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ONTOLOGY REPORT - ANNOTATIONS

Term:calcium:sodium antiporter activity
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Accession:GO:0005432 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
Synonyms:exact_synonym: sodium/calcium exchanger
 related_synonym: mitochondrial sodium/calcium ion exchange;   sodium:calcium exchange
 xref: RHEA:29255;   reactome:R-HSA-425661 "SLC8A1,2,3 exchange 3Na+ for Ca2+";   reactome:R-HSA-8949688 "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)";   reactome:R-HSA-8949703 "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)"


show annotations for term's descendants           Sort by:
calcium:sodium antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc24a4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 enables ISA (PMID:12379639) MGI PMID:12379639 NCBI chr12:102,094,986...102,239,562
Ensembl chr12:102,094,992...102,233,350 		JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 enables IMP
IBA
TAS
ISO		 (MGI:1927695|PMID:10967099)
(PMID:15336980)		 BHF-UCL
GO_Central
MGI
RGD		 PMID:7642578 PMID:10967099 PMID:11342562 PMID:15336980 PMID:15774479 More... GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:1927695 MGI:4417868 MGI:4834177 RGD:1581354 RGD:7175087 RGD:7175092 RGD:7241256 RGD:730112 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 enables ISO
IBA
IMP		 (MGI:2664655|PMID:12818181) MGI
GO_Central
RGD
UniProt		 PMID:9486131 PMID:12818181 PMID:17343909 GO_REF:0000033 GO_REF:0000096 MGI:2664655 MGI:4417868 RGD:2316984 RGD:7241257 NCBI chr 7:15,861,540...15,894,988
Ensembl chr 7:15,863,751...15,894,988 		JBrowse link
G Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 enables IMP
IBA
ISO		 (MGI:3027331|PMID:14722618), (MGI:5013898|PMID:21593315) UniProt
GO_Central
RGD
MGI		 PMID:8798769 PMID:14722618 PMID:17343909 PMID:21593315 GO_REF:0000033 GO_REF:0000096 MGI:3027331 MGI:4417868 MGI:5013898 RGD:7241257 RGD:730187 NCBI chr12:81,244,686...81,380,506
Ensembl chr12:81,244,689...81,379,954 		JBrowse link
G Slc8b1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 enables IMP
IBA
IDA
ISO		 (MGI:5902863|PMID:28445457)
(MGI:4420691|PMID:20018762), (PMID:14625281)		 UniProt
GO_Central
MGI		 PMID:14625281 PMID:20018762 PMID:28445457 GO_REF:0000033 GO_REF:0000119 MGI:4420691 MGI:4834177 MGI:5902863 NCBI chr 5:120,649,233...120,672,089
Ensembl chr 5:120,649,233...120,672,089 		JBrowse link
calcium, potassium:sodium antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc24a1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:64,830,143...64,858,902
Ensembl chr 9:64,830,143...64,858,889 		JBrowse link
G Slc24a2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 enables ISO
IBA		 (PMID:18166528) MGI
RGD
GO_Central		 PMID:11342562 PMID:12377762 PMID:18166528 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:7175087 RGD:730066 NCBI chr 4:86,901,361...87,148,780
Ensembl chr 4:86,901,361...87,148,714 		JBrowse link
G Slc24a3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 enables ISO
IDA
ISS
IBA		 (PMID:11294880) MGI
GO_Central
RGD		 PMID:11294880 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:68852 NCBI chr 2:145,009,695...145,484,086
Ensembl chr 2:145,009,674...145,484,086 		JBrowse link
G Slc24a4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 enables IDA
IBA
ISA
ISO		 (MGI:6718234|PMID:27093457)
(PMID:12379639)		 ARUK-UCL
GO_Central
MGI		 PMID:12379639 PMID:27093457 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6718234 NCBI chr12:102,094,986...102,239,562
Ensembl chr12:102,094,992...102,233,350 		JBrowse link
G Slc24a5 solute carrier family 24, member 5 enables ISO
IBA		 (PMID:18166528) MGI
GO_Central		 PMID:18166528 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:124,910,076...124,930,316
Ensembl chr 2:124,910,044...124,930,597 		JBrowse link
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 enables TAS (MGI:4359299|PMID:19683723) BHF-UCL PMID:19683723 MGI:4359299 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Slc8b1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 enables IMP
IC		 (MGI:5902676|PMID:24067497), (MGI:5902863|PMID:28445457)
(MGI:4420691|PMID:20018762)		 UniProt
BHF-UCL		 PMID:20018762 PMID:24067497 PMID:28445457 MGI:4420691 MGI:5902676 MGI:5902863 NCBI chr 5:120,649,233...120,672,089
Ensembl chr 5:120,649,233...120,672,089 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        inorganic molecular entity transmembrane transporter activity 684
          inorganic cation transmembrane transporter activity 562
            metal ion transmembrane transporter activity 444
              sodium ion transmembrane transporter activity 160
                calcium:sodium antiporter activity 9
                  calcium, potassium:sodium antiporter activity 5
                  calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential 2
Path 2
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        active transmembrane transporter activity 442
          secondary active transmembrane transporter activity 296
            antiporter activity 130
              metal cation:monoatomic cation antiporter activity 40
                calcium:monoatomic cation antiporter activity 12
                  calcium:sodium antiporter activity 9
                    calcium, potassium:sodium antiporter activity 5
                    calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential 2
paths to the root