solute carrier family 25 member 46 acts_upstream_of_or_within ISO (PMID:27390132) UniProt PMID:27390132 NCBI chrNW_004955418:4,316,790...4,342,748
Ensembl chrNW_004955418:4,316,790...4,341,973 		JBrowse link
mitochondrial cytochrome c oxidase assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apopt1 apoptogenic 1, mitochondrial involved_in ISO (PMID:25175347)
(PMID:30552096)
(MGI:6355662|PMID:30552096)		 UniProt PMID:25175347 PMID:30552096 MGI:6355662 NCBI chrNW_004955538:2,415,781...2,432,742
Ensembl chrNW_004955538:2,415,604...2,434,658 		JBrowse link
G CUNH12orf73 chromosome unknown C12orf73 homolog involved_in ISO (PMID:34969438) UniProt PMID:34969438 NCBI chrNW_004955405:38,651,787...38,656,564
Ensembl chrNW_004955405:38,651,787...38,656,564 		JBrowse link
G Fastkd3 FAST kinase domains 3 involved_in ISO (PMID:27789713) UniProt PMID:27789713 NCBI chrNW_004955504:5,401,956...5,412,216
Ensembl chrNW_004955504:5,400,544...5,411,401 		JBrowse link
G LOC102007967 mitochondrial chaperone BCS1 involved_in ISO (PMID:18628306) UniProt PMID:18628306 NCBI chrNW_004955453:14,762,237...14,766,693
Ensembl chrNW_004955453:14,762,237...14,766,383 		JBrowse link
G LOC102011844 cytochrome c oxidase assembly factor 1 homolog involved_in ISO (PMID:23260140) UniProt PMID:23260140 NCBI chrNW_004955460:182,778...285,053 JBrowse link
G LOC102015156 cytochrome c oxidase assembly protein COX14 involved_in ISO (PMID:22243966) UniProt PMID:22243966 NCBI chrNW_004955547:690,167...690,777
Ensembl chrNW_004955547:676,342...690,777 		JBrowse link
G LOC102016346 cytochrome c oxidase protein 20 homolog involved_in ISO (PMID:23125284), (PMID:24403053) UniProt PMID:23125284 PMID:24403053 NCBI chrNW_004955406:7,994,226...8,002,639 JBrowse link
G LOC102021151 cytochrome c oxidase copper chaperone involved_in ISO (PMID:19393246)
(PMID:37813994)		 CAFA
UniProt		 PMID:19393246 PMID:37813994 NCBI chrNW_004955427:19,376,482...19,384,270
Ensembl chrNW_004955427:19,376,482...19,384,270 		JBrowse link
G LOC102023128 cytochrome c oxidase assembly protein COX16 homolog, mitochondrial involved_in ISO (PMID:29381136)
(PMID:29355485)		 UniProt PMID:29355485 PMID:29381136 NCBI chrNW_004955466:130,341...142,969
Ensembl chrNW_004955466:130,341...142,969 		JBrowse link
G LOC102024671 translational activator of cytochrome c oxidase 1 acts_upstream_of_or_within ISO (PMID:27319982) MGI PMID:27319982 NCBI chrNW_004955478:8,198,563...8,204,820
Ensembl chrNW_004955478:8,199,244...8,204,577 		JBrowse link
G LOC102025739 mitochondrial inner membrane protein COX18 involved_in ISO (PMID:28330871) UniProt PMID:28330871 NCBI chrNW_004955447:382,631...390,399
Ensembl chrNW_004955447:382,679...390,037 		JBrowse link
G LOC102025968 cytochrome c oxidase assembly factor 3 homolog, mitochondrial involved_in ISO (PMID:23260140) UniProt PMID:23260140 NCBI chrNW_004955451:16,607,495...16,608,732
Ensembl chrNW_004955451:16,607,895...16,608,647 		JBrowse link
G LOC102030058 protein SCO1 homolog, mitochondrial involved_in
acts_upstream_of_or_within		 ISO (PMID:15229189)
(PMID:25683716)		 UniProt
MGI		 PMID:15229189 PMID:25683716 NCBI chrNW_004955467:6,519,873...6,535,321
Ensembl chrNW_004955467:6,519,873...6,537,753 		JBrowse link
G LOC106146232 protein SCO2 homolog, mitochondrial involved_in ISO (PMID:15229189) UniProt PMID:15229189 NCBI chrNW_004955413:33,503,882...33,505,417 JBrowse link
G Smim20 small integral membrane protein 20 involved_in ISO (PMID:26321642) UniProt PMID:26321642 NCBI chrNW_004955443:19,242,776...19,254,002
Ensembl chrNW_004955443:19,243,419...19,253,798 		JBrowse link
G Smim4 small integral membrane protein 4 involved_in ISO (PMID:34969438) UniProt PMID:34969438 NCBI chrNW_004956313:1,988...5,240
Ensembl chrNW_004956313:1,988...5,240 		JBrowse link
G Stmp1 short transmembrane mitochondrial protein 1 involved_in ISO (PMID:35450818) UniProt PMID:35450818 NCBI chrNW_004955494:7,063,374...7,077,052 JBrowse link
G Surf1 surfeit 1 involved_in ISO (PMID:24027061) UniProt PMID:24027061 NCBI chrNW_004955513:2,707,877...2,711,606
Ensembl chrNW_004955513:2,707,951...2,711,566 		JBrowse link
G Timm21 translocase of inner mitochondrial membrane 21 involved_in ISO (PMID:23260140) UniProt PMID:23260140 NCBI chrNW_004955402:57,586,651...57,598,817
Ensembl chrNW_004955402:57,586,998...57,599,869 		JBrowse link
G Tmem223 transmembrane protein 223 involved_in ISO (PMID:34969438) UniProt PMID:34969438 NCBI chrNW_004955599:450,518...451,947
Ensembl chrNW_004955599:450,971...451,880 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12543
    cellular process 11978
      cellular component organization or biogenesis 5409
        cellular component organization 5285
          cellular component assembly 2517
            protein-containing complex assembly 1169
              cytochrome complex assembly 34
                respiratory chain complex IV assembly 23
                  mitochondrial cytochrome c oxidase assembly 20
                  plasma membrane respiratory chain complex IV assembly 0
paths to the root