lymphoid leukemia - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	lymphoid leukemia	go back to main search page
Accession:	DOID:1037	browse the term
Definition:	A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. (DO)
Synonyms:	exact_synonym:	lymphoblastic leukaemia; lymphocytic leukaemia; lymphocytic leukemia; lymphocytic leukemias; lymphoid leukemias
	primary_id:	MESH:D007945
	alt_id:	DOID:10747
	xref:	EFO:0004289; ICD10CM:C91; ICD9CM:204; NCI:C7539
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants Sort by:
Rat (298) Mouse (306) Human (1687) Chinchilla (257) Bonobo (279) Dog (276) Squirrel (262) Pig (275) Green Monkey (273) Naked Mole-rat (254) All
Genes (287) Cell Lines (11)

lymphoid leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activation-induced cytidine deaminase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972

G

Bcl2-like 1

RGD

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

cyclin-dependent kinase inhibitor 2B

DNA:hypermethylation:promoter:

RGD

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

CLPTM1-like

CTD Direct Evidence: marker/mechanism

NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530

G

endoglin

disease_progression

RGD

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

ETS variant transcription factor 6

DNA:translocation: :

RGD

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

Fc gamma receptor 2A

no_association
treatment

DNA:polymorphism:exon:p.H131A (human)

RGD

PMID:15217834 PMID:20705761

RGD:11344968, RGD:11344969

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

Fc gamma receptor 2B

treatment

RGD

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

Fc gamma receptor 3A

no_association

DNA:polymorphism:exon:p.F158V (rs396991) (human)

RGD

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

glutathione-disulfide reductase

protein:increased activity:erythrocyte:

RGD

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

susceptibility

RGD

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

susceptibility

DNA:polymorphism:cds:p.I105V(human)

RGD

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

susceptibility

RGD

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

interaction protein for cytohesin exchange factors 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:43,237,903...43,451,735
Ensembl chr 1:43,269,202...43,427,969

G

lysine methyltransferase 2A

CTD Direct Evidence: marker/mechanism

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

LYL1, basic helix-loop-helix family member

CTD Direct Evidence: marker/mechanism

NCBI chr19:23,452,140...23,455,007
Ensembl chr19:23,452,140...23,455,007

G

MDS1 and EVI1 complex locus

CTD Direct Evidence: marker/mechanism

NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590

G

protection of telomeres 1

CTD Direct Evidence: marker/mechanism

PMID:23502782 PMID:24292274

NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042

G

RUNX family transcription factor 1

DNA:translocation: :

RGD

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

telomerase reverse transcriptase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

acute biphenotypic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DOT1 like histone lysine methyltransferase

treatment

RGD

NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475

G

ring finger protein 20

disease_progression

RGD

NCBI chr 5:63,976,063...64,001,754
Ensembl chr 5:63,976,045...64,001,754

acute leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ERCC excision repair 2, TFIIH core complex helicase subunit

ClinVar Annotator: match by term: Mixed Phenotype Acute Leukemia, T/Myeloid, Not Otherwise Specified

PMID:7585650 PMID:8571952 PMID:9195225 PMID:9238033 PMID:15982307 More...

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

acute lymphoblastic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

susceptibility

DNA:snps, haplotype:multiple (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22674224 PMID:22674224

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

treatment

DNA:SNP:5'UTR:rs717620(human)
DNA:SNPs: :rs717620(human)

RGD

PMID:24404132 PMID:25007187

RGD:11080959, RGD:11080979

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 2

disease_progression

mRNA:increased expression:mononuclear cell:

RGD

PMID:15521915 PMID:12100141

RGD:11081076, RGD:11081143

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

PMID:11984797 PMID:21898527

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

susceptibility

RGD

NCBI chr 3:10,162,087...10,182,835
Ensembl chr 3:10,162,096...10,191,423

G

activation-induced cytidine deaminase

treatment

RGD

NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972

G

AT-rich interaction domain 5B

CTD Direct Evidence: marker/mechanism

PMID:19684603 PMID:19684604

NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433

G

aryl hydrocarbon receptor nuclear translocator

CTD Direct Evidence: marker/mechanism

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

BCL2 associated X, apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

severity

mRNA:increased expression:bone marrow (human)

RGD

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

treatment

mRNA:increased expression:blood, mononuclear cell (human)

RGD

PMID:12469194 PMID:19020783

RGD:11353852, RGD:11353866

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

BCR activator of RhoGEF and GTPase

CTD Direct Evidence: marker/mechanism

NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016

G

caspase 8

CTD Direct Evidence: therapeutic

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

calpastatin

protein:increased expresssion:B cell

RGD

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

cyclin D1

mRNA:increased expression:bone marrow (human)

RGD

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

CD40 ligand

RGD

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CD46 molecule

protein:increased expression:peripheral blood mononuclear cell (human)

RGD

NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445

G

CD79b molecule

protein:decreased expression:bone marrow, mononuclear cell (human)

RGD

NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625

G

CD86 molecule

severity

protein:increased expression:peripheral blood, bone marrow, mononuclear cell (human)

RGD

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cyclin-dependent kinase 6

CTD Direct Evidence: marker/mechanism

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 2A

disease_progression
no_association
susceptibility

DNA:deletion: :
DNA:missense mutations:cds:
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia

CTD
ClinVar
RGD

PMID:7566978 PMID:7647780 PMID:7718873 PMID:7987387 PMID:8573142 More...

