RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Pruritus
Accession: DOID:9006202
browse the term
Definition: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
Synonyms: exact_synonym: Itching; Pruritis
primary_id: MESH:D011537
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Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
ABCB11
ATP binding cassette subfamily B member 11
ISO
ClinVar Annotator: match by term: Pruritus
ClinVar
PMID:15300568 PMID:17855769 PMID:25741868 PMID:28492532 PMID:31015375
NCBI chr10:54,458,283...54,575,943
Ensembl chr10:54,459,377...54,575,059
G
AHR
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27869817
NCBI chr21:40,778,198...40,826,491
Ensembl chr21:40,778,218...40,826,478
G
ARTN
artemin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27869817
NCBI chr20:88,869,463...88,874,036
Ensembl chr20:88,869,941...88,871,049
G
F2RL1
F2R like trypsin receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19712758
NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005
G
GRK2
G protein-coupled receptor kinase 2
severity
ISO
RGD
PMID:29530536
RGD:13513974
NCBI chr 1:6,975,202...6,995,369
Ensembl chr 1:6,975,002...6,995,259
G
GRP
gastrin releasing peptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29669290
NCBI chr18:20,496,201...20,508,551
Ensembl chr18:20,496,516...20,507,153
G
HRH1
histamine receptor H1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19652466
NCBI chr22:47,187,156...47,298,761
Ensembl chr22:47,295,011...47,296,471
G
HRH4
histamine receptor H4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19652466
NCBI chr18:56,056,522...56,095,194
Ensembl chr18:56,057,605...56,068,482
G
NMB
neuromedin B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29669290
NCBI chr29:3,703,390...3,706,463
G
OPRM1
opioid receptor mu 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27192616
NCBI chr13:81,568,295...81,650,005
Ensembl chr13:81,568,732...81,625,088
G
PDYN
prodynorphin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29669290
NCBI chr 2:54,535,516...54,551,085
Ensembl chr 2:54,535,240...54,551,104
G
SCN9A
sodium voltage-gated channel alpha subunit 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24820863
NCBI chr10:51,711,446...51,898,856
Ensembl chr10:51,714,931...51,829,621
G
TAC1
tachykinin precursor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19652466
NCBI chr21:51,339,085...51,347,561
Ensembl chr21:51,339,095...51,347,550
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
CCDC47
coiled-coil domain containing 47
ISO
ClinVar Annotator: match by term: CCDC47-related condition | ClinVar Annotator: match by term: Trichohepatoneurodevelopmental syndrome
OMIM ClinVar
PMID:25741868 PMID:28492532 PMID:30401460
NCBI chr16:57,517,759...57,545,495
Ensembl chr16:57,525,512...57,547,798
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