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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gramine
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Accession:CHEBI:28948 term browser browse the term
Definition:An aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3.
Synonyms:exact_synonym: 1-(1H-indol-3-yl)-N,N-dimethylmethanamine
 related_synonym: (1H-indol-3-ylmethyl)dimethylamine;   3-(Dimethylaminomethyl)indole;   3-(N,N-Dimethylaminomethyl)indole;   3-[(Dimethylamino)methyl]indole;   Donaxin;   Donaxine;   Formula=C11H14N2;   Gramin;   InChI=1S/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3;   InChIKey=OCDGBSUVYYVKQZ-UHFFFAOYSA-N;   Indol-3-ylmethyldimethylamine;   N,N-Dimethyl-1H-indole-3-methanamine;   SMILES=C1(=CNC2=C1C=CC=C2)CN(C)C;   beta-Dimethylaminomethylindole
 alt_id: CHEBI:24428;   CHEBI:5531
 xref: CAS:87-52-5;   HMDB:HMDB0035762;   KEGG:C08304;   KNApSAcK:C00001411;   LINCS:LSM-6572
 xref_mesh: MESH:C007884
 xref: MetaCyc:CPD-8915;   PMID:23700450;   PMID:24332729;   PMID:24979400;   PMID:25149234;   PMID:25281166;   PMID:26920698;   PMID:27037659;   PMID:27138201;   PMID:27157767;   PMID:27250087;   PMID:27280380;   PMID:27854190;   PMID:28004092;   Reaxys:140521
 cyclic_relationship: is_conjugate_base_of CHEBI:136516


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gramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 multiple interactions ISO gramine binds to and results in increased activity of ADIPOR1 protein CTD PMID:23691032 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases phosphorylation ISO gramine results in decreased phosphorylation of PPARA protein CTD PMID:23691032 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO gramine results in increased phosphorylation of PRKAA1 protein CTD PMID:23691032 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases phosphorylation ISO gramine results in increased phosphorylation of PRKAA2 protein CTD PMID:23691032 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          antiviral agent 11074
            gramine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  organic heteropolycyclic compound 18301
                                    organic heterobicyclic compound 17235
                                      benzopyrrole 9719
                                        indoles 9408
                                          aminoalkylindole 524
                                            gramine 4
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