RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: optic atrophy 1
Accession: DOID:0111441
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Definition: An optic atrophy characterized by early childhood onset of visual impairment, temporal optic disc pallor, color vision deficits, and centrocecal scotoma of variable density that has_material_basis_in heterozygous mutation in the OPA1 gene on chromosome 3q29. (DO)
Synonyms: exact_synonym: Dominant Optic Atrophy; Juvenile Optic Atrophies; Juvenile Optic Atrophy; Kjer Optic Atrophy; Kjer Type Optic Atrophy; Kjer's Optic Atrophy; Kjer-Type Optic Atrophies; Kjers Optic Atrophy; OAK; OPA1; autosomal dominant optic atrophy Kjer type; dominant optic atrophies; hereditary optic atrophy, autosomal dominant; hereditary optic atrophy, dominant; optic atrophy type 1; optic atrophy, autosomal dominant
primary_id: MESH:D029241
alt_id: OMIM:165500
xref: NCI:C169000 ; NCI:C84577
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Opa1
OPA1, mitochondrial dynamin like GTPase
ISO
DNA:nonsense mutation:exon:p.Q285X (mouse) ClinVar Annotator: match by term: Dominant hereditary optic atrophy | ClinVar Annotator: match by term: Kjer-type optic atrophy | ClinVar Annotator: match by term: Optic Atrophy Type 1 | ClinVar Annotator: match by term: Optic Atrophy, Dominant | ClinVar Annotator: match by term: Optic atrophy, juvenile DNA:SNPs, deletions:exons:multiple DNA:deletions, SNPs, insertion/deletion:exons, intron, cds:multiple DNA:splice-site mutation, nonsense mutation:intron, exon:IVS9-2A>G, c.2197C>T (p.R733X) (human) DNA:insertions, deletions, missense mutations, nonsense mutation: :multiple DNA:duplication:exons, introns:g.194832822_194840568dup (human) DNA:mutations:multiple DNA:splice-site mutation:intron:c.1065+5G>A (mouse) CTD Direct Evidence: marker/mechanism
OMIM ClinVar CTD RGD
PMID:4058877 PMID:6493699 PMID:9490303 PMID:9536098 PMID:9917792 PMID:11017079 PMID:11017080 PMID:11440988 PMID:11440989 PMID:11735024 PMID:11810270 PMID:12036970 PMID:12488262 PMID:12566046 PMID:12842213 PMID:14644237 PMID:14961560 PMID:15505825 PMID:15531309 PMID:15948788 PMID:16158427 PMID:16199547 PMID:16240368 PMID:16513463 PMID:16617242 PMID:16785854 PMID:17167772 PMID:17188070 PMID:17251483 PMID:17576681 PMID:17722006 PMID:17724190 PMID:18065439 PMID:18158317 PMID:18222991 PMID:18360822 PMID:18496845 PMID:19029523 PMID:19319978 PMID:19581274 PMID:19900585 PMID:20157015 PMID:20185555 PMID:20301426 PMID:20417568 PMID:20417570 PMID:20659957 PMID:20801516 PMID:20952381 PMID:21036400 PMID:21203403 PMID:21538838 PMID:21636302 PMID:21646330 PMID:21745197 PMID:21828197 PMID:22042570 PMID:22433900 PMID:22779427 PMID:22857269 PMID:22865259 PMID:23250881 PMID:23384603 PMID:23387428 PMID:23401657 PMID:23409176 PMID:23916084 PMID:24798923 PMID:24907432 PMID:24970096 PMID:25012220 PMID:25137924 PMID:25146915 PMID:25146916 PMID:25205859 PMID:25326637 PMID:25564500 PMID:25641387 PMID:25741868 PMID:25794858 PMID:26206283 PMID:26385429 PMID:26455272 PMID:26467025 PMID:26561570 PMID:26624494 PMID:26867657 PMID:27290639 PMID:27656661 PMID:27696015 PMID:27858935 PMID:28005958 PMID:28081242 PMID:28378518 PMID:28492532 PMID:28494813 PMID:28812649 PMID:28926202 PMID:29111013 PMID:29261183 PMID:29389947 PMID:30293569 PMID:30919572 PMID:30972688 PMID:31500643 PMID:31589614 PMID:31609081 PMID:31673222 PMID:31782039 PMID:31816670 PMID:32025183 PMID:32040484 PMID:32202296 PMID:32371413 PMID:32379273 PMID:32855858 PMID:33084218 PMID:33546218 PMID:33841295 PMID:33884488 PMID:34008892 PMID:34242285 PMID:34426522 PMID:34732400 PMID:35741767 PMID:37510321 PMID:17428816 PMID:16617242 PMID:17306754 PMID:19112530 PMID:16513463 PMID:20546606 PMID:23401657 PMID:17314202 More...
RGD:7800686 , RGD:7800699 , RGD:7800704 , RGD:7800706 , RGD:7800708 , RGD:7800709 , RGD:7800715 , RGD:7800716
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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Opa3
outer mitochondrial membrane lipid metabolism regulator OPA3
ISO
ClinVar Annotator: match by term: Optic Atrophy, Dominant
ClinVar
NCBI chr 1:78,879,612...78,910,453
Ensembl chr 1:78,880,114...78,901,469 Ensembl chr 1:78,880,114...78,901,469
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Wfs1
wolframin ER transmembrane glycoprotein
ISO
DNA:missense mutations, deletion:multiple
RGD
PMID:21538838
RGD:7800683
NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all