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Gene: TRMU (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase) Homo sapiens
Symbol: TRMU
Name: tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Description: Predicted to have several functions, including ATP binding activity; sulfurtransferase activity; and tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Localizes to mitochondrion and nucleoplasm. Implicated in aminoglycoside-induced deafness.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: LCAL3; lung cancer associated lncRNA 3; MGC99627; mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase; mitochondrial tRNA-specific 2-thiouridylase 1; MTO2; MTO2 homolog; MTU1; TRMT; TRMT1; trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase 1; TRNT1
Mus musculus (house mouse) : Trmu (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trmu (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trmu (tRNA mitochondrial 2-thiouridylase)
Pan paniscus (bonobo/pygmy chimpanzee) : TRMU (tRNA mitochondrial 2-thiouridylase)
Canis lupus familiaris (dog) : TRMU (tRNA mitochondrial 2-thiouridylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trmu (tRNA mitochondrial 2-thiouridylase)
Sus scrofa (pig) : TRMU (tRNA mitochondrial 2-thiouridylase)
Chlorocebus sabaeus (African green monkey) : TRMU (tRNA mitochondrial 2-thiouridylase)
Heterocephalus glaber (naked mole-rat) : Trmu (tRNA mitochondrial 2-thiouridylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2246,330,875 - 46,357,340 (+)EnsemblGRCh38hg38GRCh38
GRCh382246,335,714 - 46,357,340 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372246,731,298 - 46,753,237 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362245,109,962 - 45,131,901 (+)NCBINCBI36hg18NCBI36
Build 342245,051,840 - 45,073,755NCBI
Celera2230,638,682 - 30,660,621 (+)NCBI
Cytogenetic Map22q13.31NCBI
HuRef2229,675,305 - 29,697,244 (+)NCBIHuRef
CHM1_12246,690,038 - 46,711,977 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TRMU
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322577
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.