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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Bafilomycin B1
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Accession:CHEBI:199416 term browser browse the term
Synonyms:exact_synonym: [2-hydroxy-2-[3-hydroxy-4-[(4E,6E,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl] (E)-4-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-4-oxobut-2-enoate
 related_synonym: Formula=C44H65NO13;   InChI=1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)/b14-12+,18-17+,24-13+,25-20+,34-21-;   InChIKey=KFUFLYSBMNNJTF-UNPKUBMASA-N;   SMILES=O=C1OC(C(OC)C=CC=C(CC(C(C(C=C(C=C1OC)C)C)O)C)C)C(C(O)C(C2(OC(C(C)C(C2)OC(=O)/C=C/C(=O)NC3=C(O)CCC3=O)C(C)C)O)C)C
 xref_mesh: MESH:C052501


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Bafilomycin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO [Rotenone co-treated with bafilomycin B1] results in increased lipidation of and results in increased cleavage of MAP1LC3B protein
bafilomycin B1 results in increased expression of MAP1LC3B protein modified form
bafilomycin B1 promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein modified form]; Cisplatin promotes the reaction [bafilomycin B1 results in increased expression of MAP1LC3B protein modified form]		 CTD PMID:30673822 PMID:32738330 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 ISO bafilomycin B1 promotes the reaction [Cisplatin results in increased expression of SQSTM1 protein]; Cisplatin promotes the reaction [bafilomycin B1 results in increased expression of SQSTM1 protein] CTD PMID:32738330 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          oxygen atom 19520
            oxygen molecular entity 19490
              organooxygen compound 19137
                polyketide 10551
                  macrolide 5859
                    Bafilomycin B1 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  ester 17247
                                    carboxylic ester 16563
                                      lactone 12512
                                        macrocyclic lactone 5922
                                          macrolide 5859
                                            Bafilomycin B1 2
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