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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA ligase activity
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Accession:GO:0003909 term browser browse the term
Definition:Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.
Synonyms:xref: reactome:R-HSA-174456 "Joining of adjacent Okazaki fragments of the C-strand";   reactome:R-HSA-175258 "2-LTR formation due to circularization of viral DNA";   reactome:R-HSA-5358592 "DNA ligase I ligates single stranded nick in double stranded DNA";   reactome:R-HSA-5649734 "LIG3 ligates NEIL1,NEIL2-generated single strand break";   reactome:R-HSA-5651789 "LIG1 bound to POLB ligates SSB";   reactome:R-HSA-5651805 "LIG1 bound to APEX1 and PCNA ligates SSB";   reactome:R-HSA-5687675 "LIG3 ligates remaining SSBs in MMEJ";   reactome:R-HSA-5690997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER";   reactome:R-HSA-5693604 "XRCC4:LIG4 ligates DNA DSB ends during NHEJ";   reactome:R-HSA-6782227 "Ligation of newly synthesized repair patch to incised DNA in TC-NER";   reactome:R-HSA-69173 "Joining of adjacent Okazaki fragments";   reactome:R-HSA-73931 "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway"


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DNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 DNA ligase 1 enables IDA
ISO		 (PMID:15871698), (PMID:9809069) RGD PMID:9809069 PMID:15871698 PMID:1730240 RGD:724410 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lig3 DNA ligase 3 enables IDA
ISO		 (PMID:24674627)
(PMID:9809069)		 RGD PMID:9809069 PMID:24674627 PMID:17412650 RGD:2302580 NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Lig4 DNA ligase 4 enables ISO (PMID:12517771), (PMID:17290226) RGD PMID:12517771 PMID:17290226 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
DNA ligase (ATP) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 DNA ligase 1 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000002		 UniProt
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lig3 DNA ligase 3 enables ISO
IBA		 (PMID:10207110)
(PMID:7565692)
GO_REF:0000033		 RGD
GO_Central		 PMID:7565692 PMID:10207110 GO_REF:0000033 NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Lig4 DNA ligase 4 enables IDA
ISO
IBA		 (PMID:15194694)
GO_REF:0000033
(PMID:22192310), (PMID:23523427), (PMID:29980672), (PMID:8798671)		 RGD
GO_Central		 PMID:8798671 PMID:15194694 PMID:22192310 PMID:23523427 PMID:29980672 More... GO_REF:0000033, RGD:1601271 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      catalytic activity, acting on a nucleic acid 630
        catalytic activity, acting on DNA 254
          DNA ligase activity 3
            DNA ligase (ATP) activity 3
            DNA ligase (NAD+) activity 0
paths to the root