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ONTOLOGY REPORT - ANNOTATIONS

Term:procollagen-lysine 5-dioxygenase activity
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Accession:GO:0008475 term browser browse the term
Definition:Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.
Synonyms:broad_synonym: lysine hydroxylase activity;   lysine,2-oxoglutarate 5-dioxygenase activity;   lysine-2-oxoglutarate dioxygenase activity;   lysyl hydroxylase activity
 related_synonym: collagen lysine hydroxylase activity;   lysylprotocollagen dioxygenase activity;   procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating);   procollagen-lysine,2-oxoglutarate 5-dioxygenase activity;   protocollagen lysine dioxygenase activity;   protocollagen lysine hydroxylase activity;   protocollagen lysyl hydroxylase activity
 xref: EC:1.14.11.4;   MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN;   RHEA:16569;   reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines"


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procollagen-lysine 5-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plod1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 enables ISO
IBA		 MGI
GO_Central
RGD		 PMID:11714250 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1599090 NCBI chr 4:147,994,210...148,021,233
Ensembl chr 4:147,994,210...148,021,224 		JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:92,421,828...92,490,481
Ensembl chr 9:92,424,276...92,490,481 		JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 enables ISO
IBA
IDA		 (MGI:6202004|PMID:16447251), (PMID:16467571) MGI
GO_Central
UniProt		 PMID:16447251 PMID:16467571 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6202004 NCBI chr 5:137,015,873...137,025,500
Ensembl chr 5:137,015,873...137,025,502 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28850
    catalytic activity 5723
      catalytic activity, acting on a protein 2361
        peptidyl-lysine 5-dioxygenase activity 4
          procollagen-lysine 5-dioxygenase activity 3
Path 2
Term Annotations click to browse term
  molecular_function 28850
    catalytic activity 5723
      oxidoreductase activity 792
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 233
          2-oxoglutarate-dependent dioxygenase activity 63
            peptidyl-lysine 5-dioxygenase activity 4
              procollagen-lysine 5-dioxygenase activity 3
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