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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:31403 term browser browse the term
Definition:A N-alkylpiperazine that has formula C26H28N2.
Synonyms:exact_synonym: 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
 related_synonym: 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine;   1-Benzhydryl-4-cinnamylpiperazin;   1-Cinnamyl-4-(diphenylmethyl)piperazine;   Formula=C26H28N2;   InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+;   InChIKey=DERZBLKQOCDDDZ-JLHYYAGUSA-N;   SMILES=C1CN(CCN1C\\C=C\\c1ccccc1)C(c1ccccc1)c1ccccc1;   cinarizina;   cinnarizinum
 xref: Beilstein:626121;   CAS:298-57-7;   Chemspider:1264793;   DrugBank:DB00568;   Drug_Central:654;   KEGG:D01295;   LINCS:LSM-42858
 xref_mesh: MESH:D002936
 xref: PMID:12609783;   PMID:24134630;   PMID:28386684;   PMID:28567501;   PMID:29175776;   PMID:29807074;   PMID:30322124;   PMID:30803454;   PMID:30868302;   PMID:31420703;   PMID:31707814;   PMID:31750127;   PMID:32597267;   PMID:32904111;   PMID:33359616;   PMID:33946152;   PMID:34466453;   PMID:7000939;   Patent:US2882271;   Wikipedia:Cinnarizine

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cinnarizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Cinnarizine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Drd2 dopamine receptor D2 affects binding
multiple interactions
Cinnarizine binds to DRD2 protein
Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]
CTD PMID:7503767 PMID:11180191 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases response to substance ISO PRKN results in decreased susceptibility to Cinnarizine CTD PMID:15993444 NCBI chr 1:48,688,651...49,882,520 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        pharmacological role 18850
          antagonist 16338
            histamine antagonist 4619
              cinnarizine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    main group molecular entity 19710
                      s-block molecular entity 19492
                        hydrogen molecular entity 19484
                          hydrides 18850
                            inorganic hydride 17700
                              pnictogen hydride 17681
                                nitrogen hydride 17552
                                  azane 17289
                                    ammonia 17288
                                      organic amino compound 17288
                                        tertiary amino compound 8688
                                          N-alkylpiperazine 3129
                                            cinnarizine 3
paths to the root