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ONTOLOGY REPORT - ANNOTATIONS

Term:tRNA wobble position uridine thiolation
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Accession:GO:0002143 term browser browse the term
Definition:The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
Comment:In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA.
Synonyms:exact_synonym: tRNA wobble uridine thiolation;   wobble position s2U biosynthesis


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tRNA wobble position uridine thiolation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTU1 cytosolic thiouridylase subunit 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:51,097,606...51,108,409
Ensembl chr19:51,097,606...51,108,409 		JBrowse link
G CTU2 cytosolic thiouridylase subunit 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:88,706,503...88,715,396
Ensembl chr16:88,706,483...88,715,396 		JBrowse link
G MOCS3 molybdenum cofactor synthesis 3 involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr20:50,958,818...50,963,929
Ensembl chr20:50,958,818...50,963,929 		JBrowse link
G TRMU tRNA mitochondrial 2-thiouridylase involved_in IBA GO_Central GO_REF:0000033 NCBI chr22:46,335,714...46,357,340
Ensembl chr22:46,330,875...46,357,340 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19779
    metabolic process 13070
      primary metabolic process 11404
        RNA processing 1539
          tRNA processing 138
            tRNA modification 95
              tRNA thio-modification 5
                tRNA wobble position uridine thiolation 4
                  mitochondrial tRNA wobble position uridine thiolation 0
Path 2
Term Annotations click to browse term
  biological_process 19779
    metabolic process 13070
      biosynthetic process 9403
        cellular biosynthetic process 8937
          macromolecule biosynthetic process 8343
            nucleic acid biosynthetic process 5278
              RNA biosynthetic process 5157
                RNA processing 1539
                  tRNA processing 138
                    tRNA modification 95
                      tRNA wobble base modification 20
                        tRNA wobble uridine modification 17
                          tRNA wobble position uridine thiolation 4
                            mitochondrial tRNA wobble position uridine thiolation 0
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