Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:cysteine-type endopeptidase activity
go back to main search page
Accession:GO:0004197 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Synonyms:exact_synonym: thiol endopeptidase activity
 narrow_synonym: caspase activity;   lysosomal cysteine-type endopeptidase;   metacaspase activity
 xref: EC:3.4.22;   Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8";   Reactome:R-HSA-9647632 "CASP3 cleaves GSDME";   Reactome:R-HSA-9647680 "CASP1 cleaves GSDMD";   Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins";   Reactome:R-HSA-9684273 "3CLp cleaves pp1a";   Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11";   Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4";   Reactome:R-HSA-9684336 "nsp1-4 cleaves itself";   Reactome:R-HSA-9684340 "3CLp cleaves pp1ab";   Reactome:R-HSA-9684351 "pp1a cleaves itself";   Reactome:R-HSA-9684352 "nsp3-4 cleaves itself";   Reactome:R-HSA-9686088 "CASP3 cleaves GSDMD";   Reactome:R-HSA-9686930 "RIPK3 is cleaved by CASP8";   Reactome:R-HSA-9693929 "RIPK1 variant is not cleaved by CASP8";   Reactome:R-HSA-9694338 "nsp1-4 cleaves itself";   Reactome:R-HSA-9694377 "pp1a cleaves itself";   Reactome:R-HSA-9694441 "3CLp cleaves pp1a";   Reactome:R-HSA-9694551 "3CLp cleaves nsp6-11";   Reactome:R-HSA-9694601 "nsp3-4 cleaves itself";   Reactome:R-HSA-9694625 "nsp3 cleaves nsp1-4";   Reactome:R-HSA-9694732 "3CLp cleaves pp1ab";   Reactome:R-HSA-9697750 "RIPK1 is cleaved by CASP8:FLIP(L)";   Reactome:R-HSA-9710101 "CASP4, CASP5 cleave GSDMD";   Reactome:R-HSA-9729704 "SARS-CoV-2 3CLpro dimer cleaves TAB1";   Reactome:R-HSA-9729730 "SARS-CoV-2 nsp3 cleaves IRF3";   Reactome:R-HSA-9729741 "SARS-CoV-2 3CLpro dimer cleaves NLRP12";   reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome";   reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9";   reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome";   reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle";   reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage";   reactome:R-HSA-139952 "Caspase-8 processing in the DISC";   reactome:R-HSA-1678920 "TLR processing at low pH";   reactome:R-HSA-1678981 "TLR9 processing at neutral pH";   reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1";   reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta";   reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin";   reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1";   reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin";   reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)";   reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau";   reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus";   reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3";   reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1";   reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin";   reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1";   reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2";   reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha";   reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3";   reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3";   reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1";   reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin";   reactome:R-HSA-202947 "Caspase mediated cleavage of APC";   reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1";   reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55";   reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin";   reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin";   reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3";   reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)";   reactome:R-HSA-211651 "Cleavage of PAK-2 at 212";   reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta";   reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22";   reactome:R-HSA-2130349 "Generation of CLIP from lip10";   reactome:R-HSA-2130504 "Cleavage of lip22 to lip10";   reactome:R-HSA-2130706 "MHC class II antigen processing";   reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex";   reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A";   reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1";   reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC";   reactome:R-HSA-350158 "LGMN degrades GC";   reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)";   reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)";   reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK";   reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk";   reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2";   reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin";   reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2";   reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31";   reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3";   reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1";   reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin";   reactome:R-HSA-352268 "Cleavage of Satb1";   reactome:R-HSA-418845 "Activation of caspase-3";   reactome:R-HSA-418846 "Caspase cleavage of UNC5A";   reactome:R-HSA-418852 "Caspase cleavage of UNC5B";   reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1";   reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases";   reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor";   reactome:R-HSA-5681987 "LC3 is cleaved by ATG4";   reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4";   reactome:R-HSA-6814387 "CASP14 cleaves filaggrin";   reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37";   reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex";   reactome:R-HSA-933532 "Processing of caspases";   reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3"


show annotations for term's descendants           Sort by:
cysteine-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07040864.1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Atg4a autophagy related 4A, cysteine peptidase enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:104,665,345...104,765,271
Ensembl chr  X:104,665,345...104,765,268 		JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase enables ISO
IBA
IEA 		(PMID:21177865)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:21177865 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103 		JBrowse link
G Atg4c autophagy related 4C, cysteine peptidase enables ISO
IEA
IBA 		(PMID:21177865)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:21177865 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:113,867,218...113,935,534
Ensembl chr 5:113,867,092...113,934,830 		JBrowse link
G Atg4d autophagy related 4D, cysteine peptidase enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:19,807,733...19,817,321
Ensembl chr 8:19,807,766...19,817,321 		JBrowse link
G Blmh bleomycin hydrolase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212 		JBrowse link
G Capn7 calpain 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:6,545,630...6,581,908
Ensembl chr16:6,545,731...6,581,905 		JBrowse link
G Casp1 caspase 1 enables ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000002
(PMID:18667412), (PMID:21147462), (PMID:23395675), (PMID:32109412), (PMID:35705808)
UniProtKB:P10749|UniProtKB:Q9NPP4 (PMID:11821383), (PMID:15030775), (PMID:15326478), (PMID:1574116), (PMID:15882992), (PMID:16920334), (PMID:22464733), (PMID:2787508), (PMID:32109412), (PMID:32553275), (PMID:9334240) 		UniProt
InterPro
RGD		 PMID:1574116 PMID:2787508 PMID:9334240 PMID:11821383 PMID:15030775 More... GO_REF:0000002 GO_REF:0000024 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 enables
NOT|enables 		IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000033
GO_REF:0000002
(PMID:12097332) 		Ensembl
GO_Central
InterPro
RGD		 PMID:12097332 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp14 caspase 14 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405 		JBrowse link
