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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quinolone antibiotic
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Accession:CHEBI:86324 term browser browse the term
Definition:An organonitrogen heterocyclic antibiotic whose structure contains a quinolone or quinolone-related skeleton.
Synonyms:related_synonym: quinolone antibiotics


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ciprofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Ciprofloxacin results in decreased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Ciprofloxacin results in increased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases export
multiple interactions
increases expression
ISO ABCC4 protein results in increased export of Ciprofloxacin
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin
Ciprofloxacin results in increased expression of ABCC4 mRNA; Ciprofloxacin results in increased expression of ABCC4 protein
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin; Gemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin]
CTD PMID:19307362 PMID:22162766 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Ciprofloxacin results in increased expression of ABCG2 protein CTD PMID:26947806 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of AKT1 protein CTD PMID:26947806 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Ciprofloxacin results in increased expression of ALDH1A1 protein CTD PMID:26947806 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases localization
increases expression
ISO BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein]
Ciprofloxacin results in increased expression of BAX protein
CTD PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Etoposide co-treated with Ciprofloxacin] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein] CTD PMID:11832715 PMID:12063570 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Ciprofloxacin results in increased cleavage of and results in increased activity of CASP3 protein
Ciprofloxacin results in increased activity of CASP3 protein
CTD PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Ciprofloxacin results in increased activity of CASP8 protein CTD PMID:11875713 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Ciprofloxacin results in increased activity of CASP9 protein CTD PMID:11875713 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cav1 caveolin 1 increases expression ISO Ciprofloxacin results in increased expression of CAV1 protein CTD PMID:26947806 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO
EXP
Ciprofloxacin results in decreased expression of CCNB1 protein
Ciprofloxacin results in increased expression of CCNB1 mRNA; Ciprofloxacin results in increased expression of CCNB1 protein
CTD PMID:10741713 PMID:18512786 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Ciprofloxacin results in decreased expression of CCNE1 protein CTD PMID:10741713 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Ciprofloxacin results in increased expression of CD44 protein CTD PMID:26947806 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Ciprofloxacin results in increased expression of CDK1 mRNA; Ciprofloxacin results in increased expression of CDK1 protein CTD PMID:18512786 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases phosphorylation ISO Ciprofloxacin results in decreased phosphorylation of CDK2 protein CTD PMID:10741713 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Ciprofloxacin results in decreased expression of CDKN1A; Ciprofloxacin results in decreased expression of CDKN1A protein CTD PMID:10741713 PMID:12063570 PMID:12632069 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA] CTD PMID:11052920 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Chek1 checkpoint kinase 1 increases expression EXP Ciprofloxacin results in increased expression of CHEK1 protein CTD PMID:18512786 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Ciprofloxacin results in increased expression of CSF2 protein CTD PMID:11125792 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Ciprofloxacin results in decreased expression of CXCL2 protein CTD PMID:18197910 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of norclozapine; Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine] CTD PMID:11145498 PMID:11151749 PMID:15592331 PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Ciprofloxacin results in decreased expression of CYP2C11 mRNA CTD PMID:12621481 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Ciprofloxacin results in decreased activity of CYP3A4 protein CTD PMID:11145498 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Ciprofloxacin results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:12621481 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
decreases activity
EXP Ciprofloxacin inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]
Ciprofloxacin results in decreased activity of DHODH protein
CTD PMID:9776318 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression ISO Ciprofloxacin results in decreased expression of FGF15 mRNA CTD PMID:24657338 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases response to substance ISO G6PD protein mutant form results in increased susceptibility to Ciprofloxacin CTD PMID:20127091 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein] CTD PMID:29679711 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in increased expression of IFNG mRNA; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]]
Ciprofloxacin results in decreased expression of IFNG protein
CTD PMID:16006447 PMID:16968468 PMID:18337667 PMID:19401694 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]]
CTD PMID:16939481 PMID:19401694 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:16968468 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
Ciprofloxacin results in decreased expression of IL1B protein
CTD PMID:9267955 PMID:11052920 PMID:12428247 PMID:16148020 PMID:18197910 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions EXP Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]] CTD PMID:19401694 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 increases expression ISO Ciprofloxacin results in increased expression of IL3 mRNA; Ciprofloxacin results in increased expression of IL3 protein CTD PMID:11125792 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 decreases expression ISO Ciprofloxacin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:9267955 PMID:11052920 PMID:19401694 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA CTD PMID:29679711 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of MAPK1 protein CTD PMID:26947806 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of MAPK3 protein CTD PMID:26947806 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mb myoglobin multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein CTD PMID:29679711 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Ciprofloxacin results in increased expression of MCL1 protein CTD PMID:32437906 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA CTD PMID:29679711 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217
JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA CTD PMID:29679711 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Ciprofloxacin results in decreased expression of MITF protein CTD PMID:32437906 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
Ciprofloxacin results in increased expression of MMP1 mRNA
CTD PMID:12428247 PMID:16148020 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
Ciprofloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
increases expression
ISO Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin results in increased expression of MMP3 mRNA
CTD PMID:12428247 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Ciprofloxacin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:24101390 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nanog Nanog homeobox increases expression ISO Ciprofloxacin results in increased expression of NANOG protein CTD PMID:26947806 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 decreases response to substance ISO NOD2 gene SNP results in decreased susceptibility to Ciprofloxacin CTD PMID:18371140 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Ciprofloxacin results in increased expression of NR0B2 mRNA CTD PMID:24657338 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ciprofloxacin results in increased cleavage of PARP1 protein CTD PMID:10741713 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Ciprofloxacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Plk1 polo-like kinase 1 increases expression EXP Ciprofloxacin results in increased expression of PLK1 protein CTD PMID:18512786 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Ciprofloxacin results in decreased activity of PON1 protein CTD PMID:16880604 PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO Ciprofloxacin results in increased expression of POU5F1 protein CTD PMID:26947806 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prom1 prominin 1 increases expression ISO Ciprofloxacin results in increased expression of PROM1 protein CTD PMID:26947806 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Ciprofloxacin affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Ciprofloxacin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects localization
decreases expression
ISO Ciprofloxacin affects the localization of SLC2A1 mRNA
Ciprofloxacin results in decreased expression of SLC2A1 mRNA
CTD PMID:19022360 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc51b solute carrier family 51 subunit beta decreases expression ISO Ciprofloxacin results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases expression ISO Ciprofloxacin results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO Ciprofloxacin results in decreased expression of SNAI1 protein CTD PMID:26947806 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO Ciprofloxacin results in decreased expression of SNAI2 protein CTD PMID:26947806 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Ciprofloxacin results in decreased expression of SOX2 protein CTD PMID:26947806 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO
EXP
Ciprofloxacin results in increased expression of TGFB1 mRNA
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TGFB1 mRNA
CTD PMID:18337667 PMID:19371339 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases expression ISO Ciprofloxacin results in decreased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TNF mRNA; [irinotecan co-treated with Ciprofloxacin] promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]]
Ciprofloxacin results in decreased expression of TNF protein
CTD PMID:9267955 PMID:11052920 PMID:16939481 PMID:16968468 PMID:18197910 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein CTD PMID:18191106 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha affects binding
multiple interactions
ISO Ciprofloxacin binds to TOP2A protein
[Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein]; [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein]
CTD PMID:21413765 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Xirp1 xin actin-binding repeat containing 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349
JBrowse link
enoxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
affects binding
ISO
EXP
Enoxacin inhibits the reaction [CYP1A2 protein affects the metabolism of Fluvoxamine]; Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]
Enoxacin results in decreased activity of CYP1A2 protein
Enoxacin binds to CYP1A2 protein
Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
CTD PMID:7946932 PMID:8905919 PMID:15905806 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Enoxacin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO 7-nitroindazole inhibits the reaction [[Enoxacin co-treated with fenbufen] results in increased activity of NOS1 protein]; [Enoxacin co-treated with fenbufen] results in increased activity of NOS1 protein CTD PMID:9623721 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
flumequine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL2 mRNA CTD PMID:23681119 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL3 mRNA CTD PMID:23681119 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL4 mRNA CTD PMID:23681119 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL7 mRNA CTD PMID:23681119 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNA2 mRNA CTD PMID:23681119 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB1 mRNA; flumequine promotes the reaction [estragole results in increased expression of CCNB1 mRNA] CTD PMID:23681119 PMID:31029721 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB2 mRNA CTD PMID:23681119 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCND1 mRNA
flumequine results in increased expression of CCND1 mRNA
CTD PMID:23681119 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNE1 mRNA; [flumequine co-treated with estragole] results in increased expression of CCNE1 mRNA CTD PMID:23681119 PMID:31029721 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR2 mRNA CTD PMID:23681119 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR7 mRNA CTD PMID:23681119 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CDK1 mRNA CTD PMID:23681119 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CHEK1 mRNA CTD PMID:23681119 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A1 mRNA CTD PMID:23681119 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [flumequine co-treated with estragole] results in increased expression of CYP1A2 mRNA CTD PMID:23681119 PMID:31029721 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP2B10 mRNA CTD PMID:23681119 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of CYP7B1 mRNA CTD PMID:23681119 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Exo1 exonuclease 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of EXO1 mRNA CTD PMID:23681119 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of FOS mRNA CTD PMID:23681119 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of IL1B mRNA CTD PMID:23681119 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il36b interleukin 36, beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of IL36B mRNA CTD PMID:23681119 NCBI chr 3:7,024,862...7,122,489
Ensembl chr 3:7,021,973...7,031,619
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of JUN mRNA CTD PMID:23681119 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NFKB2 mRNA CTD PMID:23681119 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD18 mRNA CTD PMID:23681119 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD51 mRNA CTD PMID:23681119 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of TNF mRNA; [flumequine co-treated with estragole] results in increased expression of TNF mRNA
flumequine results in increased expression of TNF mRNA
CTD PMID:23681119 PMID:31029721 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression
multiple interactions
ISO flumequine results in decreased expression of UGT1A1 mRNA
[flumequine co-treated with estragole] results in decreased expression of UGT1A1 mRNA
CTD PMID:23681119 PMID:31029721 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression
multiple interactions
ISO flumequine results in decreased expression of UGT2B1 mRNA
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of UGT2B1 mRNA
CTD PMID:23681119 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
gatifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcg glucagon increases secretion
increases expression
multiple interactions
ISO
EXP
gatifloxacin results in increased secretion of GCG protein
gatifloxacin results in increased expression of GCG protein
[gatifloxacin co-treated with GCG protein] affects the secretion of INS1 protein; GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA]; GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA]
Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein]
gatifloxacin results in increased expression of GCG mRNA
CTD PMID:23200776 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gcgr glucagon receptor multiple interactions
affects expression
EXP GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA] CTD PMID:23200776 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression
EXP GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA] CTD PMID:23200776 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 increases expression ISO gatifloxacin results in increased expression of PCSK1 mRNA CTD PMID:23200776 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
Grepafloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export ISO ABCC1 protein affects the export of grepafloxacin CTD PMID:15948026 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO grepafloxacin results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of grepafloxacin CTD PMID:15769885 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of grepafloxacin CTD PMID:15769885 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of grepafloxacin CTD PMID:15769885 NCBI chr 9:88,696,981...88,808,465 JBrowse link
levofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd1 abhydrolase domain containing 1 decreases expression EXP Levofloxacin results in decreased expression of ABHD1 mRNA CTD PMID:24136188 NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 decreases expression EXP Levofloxacin results in decreased expression of ACSF2 mRNA CTD PMID:24136188 NCBI chr10:79,504,510...79,546,714
Ensembl chr10:79,504,511...79,546,673
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP Levofloxacin results in decreased expression of ACSL5 mRNA CTD PMID:24136188 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
JBrowse link
G Actg1 actin, gamma 1 decreases expression EXP Levofloxacin results in decreased expression of ACTG1 mRNA CTD PMID:24136188 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Acy1 aminoacylase 1 decreases expression EXP Levofloxacin results in decreased expression of ACY1 mRNA CTD PMID:24136188 NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682
JBrowse link
G Afp alpha-fetoprotein decreases expression EXP Levofloxacin results in decreased expression of AFP mRNA CTD PMID:24136188 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP Levofloxacin results in decreased expression of ALDH1B1 mRNA CTD PMID:24136188 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Angptl6 angiopoietin-like 6 increases expression EXP Levofloxacin results in increased expression of ANGPTL6 mRNA CTD PMID:24136188 NCBI chr 8:19,413,617...19,419,925
Ensembl chr 8:19,413,619...19,419,925
JBrowse link
G Anxa1 annexin A1 decreases expression EXP Levofloxacin results in decreased expression of ANXA1 mRNA CTD PMID:24136188 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa2 annexin A2 decreases expression EXP Levofloxacin results in decreased expression of ANXA2 mRNA CTD PMID:24136188 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression EXP Levofloxacin results in decreased expression of AP1S1 mRNA CTD PMID:24136188 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
JBrowse link
G Arl4a ADP-ribosylation factor like GTPase 4A increases expression EXP Levofloxacin results in increased expression of ARL4A mRNA CTD PMID:24136188 NCBI chr 6:57,079,496...57,084,156
Ensembl chr 6:57,078,812...57,085,066
JBrowse link
G Aspa aspartoacylase decreases expression EXP Levofloxacin results in decreased expression of ASPA mRNA CTD PMID:24136188 NCBI chr10:57,891,704...57,945,267
Ensembl chr10:57,892,104...57,945,272
JBrowse link
G Atg2b autophagy related 2B increases expression EXP Levofloxacin results in increased expression of ATG2B mRNA CTD PMID:24136188 NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015
JBrowse link
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 decreases expression EXP Levofloxacin results in decreased expression of ATP6V0E2 mRNA CTD PMID:24136188 NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [Levofloxacin co-treated with TNF protein] results in increased expression of BIRC2 mRNA CTD PMID:32035082 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Levofloxacin results in decreased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression EXP Levofloxacin results in decreased expression of BST2 mRNA CTD PMID:24136188 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression EXP Levofloxacin results in increased expression of BTG1 mRNA CTD PMID:24136188 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G C2cd2 C2 calcium-dependent domain containing 2 decreases expression EXP Levofloxacin results in decreased expression of C2CD2 mRNA CTD PMID:24136188 NCBI chr11:37,225,321...37,289,741
Ensembl chr11:37,227,415...37,289,739
JBrowse link
G C4b complement C4B (Chido blood group) increases expression EXP Levofloxacin results in increased expression of C4B mRNA CTD PMID:24136188 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G C5 complement C5 increases expression EXP Levofloxacin results in increased expression of C5 mRNA CTD PMID:24136188 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Ca14 carbonic anhydrase 14 decreases expression EXP Levofloxacin results in decreased expression of CAR14 mRNA CTD PMID:24136188 NCBI chr 2:183,442,263...183,449,207
Ensembl chr 2:183,441,667...183,449,693
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein CTD PMID:30876886 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccdc6 coiled-coil domain containing 6 increases expression EXP Levofloxacin results in increased expression of CCDC6 mRNA CTD PMID:24136188 NCBI chr20:18,432,177...18,528,186
Ensembl chr20:18,433,695...18,528,658
JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression EXP Levofloxacin results in decreased expression of CCDC80 mRNA CTD PMID:24136188 NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137
JBrowse link
G Cd302 CD302 molecule increases expression EXP Levofloxacin results in increased expression of CD302 mRNA CTD PMID:24136188 NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:44,722,325...44,756,045
JBrowse link