RGD:11251764, RGD:11252081, RGD:11252082, RGD:11057958

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2A, variant 1

disease_progression

RGD

G

cyclin-dependent kinase inhibitor 2B

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

CCAAT/enhancer binding protein epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814

G

complement factor B

DNA:missense mutation:p.R32Q b(human)

RGD

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

CREB binding protein

disease_progression

DNA:mutations:multiple

RGD

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cytokine receptor-like factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642

G

colony stimulating factor 3

treatment

RGD

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

chondroitin sulfate proteoglycan 4

severity

RGD

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

G

cytochrome b-245 alpha chain

mRNA:increased expression:peripheral blood mononuclear cell:

RGD

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 1, subfamily a, polypeptide 1

susceptibility
no_association

DNA:polymorphism:3"UTR:rs4646903(human)
DNA:polymorphism:cds:2452C>A(p.T461N)(human)
DNA:polymorphism:3'UTR:3801T>C(human)

RGD

PMID:22964275 PMID:23725389 PMID:16676594

RGD:11352714, RGD:11352725, RGD:11352728

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily c, polypeptide 79

CTD Direct Evidence: marker/mechanism

G

cytochrome P450, family 2, subfamily d, polypeptide 4

susceptibility

DNA:polymorphisms: :
DNA:SNP,deletion:splice junction,exon:1934G>A (human)

RGD

PMID:11037802 PMID:19593802

RGD:11352820, RGD:11252111

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 9

disease_progression
susceptibility

DNA:polymorphism: :

RGD

PMID:19650988 PMID:22215203

RGD:11353796, RGD:11353805

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

dihydrofolate reductase

disease_progression

DNA:polymorphisms, haplotype:promoter:
DNA:polymorphisms: :-317A>G, 829C>T (human)

RGD

PMID:19861437 PMID:9226157 PMID:22969948 PMID:12972803

RGD:11039542, RGD:11039543, RGD:11039544, RGD:11039545

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

DNA methyltransferase 3 alpha

treatment

DNA:mutations:exon, intron:p.R882(human)

RGD

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA nucleotidylexotransferase

protein:increased activity:peripheral blood,bone marrow:

RGD

NCBI chr 1:239,856,391...239,888,283
Ensembl chr 1:239,856,391...239,888,282

G

dihydropyrimidine dehydrogenase

disease_progression
no_association

DNA:SNP: :85T>C (human)
DNA:splice-site mutation:intron:IVS14+1G>A (human)
DNA:SNPs: :2194G>A, 1156G>T (human)

RGD

PMID:26846104 PMID:26846104 PMID:26846104

RGD:11098453, RGD:11098453, RGD:11098453

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

double homeobox 4

CTD Direct Evidence: marker/mechanism

NCBI chr16:1,558,430...1,570,045
Ensembl chr16:1,558,766...1,568,565

G

euchromatic histone lysine methyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007

G

euchromatic histone lysine methyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

endoglin

disease_progression

RGD

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

epoxide hydrolase 1

susceptibility
no_association

DNA:missense mutation, haplotype:exon:p.Y113H (human)
DNA:missense mutation, haplotype:exon:p.H139R (human)
DNA:polymorphisms:exon
DNA:SNPs:exon:rs1051740, rs2234922 (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21983886 PMID:21983886 PMID:21983886 PMID:19593802 PMID:22930568 More...

RGD:11252110, RGD:11252110, RGD:11252111, RGD:11252113, RGD:11252114

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:SNPs: :8092C>A, 19007G>A (human)
DNA:SNPs, haplotypes: :p.R194W, p.R280H, p.R399Q (human)

RGD

PMID:16723154 PMID:16435384

RGD:11252160, RGD:11340204

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 2, TFIIH core complex helicase subunit

no_association

DNA:missense mutations: :p.D312N, p.K751Q (human)
DNA:haplotype

RGD

PMID:19101034 PMID:21987080

RGD:11252192, RGD:11340201

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ETS transcription factor ERG

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Acute lymphoid leukemia

PMID:27776115 PMID:27993330

NCBI chr11:34,678,614...34,900,951
Ensembl chr11:34,678,618...34,845,871

G

ETS variant transcription factor 6

ClinVar Annotator: match by term: Acute lymphoid leukemia
CTD Direct Evidence: marker/mechanism

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

coagulation factor III, tissue factor

RGD

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

Fas cell surface death receptor

disease_progression

protein:increased expression:CD34+ bone marrow cell

RGD

PMID:10500800 PMID:9711907

RGD:11049148, RGD:11049157

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fibrinogen alpha chain

protein:increased expression:serum (human)

RGD

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

Fms related receptor tyrosine kinase 3

ClinVar Annotator: match by term: Acute lymphoid leukemia
CTD Direct Evidence: marker/mechanism

ClinVar
OMIM
CTD

PMID:11290608 PMID:11442493 PMID:14604974 PMID:14670924 PMID:15256420 More...

NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474

G

folylpolyglutamate synthase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

growth factor independent 1B transcriptional repressor

mRNA:increased expression:blood:

RGD

NCBI chr 3:11,940,232...11,952,989
Ensembl chr 3:11,940,233...11,952,942

G

growth hormone 1

treatment

RGD

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

G protein subunit beta 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Acute lymphoblastic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Lymphoblastic leukemia

OMIM
CTD
ClinVar

PMID:25485910 PMID:25741868 PMID:27108799 PMID:28492532 PMID:32134617 More...

NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124

G

glucose-6-phosphate isomerase

RGD

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

glutathione peroxidase 1

treatment

RGD

PMID:17317918 PMID:24698347

RGD:11352774, RGD:11352812

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

RGD

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

disease_progression
susceptibility
no_association

RGD

PMID:10666194 PMID:15738600 PMID:12827651 PMID:14607752

RGD:10450829, RGD:10755321, RGD:10755409, RGD:10755410

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

disease_progression
susceptibility
no_association

DNA:haplotype:cds:
DNA:transition mutation:exon:
DNA:polymorphism: :1578 a>G(human)

RGD

PMID:10666194 PMID:15738600 PMID:23979883

RGD:10450829, RGD:10755321, RGD:10755417

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

disease_progression
susceptibility

RGD

PMID:10666194 PMID:14607752

RGD:10450829, RGD:10755410

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

H1.2 linker histone, cluster member

susceptibility

DNA:SNP, haplotype:enhancer: (rs807212) (human)

RGD

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

HCK proto-oncogene, Src family tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693

G

histone deacetylase 1

disease_progression

mRNA:increased expression:bone marrow,blood:

RGD

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 2

disease_progression

mRNA:increased expression:bone marrow,blood:

RGD

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

histone deacetylase 4

treatment

RGD

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

homeostatic iron regulator

no_association

DNA:missense mutation:cds:p.H63D (human)
DNA:missense mutation:cds:p.C282Y (human)
DNA:missense mutation: :p.H63D (human)

