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ONTOLOGY REPORT - ANNOTATIONS

Term:neurotransmitter uptake
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Accession:GO:0001504 term browser browse the term
Definition:The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
Synonyms:exact_synonym: neurotransmitter import
 narrow_synonym: neurotransmitter import into glial cell;   neurotransmitter import into neuron
 broad_synonym: neurotransmitter recycling
 xref: Reactome:R-HSA-112313 "Neurotransmitter uptake and metabolism In glial cells"

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neurotransmitter uptake term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12805306) MGI
Ensembl		 PMID:12805306 GO_REF:0000107 NCBI chr20:3,801,044...3,828,680
Ensembl chr20:3,802,887...3,828,692 		JBrowse link
G SLC17A6 solute carrier family 17 member 6 acts_upstream_of_or_within ISO (PMID:11432869) MGI PMID:11432869 NCBI chr 1:42,634,754...42,677,309
Ensembl chr 1:42,636,512...42,677,165 		JBrowse link
G SLC1A6 solute carrier family 1 member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:13,537,902...13,567,333
Ensembl chr 6:13,538,064...13,558,959 		JBrowse link
G SLC1A7 solute carrier family 1 member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:79,779,277...79,832,786
Ensembl chr20:79,779,759...79,831,960 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:27,934,537...27,949,120
Ensembl chr17:27,931,945...27,949,006 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:7,904,813...7,914,344
Ensembl chr 1:7,905,297...7,917,309 		JBrowse link
G SLC6A11 solute carrier family 6 member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:46,857,117...46,978,652
Ensembl chr22:46,857,569...46,978,088 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:1,209,013...1,258,797
Ensembl chr 4:1,209,019...1,258,866 		JBrowse link
G SLC6A5 solute carrier family 6 member 5 involved_in ISO (PMID:14622583) SynGO PMID:14622583 NCBI chr 1:44,345,697...44,404,709
Ensembl chr 1:44,350,099...44,402,396 		JBrowse link
G SLC6A9 solute carrier family 6 member 9 involved_in ISO (PMID:1618338) SynGO PMID:1618338 NCBI chr20:88,774,354...88,809,726
Ensembl chr20:88,774,339...88,808,669 		JBrowse link
dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:9886065) Ensembl
MGI		 PMID:9886065 GO_REF:0000107 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15721235) Ensembl
MGI		 PMID:15721235 GO_REF:0000107 NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within ISO (PMID:12915482) MGI PMID:12915482 NCBI chr13:88,856,056...90,329,379 JBrowse link
G SLC6A2 solute carrier family 6 member 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:41,434,004...41,482,568
Ensembl chr 5:41,435,387...41,483,643 		JBrowse link
glutamate reuptake term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLN8 CLN8 transmembrane ER and ERGIC protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8095977), (PMID:9600674) Ensembl
MGI		 PMID:8095977 PMID:9600674 GO_REF:0000107 NCBI chr 8:1,424,402...1,445,505
Ensembl chr 8:1,433,953...1,445,021 		JBrowse link
G KCNJ10 potassium inwardly rectifying channel subfamily J member 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17942730) Ensembl
MGI		 PMID:17942730 GO_REF:0000107 NCBI chr20:3,873,915...3,907,587
Ensembl chr20:3,902,513...3,903,652 		JBrowse link
histamine uptake term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC18A2 solute carrier family 18 member A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:110,039,783...110,078,822
Ensembl chr 9:110,040,391...110,076,647 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:87,835,077...87,881,410
Ensembl chr13:87,833,430...87,881,081 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16061728) MGI
Ensembl		 PMID:16061728 GO_REF:0000107 NCBI chr13:87,971,305...88,076,468
Ensembl chr13:87,971,392...88,074,946 		JBrowse link
G SLC29A4 solute carrier family 29 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:16,429,879...16,450,580
Ensembl chr28:16,429,413...16,450,324 		JBrowse link
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNCA synuclein alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:38,083,154...38,194,068
Ensembl chr 7:38,081,509...38,191,479 		JBrowse link
negative regulation of serotonin uptake term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPM6B glycoprotein M6B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:12,258,386...12,429,883 JBrowse link
G NOS1 nitric oxide synthase 1 involved_in ISO (PMID:17452640) UniProt PMID:17452640 NCBI chr11:112,642,374...112,673,882 JBrowse link
G SLC18A1 solute carrier family 18 member A1 ISO G-protein mediated uptake inhibition RGD PMID:16926160 RGD:5130998 NCBI chr 8:18,214,703...18,250,025
Ensembl chr 8:18,214,701...18,249,731 		JBrowse link
G SNCA synuclein alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:38,083,154...38,194,068
Ensembl chr 7:38,081,509...38,191,479 		JBrowse link
neurotransmitter reuptake term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC1A2 solute carrier family 1 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:29,845,512...30,012,261
Ensembl chr 1:29,847,043...29,989,975 		JBrowse link
G SLC6A1 solute carrier family 6 member 1 involved_in ISO PMID:1975955
(PMID:12815026)		 SynGO PMID:1975955 PMID:12815026 RGD:632739 NCBI chr22:47,033,436...47,076,785
Ensembl chr22:47,033,467...47,078,844 		JBrowse link
G SLC6A2 solute carrier family 6 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:41,434,004...41,482,568
Ensembl chr 5:41,435,387...41,483,643 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616 		JBrowse link
