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ONTOLOGY REPORT - ANNOTATIONS

Term:calcium-dependent cysteine-type endopeptidase activity
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Accession:GO:0004198 term browser browse the term
Definition:Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
Synonyms:narrow_synonym: calpain activity
 xref: Reactome:R-HSA-9855106 "Calpain2 (m-Calpain) cleaves TLN1 (Talin-1)";   Reactome:R-HSA-9861485 "Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)";   reactome:R-HSA-8848658 "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins";   reactome:R-HSA-8863012 "Calpain cleaves p35 to p25"

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calcium-dependent cysteine-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgb androglobin enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624785:11,338,341...11,470,748
Ensembl chrNW_004624785:11,338,069...11,470,955 		JBrowse link
G Capn1 calpain 1 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:11893336 PMID:17429681 GO_REF:0000002 GO_REF:0000118 RGD:1626249 RGD:70442 NCBI chrNW_004624767:21,146,310...21,169,593
Ensembl chrNW_004624767:21,146,999...21,169,957 		JBrowse link
G Capn10 calpain 10 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:16790502 GO_REF:0000002 GO_REF:0000118 RGD:1625051 NCBI chrNW_004624847:4,911,052...4,922,549
Ensembl chrNW_004624847:4,911,737...4,922,192 		JBrowse link
G Capn11 calpain 11 enables IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624754:15,673,042...15,682,891 JBrowse link
G Capn12 calpain 12 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624794:12,114,392...12,125,633
Ensembl chrNW_004624794:12,113,970...12,124,499 		JBrowse link
G Capn13 calpain 13 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624738:12,548,357...12,655,347
Ensembl chrNW_004624738:12,583,329...12,638,646 		JBrowse link
G Capn14 calpain 14 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624738:12,975,145...13,033,344
Ensembl chrNW_004624738:12,978,086...13,006,327 		JBrowse link
G Capn15 calpain 15 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624913:1,343,471...1,367,998
Ensembl chrNW_004624913:1,356,143...1,366,817 		JBrowse link
G Capn3 calpain 3 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:11904300 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:1600775 NCBI chrNW_004624804:9,473,075...9,512,643
Ensembl chrNW_004624804:9,473,117...9,512,353 		JBrowse link
G Capn5 calpain 5 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624863:148,941...202,853
Ensembl chrNW_004624863:148,889...202,952 		JBrowse link
G Capn6 calpain 6 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624803:4,339,368...4,373,400
Ensembl chrNW_004624803:4,339,368...4,373,298 		JBrowse link
G Capn7 calpain 7 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624822:4,896,055...4,947,514 JBrowse link
G Capn8 calpain 8 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624835:5,665,473...5,697,975 JBrowse link
G Capn9 calpain 9 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624775:18,792,599...18,827,082
Ensembl chrNW_004624775:18,790,527...18,826,830 		JBrowse link
G Capns1 calpain small subunit 1 enables
contributes_to		 ISO (PMID:17646163)
(PMID:10825211)
(PMID:15640140)		 MGI
CAFA
RGD		 PMID:7982961 PMID:10825211 PMID:15640140 PMID:17646163 RGD:634695 NCBI chrNW_004624794:10,382,157...10,390,768 JBrowse link
G Capns2 calpain small subunit 2 enables ISO (PMID:17646163) MGI PMID:17646163 NCBI chrNW_004624757:1,395,102...1,396,406 JBrowse link
G LOC101710929 calpain-7-like enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624852:5,724,776...5,727,417 JBrowse link
G LOC101720177 calpain-2 catalytic subunit enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624835:5,713,119...5,742,419
Ensembl chrNW_004624835:5,713,071...5,743,056 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18442
    catalytic activity 5600
      hydrolase activity 2331
        peptidase activity 609
          endopeptidase activity 397
            cysteine-type endopeptidase activity 69
              calcium-dependent cysteine-type endopeptidase activity 18
paths to the root