RGD

PMID:10627122 PMID:10627122 PMID:17107905

RGD:10755557, RGD:10755557, RGD:10755558

NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502

G

hexokinase 1

protein:decreased activity:platelet

RGD

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

HLF transcription factor, PAR bZIP family member

CTD Direct Evidence: marker/mechanism

NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935

G

homeo box D4

ClinVar Annotator: match by term: Leukemia, acute lymphoblastic, susceptibility to
CTD Direct Evidence: marker/mechanism

NCBI chr 3:59,614,464...59,634,042
Ensembl chr 3:59,614,464...59,631,528

G

isocitrate dehydrogenase (NADP(+)) 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

interferon gamma

susceptibility

DNA:SNP: :rs2069727(human)

RGD

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

IKAROS family zinc finger 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Leukemia, acute lymphocytic, susceptibility to, 2
DNA:SNPs: (human)

CTD
ClinVar
RGD

PMID:19684604 PMID:25741868 PMID:27993330 PMID:28492532 PMID:24786325

NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416

G

IKAROS family zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:71,046,038...71,191,296
Ensembl chr 9:71,042,440...71,190,867

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:83,460,564...83,553,591
Ensembl chr10:83,465,745...83,553,591

G

interleukin 10

treatment

protein:decreased expression:blood

RGD

PMID:21653647 PMID:15860861

RGD:11049158, RGD:11049169

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interferon regulatory factor 4

DNA:SNP:intron:rs12203592 (human)

RGD

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

G

inosine triphosphatase

treatment
no_association

DNA:SNPs:exon:94C>A, 138G>A (human)
DNA:SNP:intron

RGD

PMID:22009189 PMID:22009189

RGD:10766474, RGD:10766474

NCBI chr 3:117,885,464...117,897,247
Ensembl chr 3:117,885,099...117,897,249

G

lysine demethylase 2B

mRNA:increased expression:bone marrow (human)

RGD

NCBI chr12:33,566,530...33,701,366
Ensembl chr12:33,574,657...33,701,355

G

lysine demethylase 3B

protein:increased expression:bone marrow, mononuclear cell (human)

RGD

NCBI chr18:26,380,859...26,436,701
Ensembl chr18:26,380,964...26,436,628

G

lysine demethylase 6A

severity

DNA:mutations:cds:multiple (human)

NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062

G

lysine methyltransferase 2A

CTD Direct Evidence: marker/mechanism
OMIM:247640 | OMIM:613065

PMID:24736461 PMID:25730765

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

KRAS proto-oncogene, GTPase

disease_progression

RGD

PMID:17910045 PMID:25917266

RGD:11060148, RGD:11060149

NCBI chr 4:178,185,418...178,218,484

G

MEFV innate immunity regulator, pyrin

susceptibility

DNA:polymorphisms:cds:p.E148Q,M680I(human)

RGD

NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973

G

methylenetetrahydrofolate reductase

disease_progression
treatment

DNA:missense mutation:cds:677C>T (p.A222V) (rs1801133) (human)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds:677C>T (human)

CTD
RGD

PMID:16706930 PMID:19923983 PMID:21644011

RGD:10449398, RGD:10449407

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

5-methyltetrahydrofolate-homocysteine methyltransferase

disease_progression
no_association
susceptibility

DNA:SNP::rs10925235(human)
DNA:polymorphism: :2756A>G(human)
DNA:polymorphism: :66A>G(human)

RGD

PMID:26605150 PMID:22453148 PMID:15159311 PMID:21618417

RGD:11531136, RGD:11531137, RGD:11531140, RGD:11531141

NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

DNA:haplotype:cds:
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs3776455(human)

CTD
RGD

PMID:17136115 PMID:17136115 PMID:23940529

RGD:11531133, RGD:11531135

NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425

G

MYC proto-oncogene, bHLH transcription factor

disease_progression

RGD

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

N-acetyltransferase 2

susceptibility
no_association

DNA:polymorphisms: :
DNA:polymorphisms,haplotype: :
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22200898 PMID:25804798 PMID:21888617 PMID:22215203

RGD:11532767, RGD:11532769, RGD:11353805

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

nibrin

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Acute lymphoblastic leukemia | ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Lymphoblastic leukemia

OMIM
CTD
ClinVar

PMID:9590180 PMID:11325820 PMID:12353271 PMID:14559852 PMID:15338273 More...

NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150

G

nitric oxide synthase 3

susceptibility
disease_progression

DNA:SNP: :rs3918186(human)
DNA:polymorphism, haplotype:cds,intron:P.E298D,-786T>C(human)

RGD

PMID:23922896 PMID:20510681

RGD:11533639, RGD:11533646

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

DNA:mutation: :609C>T (human)
DNA:missense mutations: :p.R139W (465C>T), p.P187S (609C>T) (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:11774269 PMID:17332311 PMID:18444911 PMID:11774269

RGD:10769347, RGD:10769359

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

NRAS proto-oncogene, GTPase

disease_progression

DNA:missense mutation:cds:

RGD

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

nuclear receptor binding SET domain protein 2

CTD Direct Evidence: therapeutic

NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641

G

5'-nucleotidase, cytosolic II

CTD Direct Evidence: marker/mechanism

NCBI chr 1:245,770,993...245,896,925
Ensembl chr 1:245,772,277...245,897,913

G

nucleoporin 214

CTD Direct Evidence: marker/mechanism

NCBI chr 3:15,255,111...15,340,568
Ensembl chr 3:15,255,119...15,340,568

G

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849

G

paired box 5

susceptibility

ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Leukemia, acute lymphoblastic, susceptibility to, 3
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD

PMID:24013638 PMID:24728327 PMID:25741868 PMID:26214592 PMID:27993330 More...

