EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2) - Rat Genome Database

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Gene: EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2) Sus scrofa
Analyze
Symbol: EDEM2
Name: ER degradation enhancing alpha-mannosidase like protein 2
RGD ID: 13972671
Description: ENCODES a protein that exhibits mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (ortholog); INVOLVED IN carbohydrate metabolic process (inferred); ERAD pathway (inferred); mannoprotein catabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); long QT syndrome (ortholog); maturity-onset diabetes of the young (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ER degradation-enhancing alpha-mannosidase-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,480,044 - 38,515,227 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11738,483,190 - 38,515,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,680,501 - 43,712,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EDEM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,480,044 - 38,515,227 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11738,483,190 - 38,515,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,680,501 - 43,712,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDEM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382035,115,364 - 35,147,336 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2035,115,364 - 35,147,336 (-)EnsemblGRCh38hg38GRCh38
GRCh372033,703,167 - 33,735,139 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362033,166,831 - 33,198,804 (-)NCBINCBI36Build 36hg18NCBI36
Build 342033,166,830 - 33,198,804NCBI
Celera2030,452,013 - 30,484,015 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,481,484 - 30,513,486 (-)NCBIHuRef
CHM1_12033,603,981 - 33,636,229 (-)NCBICHM1_1
T2T-CHM13v2.02036,836,129 - 36,868,105 (-)NCBIT2T-CHM13v2.0
Edem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,543,593 - 155,571,395 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,543,597 - 155,571,395 (-)EnsemblGRCm39 Ensembl
GRCm382155,701,673 - 155,729,475 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,701,677 - 155,729,475 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,527,409 - 155,555,211 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,393,468 - 155,420,827 (-)NCBIMGSCv36mm8
Celera2161,634,017 - 161,661,816 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
Edem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,661,741 - 164,687,559 (-)NCBIGRCr8
mRatBN7.23144,201,604 - 144,227,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,201,605 - 144,227,485 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3148,067,877 - 148,093,692 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,685,165 - 156,710,982 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,424,668 - 154,450,485 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,232,741 - 151,258,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,232,751 - 151,258,580 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,597,580 - 157,623,398 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,215,243 - 146,241,062 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13146,120,865 - 146,146,684 (-)NCBI
Celera3142,925,873 - 142,951,681 (-)NCBICelera
Cytogenetic Map3q42NCBI
Edem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,242,986 - 26,273,297 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,243,034 - 26,271,849 (+)NCBIChiLan1.0ChiLan1.0
EDEM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,847,884 - 40,879,826 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,840,988 - 40,872,861 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,443,590 - 31,475,430 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,567,799 - 32,598,998 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,567,799 - 32,598,998 (-)Ensemblpanpan1.1panPan2
EDEM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12424,137,228 - 24,165,995 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2424,137,228 - 24,165,968 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,783,395 - 23,812,161 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02424,829,442 - 24,858,209 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,829,443 - 24,858,192 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12424,116,522 - 24,145,265 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,211,487 - 24,240,251 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,650,576 - 24,679,330 (-)NCBIUU_Cfam_GSD_1.0
LOC101973161
