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G |
Areg |
amphiregulin |
multiple interactions increases expression |
ISO |
bazedoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA] bazedoxifene results in increased expression of AREG mRNA |
CTD |
PMID:19022889 |
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NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
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Asap1 |
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
increases expression |
ISO |
bazedoxifene results in increased expression of ASAP1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 7:104,670,076...104,951,090
Ensembl chr 7:104,669,672...104,801,045
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Atrnl1 |
attractin like 1 |
decreases expression |
ISO |
bazedoxifene results in decreased expression of ATRNL1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 1:278,546,113...279,098,977
Ensembl chr 1:278,557,792...278,815,473
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G |
C1qtnf6 |
C1q and TNF related 6 |
decreases expression |
ISO |
bazedoxifene results in decreased expression of C1QTNF6 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 7:119,746,150...119,752,727
Ensembl chr 7:119,746,118...119,753,290
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G |
Ccn1 |
cellular communication network factor 1 |
increases expression |
ISO |
bazedoxifene results in increased expression of CCN1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression |
ISO |
bazedoxifene results in increased expression of CCN2 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
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G |
Cdc25a |
cell division cycle 25A |
decreases expression |
ISO |
bazedoxifene results in decreased expression of CDC25A mRNA |
CTD |
PMID:19914376 |
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NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
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G |
Cdc42 |
cell division cycle 42 |
increases expression |
ISO |
bazedoxifene results in increased expression of CDC42 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
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G |
Cdh7 |
cadherin 7 |
increases expression |
ISO |
bazedoxifene results in increased expression of CDH7 mRNA |
CTD |
PMID:19914376 |
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NCBI chr13:31,081,064...31,228,884
Ensembl chr13:31,081,804...31,231,213
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G |
Col12a1 |
collagen type XII alpha 1 chain |
decreases expression |
ISO |
bazedoxifene results in decreased expression of COL12A1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein]; fulvestrant inhibits the reaction [bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]] |
CTD |
PMID:19533603 |
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NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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G |
Defb1 |
defensin beta 1 |
multiple interactions |
ISO |
[Progesterone co-treated with bazedoxifene] results in increased expression of DEFB1 mRNA |
CTD |
PMID:18367319 |
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NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176
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G |
Dtl |
denticleless E3 ubiquitin protein ligase homolog |
decreases expression |
ISO |
bazedoxifene results in decreased expression of DTL mRNA |
CTD |
PMID:19914376 |
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NCBI chr13:110,219,276...110,257,345
Ensembl chr13:110,220,283...110,257,367
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
ISO |
bazedoxifene results in increased expression of DUSP1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
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G |
Egr1 |
early growth response 1 |
increases expression |
ISO |
bazedoxifene results in increased expression of EGR1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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G |
Egr2 |
early growth response 2 |
increases expression |
ISO |
bazedoxifene results in increased expression of EGR2 mRNA |
CTD |
PMID:19914376 |
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NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
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G |
Esr1 |
estrogen receptor 1 |
affects binding |
ISO |
bazedoxifene binds to ESR1 protein |
CTD |
PMID:15961563 |
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NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Esr2 |
estrogen receptor 2 |
affects binding |
ISO |
bazedoxifene binds to ESR2 protein |
CTD |
PMID:15961563 |
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NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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G |
Fancb |
FA complementation group B |
decreases expression |
ISO |
bazedoxifene results in decreased expression of FANCB mRNA |
CTD |
PMID:19914376 |
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NCBI chr X:31,124,018...31,140,790
Ensembl chr X:31,124,018...31,140,711
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
bazedoxifene results in increased expression of FOS mRNA |
CTD |
PMID:19914376 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Gpr87 |
G protein-coupled receptor 87 |
increases expression |
ISO |
bazedoxifene results in increased expression of GPR87 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 2:149,398,949...149,418,041
Ensembl chr 2:149,398,949...149,417,212
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G |
Greb1 |
growth regulating estrogen receptor binding 1 |
decreases expression |
ISO |
bazedoxifene results in decreased expression of GREB1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
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G |
Hells |
helicase, lymphoid specific |
decreases expression |
ISO |
bazedoxifene results in decreased expression of HELLS mRNA |
CTD |
PMID:19914376 |
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NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183 Ensembl chr 1:257,766,691...257,949,183
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G |
Htr4 |
5-hydroxytryptamine receptor 4 |
increases expression |
ISO |
bazedoxifene results in increased expression of HTR4 mRNA |
CTD |
PMID:19914376 |
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NCBI chr18:57,637,013...57,820,317
Ensembl chr18:57,654,290...57,819,698
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G |
Ido1 |
indoleamine 2,3-dioxygenase 1 |
multiple interactions |
ISO |
bazedoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA] |
CTD |
PMID:18367319 |
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NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; fulvestrant inhibits the reaction [bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]] |