G Casp16 caspase 16 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:12,586,009...12,592,023
Ensembl chr10:12,586,729...12,589,053
Ensembl chr10:12,586,729...12,589,053 		JBrowse link
G Casp2 caspase 2 enables ISO
IEA
IBA 		(PMID:10980123), (PMID:21726810), (PMID:9044836)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:16183742) 		RGD
Ensembl
InterPro
GO_Central		 PMID:9044836 PMID:10980123 PMID:16183742 PMID:21726810 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 enables ISO
IEA
IBA
ISS 		(PMID:10921886), (PMID:16374543), (PMID:16920334), (PMID:17559062), (PMID:17823127), (PMID:18723680), (PMID:19240112), (PMID:20566630), (PMID:21726810), (PMID:21980415), (PMID:22253444), (PMID:23650375), (PMID:23729654), (PMID:24904167), (PMID:28459430), (PMID:30878284), (PMID:33725486), (PMID:33852854), (PMID:35594856), (PMID:36002459), (PMID:37327784), (PMID:9334240)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:12124386), (PMID:14657025), (PMID:15456877), (PMID:16183742), (PMID:19759058), (PMID:24378336), (PMID:25231987), (PMID:37327784)
GO_REF:0000024 		RGD
Ensembl
InterPro
GO_Central
UniProt		 PMID:9334240 PMID:10921886 PMID:12124386 PMID:14657025 PMID:15456877 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 enables ISO
IEA 		(PMID:16920334), (PMID:26375003), (PMID:32109412), (PMID:34671164), (PMID:37993712), (PMID:37993714)
GO_REF:0000002
(PMID:30135078), (PMID:30392956), (PMID:32109412), (PMID:34671164) 		RGD
InterPro		 PMID:16920334 PMID:26375003 PMID:30135078 PMID:30392956 PMID:32109412 More... GO_REF:0000002 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 enables ISS
IEA
IBA
ISO 		GO_REF:0000024
GO_REF:0000002
GO_REF:0000033
GO_REF:0000107
(PMID:19133298), (PMID:22253444), (PMID:22858542), (PMID:24904167), (PMID:27032039), (PMID:27911442), (PMID:32029622) 		UniProt
InterPro
GO_Central
Ensembl
RGD		 PMID:19133298 PMID:22253444 PMID:22858542 PMID:24904167 PMID:27032039 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 enables ISO
IEA
IBA 		(PMID:11257230), (PMID:16123041), (PMID:16352606), (PMID:16374543), (PMID:16916640), (PMID:17646170), (PMID:18723680), (PMID:19581639), (PMID:19617626), (PMID:20566630), (PMID:21157428), (PMID:22184066), (PMID:22253444), (PMID:22451931), (PMID:22464733), (PMID:23650375), (PMID:23897474), (PMID:24904167), (PMID:27032039), (PMID:27889207), (PMID:28863261), (PMID:31586028), (PMID:37327784)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:16183742), (PMID:19759058), (PMID:25231987), (PMID:35705808), (PMID:37327784) 		RGD
Ensembl
InterPro
GO_Central		 PMID:11257230 PMID:16123041 PMID:16183742 PMID:16352606 PMID:16374543 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 enables IDA
IEA
IBA
ISO
ISS 		GO_REF:0000107
GO_REF:0000002
GO_REF:0000117
GO_REF:0000033
MGI:1336166 (PMID:12065591), (PMID:15456877), (PMID:16183742), (PMID:21368763), (PMID:30361383), (PMID:31511692), (PMID:31748744), (PMID:31827281)
GO_REF:0000024
(PMID:11717445), (PMID:16916640), (PMID:16920334), (PMID:19240112), (PMID:21737330), (PMID:21980415), (PMID:31827280), (PMID:32929201), (PMID:33852854), (PMID:34012073), (PMID:35594856) 		Ensembl
InterPro
UniProt
GO_Central
RGD		 PMID:11717445 PMID:12065591 PMID:15456877 PMID:16183742 PMID:16916640 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:4143200 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 enables ISO
IEA
IBA 		(PMID:16183742)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
(PMID:16352606), (PMID:16916640), (PMID:16920334), (PMID:21980415), (PMID:27889207) 		RGD
InterPro
Ensembl
GO_Central		 PMID:16183742 PMID:16352606 PMID:16916640 PMID:16920334 PMID:21980415 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Casp9_v1 caspase-9-carboxyl-terminal divergent enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002
GO_REF:0000107 		GO_Central
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
G Cflar CASP8 and FADD-like apoptosis regulator enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cts7 cathepsin 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,388,299...3,424,664
