Catalysis of the reaction: a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.
Synonyms:
related_synonym:
acyl coenzyme A oxidase activity; acyl-CoA:oxygen 2-oxidoreductase activity; fatty acyl-CoA oxidase activity; fatty acyl-coenzyme A oxidase activity
xref:
EC:1.3.3.6; MetaCyc:RXN-11026; RHEA:38959; Reactome:R-HSA-390256 "ACOX1 oxidizes C26:0 CoA"; reactome:R-HSA-192335 "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)"; reactome:R-HSA-193369 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA"; reactome:R-HSA-2066787 "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA"