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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:prolymphocytic leukemia
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Accession:DOID:1039 term browser browse the term
Definition:A chronic lymphocytic leukemia that is characterized by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) in the peripheral blood, bone marrow, and spleen. (DO)
Synonyms:exact_synonym: PLL;   Prolymphocytic leukaemia;   prolymphocytic leukemias
 primary_id: MESH:D015463
 xref: ICDO:9832/3;   NCI:C3181
For additional species annotation, visit the Alliance of Genome Resources.


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T-cell prolymphocytic leukemia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO ClinVar Annotator: match by term: T-cell prolymphocytic leukemia ClinVar PMID:6504056 PMID:7792600 PMID:8755918 PMID:8797579 PMID:8808599 More... NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G C8h11orf65 similar to human chromosome 11 open reading frame 65 ISO ClinVar Annotator: match by term: T-cell prolymphocytic leukemia ClinVar PMID:6504056 PMID:7792600 PMID:8755918 PMID:8797579 PMID:8808599 More... NCBI chr 8:53,796,033...53,825,277
Ensembl chr 8:53,796,366...53,824,748 		JBrowse link
G Jak3 Janus kinase 3 ISO DNA:missense mutations:exon:pM511I, p.R657Q (human) RGD PMID:24446122 RGD:11531125 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29200404 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9058727 NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    disease of cellular proliferation 7746
      Neoplasms by Histologic Type 5353
        leukemia 625
          lymphoid leukemia 291
            prolymphocytic leukemia 5
              B-cell prolymphocytic leukemia 0
              T-cell prolymphocytic leukemia 5
              splenic manifestation of prolymphocytic leukemia 0
Path 2
Term Annotations click to browse term
  disease 18976
    disease of anatomical entity 18260
      Immune & Inflammatory Diseases 5574
        immune system disease 4782
          immune system cancer 668
            lymphatic system cancer 668
              lymphoma 580
                lymphoid leukemia 291
                  chronic lymphocytic leukemia 90
                    prolymphocytic leukemia 5
                      B-cell prolymphocytic leukemia 0
                      T-cell prolymphocytic leukemia 5
                      splenic manifestation of prolymphocytic leukemia 0
paths to the root