G Cdc42ep4 CDC42 effector protein 4 increases expression EXP Levofloxacin results in increased expression of CDC42EP4 mRNA CTD PMID:24136188 NCBI chr10:98,772,613...98,797,924
Ensembl chr10:98,772,495...98,797,695
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP Levofloxacin results in decreased expression of CDK1 mRNA CTD PMID:24136188 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP Levofloxacin results in decreased expression of CDKN3 mRNA CTD PMID:24136188 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Levofloxacin results in increased expression of CEBPB mRNA CTD PMID:24136188 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cfhr1 complement factor H-related 1 increases expression EXP Levofloxacin results in increased expression of CFHR1 mRNA CTD PMID:24136188 NCBI chr13:51,395,583...51,410,571
Ensembl chr13:51,369,211...51,410,592
JBrowse link
G Cgn cingulin decreases expression EXP Levofloxacin results in decreased expression of CGN mRNA CTD PMID:24136188 NCBI chr 2:182,308,389...182,335,747
Ensembl chr 2:182,308,714...182,334,645
JBrowse link
G Chpt1 choline phosphotransferase 1 increases expression EXP Levofloxacin results in increased expression of CHPT1 mRNA CTD PMID:24136188 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP Levofloxacin results in decreased expression of CKS2 mRNA CTD PMID:24136188 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Clec14a C-type lectin domain containing 14A increases expression EXP Levofloxacin results in increased expression of CLEC14A mRNA CTD PMID:24136188 NCBI chr 6:75,881,470...75,884,612
Ensembl chr 6:75,881,473...75,884,612
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Levofloxacin results in decreased expression of CMBL mRNA CTD PMID:24136188 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Levofloxacin results in increased expression of CPT1A mRNA CTD PMID:24136188 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression EXP Levofloxacin results in increased expression of CYP27A1 mRNA CTD PMID:24136188 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression EXP Levofloxacin results in increased expression of CYP4B1 mRNA CTD PMID:24136188 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Levofloxacin results in increased expression of CYP51 mRNA CTD PMID:24136188 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Ddc dopa decarboxylase decreases expression EXP Levofloxacin results in decreased expression of DDC mRNA CTD PMID:24136188 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Ddhd1 DDHD domain containing 1 decreases expression EXP Levofloxacin results in decreased expression of DDHD1 mRNA CTD PMID:24136188 NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO Levofloxacin results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 decreases expression EXP Levofloxacin results in decreased expression of DNAJC9 mRNA CTD PMID:24136188 NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression EXP Levofloxacin results in decreased expression of DNPH1 mRNA CTD PMID:24136188 NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression EXP Levofloxacin results in decreased expression of DTYMK mRNA CTD PMID:24136188 NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
JBrowse link
G Dut deoxyuridine triphosphatase decreases expression EXP Levofloxacin results in decreased expression of DUT mRNA CTD PMID:24136188 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression EXP Levofloxacin results in increased expression of EDEM1 mRNA CTD PMID:24136188 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 decreases expression EXP Levofloxacin results in decreased expression of ELOVL5 mRNA CTD PMID:24136188 NCBI chr 8:78,790,799...78,857,307
Ensembl chr 8:78,790,846...78,857,284
JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression EXP Levofloxacin results in increased expression of ENC1 mRNA CTD PMID:24136188 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP Levofloxacin results in decreased expression of EPHX1 mRNA CTD PMID:24136188 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Erg28 ergosterol biosynthesis 28 homolog increases expression EXP Levofloxacin results in increased expression of ERG28 mRNA CTD PMID:24136188 NCBI chr 6:105,474,112...105,483,078
Ensembl chr 6:105,474,113...105,483,078
JBrowse link
G Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 decreases expression EXP Levofloxacin results in decreased expression of ERGIC1 mRNA CTD PMID:24136188 NCBI chr10:16,531,192...16,627,183
Ensembl chr10:16,531,194...16,626,957
JBrowse link
G Fgl1 fibrinogen-like 1 increases expression EXP Levofloxacin results in increased expression of FGL1 mRNA CTD PMID:24136188 NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093
JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 decreases expression EXP Levofloxacin results in decreased expression of FKBP4 mRNA CTD PMID:24136188 NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Levofloxacin results in increased expression of FKBP5 mRNA CTD PMID:24136188 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Flna filamin A decreases expression EXP Levofloxacin results in decreased expression of FLNA mRNA CTD PMID:24136188 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052
JBrowse link
G Fndc3b fibronectin type III domain containing 3B increases expression EXP Levofloxacin results in increased expression of FNDC3B mRNA CTD PMID:24136188 NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830
JBrowse link
G Fzd8 frizzled class receptor 8 increases expression EXP Levofloxacin results in increased expression of FZD8 mRNA CTD PMID:24136188 NCBI chr17:57,312,924...57,320,551
Ensembl chr17:57,314,450...57,320,650
JBrowse link
G Gas6 growth arrest specific 6 increases expression EXP Levofloxacin results in increased expression of GAS6 mRNA CTD PMID:24136188 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression EXP Levofloxacin results in decreased expression of GCLC mRNA CTD PMID:24136188 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression EXP Levofloxacin results in decreased expression of GPD1 mRNA CTD PMID:24136188 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression EXP Levofloxacin results in decreased expression of HACD3 mRNA CTD PMID:24136188 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
JBrowse link
G Haus4 HAUS augmin-like complex, subunit 4 decreases expression EXP Levofloxacin results in decreased expression of HAUS4 mRNA CTD PMID:24136188 NCBI chr15:27,994,530...28,006,147
Ensembl chr15:27,994,532...28,005,938
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression EXP Levofloxacin results in increased expression of HERPUD1 mRNA CTD PMID:24136188 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression EXP Levofloxacin results in decreased expression of HMGB2 mRNA CTD PMID:24136188 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmgn2 high mobility group nucleosomal binding domain 2 decreases expression EXP Levofloxacin results in decreased expression of HMGN2 mRNA CTD PMID:24136188 NCBI chr 5:146,192,126...146,195,580
Ensembl chr 5:146,192,126...146,195,521
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression EXP Levofloxacin results in decreased expression of HTATIP2 mRNA CTD PMID:24136188 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO Levofloxacin results in decreased expression of ICAM1 mRNA
[Levofloxacin co-treated with TNF protein] results in increased expression of ICAM1 protein
