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ONTOLOGY REPORT - ANNOTATIONS

Term:cohesin complex
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Accession:GO:0008278 term browser browse the term
Definition:A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
Synonyms:exact_synonym: SMC/kleisin ring complex
 narrow_synonym: 14S cohesin;   9S cohesin;   Smc1-Smc3 complex
 related_synonym: SMC complex;   cohesin core heterodimer;   nuclear cohesin complex
 alt_id: GO:0000798;   GO:0008279;   GO:0008280;   GO:0043222

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cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21 RAD21 cohesin complex component part_of IEA TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624763:15,131,106...15,157,512
Ensembl chrNW_004624763:15,131,005...15,158,155 		JBrowse link
G Rad21l1 RAD21 cohesin complex component like 1 part_of IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624741:2,486,612...2,542,452
Ensembl chrNW_004624741:2,485,471...2,542,500 		JBrowse link
G Rec8 REC8 meiotic recombination protein part_of IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624820:8,361,345...8,369,356
Ensembl chrNW_004624820:8,361,400...8,368,347 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A part_of IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004624909:617,015...668,513
Ensembl chrNW_004624909:630,062...668,512 		JBrowse link
G Smc1b structural maintenance of chromosomes 1B part_of IEA InterPro GO_REF:0000002 NCBI chrNW_004624752:4,255,829...4,320,257
Ensembl chrNW_004624752:4,255,897...4,320,665 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 part_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:35,698,722...35,730,854
Ensembl chrNW_004624737:35,694,566...35,730,829 		JBrowse link
G Stag1 STAG1 cohesin complex component part_of IEA UniProt GO_REF:0000104 NCBI chrNW_004624730:12,762,099...13,158,603
Ensembl chrNW_004624730:12,761,460...13,086,965 		JBrowse link
G Stag2 STAG2 cohesin complex component part_of IEA TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624797:2,659,785...2,794,168
Ensembl chrNW_004624797:2,719,508...2,794,379 		JBrowse link
G Stag3 STAG3 cohesin complex component part_of IEA TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624740:16,706,695...16,734,142
Ensembl chrNW_004624740:16,707,999...16,732,537 		JBrowse link
meiotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21l1 RAD21 cohesin complex component like 1 part_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624741:2,486,612...2,542,452
Ensembl chrNW_004624741:2,485,471...2,542,500 		JBrowse link
G Rec8 REC8 meiotic recombination protein part_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624820:8,361,345...8,369,356
Ensembl chrNW_004624820:8,361,400...8,368,347 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A part_of IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624909:617,015...668,513
Ensembl chrNW_004624909:630,062...668,512 		JBrowse link
G Smc1b structural maintenance of chromosomes 1B part_of IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624752:4,255,829...4,320,257
Ensembl chrNW_004624752:4,255,897...4,320,665 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 part_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:35,698,722...35,730,854
Ensembl chrNW_004624737:35,694,566...35,730,829 		JBrowse link
G Stag3 STAG3 cohesin complex component part_of ISO (MGI:5050018|PMID:21527826), (PMID:17696610), (PMID:22164254)
(PMID:21242291)		 MGI
UniProt		 PMID:17696610 PMID:21242291 PMID:21527826 PMID:22164254 MGI:5050018 NCBI chrNW_004624740:16,706,695...16,734,142
Ensembl chrNW_004624740:16,707,999...16,732,537 		JBrowse link
mitotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx11 DEAD/H-box helicase 11 NOT|located_in ISO (PMID:17105772) UniProt PMID:17105772 NCBI chrNW_004624828:269,444...301,899
Ensembl chrNW_004624828:269,843...302,301 		JBrowse link
G Rad21 RAD21 cohesin complex component part_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624763:15,131,106...15,157,512
Ensembl chrNW_004624763:15,131,005...15,158,155 		JBrowse link
G Sgo2 shugoshin 2 part_of ISO (PMID:18084284) MGI PMID:18084284 NCBI chrNW_004624889:540,680...563,110
Ensembl chrNW_004624889:540,008...559,035 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A part_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624909:617,015...668,513
Ensembl chrNW_004624909:630,062...668,512 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 part_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:35,698,722...35,730,854
Ensembl chrNW_004624737:35,694,566...35,730,829 		JBrowse link
G Stag2 STAG2 cohesin complex component part_of ISO (PMID:23242214) ComplexPortal PMID:23242214 NCBI chrNW_004624797:2,659,785...2,794,168
Ensembl chrNW_004624797:2,719,508...2,794,379 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 15672
    protein-containing complex 5315
      cohesin complex 11
        meiotic cohesin complex 6
        mitotic cohesin complex 6
Path 2
Term Annotations click to browse term
  cellular_component 15672
    cellular anatomical entity 15567
      organelle 11314
        non-membrane-bounded organelle 4226
          intracellular non-membrane-bounded organelle 4224
            chromosome 1193
              cohesin complex 11
                meiotic cohesin complex 6
                mitotic cohesin complex 6
paths to the root