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ONTOLOGY REPORT - ANNOTATIONS


Term:cysteine-type endopeptidase activity
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Accession:GO:0004197 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Synonyms:exact_synonym: thiol endopeptidase activity
 narrow_synonym: caspase activity;   lysosomal cysteine-type endopeptidase;   metacaspase activity
 xref: EC:3.4.22;   EC:3.4.22.1;   EC:3.4.22.14;   EC:3.4.22.15;   EC:3.4.22.16;   EC:3.4.22.27;   EC:3.4.22.28;   EC:3.4.22.34;   EC:3.4.22.38;   EC:3.4.22.40;   EC:3.4.22.41;   EC:3.4.22.8;   MetaCyc:3.4.22.1-RXN;   MetaCyc:3.4.22.14-RXN;   MetaCyc:3.4.22.15-RXN;   MetaCyc:3.4.22.16-RXN;   MetaCyc:3.4.22.27-RXN;   MetaCyc:3.4.22.34-RXN;   MetaCyc:3.4.22.38-RXN;   MetaCyc:3.4.22.40-RXN;   MetaCyc:3.4.22.41-RXN;   Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8";   Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins";   Reactome:R-HSA-9684273 "3CLp cleaves pp1a";   Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11";   Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4";   Reactome:R-HSA-9684336 "nsp1-4 cleaves itself";   Reactome:R-HSA-9684340 "3CLp cleaves pp1ab";   Reactome:R-HSA-9684351 "pp1a cleaves itself";   Reactome:R-HSA-9684352 "nsp3-4 cleaves itself";   reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome";   reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9";   reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome";   reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle";   reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage";   reactome:R-HSA-139952 "Caspase-8 processing in the DISC";   reactome:R-HSA-1678920 "TLR processing at low pH";   reactome:R-HSA-1678981 "TLR9 processing at neutral pH";   reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1";   reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta";   reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin";   reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1";   reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin";   reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)";   reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau";   reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus";   reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3";   reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1";   reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin";   reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1";   reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2";   reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha";   reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3";   reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3";   reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1";   reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin";   reactome:R-HSA-202947 "Caspase mediated cleavage of APC";   reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1";   reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55";   reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin";   reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin";   reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3";   reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)";   reactome:R-HSA-211651 "Cleavage of PAK-2 at 212";   reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta";   reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22";   reactome:R-HSA-2130349 "Generation of CLIP from lip10";   reactome:R-HSA-2130504 "Cleavage of lip22 to lip10";   reactome:R-HSA-2130706 "MHC class II antigen processing";   reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex";   reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A";   reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1";   reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC";   reactome:R-HSA-350158 "LGMN degrades GC";   reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)";   reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)";   reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK";   reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk";   reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2";   reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin";   reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2";   reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31";   reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3";   reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1";   reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin";   reactome:R-HSA-352268 "Cleavage of Satb1";   reactome:R-HSA-418845 "Activation of caspase-3";   reactome:R-HSA-418846 "Caspase cleavage of UNC5A";   reactome:R-HSA-418852 "Caspase cleavage of UNC5B";   reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1";   reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases";   reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor";   reactome:R-HSA-5681987 "LC3 is cleaved by ATG4";   reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4";   reactome:R-HSA-6814387 "CASP14 cleaves filaggrin";   reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37";   reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex";   reactome:R-HSA-933532 "Processing of caspases";   reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3"


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cysteine-type endopeptidase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07040864.1 RGD:1600115
G Atg4b autophagy related 4B, cysteine peptidase JBrowse link 9 100,888,457 100,920,123 RGD:1600115
G Atg4c autophagy related 4C, cysteine peptidase JBrowse link 5 117,861,517 117,932,116 RGD:1600115
G Blmh bleomycin hydrolase JBrowse link 10 63,197,367 63,240,447 RGD:1600115
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1624291
RGD:13792537
RGD:1600115
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:1624291
RGD:13792537
RGD:1600115
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:1624291
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:1624291
RGD:13792537
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:1624291
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:4143200
RGD:1624291
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:1624291
G Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha JBrowse link 17 4,169,696 4,194,700 RGD:13792537
G Cts7 cathepsin 7 JBrowse link 17 3,280,311 3,285,451 RGD:13792537
G Cts8 cathepsin 8 JBrowse link 17 3,385,851 3,397,621 RGD:13792537
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:2315574
RGD:13792537
RGD:1624291
RGD:12793045
RGD:1600115
G Ctsc cathepsin C JBrowse link 1 151,918,514 151,949,979 RGD:631244
RGD:13792537
G Ctsf cathepsin F JBrowse link 1 220,114,228 220,119,976 RGD:13792537
G Ctsh cathepsin H JBrowse link 8 97,439,155 97,458,293 RGD:1624291
RGD:13792537
RGD:1600115
G Ctsj cathepsin J JBrowse link 17 4,105,890 4,110,538 RGD:13792537
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:1624291
RGD:13792537
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:2315574
RGD:13792537
RGD:1624291
RGD:12793045
G Ctsll3 cathepsin L-like 3 JBrowse link 17 4,256,311 4,259,625 RGD:13792537
G Ctsm cathepsin M JBrowse link 17 3,820,606 3,826,015 RGD:13792537
G Ctsq cathepsin Q JBrowse link 17 3,991,330 3,996,889 RGD:13792537
G Ctsql2 cathepsin Q-like 2 JBrowse link 17 4,062,294 4,068,108 RGD:13792537
G Ctsr cathepsin R JBrowse link 17 3,885,684 3,894,447 RGD:13792537
G Ctss cathepsin S JBrowse link 2 197,655,780 197,679,768 RGD:1624291
RGD:13792537
RGD:1600115
G Ctsw cathepsin W JBrowse link 1 220,844,579 220,847,967 RGD:13792537
G Ctsz cathepsin Z JBrowse link 3 172,527,107 172,537,877 RGD:1299468
RGD:13792537
G Espl1 extra spindle pole bodies like 1, separase JBrowse link 7 143,896,890 143,923,868 RGD:13792537
G Lgmn legumain JBrowse link 6 126,282,246 126,308,207 RGD:1600115
RGD:13792537
RGD:1624291
RGD:13514076
RGD:13514088
G LOC100364523 Ctsq protein-like JBrowse link 17 4,045,024 4,050,423 RGD:13792537
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:13792537
G LOC100911860 ubiquitin carboxyl-terminal hydrolase 40-like JBrowse link 9 91,037,406 91,100,490 RGD:13792537
G LOC689730 similar to ubiquitin specific peptidase 17 (homolog) RGD:13792537
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:1600115
G MGC114246 similar to cathepsin R JBrowse link 17 3,924,473 3,929,978 RGD:13792537
G Rce1 Ras converting CAAX endopeptidase 1 JBrowse link 1 219,860,826 219,863,933 RGD:13792537
G RGD1308751 similar to Cathepsin L precursor (Major excreted protein) (MEP) JBrowse link 17 4,270,207 4,273,173 RGD:13792537
