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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:31403 term browser browse the term
Definition:A N-alkylpiperazine that has formula C26H28N2.
Synonyms:exact_synonym: 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
 related_synonym: 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine;   1-Benzhydryl-4-cinnamylpiperazin;   1-Cinnamyl-4-(diphenylmethyl)piperazine;   Formula=C26H28N2;   InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+;   InChIKey=DERZBLKQOCDDDZ-JLHYYAGUSA-N;   SMILES=C1CN(CCN1C\\C=C\\c1ccccc1)C(c1ccccc1)c1ccccc1;   cinarizina;   cinnarizinum
 xref: Beilstein:626121;   CAS:298-57-7;   Chemspider:1264793;   DrugBank:DB00568;   Drug_Central:654;   KEGG:D01295;   LINCS:LSM-42858
 xref_mesh: MESH:D002936
 xref: PMID:12609783;   PMID:24134630;   PMID:28386684;   PMID:28567501;   PMID:29175776;   PMID:29807074;   PMID:30322124;   PMID:30803454;   PMID:30868302;   PMID:31420703;   PMID:31707814;   PMID:31750127;   PMID:32597267;   PMID:32904111;   PMID:33359616;   PMID:33946152;   PMID:34466453;   PMID:7000939;   Patent:US2882271;   Wikipedia:Cinnarizine

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cinnarizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Cinnarizine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Drd2 dopamine receptor D2 affects binding
multiple interactions
Cinnarizine binds to DRD2 protein
Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]
CTD PMID:7503767 PMID:11180191 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases response to substance ISO PRKN results in decreased susceptibility to Cinnarizine CTD PMID:15993444 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19747
    role 19720
      biological role 19718
        pharmacological role 18978
          antagonist 17005
            histamine antagonist 4863
              cinnarizine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19747
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19547
                        hydrogen molecular entity 19540
                          hydrides 19024
                            inorganic hydride 17952
                              pnictogen hydride 17937
                                nitrogen hydride 17834
                                  azane 17617
                                    ammonia 17616
                                      organic amino compound 17616
                                        tertiary amino compound 9927
                                          N-alkylpiperazine 3362
                                            cinnarizine 3
paths to the root