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ONTOLOGY REPORT - ANNOTATIONS

Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction

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acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase involved_in ISO (MGI:5770160|PMID:26989199) UniProt PMID:26989199 MGI:5770160 NCBI chrNW_004624768:16,283,369...16,404,476
Ensembl chrNW_004624768:16,297,464...16,402,624 		JBrowse link
G Acr acrosin involved_in ISO (PMID:2550339), (PMID:37004249) UniProt PMID:2550339 PMID:37004249 NCBI chrNW_004624752:42,847...49,438 JBrowse link
G Adcy3 adenylate cyclase 3 involved_in ISO (MGI:3576427|PMID:15705663) UniProt PMID:15705663 MGI:3576427 NCBI chrNW_004624738:7,163,189...7,249,249
Ensembl chrNW_004624738:7,163,354...7,249,190 		JBrowse link
G Garin1b golgi associated RAB2 interactor 1B involved_in ISO (MGI:6814641|PMID:34714330) UniProt PMID:34714330 MGI:6814641 NCBI chrNW_004624783:7,463,302...7,477,399
Ensembl chrNW_004624783:7,459,939...7,477,360 		JBrowse link
G Glra1 glycine receptor alpha 1 acts_upstream_of_or_within ISO (PMID:11076688) MGI PMID:11076688 NCBI chrNW_004624733:37,153,348...37,238,201
Ensembl chrNW_004624733:37,153,863...37,235,485 		JBrowse link
G Glrb glycine receptor beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11076688) MGI
Ensembl		 PMID:11076688 GO_REF:0000107 NCBI chrNW_004624848:1,301,051...1,383,931
Ensembl chrNW_004624848:1,298,174...1,384,513 		JBrowse link
G Iftap intraflagellar transport associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30521625) TreeGrafter
MGI
Ensembl		 PMID:30521625 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624767:10,604,914...10,678,207
Ensembl chrNW_004624767:10,604,254...10,678,224 		JBrowse link
G Ovch2 ovochymase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624817:9,388,339...9,426,174
Ensembl chrNW_004624817:9,403,209...9,426,135 		JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 acts_upstream_of_or_within ISO (PMID:16371590) MGI PMID:16371590 NCBI chrNW_004624828:7,208,995...7,216,188 JBrowse link
G Plcd4 phospholipase C delta 4 acts_upstream_of_or_within ISO (PMID:11340203) MGI PMID:11340203 NCBI chrNW_004624823:6,418,359...6,446,848
Ensembl chrNW_004624823:6,418,922...6,442,418 		JBrowse link
G Prnd prion like protein doppel involved_in ISO (MGI:3045928|PMID:15161660) UniProt PMID:15161660 MGI:3045928 NCBI chrNW_004624741:5,814,894...5,820,087
Ensembl chrNW_004624741:5,814,931...5,820,072 		JBrowse link
G Spesp1 sperm equatorial segment protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20375058) TreeGrafter
MGI
InterPro		 PMID:20375058 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624781:4,352,305...4,365,716 JBrowse link
G St14 ST14 transmembrane serine protease matriptase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624812:4,584,043...4,620,410
Ensembl chrNW_004624812:4,583,946...4,620,547 		JBrowse link
G Stx2 syntaxin 2 involved_in ISO (MGI:3584221|PMID:15774481) HGNC-UCL PMID:15774481 MGI:3584221 NCBI chrNW_004624747:27,247,947...27,272,698
Ensembl chrNW_004624747:27,249,608...27,272,728 		JBrowse link
G Syt6 synaptotagmin 6 involved_in ISO (MGI:3584221|PMID:15774481) HGNC-UCL PMID:15774481 MGI:3584221 NCBI chrNW_004624772:9,753,485...9,810,815
Ensembl chrNW_004624772:9,753,416...9,810,757 		JBrowse link
G Syt8 synaptotagmin 8 involved_in ISO (MGI:3584221|PMID:15774481) HGNC-UCL PMID:15774481 MGI:3584221 NCBI chrNW_004624767:14,673,307...14,733,984
Ensembl chrNW_004624767:14,731,508...14,733,893 		JBrowse link
G Tnp2 transition protein 2 acts_upstream_of_or_within ISO (PMID:11385107) MGI PMID:11385107 NCBI chrNW_004624824:8,453,667...8,454,987 JBrowse link
G Trim36 tripartite motif containing 36 acts_upstream_of_or_within ISO (PMID:12917430) MGI PMID:12917430 NCBI chrNW_004624733:6,826,652...6,864,768 JBrowse link
acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab3a RAB3A, member RAS oncogene family involved_in ISO (PMID:22248876) UniProt PMID:22248876 NCBI chrNW_004624908:1,532,857...1,537,159
Ensembl chrNW_004624908:1,530,312...1,536,129 		JBrowse link
G Syt6 synaptotagmin 6 involved_in ISO (PMID:11437455) BHF-UCL PMID:11437455 NCBI chrNW_004624772:9,753,485...9,810,815
Ensembl chrNW_004624772:9,753,416...9,810,757 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO (PMID:22248876) UniProt PMID:22248876 NCBI chrNW_004624915:327,633...530,522
Ensembl chrNW_004624915:327,401...531,886 		JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO (PMID:19004505) UniProt PMID:19004505 NCBI chrNW_004624775:12,903,145...12,910,048
Ensembl chrNW_004624775:12,902,697...12,910,149 		JBrowse link
acrosome matrix dispersal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin ISO RGD PMID:28859281 RGD:13464336 NCBI chrNW_004624752:42,847...49,438 JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624730:4,154,862...4,160,635
Ensembl chrNW_004624730:4,151,688...4,160,614 		JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO (PMID:19004505)
