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ONTOLOGY REPORT - ANNOTATIONS

Term:cohesin complex
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Accession:GO:0008278 term browser browse the term
Definition:A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
Synonyms:exact_synonym: SMC/kleisin ring complex
 narrow_synonym: 14S cohesin;   9S cohesin;   Smc1-Smc3 complex
 related_synonym: SMC complex;   cohesin core heterodimer;   nuclear cohesin complex
 alt_id: GO:0000798;   GO:0008279;   GO:0008280;   GO:0043222


show annotations for term's descendants           Sort by:
cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAD21 RAD21 cohesin complex component part_of IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:21,772,821...21,802,453
Ensembl chr 4:21,772,855...21,802,715 		JBrowse link
G RAD21L1 RAD21 cohesin complex component like 1 part_of IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr17:34,035,526...34,064,215 JBrowse link
G REC8 REC8 meiotic recombination protein part_of IEA InterPro GO_REF:0000002 NCBI chr 7:75,118,743...75,127,759
Ensembl chr 7:75,118,744...75,125,537 		JBrowse link
G SMC1A structural maintenance of chromosomes 1A part_of IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr  X:46,143,738...46,202,187
Ensembl chr  X:46,144,920...46,218,543 		JBrowse link
G SMC1B structural maintenance of chromosomes 1B part_of IEA InterPro GO_REF:0000002 NCBI chr 5:3,976,098...4,067,148
Ensembl chr 5:3,976,140...4,067,395 		JBrowse link
G SMC3 structural maintenance of chromosomes 3 part_of IEA Ensembl GO_REF:0000107 NCBI chr14:120,969,629...121,008,924
Ensembl chr14:120,969,631...121,021,497 		JBrowse link
G SNPH syntaphilin part_of IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr17:33,986,511...34,028,610
Ensembl chr17:33,986,513...34,043,995 		JBrowse link
G STAG1 STAG1 cohesin complex component part_of IEA
IBA		 Ensembl
TreeGrafter
GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr13:77,321,872...77,863,533
Ensembl chr13:77,321,872...77,863,491 		JBrowse link
G STAG2 STAG2 cohesin complex component part_of IEA
IBA		 UniProt
TreeGrafter
GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:101,476,117...101,617,405
Ensembl chr  X:101,478,247...101,617,563 		JBrowse link
G STAG3 STAG3 cohesin complex component part_of IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr 3:8,175,908...8,211,898
Ensembl chr 3:8,175,915...8,211,889 		JBrowse link
meiotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr  X:46,218,540...46,220,942
Ensembl chr  X:46,218,548...46,220,883 		JBrowse link
G RAD21 RAD21 cohesin complex component part_of IBA GO_Central GO_REF:0000033 NCBI chr 4:21,772,821...21,802,453
Ensembl chr 4:21,772,855...21,802,715 		JBrowse link
G RAD21L1 RAD21 cohesin complex component like 1 part_of ISO (MGI:4942240|PMID:21242291), (MGI:5050018|PMID:21527826), (PMID:22164254) MGI PMID:21242291 PMID:21527826 PMID:22164254 MGI:4942240 MGI:5050018 NCBI chr17:34,035,526...34,064,215 JBrowse link
G REC8 REC8 meiotic recombination protein part_of IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:75,118,743...75,127,759
Ensembl chr 7:75,118,744...75,125,537 		JBrowse link
G SMC1A structural maintenance of chromosomes 1A part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:46,143,738...46,202,187
Ensembl chr  X:46,144,920...46,218,543 		JBrowse link
G SMC1B structural maintenance of chromosomes 1B part_of IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:3,976,098...4,067,148
Ensembl chr 5:3,976,140...4,067,395 		JBrowse link
G SMC3 structural maintenance of chromosomes 3 part_of IEA Ensembl GO_REF:0000107 NCBI chr14:120,969,629...121,008,924
Ensembl chr14:120,969,631...121,021,497 		JBrowse link
G STAG3 STAG3 cohesin complex component part_of IEA Ensembl GO_REF:0000107 NCBI chr 3:8,175,908...8,211,898
Ensembl chr 3:8,175,915...8,211,889 		JBrowse link
mitotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDX11 DEAD/H-box helicase 11 NOT|located_in ISO (PMID:17105772) UniProt PMID:17105772 NCBI chr 5:67,359,399...67,395,739
Ensembl chr 5:67,364,877...67,395,730 		JBrowse link
G RAD21 RAD21 cohesin complex component part_of IEA Ensembl GO_REF:0000107 NCBI chr 4:21,772,821...21,802,453
Ensembl chr 4:21,772,855...21,802,715 		JBrowse link
G SGO2 shugoshin 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr15:104,099,378...104,150,723
Ensembl chr15:104,099,384...104,150,720 		JBrowse link
G SMC1A structural maintenance of chromosomes 1A part_of IEA Ensembl GO_REF:0000107 NCBI chr  X:46,143,738...46,202,187
Ensembl chr  X:46,144,920...46,218,543 		JBrowse link
G SMC3 structural maintenance of chromosomes 3 part_of IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr14:120,969,629...121,008,924
Ensembl chr14:120,969,631...121,021,497 		JBrowse link
G STAG2 STAG2 cohesin complex component part_of IEA Ensembl GO_REF:0000107 NCBI chr  X:101,476,117...101,617,405
Ensembl chr  X:101,478,247...101,617,563 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18491
    protein-containing complex 5894
      cohesin complex 13
        meiotic cohesin complex 8
        mitotic cohesin complex 6
Path 2
Term Annotations click to browse term
  cellular_component 18491
    cellular anatomical entity 18263
      organelle 12233
        non-membrane-bounded organelle 4528
          intracellular non-membrane-bounded organelle 4526
            chromosome 1286
              cohesin complex 13
                meiotic cohesin complex 8
                mitotic cohesin complex 6
paths to the root