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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sertindole
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Accession:CHEBI:9122 term browser browse the term
Definition:A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group.
Synonyms:exact_synonym: 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
 related_synonym: 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one;   Formula=C24H26ClFN4O;   InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31);   InChIKey=GZKLJWGUPQBVJQ-UHFFFAOYSA-N;   SMILES=Fc1ccc(cc1)-n1cc(C2CCN(CC2)CCN2CCNC2=O)c2cc(Cl)ccc12;   SerLect;   Serdolect;   sertindol;   sertindolum
 xref: Beilstein:5364890;   CAS:106516-24-9;   DrugBank:DB06144;   Drug_Central:2435;   HMDB:HMDB0015618;   KEGG:C07567;   KEGG:D00561;   LINCS:LSM-5765
 xref_mesh: MESH:C066304
 xref: PMID:15461313;   PMID:15989577;   PMID:16317317;   PMID:16529528;   PMID:18484920;   PMID:21080854;   PMID:23432404;   PMID:9694935;   Reaxys:5364890;   Wikipedia:Sertindole


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sertindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions		 ISO sertindole results in decreased activity of KCNH2 protein
sertindole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]		 CTD PMID:16278312 PMID:21158687 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      biological role 19808
        pharmacological role 19055
          antagonist 17244
            histamine antagonist 4893
              H1-receptor antagonist 4146
                sertindole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            organic molecule 19680
                              organic cyclic compound 19493
                                organic heterocyclic compound 18871
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17245
                                      benzopyrrole 9723
                                        indoles 9412
                                          phenylindole 58
                                            sertindole 1
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