CTD PMID:32035082 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP Levofloxacin results in increased expression of IDI1 mRNA CTD PMID:24136188 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifng interferon gamma increases expression EXP Levofloxacin results in increased expression of IFNG CTD PMID:24136188 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Levofloxacin results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein CTD PMID:30876886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression ISO Levofloxacin results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein CTD PMID:30876886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor increases expression EXP Levofloxacin results in increased expression of IL6R mRNA CTD PMID:24136188 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 increases expression EXP Levofloxacin results in increased expression of IP6K2 mRNA CTD PMID:24136188 NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
JBrowse link
G Ivns1abp influenza virus NS1A binding protein increases expression EXP Levofloxacin results in increased expression of IVNS1ABP mRNA CTD PMID:24136188 NCBI chr13:63,427,040...63,446,701
Ensembl chr13:63,427,041...63,446,701
JBrowse link
G Klf15 Kruppel-like factor 15 increases expression EXP Levofloxacin results in increased expression of KLF15 mRNA CTD PMID:24136188 NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
JBrowse link
G Klf9 Kruppel-like factor 9 increases expression EXP Levofloxacin results in increased expression of KLF9 mRNA CTD PMID:24136188 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression EXP Levofloxacin results in decreased expression of KPNA2 mRNA CTD PMID:24136188 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Kpnb1 karyopherin subunit beta 1 decreases expression EXP Levofloxacin results in decreased expression of KPNB1 mRNA CTD PMID:24136188 NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605
JBrowse link
G Krt18 keratin 18 decreases expression EXP Levofloxacin results in decreased expression of KRT18 mRNA CTD PMID:24136188 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Levofloxacin results in increased expression of LBP mRNA CTD PMID:24136188 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 decreases expression EXP Levofloxacin results in decreased expression of LCMT1 mRNA CTD PMID:24136188 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112
JBrowse link
G Lmnb1 lamin B1 decreases expression EXP Levofloxacin results in decreased expression of LMNB1 mRNA CTD PMID:24136188 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Lmo7 LIM domain 7 decreases expression EXP Levofloxacin results in decreased expression of LMO7 mRNA CTD PMID:24136188 NCBI chr15:78,567,029...78,769,833
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G Lpin1 lipin 1 increases expression EXP Levofloxacin results in increased expression of LPIN1 mRNA CTD PMID:24136188 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like increases expression EXP Levofloxacin results in increased expression of LURAP1L mRNA CTD PMID:24136188 NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438
JBrowse link
G Manba mannosidase beta decreases expression EXP Levofloxacin results in decreased expression of MANBA mRNA CTD PMID:24136188 NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO [TNF protein co-treated with Levofloxacin] results in increased lipidation of MAP1LC3B protein; TNF protein promotes the reaction [Levofloxacin results in increased expression of MAP1LC3B protein] CTD PMID:33609687 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A increases expression EXP Levofloxacin results in increased expression of MFSD2A mRNA CTD PMID:24136188 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression EXP Levofloxacin results in increased expression of NAMPT mRNA CTD PMID:24136188 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression EXP Levofloxacin results in decreased expression of NEDD9 mRNA CTD PMID:24136188 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression EXP Levofloxacin results in decreased expression of NFE2L2 mRNA CTD PMID:24136188 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
EXP
ISO
Levofloxacin results in increased expression of NFKBIA mRNA
[Levofloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA
CTD PMID:24136188 PMID:32035082 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression EXP Levofloxacin results in increased expression of NFKBIZ mRNA CTD PMID:24136188 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Nrbp2 nuclear receptor binding protein 2 increases expression EXP Levofloxacin results in increased expression of NRBP2 mRNA CTD PMID:24136188 NCBI chr 7:107,798,642...107,805,230
Ensembl chr 7:107,799,497...107,805,230
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression EXP Levofloxacin results in increased expression of NUDT4 mRNA CTD PMID:24136188 NCBI chr 7:30,188,100...30,204,620
Ensembl chr 7:30,188,100...30,204,615
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP Levofloxacin results in increased expression of NUPR1 mRNA CTD PMID:24136188 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Omd osteomodulin increases expression EXP Levofloxacin results in increased expression of OMD mRNA CTD PMID:24136188 NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441
JBrowse link
G Osbpl1a oxysterol binding protein-like 1A decreases expression EXP Levofloxacin results in decreased expression of OSBPL1A mRNA CTD PMID:24136188 NCBI chr18:3,904,006...4,094,635
Ensembl chr18:3,904,006...4,094,585
JBrowse link
G Palmd palmdelphin decreases expression EXP Levofloxacin results in decreased expression of PALMD mRNA CTD PMID:24136188 NCBI chr 2:204,889,526...204,941,355
Ensembl chr 2:204,889,533...204,941,519
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 increases expression EXP Levofloxacin results in increased expression of PBLD1 mRNA CTD PMID:24136188 NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression
decreases expression
EXP
ISO
Levofloxacin results in increased expression of PID1 mRNA
Levofloxacin results in decreased expression of PID1 mRNA
CTD PMID:24136188 PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U increases expression EXP Levofloxacin results in increased expression of PIGU mRNA CTD PMID:24136188 NCBI chr 3:143,784,831...143,881,268
Ensembl chr 3:143,784,832...143,880,807
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression EXP Levofloxacin results in increased expression of PLA2G12A mRNA CTD PMID:24136188 NCBI chr 2:218,436,450...218,452,760
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Plgrkt plasminogen receptor with a C-terminal lysine decreases expression EXP Levofloxacin results in decreased expression of PLGRKT mRNA CTD PMID:24136188 NCBI chr 1:227,099,005...227,111,277
Ensembl chr 1:227,099,015...227,111,194
JBrowse link
G Plin3 perilipin 3 decreases expression EXP Levofloxacin results in decreased expression of PLIN3 mRNA CTD PMID:24136188 NCBI chr 9:1,111,178...1,123,117 JBrowse link
G Plp2 proteolipid protein 2 decreases expression EXP Levofloxacin results in decreased expression of PLP2 mRNA CTD PMID:24136188 NCBI chr  X:14,834,249...14,837,648
Ensembl chr  X:14,834,231...14,838,514
JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit increases expression EXP Levofloxacin results in increased expression of POLG2 mRNA CTD PMID:24136188 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Levofloxacin results in decreased expression of PPARA mRNA CTD PMID:25689681 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase increases expression EXP Levofloxacin results in increased expression of PPCS mRNA CTD PMID:24136188 NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933
JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression EXP Levofloxacin results in decreased expression of PPIF mRNA CTD PMID:24136188 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A decreases expression EXP Levofloxacin results in decreased expression of PPP1R14A mRNA CTD PMID:24136188 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 decreases expression EXP Levofloxacin results in decreased expression of PRKAG2 mRNA CTD PMID:24136188 NCBI chr 4:10,010,574...10,252,152
Ensembl chr 4:10,010,890...10,252,142
JBrowse link
G Proser2 proline and serine rich 2 increases expression EXP Levofloxacin results in increased expression of PROSER2 mRNA CTD PMID:24136188 NCBI chr17:72,151,961...72,187,524
Ensembl chr17:72,151,872...72,185,825
JBrowse link
G Prxl2b peroxiredoxin like 2B increases expression EXP Levofloxacin results in increased expression of PRXL2B mRNA CTD PMID:24136188 NCBI chr 5:165,462,610...165,465,213 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Levofloxacin results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression EXP Levofloxacin results in decreased expression of PTTG1 mRNA CTD PMID:24136188 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 increases expression EXP Levofloxacin results in increased expression of RAPGEF4 mRNA CTD PMID:24136188 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Levofloxacin co-treated with Lipopolysaccharides] affects the localization of RELA protein CTD PMID:32035082 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Retreg1 reticulophagy regulator 1 increases expression EXP Levofloxacin results in increased expression of RETREG1 mRNA CTD PMID:24136188 NCBI chr 2:76,335,609...76,474,817 JBrowse link
G RGD1308742 similar to Complement C5 precursor increases expression EXP Levofloxacin results in increased expression of RGD1308742 mRNA CTD PMID:24136188 NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054
JBrowse link
G RGD1309534 similar to RIKEN cDNA 4931406C07 decreases expression EXP Levofloxacin results in decreased expression of RGD1309534 mRNA CTD PMID:24136188 NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473
JBrowse link
G RGD1311251 similar to RIKEN cDNA 4930550C14 increases expression EXP Levofloxacin results in increased expression of RGD1311251 mRNA CTD PMID:24136188 NCBI chr 8:53,796,033...53,825,277
Ensembl chr 8:53,796,366...53,824,748
JBrowse link
G Rmdn2 regulator of microtubule dynamics 2 decreases expression EXP Levofloxacin results in decreased expression of RMDN2 mRNA CTD PMID:24136188 NCBI chr 6:15,372,569...15,443,000
Ensembl chr 6:15,375,496...15,441,480
JBrowse link
G Rnd2 Rho family GTPase 2 increases expression EXP Levofloxacin results in increased expression of RND2 mRNA CTD PMID:24136188 NCBI chr10:86,399,177...86,402,750
Ensembl chr10:86,399,148...86,402,742
JBrowse link
G Rnf4 ring finger protein 4 decreases expression EXP Levofloxacin results in decreased expression of RNF4 mRNA CTD PMID:24136188 NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566
JBrowse link
G Rnpepl1 arginyl aminopeptidase like 1 increases expression EXP Levofloxacin results in increased expression of RNPEPL1 mRNA CTD PMID:24136188 NCBI chr 9:93,476,600...93,486,331
Ensembl chr 9:93,472,390...93,486,331
JBrowse link
G Rpa1 replication protein A1 decreases expression EXP Levofloxacin results in decreased expression of RPA1 mRNA CTD PMID:24136188 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression EXP Levofloxacin results in decreased expression of RRM2 mRNA CTD PMID:24136188 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rsrp1 arginine and serine rich protein 1 decreases expression EXP Levofloxacin results in decreased expression of RSRP1 mRNA CTD PMID:24136188 NCBI chr 5:147,147,774...147,151,523
Ensembl chr 5:147,147,784...147,151,523
JBrowse link
G Rxra retinoid X receptor alpha increases expression EXP Levofloxacin results in increased expression of RXRA mRNA CTD PMID:24136188 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Levofloxacin results in increased expression of SC5D mRNA CTD PMID:24136188 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Sdc4 syndecan 4 increases expression EXP Levofloxacin results in increased expression of SDC4 mRNA CTD PMID:24136188 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Serpina11 serpin family A member 11 increases expression EXP Levofloxacin results in increased expression of SERPINA11 mRNA CTD PMID:24136188 NCBI chr 6:122,903,246...122,912,695
Ensembl chr 6:122,903,250...122,912,670
JBrowse link
G Serpinh1 serpin family H member 1 decreases expression EXP Levofloxacin results in decreased expression of SERPINH1 mRNA CTD PMID:24136188 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Sesn2 sestrin 2 increases expression EXP Levofloxacin results in increased expression of SESN2 mRNA CTD PMID:24136188 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression EXP Levofloxacin results in decreased expression of SFPQ mRNA CTD PMID:24136188 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 increases expression EXP Levofloxacin results in increased expression of SH3BP5 mRNA CTD PMID:24136188 NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
JBrowse link
G Slc13a3 solute carrier family 13 member 3 increases expression EXP Levofloxacin results in increased expression of SLC13A3 mRNA CTD PMID:24136188 NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606
JBrowse link
G Slc17a3 solute carrier family 17 member 3 decreases expression EXP Levofloxacin results in decreased expression of SLC17A3 mRNA CTD PMID:24136188 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256
JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression EXP Levofloxacin results in increased expression of SLC38A2 mRNA CTD PMID:24136188 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Levofloxacin results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Levofloxacin results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Spa17 sperm autoantigenic protein 17 decreases expression EXP Levofloxacin results in decreased expression of SPA17 mRNA CTD PMID:24136188 NCBI chr 8:37,307,432...37,318,645
Ensembl chr 8:37,307,557...37,318,639
JBrowse link
G Srxn1 sulfiredoxin 1 decreases expression EXP Levofloxacin results in decreased expression of SRXN1 mRNA CTD PMID:24136188 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Ssx2ip SSX family member 2 interacting protein decreases expression EXP Levofloxacin results in decreased expression of SSX2IP mRNA CTD PMID:24136188 NCBI chr 2:235,298,012...235,330,750
Ensembl chr 2:235,298,088...235,330,745
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Levofloxacin results in increased expression of STAT3 mRNA CTD PMID:24136188 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Steap3 STEAP3 metalloreductase decreases expression EXP Levofloxacin results in decreased expression of STEAP3 mRNA CTD PMID:24136188 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP Levofloxacin results in decreased expression of STMN1 mRNA CTD PMID:24136188 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Sumf1 sulfatase modifying factor 1 increases expression EXP Levofloxacin results in increased expression of SUMF1 mRNA CTD PMID:24136188 NCBI chr 4:141,078,735...141,160,711
