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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:suprofen
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Accession:CHEBI:9362 term browser browse the term
Definition:An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.
Synonyms:exact_synonym: 2-[4-(thiophen-2-ylcarbonyl)phenyl]propanoic acid
 related_synonym: (+-)-2-(p-(2-thenoyl)phenyl)propionic acid;   2-(4-(2-Thenoyl)phenyl)propionsaeure;   2-[4-(Thiophene-2-carbonyl)-phenyl]-propionic acid;   4-(2-Thenoyl)hydratropsaeure;   Formula=C14H12O3S;   InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17);   InChIKey=MDKGKXOCJGEUJW-UHFFFAOYSA-N;   PROFENAL;   SMILES=CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1;   SUTOPROFEN;   alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid;   p-2-thenoylhydratropic acid;   suprofene;   suprofenum
 alt_id: CHEBI:193117
 xref: Beilstein:1430606;   CAS:40828-46-4;   DrugBank:DB00870;   Drug_Central:2546;   KEGG:C07320;   KEGG:D00452;   LINCS:LSM-4406
 xref_mesh: MESH:D013496
 xref: PMID:11195850;   PMID:11409928;   PMID:14570769;   PMID:14664336;   PMID:27559371;   PMID:7918773;   PMID:8058269;   Patent:DE2353357;   Patent:US4035376;   Reaxys:1430606;   Wikipedia:Suprofen


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suprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Suprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Suprofen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Suprofen results in increased expression of GCLM mRNA CTD PMID:11909699 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      application 19661
        anti-inflammatory agent 16598
          anti-inflammatory drug 14940
            non-steroidal anti-inflammatory drug 14255
              suprofen 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      monocarboxylic acid 18008
                                        suprofen 3
paths to the root