Ensembl chr17:3,388,299...3,393,439 		JBrowse link
G Cts7l1 cathepsin 7 like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,306,668...3,311,964
Ensembl chr17:3,307,748...3,311,679 		JBrowse link
G Cts7l2 cathepsin 7 like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,903,602...3,907,088
Ensembl chr17:3,903,602...3,906,568 		JBrowse link
G Cts8 cathepsin 8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,468,710...3,480,881
Ensembl chr17:3,468,710...3,480,881 		JBrowse link
G Cts8l1 cathepsin 8-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,445,043...3,452,682
Ensembl chr17:3,445,043...3,452,682 		JBrowse link
G Ctsb cathepsin B enables IDA
IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:30487519)
(PMID:22952693), (PMID:6203523)
PMID:12788072
GO_REF:0000003 		Ensembl
InterPro
GO_Central
RGD
UniProt		 PMID:6203523 PMID:22952693 PMID:30487519 PMID:16960372 PMID:12788072 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107, RGD:2315574, RGD:12793045 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsc cathepsin C enables NAS
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:11788364 GO_REF:0000033, RGD:631244 NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Ctsf cathepsin F enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:202,152,777...202,158,525
Ensembl chr 1:202,152,728...202,158,525 		JBrowse link
G Ctsh cathepsin H enables ISO
IEA
IBA
ISS 		(PMID:6203523)
GO_REF:0000107
GO_REF:0000003
GO_REF:0000033
(PMID:17500053)
GO_REF:0000024 		RGD
Ensembl
UniProt
GO_Central		 PMID:6203523 PMID:17500053 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
G Ctsj cathepsin J enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,738,729...3,743,381
Ensembl chr17:3,738,729...3,743,377 		JBrowse link
G Ctsk cathepsin K enables ISO
IEA
IBA 		(PMID:22952693)
GO_REF:0000003
GO_REF:0000033 		RGD
UniProt
GO_Central		 PMID:22952693 GO_REF:0000003 GO_REF:0000033 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ctsl cathepsin L enables IDA
IEA
IBA
ISO 		GO_REF:0000003
GO_REF:0000033
PMID:12788072
(PMID:12809493), (PMID:14511383), (PMID:22952693), (PMID:28743268) 		UniProt
GO_Central
RGD		 PMID:12809493 PMID:14511383 PMID:22952693 PMID:28743268 PMID:16960372 More... GO_REF:0000003 GO_REF:0000033, RGD:2315574, RGD:12793045 NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548 		JBrowse link
G Ctsll3 cathepsin L-like 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,888,544...3,893,125
Ensembl chr17:3,889,811...3,892,881 		JBrowse link
G Ctsm cathepsin M enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,236,848...3,242,265
Ensembl chr17:3,236,859...3,242,265 		JBrowse link
G Ctsml1 cathepsin M like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,752,000...3,760,046
Ensembl chr17:3,752,000...3,760,046 		JBrowse link
G Ctso cathepsin O enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:167,230,407...167,254,761
Ensembl chr 2:167,230,330...167,253,702 		JBrowse link
G Ctsq cathepsin Q enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,627,996...3,633,564
Ensembl chr17:3,629,082...3,633,428 		JBrowse link
G Ctsr cathepsin R enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,522,365...3,531,128
Ensembl chr17:3,522,365...3,531,121 		JBrowse link
G Ctss cathepsin S enables ISO
IEA
IBA 		(PMID:12788072), (PMID:22952693), (PMID:8612130)
GO_REF:0000003
GO_REF:0000033
(PMID:15308097) 		RGD
UniProt
GO_Central		 PMID:8612130 PMID:12788072 PMID:15308097 PMID:22952693 GO_REF:0000003 GO_REF:0000033 NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Ctsz cathepsin Z enables TAS
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:12553736 GO_REF:0000033, RGD:1299468 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645 		JBrowse link
G ENSRNOG00000069467 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr11:64,896,331...64,896,753 JBrowse link
G Espl1 extra spindle pole bodies like 1, separase enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984 		JBrowse link