Ensembl chr 4:141,078,741...141,160,708
JBrowse link
G Synrg synergin, gamma increases expression EXP Levofloxacin results in increased expression of SYNRG mRNA CTD PMID:24136188 NCBI chr10:68,848,828...68,931,252 JBrowse link
G Syvn1 synoviolin 1 increases expression EXP Levofloxacin results in increased expression of SYVN1 mRNA CTD PMID:24136188 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 decreases expression EXP Levofloxacin results in decreased expression of TCIRG1 mRNA CTD PMID:24136188 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
JBrowse link
G Tef TEF transcription factor, PAR bZIP family member increases expression EXP Levofloxacin results in increased expression of TEF mRNA CTD PMID:24136188 NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783
JBrowse link
G Tjp2 tight junction protein 2 decreases expression EXP Levofloxacin results in decreased expression of TJP2 mRNA CTD PMID:24136188 NCBI chr 1:221,709,745...221,838,383
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
G Tkt transketolase decreases expression EXP Levofloxacin results in decreased expression of TKT mRNA CTD PMID:24136188 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tmem176b transmembrane protein 176B increases expression EXP Levofloxacin results in increased expression of TMEM176B mRNA CTD PMID:24136188 NCBI chr 4:77,766,928...77,774,740
Ensembl chr 4:77,766,928...77,774,384
JBrowse link
G Tmem38b transmembrane protein 38B increases expression EXP Levofloxacin results in increased expression of TMEM38B mRNA CTD PMID:24136188 NCBI chr 5:68,460,304...68,496,026
Ensembl chr 5:68,460,304...68,496,025
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Levofloxacin co-treated with TNF protein] results in increased expression of ICAM1 protein; [Levofloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA; [TNF protein co-treated with Levofloxacin] results in increased lipidation of MAP1LC3B protein; TNF protein promotes the reaction [Levofloxacin results in increased expression of MAP1LC3B protein]
[Levofloxacin co-treated with TNF protein] results in increased expression of BIRC2 mRNA; [Levofloxacin co-treated with TNF protein] results in increased expression of ICAM1 protein; [Levofloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA; [Levofloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA
CTD PMID:30876886 PMID:32035082 PMID:33609687 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO [Levofloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA CTD PMID:32035082 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Levofloxacin results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 decreases expression EXP Levofloxacin results in decreased expression of TNFRSF9 mRNA CTD PMID:24136188 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
JBrowse link
G Tob2 transducer of ERBB2, 2 increases expression EXP Levofloxacin results in increased expression of TOB2 mRNA CTD PMID:24136188 NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688
JBrowse link
G Tpm3 tropomyosin 3 decreases expression EXP Levofloxacin results in decreased expression of TPM3 mRNA CTD PMID:24136188 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression EXP Levofloxacin results in increased expression of TSC22D3 mRNA CTD PMID:24136188 NCBI chr  X:104,217,898...104,277,935
Ensembl chr  X:104,217,925...104,276,861
JBrowse link
G Tstd3 thiosulfate sulfurtransferase like domain containing 3 decreases expression EXP Levofloxacin results in decreased expression of TSTD3 mRNA CTD PMID:24136188 NCBI chr 5:35,294,652...35,304,101
Ensembl chr 5:35,294,645...35,304,101
JBrowse link
G Tuba1c tubulin, alpha 1C decreases expression EXP Levofloxacin results in decreased expression of TUBA1C mRNA CTD PMID:24136188 NCBI chr 7:130,192,050...130,199,655
Ensembl chr 7:130,192,016...130,199,647
Ensembl chr  X:130,192,016...130,199,647
JBrowse link
G Tubb4b tubulin, beta 4B class IVb decreases expression EXP Levofloxacin results in decreased expression of TUBB4B mRNA CTD PMID:24136188 NCBI chr 3:8,037,844...8,040,294
Ensembl chr 3:8,037,799...8,040,296
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Levofloxacin results in decreased expression of TUBB5 mRNA CTD PMID:24136188 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tubb6 tubulin, beta 6 class V decreases expression EXP Levofloxacin results in decreased expression of TUBB6 mRNA CTD PMID:24136188 NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418
JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression EXP Levofloxacin results in increased expression of USP2 mRNA CTD PMID:24136188 NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Levofloxacin results in increased expression of VCAM1 mRNA CTD PMID:24136188 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vim vimentin decreases expression EXP Levofloxacin results in decreased expression of VIM mRNA CTD PMID:24136188 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression EXP Levofloxacin results in increased expression of VMP1 mRNA CTD PMID:24136188 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007
JBrowse link
G Wasl WASP like actin nucleation promoting factor increases expression EXP Levofloxacin results in increased expression of WASL mRNA CTD PMID:24136188 NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression EXP Levofloxacin results in increased expression of WIPI1 mRNA CTD PMID:24136188 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
JBrowse link
G Xpo1 exportin 1 decreases expression EXP Levofloxacin results in decreased expression of XPO1 mRNA CTD PMID:24136188 NCBI chr14:97,233,263...97,275,536
Ensembl chr14:97,233,270...97,275,498
JBrowse link
G Zfp354a zinc finger protein 354A increases expression EXP Levofloxacin results in increased expression of ZFP354A mRNA CTD PMID:24136188 NCBI chr10:35,396,242...35,408,065
Ensembl chr10:35,396,231...35,408,068
JBrowse link
G Zfp446 zinc finger protein 446 increases expression EXP Levofloxacin results in increased expression of ZFP446 mRNA CTD PMID:24136188 NCBI chr 1:73,594,953...73,612,685 JBrowse link
moxifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma decreases expression ISO moxifloxacin results in decreased expression of IFNG protein CTD PMID:16006447 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO moxifloxacin results in decreased secretion of IL1B protein CTD PMID:16352735 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 decreases expression ISO moxifloxacin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO moxifloxacin results in decreased activity of KCNH2 protein CTD PMID:24052561 PMID:27553911 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK1 protein CTD PMID:16352735 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK3 protein CTD PMID:16352735 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases secretion
decreases secretion
ISO Moxifloxacin results in increased secretion of MMP1 protein
Moxifloxacin results in decreased secretion of MMP1 protein
CTD PMID:24890593 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases secretion
increases secretion
ISO Moxifloxacin results in decreased secretion of MMP3 protein
Moxifloxacin results in increased secretion of MMP3 protein
