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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sertindole
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Accession:CHEBI:9122 term browser browse the term
Definition:A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group.
Synonyms:exact_synonym: 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
 related_synonym: 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one;   Formula=C24H26ClFN4O;   InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31);   InChIKey=GZKLJWGUPQBVJQ-UHFFFAOYSA-N;   SMILES=Fc1ccc(cc1)-n1cc(C2CCN(CC2)CCN2CCNC2=O)c2cc(Cl)ccc12;   SerLect;   Serdolect;   sertindol;   sertindolum
 xref: Beilstein:5364890;   CAS:106516-24-9;   DrugBank:DB06144;   Drug_Central:2435;   HMDB:HMDB0015618;   KEGG:C07567;   KEGG:D00561;   LINCS:LSM-5765
 xref_mesh: MESH:C066304
 xref: PMID:15461313;   PMID:15989577;   PMID:16317317;   PMID:16529528;   PMID:18484920;   PMID:21080854;   PMID:23432404;   PMID:9694935;   Reaxys:5364890;   Wikipedia:Sertindole


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sertindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO sertindole results in decreased activity of KCNH2 protein
sertindole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD PMID:16278312 PMID:21158687 PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        pharmacological role 18833
          antagonist 16278
            histamine antagonist 4619
              H1-receptor antagonist 4116
                sertindole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17979
                                    organic heterobicyclic compound 16780
                                      benzopyrrole 9542
                                        indoles 9214
                                          phenylindole 49
                                            sertindole 1
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