G Lgmn legumain enables IMP
IEA
IBA
ISO
ISS 		PMID:9065484
GO_REF:0000003
GO_REF:0000107
GO_REF:0000033
(PMID:22718532), (PMID:25326800), (PMID:37347855), (PMID:9742219)
(PMID:18374643), (PMID:22718532), (PMID:25326800), (PMID:9065484), (PMID:9821970), (PMID:9872320)
GO_REF:0000024
GO_REF:0000002
(PMID:9065484) 		UniProt
Ensembl
GO_Central
RGD
InterPro		 PMID:9065484 PMID:9742219 PMID:9821970 PMID:9872320 PMID:18374643 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:13514076, RGD:13514088 NCBI chr 6:127,308,913...127,347,355
Ensembl chr 6:121,544,053...121,582,480 		JBrowse link
G Malt1 MALT1 paracaspase enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:61,212,290...61,266,272
Ensembl chr18:58,942,299...58,994,260 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 enables ISO
IEA 		(PMID:14581477)
GO_REF:0000107 		RGD
Ensembl		 PMID:14581477 GO_REF:0000107 NCBI chr16:75,278,325...75,316,736
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Testin testin gene enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:3,829,012...3,864,995
Ensembl chr17:3,846,899...3,859,385 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 enables ISO
IEA 		(PMID:8639624)
GO_REF:0000107 		RGD
Ensembl		 PMID:8639624 GO_REF:0000107 NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
G Usp1 ubiquitin specific peptidase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:113,587,564...113,598,934
Ensembl chr 5:113,587,564...113,598,932 		JBrowse link
G Usp10 ubiquitin specific peptidase 10 enables ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:21962518) 		UniProt
Ensembl
RGD		 PMID:21962518 GO_REF:0000024 GO_REF:0000107 NCBI chr19:47,972,858...48,014,900
Ensembl chr19:47,972,611...48,014,897 		JBrowse link
G Usp11 ubiquitin specific peptidase 11 enables TAS
ISS
ISO 		GO_REF:0000024
(PMID:28992046) 		UniProt
RGD		 PMID:28992046 PMID:12084015 GO_REF:0000024, RGD:1304526 NCBI chr  X:4,026,865...4,043,036
Ensembl chr  X:1,473,350...1,489,520 		JBrowse link
G Usp12 ubiquitin specific peptidase 12 enables ISO (PMID:19075014) RGD PMID:19075014 NCBI chr12:8,309,845...8,363,686
Ensembl chr12:8,309,750...8,363,656 		JBrowse link
G Usp13 ubiquitin specific peptidase 13 enables ISO (PMID:21811243) RGD PMID:21811243 NCBI chr 2:115,576,912...115,689,153
Ensembl chr 2:115,577,091...115,686,222 		JBrowse link
G Usp15 ubiquitin specific peptidase 15 enables ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:21947082), (PMID:22344298) 		UniProt
Ensembl
RGD		 PMID:21947082 PMID:22344298 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721 		JBrowse link
G Usp16 ubiquitin specific peptidase 16 enables ISO
IEA
ISS 		(PMID:17914355)
GO_REF:0000107
GO_REF:0000104
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:17914355 GO_REF:0000024 GO_REF:0000104 GO_REF:0000107 NCBI chr11:40,166,651...40,196,792
Ensembl chr11:26,681,414...26,710,539 		JBrowse link
G Usp20 ubiquitin specific peptidase 20 enables ISO
IEA 		(PMID:19424180)
GO_REF:0000107 		RGD
Ensembl		 PMID:19424180 GO_REF:0000107 NCBI chr 3:14,272,737...14,306,409
Ensembl chr 3:14,272,908...14,306,409 		JBrowse link
G Usp27x ubiquitin specific peptidase 27, X-linked enables ISO (PMID:31534008), (PMID:32027733) RGD PMID:31534008 PMID:32027733 NCBI chr  X:17,795,506...17,798,741
Ensembl chr  X:15,124,596...15,125,912 		JBrowse link
G Usp29 ubiquitin specific peptidase 29 enables ISO
IEA 		(PMID:32457395)
GO_REF:0000107 		RGD
Ensembl		 PMID:32457395 GO_REF:0000107 NCBI chr 1:66,874,216...67,097,731
Ensembl chr 1:66,874,017...67,097,686 		JBrowse link
G Usp30 ubiquitin specific peptidase 30 enables ISO
IEA 		(PMID:24896179)
GO_REF:0000107 		RGD
Ensembl		 PMID:24896179 GO_REF:0000107 NCBI chr12:42,501,345...42,555,311
Ensembl chr12:42,501,348...42,555,616 		JBrowse link
G Usp33 ubiquitin specific peptidase 33 enables ISO
IEA 		(PMID:19363159), (PMID:19424180), (PMID:23486064)
GO_REF:0000107 		RGD
Ensembl		 PMID:19363159 PMID:19424180 PMID:23486064 GO_REF:0000107 NCBI chr 2:241,283,209...241,328,479
