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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sparfloxacin
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Accession:CHEBI:9212 term browser browse the term
Definition:A fluoroquinolone antibiotic that has formula C19H22F2N4O3.
Synonyms:exact_synonym: 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: Formula=C19H22F2N4O3;   InChI=1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+;   InChIKey=DZZWHBIBMUVIIW-DTORHVGOSA-N;   SMILES=C[C@H]1CN(C[C@@H](C)N1)c1c(F)c(N)c2c(c1F)n(cc(C(O)=O)c2=O)C1CC1;   cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
 xref: Beilstein:3658018;   CAS:110871-86-8;   DrugBank:DB01208;   Drug_Central:2466;   KEGG:C07662;   KEGG:D00590;   LINCS:LSM-5251
 xref_mesh: MESH:C061363
 xref: Wikipedia:Sparfloxacin


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sparfloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression		 EXP sparfloxacin results in increased activity of MMP2 protein
sparfloxacin results in increased expression of MMP2 mRNA		 CTD PMID:21058936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
increases expression		 EXP sparfloxacin results in increased activity of MMP9 protein
sparfloxacin results in increased expression of MMP9 mRNA		 CTD PMID:21058936 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          quinolone antibiotic 2086
            sparfloxacin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        tertiary amino compound 10131
                                          N-arylpiperazine 3433
                                            sparfloxacin 2
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