G SLC6A5 solute carrier family 6 member 5 involved_in ISO (PMID:23486948) SynGO PMID:23486948 NCBI chr 1:44,345,697...44,404,709
Ensembl chr 1:44,350,099...44,402,396 		JBrowse link
positive regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9886065) Ensembl
MGI		 PMID:9886065 GO_REF:0000107 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G NAT8L N-acetyltransferase 8 like involved_in ISO (PMID:19014384) UniProt PMID:19014384 NCBI chr27:46,697,086...46,703,494
Ensembl chr27:46,698,845...46,703,413 		JBrowse link
G RAB3B RAB3B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:80,963,320...81,036,058
Ensembl chr20:80,963,398...81,035,657 		JBrowse link
positive regulation of glutamate uptake involved in transmission of nerve impulse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGB1 integrin subunit beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25716834) Ensembl
ARUK-UCL		 PMID:25716834 GO_REF:0000107 NCBI chr 9:32,201,030...32,258,247
Ensembl chr 9:32,202,204...32,258,154 		JBrowse link
G SLC17A8 solute carrier family 17 member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:95,673,205...95,740,037
Ensembl chr11:95,674,195...95,739,040 		JBrowse link
positive regulation of neurotransmitter uptake term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:22314364) ParkinsonsUK-UCL PMID:22314364 NCBI chr13:88,856,056...90,329,379 JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 Ensembl chr13:89,318,323...90,034,758 JBrowse link
regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12223553) Ensembl
MGI		 PMID:12223553 GO_REF:0000107 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G GDNF glial cell derived neurotrophic factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:36,662,033...36,691,761
Ensembl chr 4:36,665,009...36,684,257 		JBrowse link
G TOR1A torsin family 1 member A involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:8,312,652...8,323,932
Ensembl chr12:8,312,650...8,322,907 		JBrowse link
regulation of glutamate uptake involved in transmission of nerve impulse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PER2 period circadian regulator 2 involved_in ISO (PMID:16595674) UniProt PMID:16595674 NCBI chr10:124,270,917...124,316,031
Ensembl chr10:124,269,543...124,315,904 		JBrowse link
regulation of neurotransmitter uptake term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in ISO (PMID:19118188) ARUK-UCL PMID:19118188 NCBI chr 2:66,037,224...66,320,860
Ensembl chr 2:66,037,261...66,321,306 		JBrowse link
G ARL6IP5 ARF like GTPase 6 interacting protein 5 involved_in ISO PMID:11242046 SynGO PMID:11242046 RGD:1299537 NCBI chr22:30,110,881...30,132,186
Ensembl chr22:30,111,017...30,135,240 		JBrowse link
G DRD2 dopamine receptor D2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G DRD3 dopamine receptor D3 involved_in ISO (PMID:27393374) SynGO PMID:27393374 NCBI chr22:66,683,987...66,737,645
Ensembl chr22:66,691,177...66,736,690 		JBrowse link
G FLOT1 flotillin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,714,354...41,725,820
Ensembl chr17:41,714,402...41,725,397 		JBrowse link
G GFAP glial fibrillary acidic protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15135219) MGI
Ensembl		 PMID:15135219 GO_REF:0000107 NCBI chr16:61,489,090...61,499,672
Ensembl chr16:61,489,421...61,500,646 		JBrowse link
G SYNGR3 synaptogyrin 3 involved_in ISO PMID:19357284 SynGO PMID:19357284 RGD:13702442 NCBI chr 5:1,886,899...1,891,293
Ensembl chr 5:1,886,864...1,891,368 		JBrowse link
regulation of serotonin uptake term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGB3 integrin subunit beta 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:59,372,171...59,431,434
Ensembl chr16:59,374,889...59,410,857 		JBrowse link
serotonin uptake term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC18A1 solute carrier family 18 member A1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:19008227 GO_REF:0000107 RGD:5131091 NCBI chr 8:18,214,703...18,250,025
Ensembl chr 8:18,214,701...18,249,731 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:20007701 GO_REF:0000107 RGD:5130957 NCBI chr 9:110,039,783...110,078,822
Ensembl chr 9:110,040,391...110,076,647 		JBrowse link
G SLC18A3 solute carrier family 18 member A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:42,216,187...42,219,665
Ensembl chr 9:42,216,568...42,218,166 		JBrowse link
G SLC18B1 solute carrier family 18 member B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:40,721,153...40,750,423
Ensembl chr13:40,721,186...40,750,526 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:87,744,600...87,780,846
Ensembl chr13:87,745,023...87,781,073 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:87,835,077...87,881,410
Ensembl chr13:87,833,430...87,881,081 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:87,971,305...88,076,468
Ensembl chr13:87,971,392...88,074,946 		JBrowse link
G SLC29A4 solute carrier family 29 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:16,429,879...16,450,580
Ensembl chr28:16,429,413...16,450,324 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:12944413 GO_REF:0000107 GO_REF:0000118 RGD:1580638 NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19806
    localization 5944
      establishment of localization 5256
        transport 4402
          import into cell 931
            neurotransmitter uptake 45
              histamine uptake + 4
              negative regulation of neurotransmitter uptake + 4
              neurotransmitter reuptake + 29
              positive regulation of neurotransmitter uptake + 7
              regulation of neurotransmitter uptake + 21
paths to the root