Ensembl chr 2:241,292,985...241,328,479 		JBrowse link
G Usp34 ubiquitin specific peptidase 34 enables ISO
IEA 		(PMID:21383061)
GO_REF:0000107 		RGD
Ensembl		 PMID:21383061 GO_REF:0000107 NCBI chr14:97,285,799...97,476,376
Ensembl chr14:97,286,018...97,476,376 		JBrowse link
G Usp37 ubiquitin specific peptidase 37 enables ISO
IEA 		(PMID:21596315)
GO_REF:0000107 		RGD
Ensembl		 PMID:21596315 GO_REF:0000107 NCBI chr 9:83,467,966...83,567,848
Ensembl chr 9:76,018,991...76,084,044 		JBrowse link
G Usp48 ubiquitin specific peptidase 48 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:149,800,189...149,867,838
Ensembl chr 5:149,800,179...149,867,719 		JBrowse link
G Usp49 ubiquitin specific peptidase 49 enables ISO
IEA 		(PMID:23824326)
GO_REF:0000107 		RGD
Ensembl		 PMID:23824326 GO_REF:0000107 NCBI chr 9:13,305,640...13,366,132
Ensembl chr 9:13,308,178...13,366,132 		JBrowse link
G Usp7 ubiquitin specific peptidase 7 enables ISO
IEA
ISS 		(PMID:21745816)
(PMID:21268065)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:21268065 PMID:21745816 GO_REF:0000024 GO_REF:0000107 NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355 		JBrowse link
G Usp9x ubiquitin specific peptidase 9, X-linked enables ISO (PMID:30951545) RGD PMID:30951545 NCBI chr  X:9,588,825...9,726,993
Ensembl chr  X:9,588,825...9,696,711 		JBrowse link
calcium-dependent cysteine-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgb androglobin enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:4,753,621...4,896,268
Ensembl chr 1:4,753,621...4,896,190 		JBrowse link
G Capn1 calpain 1 enables IMP
IDA
ISO
IBA
IEA 		(PMID:15640140)
PMID:22711986
(PMID:16411745), (PMID:19617626), (PMID:2407243)
(PMID:17529984)
GO_REF:0000033
GO_REF:0000003
GO_REF:0000002 		RGD
GO_Central
UniProt
InterPro		 PMID:2407243 PMID:15640140 PMID:16411745 PMID:17529984 PMID:19617626 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033, RGD:70442, RGD:1626249, RGD:8553623 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn10 calpain 10 enables IDA
ISO
NAS
IEA
IBA 		(PMID:15044459)
PMID:15471947
GO_REF:0000107
GO_REF:0000033
GO_REF:0000002 		RGD
Ensembl
GO_Central
InterPro		 PMID:15044459 PMID:16790502 PMID:15471947 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:1625051, RGD:8553339 NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494 		JBrowse link
G Capn11 calpain 11 enables IEA
IBA 		GO_REF:0000002
GO_REF:0000033 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 9:15,344,059...15,365,604
Ensembl chr 9:15,344,089...15,365,601 		JBrowse link
G Capn12 calpain 12 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:84,171,059...84,183,161
Ensembl chr 1:84,171,059...84,183,119 		JBrowse link
G Capn13 calpain 13 enables IEA
IBA 		GO_REF:0000002
GO_REF:0000033 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:22,071,845...22,166,864
Ensembl chr 6:22,071,845...22,166,850 		JBrowse link
G Capn15 calpain 15 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr10:14,972,807...14,999,411
Ensembl chr10:14,972,800...14,999,508 		JBrowse link
G Capn2 calpain 2 contributes_to
enables 		IDA
ISO
IEA
IBA 		(PMID:12150984)
PMID:22711986
GO_REF:0000002
(PMID:22555453), (PMID:22711986)
GO_REF:0000033
GO_REF:0000003
GO_REF:0000107 		RGD
InterPro
GO_Central
UniProt
Ensembl		 PMID:12150984 PMID:22555453 PMID:22711986 PMID:14976200 PMID:7982961 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107, RGD:1578398, RGD:634695, RGD:1626249, RGD:2303056, RGD:8553623 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Capn3 calpain 3 enables TAS
IDA
IEA
ISO
IBA 		GO_REF:0000104
(PMID:15138196)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000003
GO_REF:0000002 		UniProt
RGD
GO_Central
Ensembl
InterPro		 PMID:15138196 PMID:12663060 PMID:11904300 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107, RGD:634694, RGD:1600775 NCBI chr 3:107,407,518...107,457,858
Ensembl chr 3:107,407,850...107,457,858 		JBrowse link
G Capn5 calpain 5 enables IEA
IBA 		GO_REF:0000002
GO_REF:0000033 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:152,416,252...152,472,923
