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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cinnarizine
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Accession:CHEBI:31403 term browser browse the term
Definition:A N-alkylpiperazine that has formula C26H28N2.
Synonyms:exact_synonym: 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
 related_synonym: 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine;   1-Benzhydryl-4-cinnamylpiperazin;   1-Cinnamyl-4-(diphenylmethyl)piperazine;   Formula=C26H28N2;   InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+;   InChIKey=DERZBLKQOCDDDZ-JLHYYAGUSA-N;   SMILES=C1CN(CCN1C\\C=C\\c1ccccc1)C(c1ccccc1)c1ccccc1;   cinarizina;   cinnarizinum
 xref: Beilstein:626121;   CAS:298-57-7;   Chemspider:1264793;   DrugBank:DB00568;   Drug_Central:654;   KEGG:D01295;   LINCS:LSM-42858
 xref_mesh: MESH:D002936
 xref: PMID:12609783;   PMID:24134630;   PMID:28386684;   PMID:28567501;   PMID:29175776;   PMID:29807074;   PMID:30322124;   PMID:30803454;   PMID:30868302;   PMID:31420703;   PMID:31707814;   PMID:31750127;   PMID:32597267;   PMID:32904111;   PMID:33359616;   PMID:33946152;   PMID:34466453;   PMID:7000939;   Patent:US2882271;   Wikipedia:Cinnarizine


show annotations for term's descendants           Sort by:
cinnarizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Cinnarizine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Drd2 dopamine receptor D2 affects binding
multiple interactions		 ISO
EXP		 Cinnarizine binds to DRD2 protein
Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]		 CTD PMID:7503767 PMID:11180191 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases response to substance ISO PRKN results in decreased susceptibility to Cinnarizine CTD PMID:15993444 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      biological role 19808
        pharmacological role 19055
          antagonist 17244
            histamine antagonist 4893
              cinnarizine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    main group molecular entity 19782
                      s-block molecular entity 19620
                        hydrogen molecular entity 19607
                          hydrides 19113
                            inorganic hydride 18117
                              pnictogen hydride 18106
                                nitrogen hydride 18013
                                  azane 17821
                                    ammonia 17820
                                      organic amino compound 17820
                                        tertiary amino compound 10138
                                          N-alkylpiperazine 3396
                                            cinnarizine 3
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