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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenylindole
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Accession:CHEBI:48559 term browser browse the term
Synonyms:related_synonym: phenylindoles

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bazedoxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin multiple interactions
increases expression		 ISO bazedoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]
bazedoxifene results in increased expression of AREG mRNA		 CTD PMID:19022889 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 increases expression ISO bazedoxifene results in increased expression of ASAP1 mRNA CTD PMID:19914376 NCBI chr 7:104,670,076...104,951,090
Ensembl chr 7:104,669,672...104,801,045 		JBrowse link
G Atrnl1 attractin like 1 decreases expression ISO bazedoxifene results in decreased expression of ATRNL1 mRNA CTD PMID:19914376 NCBI chr 1:278,546,113...279,098,977
Ensembl chr 1:278,557,792...278,815,473 		JBrowse link
G C1qtnf6 C1q and TNF related 6 decreases expression ISO bazedoxifene results in decreased expression of C1QTNF6 mRNA CTD PMID:19914376 NCBI chr 7:119,746,150...119,752,727
Ensembl chr 7:119,746,118...119,753,290 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO bazedoxifene results in increased expression of CCN1 mRNA CTD PMID:19914376 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO bazedoxifene results in increased expression of CCN2 mRNA CTD PMID:19914376 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO bazedoxifene results in decreased expression of CDC25A mRNA CTD PMID:19914376 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519 		JBrowse link
G Cdc42 cell division cycle 42 increases expression ISO bazedoxifene results in increased expression of CDC42 mRNA CTD PMID:19914376 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300 		JBrowse link
G Cdh7 cadherin 7 increases expression ISO bazedoxifene results in increased expression of CDH7 mRNA CTD PMID:19914376 NCBI chr13:31,081,064...31,228,884
Ensembl chr13:31,081,804...31,231,213 		JBrowse link
G Col12a1 collagen type XII alpha 1 chain decreases expression ISO bazedoxifene results in decreased expression of COL12A1 mRNA CTD PMID:19914376 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein]; fulvestrant inhibits the reaction [bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]] CTD PMID:19533603 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Defb1 defensin beta 1 multiple interactions ISO [Progesterone co-treated with bazedoxifene] results in increased expression of DEFB1 mRNA CTD PMID:18367319 NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176 		JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog decreases expression ISO bazedoxifene results in decreased expression of DTL mRNA CTD PMID:19914376 NCBI chr13:110,219,276...110,257,345
Ensembl chr13:110,220,283...110,257,367 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO bazedoxifene results in increased expression of DUSP1 mRNA CTD PMID:19914376 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Egr1 early growth response 1 increases expression ISO bazedoxifene results in increased expression of EGR1 mRNA CTD PMID:19914376 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Egr2 early growth response 2 increases expression ISO bazedoxifene results in increased expression of EGR2 mRNA CTD PMID:19914376 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO bazedoxifene binds to ESR1 protein CTD PMID:15961563 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO bazedoxifene binds to ESR2 protein CTD PMID:15961563 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Fancb FA complementation group B decreases expression ISO bazedoxifene results in decreased expression of FANCB mRNA CTD PMID:19914376 NCBI chr  X:31,124,018...31,140,790
Ensembl chr  X:31,124,018...31,140,711 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO bazedoxifene results in increased expression of FOS mRNA CTD PMID:19914376 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gpr87 G protein-coupled receptor 87 increases expression ISO bazedoxifene results in increased expression of GPR87 mRNA CTD PMID:19914376 NCBI chr 2:149,398,949...149,418,041
Ensembl chr 2:149,398,949...149,417,212 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 decreases expression ISO bazedoxifene results in decreased expression of GREB1 mRNA CTD PMID:19914376 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819 		JBrowse link
G Hells helicase, lymphoid specific decreases expression ISO bazedoxifene results in decreased expression of HELLS mRNA CTD PMID:19914376 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183 		JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 increases expression ISO bazedoxifene results in increased expression of HTR4 mRNA CTD PMID:19914376 NCBI chr18:57,637,013...57,820,317
Ensembl chr18:57,654,290...57,819,698 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions ISO bazedoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA] CTD PMID:18367319 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; fulvestrant inhibits the reaction [bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]] CTD PMID:19533603 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kcnt2 potassium sodium-activated channel subfamily T member 2 increases expression ISO bazedoxifene results in increased expression of KCNT2 mRNA CTD PMID:19914376 NCBI chr13:57,130,855...57,520,263
Ensembl chr13:57,131,395...57,521,836 		JBrowse link
G Kif13a kinesin family member 13A increases expression ISO bazedoxifene results in increased expression of KIF13A mRNA CTD PMID:19914376 NCBI chr17:18,151,582...18,335,027
Ensembl chr17:18,151,982...18,335,019 		JBrowse link
G Lamb1 laminin subunit beta 1 increases expression ISO bazedoxifene results in increased expression of LAMB1 mRNA CTD PMID:19914376 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079 		JBrowse link
G Lipc lipase C, hepatic type increases expression ISO bazedoxifene results in increased expression of LIPC mRNA CTD PMID:15961563 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO bazedoxifene results in decreased expression of MCM10 mRNA CTD PMID:19914376 NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478 		JBrowse link
G Mdfi MyoD family inhibitor increases expression ISO bazedoxifene results in increased expression of MDFI mRNA CTD PMID:19914376 NCBI chr 9:15,166,118...15,184,469
Ensembl chr 9:15,166,118...15,184,468 		JBrowse link
G Mgp matrix Gla protein decreases expression ISO bazedoxifene results in decreased expression of MGP mRNA CTD PMID:19914376 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225 		JBrowse link