G RGD1561481 similar to ubiquitin specific protease 12 JBrowse link 16 70,081,041 70,085,061 RGD:13792537
G RGD1564657 similar to cathepsin 1 precursor JBrowse link 17 3,210,130 3,214,421 RGD:13792537
G RGD1564827 similar to cathepsin M JBrowse link 17 4,119,288 4,123,365 RGD:13792537
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1600115
RGD:1624291
G Testin testin gene JBrowse link 17 4,194,796 4,225,376 RGD:13792537
G Uchl1 ubiquitin C-terminal hydrolase L1 JBrowse link 14 43,133,224 43,143,942 RGD:1624291
G Usp1 ubiquitin specific peptidase 1 JBrowse link 5 117,583,502 117,594,872 RGD:1600115
RGD:13792537
G Usp10 ubiquitin specific peptidase 10 JBrowse link 19 52,566,274 52,608,820 RGD:1624291
RGD:13792537
RGD:1600115
G Usp11 ubiquitin specific peptidase 11 JBrowse link X 1,687,820 1,703,991 RGD:1304526
G Usp12 ubiquitin specific peptidase 12 JBrowse link 12 10,037,686 10,087,685 RGD:1624291
RGD:13792537
G Usp13 ubiquitin specific peptidase 13 JBrowse link 2 119,197,153 119,317,507 RGD:1624291
RGD:13792537
G Usp15 ubiquitin specific peptidase 15 JBrowse link 7 66,595,707 66,687,707 RGD:1600115
RGD:1624291
G Usp16 ubiquitin specific peptidase 16 JBrowse link 11 27,101,213 27,130,345 RGD:1624291
RGD:1600115
G Usp18 ubiquitin specific peptidase 18 JBrowse link 4 153,812,312 153,834,374 RGD:13792537
G Usp20 ubiquitin specific peptidase 20 JBrowse link 3 9,822,586 9,856,057 RGD:1624291
G Usp24 ubiquitin specific peptidase 24 JBrowse link 5 125,896,725 126,030,411 RGD:13792537
G Usp25 ubiquitin specific peptidase 25 JBrowse link 11 15,436,080 15,558,646 RGD:13792537
G Usp26 ubiquitin specific peptidase 26 JBrowse link X 139,030,239 139,079,336 RGD:13792537
G Usp28 ubiquitin specific peptidase 28 JBrowse link 8 53,295,188 53,355,572 RGD:13792537
G Usp29 ubiquitin specific peptidase 29 JBrowse link 1 69,988,673 70,042,015 RGD:13792537
G Usp30 ubiquitin specific peptidase 30 JBrowse link 12 48,262,663 48,316,580 RGD:1624291
RGD:13792537
G Usp33 ubiquitin specific peptidase 33 JBrowse link 2 257,567,179 257,602,817 RGD:1624291
G Usp34 ubiquitin specific peptidase 34 JBrowse link 14 108,060,653 108,264,706 RGD:1624291
RGD:13792537
G Usp35 ubiquitin specific peptidase 35 JBrowse link 1 162,283,866 162,307,610 RGD:13792537
G Usp36 ubiquitin specific peptidase 36 JBrowse link 10 107,292,828 107,324,355 RGD:13792537
G Usp37 ubiquitin specific peptidase 37 JBrowse link 9 81,717,626 81,818,421 RGD:1624291
RGD:13792537
G Usp38 ubiquitin specific peptidase 38 JBrowse link 19 30,668,258 30,699,852 RGD:13792537
G Usp40 ubiquitin specific peptidase 40 JBrowse link 9 95,072,096 95,143,092 RGD:13792537
G Usp42 ubiquitin specific peptidase 42 JBrowse link 12 12,840,131 12,878,207 RGD:13792537
G Usp46 ubiquitin specific peptidase 46 JBrowse link 14 36,687,134 36,755,360 RGD:13792537
G Usp47 ubiquitin specific peptidase 47 JBrowse link 1 176,854,589 176,937,763 RGD:13792537
G Usp48 ubiquitin specific peptidase 48 JBrowse link 5 155,935,102 156,002,722 RGD:13792537
G Usp49 ubiquitin specific peptidase 49 JBrowse link 9 15,314,875 15,375,365 RGD:1624291
G Usp5 ubiquitin specific peptidase 5 JBrowse link 4 157,332,735 157,347,803 RGD:13792537
G Usp7 ubiquitin specific peptidase 7 JBrowse link 10 6,930,462 7,019,910 RGD:1600115
RGD:13792537
RGD:1624291
G Usp9x ubiquitin specific peptidase 9, X-linked JBrowse link X 10,510,033 10,660,555 RGD:13792537
G Usp9y ubiquitin specific peptidase 9, Y-linked JBrowse link Y 1,260,512 1,403,417 RGD:13792537
calcium-dependent cysteine-type endopeptidase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgb androglobin JBrowse link 1 4,445,039 4,588,507 RGD:1600115
G Capn1 calpain 1 JBrowse link 1 221,346,081 221,370,965 RGD:70442
RGD:1624291
RGD:1600115
RGD:8553623
RGD:2303057
RGD:1626249
G Capn10 calpain 10 JBrowse link 9 100,104,000 100,112,833 RGD:1625051
RGD:13792537
RGD:1600115
RGD:8553339
RGD:1624291
G Capn11 calpain 11 JBrowse link 9 17,728,845 17,750,357 RGD:1600115
RGD:13792537
G Capn12 calpain 12 JBrowse link 1 87,066,289 87,078,348 RGD:13792537
G Capn13 calpain 13 JBrowse link 6 24,579,590 24,676,536 RGD:13792537
G Capn15 calpain 15 JBrowse link 10 15,319,772 15,346,607 RGD:13792537
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:1578398
RGD:1624291
RGD:8553623
RGD:2303057
RGD:2303056
RGD:1626249
RGD:634695
G Capn3 calpain 3 JBrowse link 3 112,227,486 112,278,408 RGD:634694
RGD:13792537
RGD:1600115
RGD:1624291
RGD:1600775
G Capn5 calpain 5 JBrowse link 1 163,073,134 163,129,736 RGD:1600115
RGD:13792537
G Capn6 calpain 6 JBrowse link X 115,049,113 115,073,824 RGD:1600115
RGD:13792537
G Capn7 calpain 7 JBrowse link 16 7,435,541 7,472,483 RGD:1600115
G Capn8 calpain 8 JBrowse link 13 100,980,149 101,043,110 RGD:1624291
RGD:13792537
G Capn9 calpain 9 JBrowse link 19 57,341,938 57,378,901 RGD:724622
RGD:13792537
G Capns1 calpain, small subunit 1 JBrowse link 1 91,058,528 91,064,880 RGD:634695
RGD:1624291
G Capns2 calpain, small subunit 2 JBrowse link 19 15,485,258 15,486,200 RGD:1624291
cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:13792537
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:13792537
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:1624291
RGD:13792537
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
RGD:13792537
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:13792537
G Casp6 caspase 6 JBrowse link 2 235,341,326 235,353,715 RGD:13792537
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:1624291
RGD:13792537
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:1600115
RGD:1624291
RGD:13792537
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:13792537
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:13792537
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:13792537
cysteine-type endopeptidase activity involved in apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:13792537
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:13792537
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:13792537
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
RGD:1600115
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:13792537
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:1624291
RGD:13792537
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:1624291
RGD:13792537
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:13792537
cysteine-type endopeptidase activity involved in execution phase of apoptosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:13792537
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:13792537
G Casp14 caspase 14 JBrowse link 7 13,938,376 13,944,286 RGD:13792537
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:1600115
RGD:13792537
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:13792537
G Casp6 caspase 6 JBrowse link 2 235,341,326 235,353,715 RGD:1624291
RGD:13792537
RGD:1600115
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:1624291
RGD:13792537
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:13792537
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:13792537
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:13792537
G LOC103689977 caspase-6 JBrowse link 2 230,186,170 230,198,555 RGD:1600115
GPI-anchor transamidase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 JBrowse link 7 117,394,367 117,397,950 RGD:1331364
G Pigk phosphatidylinositol glycan anchor biosynthesis, class K JBrowse link 2 257,911,099 257,997,735 RGD:1624291
RGD:13792537
RGD:1600115
G Pigt phosphatidylinositol glycan anchor biosynthesis, class T JBrowse link 3 160,945,556 160,954,738 RGD:13792537
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U JBrowse link 3 150,803,096 150,885,597 RGD:1600115
RGD:13792537
SUMO-specific endopeptidase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Senp2 SUMO specific peptidase 2 JBrowse link 11 82,627,973 82,664,702 RGD:1600115
RGD:1624291
G Senp6 SUMO specific peptidase 6 JBrowse link 8 87,486,050 87,568,088 RGD:1624291
RGD:13792537
G Senp7 SUMO specific peptidase 7 JBrowse link 11 46,880,928 47,047,052 RGD:13792537

Term paths to the root
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Term Annotations click to browse term
  molecular_function 20377
    catalytic activity 6066
      hydrolase activity 2631
        peptidase activity 701
          endopeptidase activity 496
            cysteine-type endopeptidase activity 105
              GPI-anchor transamidase activity 4
              calcium-dependent cysteine-type endopeptidase activity 16
              cysteine-type endopeptidase activity involved in apoptotic process + 13
              ubiquitin-like protein-specific endopeptidase activity + 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.