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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:31403 term browser browse the term
Definition:A N-alkylpiperazine that has formula C26H28N2.
Synonyms:exact_synonym: 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
 related_synonym: 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine;   1-Benzhydryl-4-cinnamylpiperazin;   1-Cinnamyl-4-(diphenylmethyl)piperazine;   Formula=C26H28N2;   InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+;   InChIKey=DERZBLKQOCDDDZ-JLHYYAGUSA-N;   SMILES=C1CN(CCN1C\\C=C\\c1ccccc1)C(c1ccccc1)c1ccccc1;   cinarizina;   cinnarizinum
 xref: Beilstein:626121;   CAS:298-57-7;   DrugBank:DB00568;   Drug_Central:654;   KEGG:D01295
 xref_mesh: MESH:D002936
 xref: Patent:US2882271;   Wikipedia:Cinnarizine

show annotations for term's descendants           Sort by:
cinnarizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Cinnarizine results in decreased activity of ABCB11 protein CTD PMID:20829430, PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Drd2 dopamine receptor D2 affects binding
multiple interactions
Cinnarizine binds to DRD2 protein
Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]
CTD PMID:7503767, PMID:11180191 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases response to substance ISO PRKN results in decreased susceptibility to Cinnarizine CTD PMID:15993444 NCBI chr 1:48,880,015...50,069,998 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          antagonist 16197
            histamine antagonist 4603
              cinnarizine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          N-alkylpiperazine 3075
                                            cinnarizine 3
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.