(PMID:19246320)		 UniProt PMID:19004505 PMID:19246320 NCBI chrNW_004624740:15,037,818...15,044,207
Ensembl chrNW_004624740:15,037,943...15,044,193 		JBrowse link
positive regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO (PMID:20394732) UniProt PMID:20394732 NCBI chrNW_004624913:1,926,405...1,952,426
Ensembl chrNW_004624913:1,891,156...1,949,633 		JBrowse link
G Ccdc87 coiled-coil domain containing 87 involved_in ISO (MGI:6201938|PMID:29733332) UniProt PMID:29733332 MGI:6201938 NCBI chrNW_004624767:19,815,664...19,818,796
Ensembl chrNW_004624767:19,815,707...19,818,268 		JBrowse link
G Fam170b family with sequence similarity 170 member B involved_in ISO (MGI:5705205|PMID:26179146) UniProt PMID:26179146 MGI:5705205 NCBI chrNW_004624928:821,167...823,610 JBrowse link
G Glra1 glycine receptor alpha 1 involved_in ISO (PMID:11751269) UniProt PMID:11751269 NCBI chrNW_004624733:37,153,348...37,238,201
Ensembl chrNW_004624733:37,153,863...37,235,485 		JBrowse link
G LOC101714413 IQ domain-containing protein F1 involved_in ISO (MGI:5708001|PMID:25380116) UniProt PMID:25380116 MGI:5708001 NCBI chrNW_004624730:5,706,146...5,706,571 JBrowse link
G Pla2g10 phospholipase A2 group X involved_in ISO (MGI:4459353|PMID:20424324) UniProt PMID:20424324 MGI:4459353 NCBI chrNW_004624782:3,871,034...3,887,476
Ensembl chrNW_004624782:3,870,940...3,887,426 		JBrowse link
G Plb1 phospholipase B1 acts_upstream_of_or_within ISO (PMID:23943622) MGI PMID:23943622 NCBI chrNW_004624738:10,454,878...10,580,378
Ensembl chrNW_004624738:10,455,186...10,569,907 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624741:9,030,817...9,859,597
Ensembl chrNW_004624741:9,031,204...9,856,556 		JBrowse link
G Prss37 serine protease 37 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624765:21,838,292...21,844,887
Ensembl chrNW_004624765:21,837,894...21,844,400 		JBrowse link
G Rln2 relaxin 2 involved_in ISO (PMID:16926527) CACAO PMID:16926527 NCBI chrNW_004624736:9,886,285...9,891,887
Ensembl chrNW_004624736:9,886,148...9,891,191 		JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004624740:15,037,818...15,044,207
Ensembl chrNW_004624740:15,037,943...15,044,193 		JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO (PMID:18667750), (PMID:20394732) UniProt PMID:18667750 PMID:20394732 NCBI chrNW_004624775:12,903,145...12,910,048
Ensembl chrNW_004624775:12,902,697...12,910,149 		JBrowse link
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stxbp1 syntaxin binding protein 1 involved_in ISO (PMID:23091057) UniProt PMID:23091057 NCBI chrNW_004624760:7,843,741...7,914,444
Ensembl chrNW_004624760:7,842,640...7,914,484 		JBrowse link
regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4galt1 beta-1,4-galactosyltransferase 1 acts_upstream_of_or_within ISO (PMID:9374408) MGI PMID:9374408 NCBI chrNW_004624736:37,848,431...37,927,291
Ensembl chrNW_004624736:37,848,117...37,927,980 		JBrowse link
G Hvcn1 hydrogen voltage gated channel 1 involved_in ISO (PMID:30478045) UniProt PMID:30478045 NCBI chrNW_004624747:21,237,736...21,266,531
Ensembl chrNW_004624747:21,256,918...21,264,984 		JBrowse link
G Pkdrej polycystin family receptor for egg jelly acts_upstream_of_or_within ISO (PMID:18562295) MGI PMID:18562295 NCBI chrNW_004624752:3,630,908...3,632,330 JBrowse link
G Serpina10 serpin family A member 10 NOT|involved_in ISO (PMID:11751269) UniProt PMID:11751269 NCBI chrNW_004624734:10,619,044...10,630,963
Ensembl chrNW_004624734:10,620,620...10,631,306 		JBrowse link
G Spink1 serine peptidase inhibitor Kazal type 1 acts_upstream_of_or_within ISO (PMID:22228629) MGI PMID:22228629 NCBI chrNW_004624774:7,281,298...7,287,735
Ensembl chrNW_004624774:7,281,227...7,287,791 		JBrowse link
G Zp2 zona pellucida glycoprotein 2 NOT|involved_in ISO (PMID:11751269), (PMID:20394732) UniProt PMID:11751269 PMID:20394732 NCBI chrNW_004624782:7,275,156...7,287,480
Ensembl chrNW_004624782:7,275,207...7,287,114 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15052
    reproductive process 1555
      acrosome reaction 39
        acrosomal vesicle exocytosis + 7
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 0
        positive regulation of acrosome reaction 12
        protein localization involved in acrosome reaction 0
        regulation of acrosome reaction + 18
Path 2
Term Annotations click to browse term
  biological_process 15052
    reproductive process 1555
      sexual reproduction 987
        fertilization 180
          single fertilization 138
            acrosome reaction 39
              acrosomal vesicle exocytosis + 7
              acrosome matrix dispersal 1
              membrane fusion involved in acrosome reaction 0
              negative regulation of acrosome reaction 0
              positive regulation of acrosome reaction 12
              protein localization involved in acrosome reaction 0
              regulation of acrosome reaction + 18
paths to the root