Ensembl chr 1:152,416,252...152,472,923 		JBrowse link
G Capn6 calpain 6 enables
NOT|enables 		IEA
IBA 		GO_REF:0000002
GO_REF:0000033 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr  X:107,380,774...107,405,489
Ensembl chr  X:107,380,774...107,405,489 		JBrowse link
G Capn7 calpain 7 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:6,545,630...6,581,908
Ensembl chr16:6,545,731...6,581,905 		JBrowse link
G Capn8 calpain 8 enables IEA
ISO
IBA 		GO_REF:0000002
(PMID:17646163)
GO_REF:0000033
GO_REF:0000003 		InterPro
RGD
GO_Central
UniProt		 PMID:17646163 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr13:94,252,218...94,316,146
Ensembl chr13:94,253,054...94,316,146 		JBrowse link
G Capn9 calpain 9 enables TAS
IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro
RGD		 PMID:9524069 GO_REF:0000002 GO_REF:0000033, RGD:724622 NCBI chr19:52,549,448...52,586,413
Ensembl chr19:52,549,448...52,586,413 		JBrowse link
G Capns1 calpain, small subunit 1 contributes_to
enables 		IDA
ISO
IEA 		(PMID:17646163)
GO_REF:0000107
(PMID:15640140)
MGI:2179226 (PMID:10825211) 		RGD
Ensembl		 PMID:10825211 PMID:15640140 PMID:17646163 PMID:7982961 GO_REF:0000107, RGD:634695 NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795 		JBrowse link
G Capns2 calpain, small subunit 2 enables ISO (PMID:17646163) RGD PMID:17646163 NCBI chr19:14,104,334...14,105,276 JBrowse link
GPI-anchor transamidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 TAS RGD PMID:10702226 RGD:1331364 NCBI chr 7:108,051,896...108,055,479
Ensembl chr 7:108,051,861...108,055,484 		JBrowse link
G Pigk phosphatidylinositol glycan anchor biosynthesis, class K enables IEA
ISO 		GO_REF:0000002
(PMID:10793132), (PMID:35551457), (PMID:37684232)
GO_REF:0000107 		InterPro
RGD
Ensembl		 PMID:10793132 PMID:35551457 PMID:37684232 GO_REF:0000002 GO_REF:0000107 NCBI chr 2:241,630,021...241,715,493
Ensembl chr 2:241,630,053...241,716,134 		JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U enables IEA
ISO 		GO_REF:0000107
(PMID:35165458) 		Ensembl
RGD		 PMID:35165458 GO_REF:0000107 NCBI chr 3:143,784,831...143,881,268
Ensembl chr 3:143,784,832...143,880,807 		JBrowse link
SUMO-specific endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Senp1 SUMO specific peptidase 1 enables ISO
IEA 		(PMID:16608850), (PMID:17591783), (PMID:34048572), (PMID:37257451)
MGI:3582213 (PMID:15923632)
GO_REF:0000107 		RGD
Ensembl		 PMID:15923632 PMID:16608850 PMID:17591783 PMID:34048572 PMID:37257451 GO_REF:0000107 NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598 		JBrowse link
G Senp2 SUMO specific peptidase 2 enables ISS
ISO
IEA 		GO_REF:0000024
(PMID:11896061), (PMID:16608850), (PMID:17591783)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:11896061 PMID:16608850 PMID:17591783 GO_REF:0000024 GO_REF:0000107 NCBI chr11:78,981,429...79,018,274
Ensembl chr11:78,981,432...79,018,238 		JBrowse link
G Senp5 SUMO specific peptidase 5 enables ISO (PMID:16608850), (PMID:17591783) RGD PMID:16608850 PMID:17591783 NCBI chr11:68,784,699...68,819,569
Ensembl chr11:68,784,957...68,819,562 		JBrowse link
G Senp6 SUMO specific peptidase 6 enables ISO
IBA
IEA 		(PMID:20212317)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:20212317 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170 		JBrowse link
G Senp7 SUMO specific peptidase 7 enables ISS
IBA
ISO 		GO_REF:0000024
GO_REF:0000033
(PMID:28095500) 		UniProt
GO_Central
RGD		 PMID:28095500 GO_REF:0000024 GO_REF:0000033 NCBI chr11:44,423,733...44,584,129
Ensembl chr11:44,423,735...44,564,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21054
    catalytic activity 6213
      hydrolase activity 2572
        peptidase activity 706
          endopeptidase activity 469
            cysteine-type endopeptidase activity 88
              GPI-anchor transamidase activity 3
              calcium-dependent cysteine-type endopeptidase activity 16
              ubiquitin-like protein-specific endopeptidase activity + 5
paths to the root