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640173,144,037 - 173,171,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,578,236 - 5,605,810 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,578,267 - 5,605,512 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDEM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1239,417,994 - 39,452,398 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl239,417,590 - 39,452,497 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605087,359,738 - 87,392,953 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248424,259,605 - 4,292,518 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248424,259,551 - 4,288,181 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EDEM2
742 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 10 2 3 3
Low 2 2 13
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007977   ⟹   ENSSSCP00000007764
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1738,483,197 - 38,515,222 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000048248   ⟹   ENSSSCP00000038158
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1738,480,044 - 38,515,224 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000070163   ⟹   ENSSSCP00000064253
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1738,480,038 - 38,515,227 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000074936   ⟹   ENSSSCP00000067886
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1738,480,044 - 38,515,227 (-)Ensembl
RefSeq Acc Id: XM_003359958   ⟹   XP_003360006
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11738,483,190 - 38,515,243 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003360006   ⟸   XM_003359958
- UniProtKB: A0A480QI21 (UniProtKB/TrEMBL),   A0A480JUK1 (UniProtKB/TrEMBL),   A0A8D1AUC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000067886   ⟸   ENSSSCT00000074936
RefSeq Acc Id: ENSSSCP00000064253   ⟸   ENSSSCT00000070163
RefSeq Acc Id: ENSSSCP00000007764   ⟸   ENSSSCT00000007977
RefSeq Acc Id: ENSSSCP00000038158   ⟸   ENSSSCT00000048248


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007291 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005002243 UniProtKB/TrEMBL
  ENSSSCG00015078135 UniProtKB/TrEMBL
  ENSSSCG00030024324 UniProtKB/TrEMBL
  ENSSSCG00035065042 UniProtKB/TrEMBL
  ENSSSCG00040057485 UniProtKB/TrEMBL
  ENSSSCG00045010716 UniProtKB/TrEMBL
  ENSSSCG00050035793 UniProtKB/TrEMBL
  ENSSSCG00055019692 UniProtKB/TrEMBL
  ENSSSCG00060075588 UniProtKB/TrEMBL
  ENSSSCG00065050711 UniProtKB/TrEMBL
  ENSSSCG00070007186 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007977.5 UniProtKB/TrEMBL
  ENSSSCT00000048248.3 UniProtKB/TrEMBL
  ENSSSCT00000074936 ENTREZGENE
  ENSSSCT00000074936.2 UniProtKB/TrEMBL
  ENSSSCT00005003344.1 UniProtKB/TrEMBL
  ENSSSCT00005003348.1 UniProtKB/TrEMBL
  ENSSSCT00015105669.1 UniProtKB/TrEMBL
  ENSSSCT00015105726.1 UniProtKB/TrEMBL
  ENSSSCT00015105795.1 UniProtKB/TrEMBL
  ENSSSCT00030033861.1 UniProtKB/TrEMBL
  ENSSSCT00035087589.1 UniProtKB/TrEMBL
  ENSSSCT00035087601.1 UniProtKB/TrEMBL
  ENSSSCT00035087630.1 UniProtKB/TrEMBL
  ENSSSCT00035087680.1 UniProtKB/TrEMBL
  ENSSSCT00040077929.1 UniProtKB/TrEMBL
  ENSSSCT00040078049.1 UniProtKB/TrEMBL
  ENSSSCT00040078131.1 UniProtKB/TrEMBL
  ENSSSCT00040078277.1 UniProtKB/TrEMBL
  ENSSSCT00045018226.1 UniProtKB/TrEMBL
  ENSSSCT00050048098.1 UniProtKB/TrEMBL
  ENSSSCT00050048108.1 UniProtKB/TrEMBL
  ENSSSCT00050048114.1 UniProtKB/TrEMBL
  ENSSSCT00055038590.1 UniProtKB/TrEMBL
  ENSSSCT00060103486.1 UniProtKB/TrEMBL
  ENSSSCT00060103535.1 UniProtKB/TrEMBL
  ENSSSCT00065069445.1 UniProtKB/TrEMBL
  ENSSSCT00065069448.1 UniProtKB/TrEMBL
  ENSSSCT00065069459.1 UniProtKB/TrEMBL
  ENSSSCT00065069464.1 UniProtKB/TrEMBL
  ENSSSCT00070013826.1 UniProtKB/TrEMBL
  ENSSSCT00070013844.1 UniProtKB/TrEMBL
  ENSSSCT00070013861.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
InterPro 6hp_glycosidase-like_sf UniProtKB/TrEMBL
  EDEM1/2/3 UniProtKB/TrEMBL
  Glyco_hydro_47 UniProtKB/TrEMBL
  Seven-hairpin_glycosidases UniProtKB/TrEMBL
KEGG Report ssc:100621927 UniProtKB/TrEMBL
NCBI Gene EDEM2 ENTREZGENE
PANTHER ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 UniProtKB/TrEMBL
  PTHR45679 UniProtKB/TrEMBL
Pfam Glyco_hydro_47 UniProtKB/TrEMBL
PRINTS GLYHDRLASE47 UniProtKB/TrEMBL
Superfamily-SCOP SSF48225 UniProtKB/TrEMBL
UniProt A0A287A2J0_PIG UniProtKB/TrEMBL
  A0A480JUK1 ENTREZGENE, UniProtKB/TrEMBL
  A0A480QI21 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T8R3_PIG UniProtKB/TrEMBL
  A0A4X1T8S3_PIG UniProtKB/TrEMBL
  A0A4X1T9B1_PIG UniProtKB/TrEMBL
  A0A8D0I0I1_PIG UniProtKB/TrEMBL
  A0A8D0Q756_PIG UniProtKB/TrEMBL
  A0A8D1AUC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1Z5G0_PIG UniProtKB/TrEMBL
  F1S4X4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:95687 ENTREZGENE