G Msl1 MSL complex subunit 1 increases expression ISO bazedoxifene results in increased expression of MSL1 mRNA CTD PMID:19914376 NCBI chr10:86,710,925...86,722,659
Ensembl chr10:86,711,240...86,721,246 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 decreases expression ISO bazedoxifene results in decreased expression of MYBL1 mRNA CTD PMID:19914376 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114 		JBrowse link
G P2ry14 purinergic receptor P2Y14 multiple interactions ISO bazedoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA] CTD PMID:18367319 NCBI chr 2:149,331,948...149,379,336
Ensembl chr 2:149,331,948...149,347,796 		JBrowse link
G Pitrm1 pitrilysin metallopeptidase 1 increases expression ISO bazedoxifene results in increased expression of PITRM1 mRNA CTD PMID:19914376 NCBI chr17:68,477,423...68,509,113
Ensembl chr17:68,477,446...68,509,120 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 decreases expression ISO bazedoxifene results in decreased expression of RC3H2 mRNA CTD PMID:19914376 NCBI chr 3:21,621,976...21,676,789
Ensembl chr 3:21,623,041...21,670,014 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]; bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of RELA protein] CTD PMID:19533603 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rnf146 ring finger protein 146 increases expression ISO bazedoxifene results in increased expression of RNF146 mRNA CTD PMID:19914376 NCBI chr 1:30,856,923...30,873,814
Ensembl chr 1:30,863,217...30,873,808 		JBrowse link
G Sbspon somatomedin B and thrombospondin, type 1 domain containing increases expression ISO bazedoxifene results in increased expression of SBSPON mRNA CTD PMID:19914376 NCBI chr 5:2,813,004...2,847,697
Ensembl chr 5:2,813,131...2,843,483 		JBrowse link
G Sez6l2 seizure related 6 homolog like 2 decreases expression ISO bazedoxifene results in decreased expression of SEZ6L2 mRNA CTD PMID:19914376 NCBI chr 1:198,383,201...198,403,544
Ensembl chr 1:198,383,201...198,403,544 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO bazedoxifene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 multiple interactions ISO [Progesterone co-treated with bazedoxifene] results in increased expression of SPINK1 mRNA CTD PMID:18367319 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119 		JBrowse link
G Tmem252 transmembrane protein 252 increases expression ISO bazedoxifene results in increased expression of TMEM252 mRNA CTD PMID:19914376 NCBI chr 1:242,572,558...242,577,817
Ensembl chr 1:242,572,533...242,577,817 		JBrowse link
G Ubr4 ubiquitin protein ligase E3 component n-recognin 4 increases expression ISO bazedoxifene results in increased expression of UBR4 mRNA CTD PMID:19914376 NCBI chr 5:157,848,162...157,956,137
Ensembl chr 5:157,848,206...157,956,132 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO bazedoxifene results in decreased expression of UHRF1 mRNA CTD PMID:19914376 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954 		JBrowse link
G Zfp367 zinc finger protein 367 decreases expression ISO bazedoxifene results in decreased expression of ZNF367 mRNA CTD PMID:19914376 NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021 		JBrowse link
sertindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions		 ISO sertindole results in decreased activity of KCNH2 protein
sertindole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]		 CTD PMID:16278312 PMID:21158687 PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      atom 19873
        nonmetal atom 19751
          nitrogen atom 18640
            nitrogen molecular entity 18640
              organonitrogen compound 18414
                organonitrogen heterocyclic compound 17579
                  benzopyrrole 9549
                    indoles 9219
                      phenylindole 49
                        1-(3,5-dimethyl-1-pyrazolyl)-3-[2-(4-methoxyphenyl)-1-indolyl]-2-propanol 0
                        2-(1-methyl-2-phenyl-3-indolyl)ethanol 0
                        2-(2-methoxyphenyl)-1H-indole 0
                        2-(4-hydroxyphenyl)-3-methyl-1-(10-pentylsulfonyldecyl)-5-indolol 0
                        2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide 0
                        2-[5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide 0
                        2-oxo-N-[2-[(2-phenyl-1H-indol-3-yl)thio]ethyl]-1-benzopyran-3-carboxamide 0
                        2-phenyl-1H-indole 0
                        5-(diaminomethylideneamino)-2-[[4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]amino]pentanoic acid methyl ester 0
                        LSM-4947 0
                        N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide 0
                        N-[2-[[2-(4-methylphenyl)-1H-indol-3-yl]thio]ethyl]-2-oxo-1-benzopyran-3-carboxamide 0
                        Zindoxifene 0
                        bazedoxifene 48
                        sertindole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organic heteropolycyclic compound 17900
                                    organic heterobicyclic compound 16826
                                      benzopyrrole 9549
                                        indoles 9219
                                          phenylindole 49
                                            1-(3,5-dimethyl-1-pyrazolyl)-3-[2-(4-methoxyphenyl)-1-indolyl]-2-propanol 0
                                            2-(1-methyl-2-phenyl-3-indolyl)ethanol 0
                                            2-(2-methoxyphenyl)-1H-indole 0
                                            2-(4-hydroxyphenyl)-3-methyl-1-(10-pentylsulfonyldecyl)-5-indolol 0
                                            2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide 0
                                            2-[5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide 0
                                            2-oxo-N-[2-[(2-phenyl-1H-indol-3-yl)thio]ethyl]-1-benzopyran-3-carboxamide 0
                                            2-phenyl-1H-indole 0
                                            5-(diaminomethylideneamino)-2-[[4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]amino]pentanoic acid methyl ester 0
                                            LSM-4947 0
                                            N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide 0
                                            N-[2-[[2-(4-methylphenyl)-1H-indol-3-yl]thio]ethyl]-2-oxo-1-benzopyran-3-carboxamide 0
                                            Zindoxifene 0
                                            bazedoxifene 48
                                            sertindole 1
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