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ONTOLOGY REPORT - ANNOTATIONS

Term:7-methylguanosine mRNA capping
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Accession:GO:0006370 term browser browse the term
Definition:The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively.
Synonyms:exact_synonym: 5' mRNA capping;   5'-end mRNA processing;   mRNA capping
 broad_synonym: 5' end capping;   5'-end processing

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7-methylguanosine mRNA capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmtr1 cap methyltransferase 1 involved_in ISO (PMID:21310715)
(PMID:20713356)		 UniProt PMID:20713356 PMID:21310715 NCBI chrNW_004955437:5,721,420...5,766,316
Ensembl chrNW_004955437:5,722,352...5,765,730 		JBrowse link
G Cmtr2 cap methyltransferase 2 involved_in ISO (PMID:21310715) UniProt PMID:21310715 NCBI chrNW_004955484:3,999,655...4,006,632
Ensembl chrNW_004955484:3,999,665...4,006,632 		JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 involved_in ISO (PMID:12434151) UniProt PMID:12434151 NCBI chrNW_004955419:27,778,300...27,819,878
Ensembl chrNW_004955419:27,778,300...27,819,878 		JBrowse link
G Ramac RNA guanine-7 methyltransferase activating subunit involved_in ISO (PMID:22099306) UniProt PMID:22099306 NCBI chrNW_004955416:13,686,997...13,691,792 JBrowse link
G Rngtt RNA guanylyltransferase and 5'-phosphatase involved_in ISO (PMID:9473487) UniProt PMID:9473487 NCBI chrNW_004955411:15,486,532...15,766,880
Ensembl chrNW_004955411:15,486,303...15,766,864 		JBrowse link
G Rnmt RNA guanine-7 methyltransferase involved_in ISO (PMID:27422871)
(PMID:9790902)		 UniProt PMID:9790902 PMID:27422871 NCBI chrNW_004955402:319,520...344,129 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    metabolic process 7488
      primary metabolic process 6455
        RNA processing 583
          mRNA processing 280
            7-methylguanosine mRNA capping 6
Path 2
Term Annotations click to browse term
  biological_process 12362
    metabolic process 7488
      primary metabolic process 6455
        nucleobase-containing compound metabolic process 3737
          nucleic acid metabolic process 3370
            nucleic acid biosynthetic process 2838
              RNA biosynthetic process 2744
                RNA processing 583
                  RNA 5'-end processing 22
                    RNA capping 7
                      7-methylguanosine RNA capping 6
                        7-methylguanosine mRNA capping 6
paths to the root