NCBI chr 5:58,763,334...58,945,719
Ensembl chr 5:58,765,036...58,944,326

G

paraoxonase 1

susceptibility

DNA:missense mutations:cds:p.L55M (rs854560), p.Q192R (rs662) (human)

RGD

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

PRAME like, X-linked 1

severity

mRNA:increased expression:blood (human)

RGD

NCBI chr X:98,567,994...98,574,654
Ensembl chr X:98,569,415...98,572,096

G

PR/SET domain 14

CTD Direct Evidence: marker/mechanism

NCBI chr 5:6,082,163...6,092,712
Ensembl chr 5:6,082,442...6,092,712

G

phosphatase and tensin homolog

OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RT1 class II, locus Ba

DNA:polymorphisms, haplotype:cds:HLA-DQA1*01 (human)

RGD

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Bb

DNA:polymorphisms, haplotypes:cds:multiple
DNA:polymorphisms, haplotype:cds:HLA-DQB1*0501 (human)

RGD

PMID:22434102 PMID:9744491

RGD:11041749, RGD:11041762

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RUNX family transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

solute carrier family 19 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

small nuclear ribonucleoprotein polypeptide E

severity

mRNA:decreased expression:bone marrow, blood, mononuclear cell (human)

RGD

NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310
Ensembl chr 8:45,050,986...45,057,310

G

TAL bHLH transcription factor 1, erythroid differentiation factor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976

G

TAL bHLH transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:68,411,012...68,417,569
Ensembl chr 5:68,411,012...68,417,569

G

transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314

G

transcobalamin 2

protein:altered activity:plasma:

RGD

NCBI chr14:78,813,343...78,828,549
Ensembl chr14:78,813,343...78,828,489

G

telomerase reverse transcriptase

DNA:SNPs:promoter, introns:g.1296486C>T, g.12866516A>C, g.1279790G>A (rs2735940, rs2736100, rs10069690) (human)

RGD

PMID:23066086 PMID:15621763

RGD:11038654, RGD:11038667

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transmembrane 9 superfamily member 2

mRNA:increased expression:bone marrow, mononuclear cells (human)

RGD

NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thiopurine S-methyltransferase

treatment
no_association

DNA:SNPs:multiple
DNA:SNPs:introns:12356C>T, 16638C>T, 26354G>T (rs4449636, rs2518463, rs2842949) (human)
DNA:SNPs:exon:374C>T, 719A>G (rs2842934, rs1142345) (human)
DNA:SNPs: :multiple

RGD

PMID:17164697 PMID:22009189 PMID:22009189 PMID:24499706

RGD:11038720, RGD:10766474, RGD:10766474, RGD:11038723

NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709

G

thymidylate synthetase

treatment

DNA:repeats: : rs347430033(human)

RGD

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitously transcribed tetratricopeptide repeat containing, Y-linked

severity

DNA:mutations:cds:multiple (human)

RGD

NCBI chr Y:942,838...1,105,313
Ensembl chr Y:924,168...1,103,422

G

V-set pre-B cell surrogate light chain 1A

CTD Direct Evidence: marker/mechanism

NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846

G

X-ray repair cross complementing 1

susceptibility
no_association

DNA:missense mutation, haplotype: :p.R399Q (human)
DNA:missense mutation: :p.R194W (human)
DNA:missense mutation: :p.R399Q (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21983886 PMID:21983886 PMID:19101034 PMID:19101034

RGD:11252110, RGD:11252192, RGD:11252192

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

Acute Lymphoblastic Leukemia, with Lymphomatous Features

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:10988075 PMID:11423618 PMID:11853795 PMID:11861307 PMID:11964322 More...

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

cytokine receptor-like factor 2

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:19907440 PMID:19965641 PMID:20018760 PMID:22368272

NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642

G

cytochrome P450, family 2, subfamily b, polypeptide 3

susceptibility

DNA:polymorphism:G15631T

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

Fibroblast growth factor receptor 1

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:25705862 PMID:26619011 PMID:26942290 PMID:33448156

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

interleukin 7 receptor

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:22897847 PMID:22955920

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

insulin-like 6

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:18805579 PMID:19470474 PMID:20585391 PMID:22368270 PMID:22955920

NCBI chr 1:227,069,958...227,073,493
Ensembl chr 1:227,069,958...227,073,493

G

Janus kinase 1

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:16239216 PMID:19139102 PMID:19470474 PMID:19838194 PMID:20167706 More...

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:18805579 PMID:19470474 PMID:20585391 PMID:22368270 PMID:22955920

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Janus kinase 3

ClinVar Annotator: match by term: LYMPHOMATOUS ALL

PMID:10982185 PMID:16843266 PMID:18270328 PMID:20132407 PMID:20372971 More...

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

adult T-cell leukemia/lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

baculoviral IAP repeat-containing 5

CTD Direct Evidence: marker/mechanism

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

caspase recruitment domain family, member 11

CTD Direct Evidence: marker/mechanism

NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112

G

C-C motif chemokine receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

C-C motif chemokine receptor 7

CTD Direct Evidence: marker/mechanism

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

CD163 molecule

disease_progression

protein:increased expression:lymph node tumor (human)

RGD

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

CD274 molecule

disease_progression

RGD

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

Cd28 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

Cd68 molecule

disease_progression

protein:increased expression:lymph node tumor (human)

RGD

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

Cd80 molecule

RGD

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

RGD

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

casein kinase 1, alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271

G

casein kinase 2 alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

casein kinase 2 beta

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133

G

cytotoxic T-lymphocyte-associated protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

Fas cell surface death receptor

susceptibility

DNA:polymorphism:promoter: -670 G>A(human)
protein:increased expression:peripheral blood mononuclear cell:

RGD

PMID:17962369 PMID:7513372

RGD:11049147, RGD:11049453

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

forkhead box P3

disease_progression

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23962110 PMID:23797717

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

FYN proto-oncogene, Src family tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

G protein-coupled receptor 183

CTD Direct Evidence: marker/mechanism

NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559

G

heterogeneous nuclear ribonucleoprotein A2/B1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

inducible T-cell co-stimulator

CTD Direct Evidence: marker/mechanism

NCBI chr 9:62,368,075...62,406,900
Ensembl chr 9:62,383,832...62,405,672

G

interferon, alpha 1

CTD Direct Evidence: therapeutic

NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925

G

interferon gamma

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23962110 PMID:8800741

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

IKAROS family zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:71,046,038...71,191,296
Ensembl chr 9:71,042,440...71,190,867

G

interleukin 10

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23962110 PMID:8704212

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

CTD Direct Evidence: marker/mechanism

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

disease_progression

protein:increased expression:serum

RGD

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

protein:increased expression:serum (human)

RGD

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interferon regulatory factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

