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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hypertensive Nephrosclerosis
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Accession:DOID:9002721 term browser browse the term
Definition:Fibrosis of the kidney caused by chronic hypertension.
Synonyms:exact_synonym: HTNS


show annotations for term's descendants           Sort by:
Hypertensive Nephrosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme treatment
severity		 ISO
IEP		 protein:increased expression:nephron tubule, kidney interstitium (human) RGD PMID:10580398 PMID:21346373 RGD:12879397, RGD:40818408 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACE2 angiotensin converting enzyme 2 severity IEP mRNA, protein:decreased expression, increased expression:nephron tubule, kidney interstitium (human) RGD PMID:21346373 RGD:40818408 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G MIR214 microRNA 214 IEP RNA:increased expression:kidney RGD PMID:30049682 RGD:38500245 NCBI chr 1:172,138,798...172,138,907
Ensembl chr 1:172,138,798...172,138,907 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 121159
    disease of anatomical entity 111930
      Urogenital Diseases 14367
        urinary system disease 4888
          kidney disease 4417
            nephrosclerosis 18
              Hypertensive Nephrosclerosis 3
Path 2
Term Annotations click to browse term
  disease 121159
    disease of anatomical entity 111930
      cardiovascular system disease 20568
        vascular disease 15463
          artery disease 10667
            hypertension 2931
              secondary hypertension 78
                renal hypertension 78
                  nephrosclerosis 18
                    Hypertensive Nephrosclerosis 3
paths to the root