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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Anthracycline-induced Cardiotoxicity
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Accession:DOID:9007659 term browser browse the term
Definition:Cardiomyopathy in cancer patients caused by the use of the drug anthracyline.
Synonyms:exact_synonym: anthracycline-induced cardiomyopathy
 narrow_synonym: acute ACT;   acute anthracycline-induced cardiomyopathy;   chronic ACT


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Anthracycline-induced Cardiotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A susceptibility ISO DNA:missense mutation:cds:p.G671V (human) RGD PMID:16330681 RGD:11041175 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acvr2b activin A receptor type 2B treatment ISO human construct in mouse model RGD PMID:30765322 RGD:329849112 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Capn2 calpain 2 treatment IEP RGD PMID:25634181 RGD:13792617 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit ISO associated with Leukemia, Myeloid, Acute;DNA:SNP:exon:p.K751Q (rs13181) (human) RGD PMID:24284041 RGD:11252190 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18970
    Wounds and Injuries 983
      Radiation Injuries 82
        Cardiotoxicity 32
          Anthracycline-induced Cardiotoxicity 4
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