G

Janus kinase 3

DNA:missense mutations: :p.L156P, p.R172Q, p.E183G (human)

RGD

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

MYB proto-oncogene, transcription factor

disease_progression

mRNA:splice variants:CD4+ T cell:

RGD

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

notch receptor 1

DNA:mutations:multiple (human)

RGD

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

NRAS proto-oncogene, GTPase

disease_progression

RGD

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

phospholipase C, gamma 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

protein kinase C, beta

CTD Direct Evidence: marker/mechanism

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

TAL bHLH transcription factor 2

RGD

NCBI chr 5:68,411,012...68,417,569
Ensembl chr 5:68,411,012...68,417,569

G

telomeric repeat binding factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819

G

T-cell leukemia, homeobox 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:1717256 PMID:1683261

NCBI chr 1:244,005,057...244,011,318
Ensembl chr 1:244,005,057...244,011,318

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421

G

tumor protein p53

GAD

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p73

CTD Direct Evidence: marker/mechanism

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

vav guanine nucleotide exchange factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937

B-cell acute lymphoblastic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ERCC excision repair 4, endonuclease catalytic subunit

ClinVar Annotator: match by term: Precursor B-cell acute lymphoblastic leukemia

PMID:23623386 PMID:25741868

NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369

G

neurofibromin 1

ClinVar Annotator: match by term: Precursor B-cell acute lymphoblastic leukemia

PMID:9536098 PMID:17576681 PMID:23656349 PMID:25741868 PMID:28492532

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

WT1 transcription factor

ClinVar Annotator: match by term: B Acute Lymphoblastic Leukemia

PMID:8621495 PMID:12640141 PMID:16987884 PMID:25741868 PMID:28492532 More...

NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643

B-Cell Chronic Lymphocytic Leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

susceptibility

DNA:SNPs,haplotype: :rs1481012,rs2231142(human)

RGD

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acyl-CoA oxidase-like

CTD Direct Evidence: marker/mechanism

NCBI chr 3:115,061,069...115,367,032
Ensembl chr 3:115,061,060...115,364,686

G

activation-induced cytidine deaminase

disease_progression

RGD

NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972

G

apolipoprotein E

disease_progression

RGD

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

ATM serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

BCL11 transcription factor A

DNA:translocation:5' utr: (human)

RGD

NCBI chr14:98,029,018...98,124,181
Ensembl chr14:98,030,461...98,124,180

G

BCL2, apoptosis regulator

treatment
severity
no_association

CTD Direct Evidence: marker/mechanism
protein:increased expression:B cell (human)
DNA:snp:promoter:g.-938C>A (human)

CTD
RGD

PMID:21750559 PMID:23770605 PMID:17296974 PMID:20001236 PMID:17959858 More...

RGD:11522735, RGD:11526110, RGD:11526105, RGD:11526104

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2 modifying factor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12068308 PMID:12198537 PMID:12692057 PMID:12960123 PMID:14612909 More...

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

Bruton tyrosine kinase

treatment

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia

PMID:24869598 PMID:25741868 PMID:28492532 PMID:23045577

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

G

Cbl proto-oncogene

severity

mRNA,protein:increased expression:CD5+ B cell:
DNA:hypophosphorylation:CD5+ B cell:

RGD

PMID:17804547 PMID:17804547

RGD:11038803, RGD:11038803

NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176

G

coiled-coil domain containing 50

RGD

NCBI chr11:73,332,798...73,395,333
Ensembl chr11:73,334,248...73,395,150

G

CD40 molecule

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD40 ligand

mouse-human chimeric gene in human

RGD

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

Cd5 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313

G

CD79b molecule

protein:decreased expression:B lymphocyte, cell surface (human)
DNA:polymorphism:multiple (human)
mRNA, protein:splice variants, alternative forms:exon 3 (human)

RGD

PMID:9269755 PMID:10552962 PMID:10090943

RGD:11250403, RGD:151665202, RGD:151665190

NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625

G

CD86 molecule

severity

protein:increased expression:peripheral blood mononuclear cell (human)

RGD

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cytoplasmic polyadenylation element binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:135,300,048...135,407,688
Ensembl chr 1:135,300,461...135,409,760

G

cytotoxic T-lymphocyte-associated protein 4

protein:increased expression:T cell

RGD

PMID:16094420 PMID:15914560

RGD:11344923, RGD:11352246

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

dyskerin pseudouridine synthase 1

RGD

G

DNA methyltransferase 3 beta

mRNA:decreased expression: B cell

RGD

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

ERCC excision repair 2, TFIIH core complex helicase subunit

severity

DNA:SNP: :p.K751Q (rs13181) (human)

RGD

PMID:22739018 PMID:19484764

RGD:11252203, RGD:11252204

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

FERM, ARH/RhoGEF and pleckstrin domain protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:94,053,650...94,161,982
Ensembl chr 9:94,053,726...94,162,212

G

Fas cell surface death receptor

disease_progression

RGD

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:25741868 PMID:26619011

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

G

Fc gamma receptor 3A

no_association

DNA:SNP:exon:p.F158V (rs396991) (human)

RGD

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

GNAS complex locus

disease_progression

DNA:polymorphism:393T>C (human)

RGD

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

intercellular adhesion molecule 1

severity

RGD

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

susceptibility

DNA:polymorphism: :847A>T(human)

RGD

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

disease_progression
no_association

protein:increased expression:serum
DNA:SNPs: :multiple
DNA:SNPs: :rs1800890, rs4072227, rs17015865 (human)

RGD

PMID:22945689 PMID:10638947 PMID:19573080 PMID:19573080

RGD:11041895, RGD:11049174, RGD:11049165, RGD:11049165

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 19

CTD Direct Evidence: marker/mechanism

NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473

G

interleukin 1 alpha

RGD

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

severity

DNA:SNP:promoter:-511C>T (human)
protein:decreased expression:plasma:

RGD

PMID:18271063 PMID:10870116

RGD:11051967, RGD:11522755

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

protein:decreased expression:plasma:

RGD

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 6

protein:increased expression:plasma:
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18006695 PMID:10870116

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interferon regulatory factor 4

disease_progression

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18758461 PMID:12393648 PMID:12079517

RGD:11526160, RGD:11530024

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

G

integrin subunit alpha 4

CTD Direct Evidence: marker/mechanism

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More...

