Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
Synonyms:
narrow_synonym:
DNA-directed RNA polymerase I activity; DNA-directed RNA polymerase II activity; DNA-directed RNA polymerase III activity; RNA polymerase I activity; RNA polymerase II activity; RNA polymerase III activity
EC:2.7.7.6; MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN; Reactome:R-HSA-9670149 "TERRA transcription"; Reactome:R-HSA-9697084 "Defective rpoB in Mtb RNAP transcribes RNA polyanion"; Reactome:R-HSA-9697085 "RNAP transcribes Mtb RNA polyanion"; reactome:R-HSA-111264 "Addition of nucleotides between position +11 and +30"; reactome:R-HSA-167113 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition"; reactome:R-HSA-167115 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript"; reactome:R-HSA-167117 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition"; reactome:R-HSA-167121 "Addition of the third nucleotide on the nascent HIV-1 transcript"; reactome:R-HSA-167136 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript"; reactome:R-HSA-174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"; reactome:R-HSA-203901 "Pol II mediated transcription of microRNA genes"; reactome:R-HSA-427366 "Transcription of intergenic spacer of the rRNA gene"; reactome:R-HSA-5601926 "RNA polymerase II polymerizes primary piRNA transcript"; reactome:R-HSA-6781824 "Active RNA Pol II complex transcribes lesion-containing DNA template"; reactome:R-HSA-68913 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin"; reactome:R-HSA-74986 "Elongation of pre-rRNA transcript"; reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent transcript"; reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition"; reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript"; reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition"
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