CTD |
PMID:19533603 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Kcnt2 |
potassium sodium-activated channel subfamily T member 2 |
increases expression |
ISO |
bazedoxifene results in increased expression of KCNT2 mRNA |
CTD |
PMID:19914376 |
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NCBI chr13:57,130,855...57,520,263
Ensembl chr13:57,131,395...57,521,836
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G |
Kif13a |
kinesin family member 13A |
increases expression |
ISO |
bazedoxifene results in increased expression of KIF13A mRNA |
CTD |
PMID:19914376 |
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NCBI chr17:18,151,582...18,335,027
Ensembl chr17:18,151,982...18,335,019
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G |
Lamb1 |
laminin subunit beta 1 |
increases expression |
ISO |
bazedoxifene results in increased expression of LAMB1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
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G |
Lipc |
lipase C, hepatic type |
increases expression |
ISO |
bazedoxifene results in increased expression of LIPC mRNA |
CTD |
PMID:15961563 |
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NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
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G |
Mcm10 |
minichromosome maintenance 10 replication initiation factor |
decreases expression |
ISO |
bazedoxifene results in decreased expression of MCM10 mRNA |
CTD |
PMID:19914376 |
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NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
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G |
Mdfi |
MyoD family inhibitor |
increases expression |
ISO |
bazedoxifene results in increased expression of MDFI mRNA |
CTD |
PMID:19914376 |
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NCBI chr 9:15,166,118...15,184,469
Ensembl chr 9:15,166,118...15,184,468
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G |
Mgp |
matrix Gla protein |
decreases expression |
ISO |
bazedoxifene results in decreased expression of MGP mRNA |
CTD |
PMID:19914376 |
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NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
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G |
Msl1 |
MSL complex subunit 1 |
increases expression |
ISO |
bazedoxifene results in increased expression of MSL1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr10:86,710,925...86,722,659
Ensembl chr10:86,711,240...86,721,246
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G |
Mybl1 |
MYB proto-oncogene like 1 |
decreases expression |
ISO |
bazedoxifene results in decreased expression of MYBL1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
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G |
P2ry14 |
purinergic receptor P2Y14 |
multiple interactions |
ISO |
bazedoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA] |
CTD |
PMID:18367319 |
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NCBI chr 2:149,331,948...149,379,336
Ensembl chr 2:149,331,948...149,347,796
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G |
Pitrm1 |
pitrilysin metallopeptidase 1 |
increases expression |
ISO |
bazedoxifene results in increased expression of PITRM1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr17:68,477,423...68,509,113
Ensembl chr17:68,477,446...68,509,120
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G |
Rc3h2 |
ring finger and CCCH-type domains 2 |
decreases expression |
ISO |
bazedoxifene results in decreased expression of RC3H2 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 3:21,621,976...21,676,789
Ensembl chr 3:21,623,041...21,670,014
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]; bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of RELA protein] |
CTD |
PMID:19533603 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Rnf146 |
ring finger protein 146 |
increases expression |
ISO |
bazedoxifene results in increased expression of RNF146 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 1:30,856,923...30,873,814
Ensembl chr 1:30,863,217...30,873,808
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G |
Sbspon |
somatomedin B and thrombospondin, type 1 domain containing |
increases expression |
ISO |
bazedoxifene results in increased expression of SBSPON mRNA |
CTD |
PMID:19914376 |
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NCBI chr 5:2,813,004...2,847,697
Ensembl chr 5:2,813,131...2,843,483
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G |
Sez6l2 |
seizure related 6 homolog like 2 |
decreases expression |
ISO |
bazedoxifene results in decreased expression of SEZ6L2 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 1:198,383,201...198,403,544
Ensembl chr 1:198,383,201...198,403,544
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
bazedoxifene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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G |
Spink1 |
serine peptidase inhibitor, Kazal type 1 |
multiple interactions |
ISO |
[Progesterone co-treated with bazedoxifene] results in increased expression of SPINK1 mRNA |
CTD |
PMID:18367319 |
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NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
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G |
Tmem252 |
transmembrane protein 252 |
increases expression |
ISO |
bazedoxifene results in increased expression of TMEM252 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 1:242,572,558...242,577,817
Ensembl chr 1:242,572,533...242,577,817
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G |
Ubr4 |
ubiquitin protein ligase E3 component n-recognin 4 |
increases expression |
ISO |
bazedoxifene results in increased expression of UBR4 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 5:157,848,162...157,956,137
Ensembl chr 5:157,848,206...157,956,132
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G |
Uhrf1 |
ubiquitin-like with PHD and ring finger domains 1 |
decreases expression |
ISO |
bazedoxifene results in decreased expression of UHRF1 mRNA |
CTD |
PMID:19914376 |
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NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
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G |
Zfp367 |
zinc finger protein 367 |
decreases expression |
ISO |
bazedoxifene results in decreased expression of ZNF367 mRNA |
CTD |
PMID:19914376 |
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NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity multiple interactions |
ISO |
sertindole results in decreased activity of KCNH2 protein sertindole inhibits the reaction [KCNH2 protein results in increased transport of Thallium] |
CTD |
PMID:16278312 PMID:21158687 PMID:24052561 |
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NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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