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ONTOLOGY REPORT - ANNOTATIONS

Term:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
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Accession:GO:0004571 term browser browse the term
Definition:Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.
Synonyms:narrow_synonym: ManI activity;   mannose-9 processing alpha-mannosidase activity;   mannosidase 1A activity;   mannosidase 1B activity
 related_synonym: 1,2-alpha-mannosidase;   1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity;   exo-alpha-1,2-mannanase activity;   glycoprotein processing mannosidase I;   man9-mannosidase activity;   mannosidase I
 xref: EC:3.2.1.113;   KEGG_REACTION:R12479;   Reactome:R-HSA-4793949 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)";   Reactome:R-HSA-9036008 "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)";   Reactome:R-HSA-9036011 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)";   Reactome:R-HSA-9036012 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)";   Reactome:R-HSA-9696807 "N-glycan mannose trimming of Spike";   reactome:R-HSA-6782685 "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5";   reactome:R-HSA-901024 "MAN1B1 hydrolyses 1,2-linked mannose (a branch)";   reactome:R-HSA-901036 "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)";   reactome:R-HSA-901039 "MAN1B1 hydrolyses 1,2-linked mannose (c branch)";   reactome:R-HSA-901074 "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)";   reactome:R-HSA-964737 "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2";   reactome:R-HSA-964825 "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2";   reactome:R-HSA-964830 "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2"


show annotations for term's descendants           Sort by:
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARL8B ADP ribosylation factor like GTPase 8B enables IEA InterPro GO_REF:0000002 NCBI chr13:61,640,619...61,696,819
Ensembl chr13:61,640,671...61,698,374 		JBrowse link
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 NOT|enables ISO
IEA		 (PMID:12610306) UniProt
Ensembl
InterPro		 PMID:12610306 GO_REF:0000002 GO_REF:0000107 NCBI chr13:61,703,601...61,732,231
Ensembl chr13:61,703,621...61,732,119 		JBrowse link
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 NOT|enables ISO
IEA		 (PMID:15537790) UniProt
Ensembl
InterPro		 PMID:15537790 GO_REF:0000002 GO_REF:0000107 NCBI chr17:38,483,190...38,515,243
Ensembl chr17:38,480,044...38,515,227 		JBrowse link
G EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 enables IEA
IBA		 InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:125,908,861...125,983,073
Ensembl chr 9:125,908,864...125,983,029 		JBrowse link
G LOC110258087 endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033
G MAN1A1 mannosidase alpha class 1A member 1 enables IEA
IBA		 InterPro
UniProt
Ensembl
GO_Central
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 1:42,729,722...42,896,290
Ensembl chr 1:42,729,722...42,896,283 		JBrowse link
G MAN1A2 mannosidase alpha class 1A member 2 enables IEA InterPro GO_REF:0000002 NCBI chr 4:103,214,929...103,377,132
Ensembl chr 4:103,214,939...103,376,673 		JBrowse link
G MAN1B1 mannosidase alpha class 1B member 1 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033
G MAN1C1 mannosidase alpha class 1C member 1 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:83,089,942...83,228,648
Ensembl chr 6:83,089,072...83,228,008 		JBrowse link
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Term Annotations click to browse term
  molecular_function 18629
    catalytic activity 5574
      hydrolase activity 2359
        hydrolase activity, acting on glycosyl bonds 128
          hydrolase activity, hydrolyzing O-glycosyl compounds 101
            mannosidase activity 17
              alpha-mannosidase activity 16
                mannosyl-oligosaccharide mannosidase activity 10
                  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity 9
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