NCBI chr 4:178,185,418...178,218,484

G

lymphoid enhancer binding factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172

G

microRNA 143

CTD Direct Evidence: marker/mechanism

NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110

G

microRNA 145

CTD Direct Evidence: marker/mechanism

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

G

membrane spanning 4-domains A1

RGD

NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

MYD88, innate immune signal transduction adaptor

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

purinergic receptor P2X 7

CTD Direct Evidence: marker/mechanism

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

platelet and endothelial cell adhesion molecule 1

severity

protein:increased expression:B cell (human)

RGD

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

phospholipase C, gamma 2

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia

PMID:24869598 PMID:27542411 PMID:28492532

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

phorbol-12-myristate-13-acetate-induced protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

DNA polymerase beta

CTD Direct Evidence: marker/mechanism

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812

G

protein phosphatase 2, regulatory subunit B', gamma

CTD Direct Evidence: marker/mechanism

NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346

G

PRAME like, X-linked 1

protein:increased expression:mononuclear cell (human)

RGD

NCBI chr X:98,567,994...98,574,654
Ensembl chr X:98,569,415...98,572,096

G

protein kinase D2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 11

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12161469 PMID:12717436 PMID:14644997 PMID:14982869 PMID:15385933 More...

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

glutaminyl-peptide cyclotransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:15,964,656...15,996,730
Ensembl chr 6:15,964,657...15,996,711

G

RB transcriptional corepressor like 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

splicing factor 3b, subunit 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:22158541 PMID:23634996 PMID:25741868 PMID:26619011

NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300

G

splicing factor 3b, subunit 2

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759

G

SP140 nuclear body protein

CTD Direct Evidence: marker/mechanism

NCBI chr 9:86,224,472...86,274,724
Ensembl chr 9:86,224,513...86,274,542

G

telomerase reverse transcriptase

disease_progression

RGD

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transferrin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

thrombomodulin

RGD

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

tumor necrosis factor

disease_progression

protein:increased expression:bone marrow, blood, lymphocyte

RGD

PMID:12010662 PMID:22945689

RGD:10449463, RGD:11041895

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 10b

susceptibility

DNA:missense mutation:cds:p.E228A (c.683A>C) (human)
DNA:SNP: :1322A>G (human)

RGD

PMID:16217763 PMID:15531454

RGD:11038717, RGD:11038718

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

TNF receptor superfamily member 11A

CTD Direct Evidence: marker/mechanism

NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695

G

TNF superfamily member 11

CTD Direct Evidence: marker/mechanism

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

TNF superfamily member 13

protein:increased expression:serum

RGD

NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421

G

DNA topoisomerase II binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674

G

tumor protein p53

disease_progression

DNA:deletion: :
ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
RGD

PMID:253702 PMID:1359493 PMID:1565143 PMID:1565144 PMID:1631137 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vitamin D receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

exportin 1

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

X-ray repair cross complementing 1

severity
no_association

DNA:SNP: :p.R399Q (rs25487) (human)
DNA:SNP: :p.R194W (rs1799782), p.R280H (25489) (human)

RGD

PMID:19484764 PMID:19484764

RGD:11252204, RGD:11252204

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

B-lymphoblastic leukemia/lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

treatment

RGD

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1, member C3

treatment

RGD

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

activating transcription factor 7 interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr 4:169,385,872...169,471,652
Ensembl chr 4:169,385,872...169,471,650

G

Bcl2-like 1

severity

RGD

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

BCR activator of RhoGEF and GTPase

BCR/ABL fusion

RGD

NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016

G

bromodomain containing 2

RGD

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

G

cellular communication network factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

mRNA:increased expression:B cell (mouse)

RGD

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 2A

treatment
susceptibility

DNA:mutation:cds:c.442C>T,p.A148T,rs3731249 (human)

RGD

PMID:16618932 PMID:26104880 PMID:21622646

RGD:11251751, RGD:11057958, RGD:11251772

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2A, variant 2

treatment

RGD

PMID:21622646 PMID:16618932

RGD:11251772, RGD:11251751

G

cytokine receptor-like factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642

G

cytochrome P450, family 3, subfamily a, polypeptide 9

treatment

DNA:polymorphisms: :

RGD

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

double homeobox 4

CTD Direct Evidence: marker/mechanism

NCBI chr16:1,558,430...1,570,045
Ensembl chr16:1,558,766...1,568,565

G

ETS variant transcription factor 6

CTD Direct Evidence: marker/mechanism

PMID:15217836 PMID:24413735 PMID:25807284

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

coagulation factor XIII A1 chain

protein:increased expression:B lymphoblast:

RGD

NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700

G

coagulation factor III, tissue factor

treatment

RGD

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fumarate hydratase

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

Fms related receptor tyrosine kinase 3

mRNA,protein:increased expression:bone marrow:

RGD

NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

indoleamine 2,3-dioxygenase 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

IKAROS family zinc finger 1

disease_progression

DNA:mutations: :
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:24141364 PMID:22699455

NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416

G

interleukin 5

RGD

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interferon regulatory factor 4

RGD

PMID:25006123 PMID:20585039 PMID:21818355

RGD:11526159, RGD:11530030, RGD:11530020

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

G

interferon regulatory factor 8

RGD

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

G

intestine-specific homeobox

CTD Direct Evidence: marker/mechanism

NCBI chr19:13,217,637...13,239,754
Ensembl chr19:13,218,552...13,239,760

G

MAX dimerization protein MGA

CTD Direct Evidence: marker/mechanism

NCBI chr 3:106,851,216...106,942,908
Ensembl chr 3:106,851,140...106,941,043

G

MYB proto-oncogene, transcription factor

disease_progression

mRNA:splice variants:cds:

RGD

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

MYC proto-oncogene, bHLH transcription factor

RGD

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

paired box 5

CTD Direct Evidence: marker/mechanism

PMID:24013638 PMID:30643249

NCBI chr 5:58,763,334...58,945,719
Ensembl chr 5:58,765,036...58,944,326

G

platelet derived growth factor receptor alpha

treatment

RGD

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RUNX family transcription factor 1

onset

DNA:amplification
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15217836 PMID:24413735 PMID:21822204

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5A

protein:increased phosphorylation:bone marrow (human)

RGD

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

G

serine/threonine kinase 11

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:26080840 PMID:26295973 PMID:28492532

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

SUFU negative regulator of hedgehog signaling

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577

G

transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314

G

tryptophan 2,3-dioxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511

G

tissue factor pathway inhibitor

treatment

RGD

NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880

G

TNF superfamily member 13

RGD

NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421

G

tumor protein p53

disease_progression

DNA:mutations: :

RGD

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

WT1 transcription factor

ClinVar Annotator: match by term: Pre-B-cell acute lymphoblastic leukemia

PMID:8621495 PMID:12640141 PMID:16987884 PMID:25741868 PMID:28492532 More...

NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643

B-lymphoblastic leukemia/lymphoma with BCR-ABL1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mutS homolog 6

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1

PMID:22658618 PMID:25741868 PMID:28492532

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone morphogenetic protein receptor type 1A

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532 PMID:30093976

NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532 PMID:33471991

NCBI chr 1:176,665,076...176,689,053
Ensembl chr 1:176,665,076...176,688,990

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RecQ like helicase 4

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:10678659 PMID:12734318 PMID:12838562 PMID:12952869 PMID:15897384 More...

NCBI chr 7:108,423,453...108,430,790
Ensembl chr 7:108,423,455...108,430,619

B-lymphoblastic leukemia/lymphoma with hyperdiploidy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Cbl proto-oncogene

ClinVar Annotator: match by term: B lymphoblastic leukemia lymphoma with hyperdiploidy

PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176

B-lymphoblastic leukemia/lymphoma with hypodiploidy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

succinate dehydrogenase complex flavoprotein subunit A

ClinVar Annotator: match by term: B-lymphoblastic leukemia/lymphoma with hypodiploidy

PMID:25741868 PMID:28492532

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

childhood acute lymphocytic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CCCTC-binding factor

disease_progression

mRNA, protein:increased expression:bone marrow, blood (human)

RGD

NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123

chronic lymphocytic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate kinase 3

protein:increased expression:peripheral blood mononuclear cell

RGD

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

Rho GTPase activating protein 44

mRNA:increased expression: (human)

RGD

NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12068308 PMID:12198537 PMID:12960123 PMID:14612909 PMID:14679157 More...

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

CD40 ligand

protein:increased expression:serum (human)

RGD

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CD79b molecule

protein:decreased expression:peripheral blood cells (human)
mRNA, protein:splice variants, alternative forms:exon 3 (human)
protein:decreased expression:blood, B cell (human)
protein:decreased expression:blood cells (human)

RGD

PMID:10516749 PMID:10090943 PMID:10329919 PMID:10753858

RGD:151665125, RGD:151665190, RGD:11531139, RGD:151665152

NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625

G

CD86 molecule

DNA:hypermethylation (human)

RGD

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:25741868 PMID:26619011

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

interleukin 5

protein:increased expression:serum

RGD

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interferon regulatory factor 4

disease_progression

DNA:SNPs:3' utr:multiple
DNA:SNP: :rs872071 (human)
DNA:missense mutation:exon:p.L116R (human)

RGD

PMID:23897826 PMID:20123861 PMID:20731705 PMID:23926303 PMID:20090783 More...

RGD:11526156, RGD:11530031, RGD:11530029, RGD:11530026, RGD:11530021, RGD:11526158

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More...

NCBI chr 4:178,185,418...178,218,484

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172

G

microRNA 155

miRNA:increased expression:peripheral blood mononuclear cell

RGD

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

microRNA 21

miRNA:increased expression:peripheral blood mononuclear cell

RGD

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

MYC proto-oncogene, bHLH transcription factor

disease_progression

RGD

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

paraoxonase 1

susceptibility

DNA:missense mutations:cds:p.L55M, p.Q192R (human)

RGD

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

protein tyrosine phosphatase, non-receptor type 11

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12717436 PMID:14644997 PMID:15385933 PMID:15710330 PMID:15928039 More...

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 22

susceptibility

DNA:snp:cds:p.R620W (rs2476601) (human)
protein:increased expression:B cell (human)

RGD

PMID:23287625 PMID:22569400

RGD:11533998, RGD:11535006

NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779

G

splicing factor 3b, subunit 1

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300

G

splicing factor 3b, subunit 2

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759

G

signal transducer and activator of transcription 3

protein:increased phosphorylation:peripheral blood mononuclear cell

RGD

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tumor protein p53

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:253702 PMID:1359493 PMID:1565143 PMID:1565144 PMID:1631137 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

exportin 1

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

hairy cell leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione peroxidase 1

RGD

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

interleukin 1 receptor antagonist

treatment

RGD

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

mitogen activated protein kinase kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421

T-cell acute lymphoblastic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

aldo-keto reductase family 1, member C3

treatment

RGD

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

BCL2 associated X, apoptosis regulator

ClinVar Annotator: match by term: T-cell acute lymphoblastic leukemia

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL10, immune signaling adaptor

ClinVar Annotator: match by term: T-cell acute lymphoblastic leukemia

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL11 transcription factor B

CTD Direct Evidence: marker/mechanism

NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224

G

BCL2, apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase recruitment domain family, member 11

mRNA:increased expression:peripheral blood mononuclear cell (human)

RGD

NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112

G

cyclin D3

CTD Direct Evidence: marker/mechanism

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin-dependent kinase inhibitor 2A

disease_progression

DNA:deletion, missense, nonsense mutations:cds:

RGD

PMID:16407836 PMID:8637233 PMID:19759355 PMID:17507663 PMID:23178376

RGD:11251741, RGD:11251776, RGD:11251774, RGD:11251765, RGD:11251744

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2A, variant 1

disease_progression

RGD

PMID:17507663 PMID:16407836

RGD:11251765, RGD:11251741

G

cyclin-dependent kinase inhibitor 2A, variant 2

disease_progression

RGD

PMID:19759355 PMID:16407836

RGD:11251774, RGD:11251741

G

CCR4-NOT transcription complex, subunit 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:65,555,924...65,572,167
Ensembl chr 1:65,555,924...65,572,167

G

colony stimulating factor 3 receptor

ClinVar Annotator: match by term: Early T cell progenitor acute lymphoblastic leukemia

PMID:23604229 PMID:23634996 PMID:23656643 PMID:24081659 PMID:24403076 More...

NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881

G

CCCTC-binding factor

CTD Direct Evidence: marker/mechanism

NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123

G

C-X-C motif chemokine receptor 4

treatment

RGD

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

DNA methyltransferase 3 alpha

disease_progression
susceptibility

DNA:mutations: :
ClinVar Annotator: match by term: Early T cell progenitor acute lymphoblastic leukemia
associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:missense mutation:exon:p.R882H(human)

PMID:23341344 PMID:26072070

RGD:9589073, RGD:11041131

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

RGD

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

F-box and WD repeat domain containing 7

CTD Direct Evidence: marker/mechanism

PMID:19246562 PMID:24394663

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

G

interleukin 7 receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

Janus kinase 1

DNA:missense mutation: :c.1972G>T (p.V658F) (human)

RGD

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 3

RGD

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

KRAS proto-oncogene, GTPase

DNA:missense mutation: :p.G12D (mouse)

RGD

NCBI chr 4:178,185,418...178,218,484

G

LIM domain only 1

CTD Direct Evidence: marker/mechanism

PMID:2034676 PMID:3259177 PMID:19246562

NCBI chr 1:163,132,338...163,168,521
Ensembl chr 1:163,132,339...163,168,522

G

LIM domain only 2

CTD Direct Evidence: marker/mechanism

PMID:2034676 PMID:19246562 PMID:24394663

NCBI chr 3:90,355,234...90,377,970
Ensembl chr 3:90,365,883...90,377,953

G

LYL1, basic helix-loop-helix family member

NCBI chr19:23,452,140...23,455,007
Ensembl chr19:23,452,140...23,455,007

G

mechanistic target of rapamycin kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYB proto-oncogene, transcription factor

CTD Direct Evidence: marker/mechanism

PMID:17435759 PMID:28671688

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

MYCN proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590

G

nibrin

NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150

G

notch receptor 1

ClinVar Annotator: match by term: Early T cell progenitor acute lymphoblastic leukemia
CTD Direct Evidence: marker/mechanism

PMID:19246562 PMID:19318552 PMID:21498710 PMID:24394663 PMID:25585350 More...

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

nucleoporin 98 and 96 precursor

DNA:translocation:cds: (human)

RGD

NCBI chr 1:156,494,423...156,591,415
Ensembl chr 1:156,494,423...156,591,415

G

platelet derived growth factor receptor alpha

RGD

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

PHD finger protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127

G

protein tyrosine phosphatase, non-receptor type 11

ClinVar Annotator: match by term: Early T cell progenitor acute lymphoblastic leukemia

PMID:11992261 PMID:12161469 PMID:15240615 PMID:16358218 PMID:17020470 More...

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627

G

ribosomal protein L10

CTD Direct Evidence: marker/mechanism

NCBI chr X:152,054,562...152,056,769
Ensembl chr X:152,054,452...152,056,761

G

ribosomal protein L11

DNA:missense mutation, frameshift mutation:p.R18P, p.G30fs (human)

RGD

NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599

G

ribosomal protein L5

DNA:snps, insertion, deletion:cds:multiple (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23263491 PMID:23263491

NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290

G

RUNX family transcription factor 1

disease_progression

RGD

PMID:16051740 PMID:21828118

RGD:11251682, RGD:11251708

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

CTD Direct Evidence: marker/mechanism

NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975

G

Spi-1 proto-oncogene

CTD Direct Evidence: marker/mechanism

NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393

G

signal transducer and activator of transcription 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5B

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

TAL bHLH transcription factor 1, erythroid differentiation factor

CTD Direct Evidence: marker/mechanism

PMID:19246562 PMID:24394663

NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976

G

Tcl1 family Akt coactivator A

mRNA:increased expression:peripheral blood lymphocyte (human)

RGD

NCBI chr 6:124,125,032...124,131,025
Ensembl chr 6:124,125,032...124,131,025

G

T-cell leukemia, homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:244,005,057...244,011,318
Ensembl chr 1:244,005,057...244,011,318

G

tyrosine kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044

G

zinc finger protein 36, C3H type-like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064

T-cell large granular lymphocyte leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

signal transducer and activator of transcription 5B

CTD Direct Evidence: marker/mechanism

PMID:26192916 PMID:29200404

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

T-cell prolymphocytic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: T-cell prolymphocytic leukemia

PMID:6504056 PMID:7792600 PMID:8755918 PMID:8797579 PMID:8808599 More...

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

similar to human chromosome 11 open reading frame 65

ClinVar Annotator: match by term: T-cell prolymphocytic leukemia

PMID:6504056 PMID:7792600 PMID:8755918 PMID:8797579 PMID:8808599 More...

NCBI chr 8:53,796,033...53,825,277
Ensembl chr 8:53,796,366...53,824,748

G

Janus kinase 3

DNA:missense mutations:exon:pM511I, p.R657Q (human)

RGD

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

signal transducer and activator of transcription 5B

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421

X-Linked Acute Leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Janus kinase 1

ClinVar Annotator: match by term: Leukemia, acute, X-linked

PMID:16239216 PMID:19139102 PMID:19470474 PMID:19838194 PMID:21436584 More...

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

Term paths to the root

Path 1
Term	Annotations
disease	21128
disease of cellular proliferation	7667
Neoplasms by Histologic Type	5258
leukemia	620
lymphoid leukemia	287
acute leukemia +	275
aggressive NK-cell leukemia	0
chronic lymphocytic leukemia +	90
prolymphocytic leukemia +	5
Path 2
Term	Annotations
disease	21128
disease of anatomical entity	18212
Immune & Inflammatory Diseases	5564
immune system disease	4771
immune system cancer	663
lymphatic system cancer	663
lymphoma	575
lymphoid leukemia	287
acute leukemia +	275
aggressive NK-cell leukemia	0
chronic lymphocytic leukemia +	90
prolymphocytic leukemia +	5

paths to the root