CTD PMID:24890593 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion ISO Moxifloxacin results in decreased secretion of MMP9 protein CTD PMID:24890593 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Moxifloxacin results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO moxifloxacin results in decreased expression of RELA protein CTD PMID:16352735 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO moxifloxacin results in decreased secretion of TNF protein CTD PMID:16352735 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein CTD PMID:18191106 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,696,981...88,808,465 JBrowse link
nalidixic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO Nalidixic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] CTD PMID:16148020 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Nalidixic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Nalidixic Acid results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
norfloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Norfloxacin results in increased expression of AIFM1 protein CTD PMID:32320760 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Norfloxacin results in increased expression of BAD protein CTD PMID:32320760 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Norfloxacin results in increased expression of BAX protein CTD PMID:32320760 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Norfloxacin results in decreased expression of BCL2 protein CTD PMID:32320760 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp2 caspase 2 affects activity ISO Norfloxacin affects the activity of CASP2 protein CTD PMID:32320760 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp8 caspase 8 affects activity ISO Norfloxacin affects the activity of CASP8 protein CTD PMID:32320760 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding
multiple interactions
EXP Norfloxacin binds to CYP1A2 protein
Norfloxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
CTD PMID:8905919 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Norfloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Norfloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; Norfloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Norfloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
[biphenylylacetic acid co-treated with Norfloxacin] results in increased expression of IL1B mRNA; [biphenylylacetic acid co-treated with Norfloxacin] results in increased expression of IL1B protein
CTD PMID:16148020 PMID:16824509 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Norfloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Norfloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein] CTD PMID:16148020 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Norfloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Norfloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
Norfloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Norfloxacin affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Norfloxacin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Ofloxacin results in decreased activity of ABCB11 protein
Ofloxacin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Ofloxacin affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Ofloxacin results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline] CTD PMID:11408986 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] CTD PMID:11408986 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Ofloxacin results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] CTD PMID:16148020 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Ofloxacin results in decreased expression of ITGB4 protein CTD PMID:14687228 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Ofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Ofloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP Ofloxacin results in increased expression of MMP3 mRNA CTD PMID:20688128 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Ofloxacin results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Ofloxacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression ISO Ofloxacin results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression EXP Ofloxacin results in increased expression of PLAUR mRNA CTD PMID:20688128 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ofloxacin results in increased expression of PTGS2 mRNA CTD PMID:20688128 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Ofloxacin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO
EXP
Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects localization
decreases expression
ISO Ofloxacin affects the localization of SLC2A1 mRNA
Ofloxacin results in decreased expression of SLC2A1 mRNA
CTD PMID:19022360 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Ofloxacin results in increased expression of TNFRSF12A mRNA CTD PMID:20688128 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:88,696,981...88,808,465 JBrowse link
pipemidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Pipemidic Acid CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
Prulifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport EXP ABCB1 protein affects the transport of prulifloxacin metabolite CTD PMID:15618759 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of prulifloxacin metabolite CTD PMID:15618759 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Ar androgen receptor affects localization
multiple interactions
ISO prulifloxacin affects the localization of AR protein
prulifloxacin binds to and results in increased activity of AR protein
CTD PMID:28478275 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
Sitafloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of sitafloxacin CTD PMID:15769885 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of sitafloxacin CTD PMID:15769885 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of sitafloxacin CTD PMID:15769885 NCBI chr 9:88,696,981...88,808,465 JBrowse link
trovafloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression EXP trovafloxacin results in decreased expression of ACACA mRNA CTD PMID:24136188 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 decreases expression EXP trovafloxacin results in decreased expression of ACSF2 mRNA CTD PMID:24136188 NCBI chr10:79,504,510...79,546,714
Ensembl chr10:79,504,511...79,546,673
JBrowse link
G Actb actin, beta decreases expression EXP trovafloxacin results in decreased expression of ACTB mRNA CTD PMID:24136188 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Actg1 actin, gamma 1 decreases expression EXP trovafloxacin results in decreased expression of ACTG1 mRNA CTD PMID:24136188 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Acy1 aminoacylase 1 decreases expression EXP trovafloxacin results in decreased expression of ACY1 mRNA CTD PMID:24136188 NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682
JBrowse link
G Adap2 ArfGAP with dual PH domains 2 increases expression EXP trovafloxacin results in increased expression of ADAP2 mRNA CTD PMID:24136188 NCBI chr10:65,138,006...65,166,147
Ensembl chr10:65,138,020...65,165,604
JBrowse link
G Adipor2 adiponectin receptor 2 decreases expression EXP trovafloxacin results in decreased expression of ADIPOR2 mRNA CTD PMID:24136188 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ADRB2 mRNA CTD PMID:18930950 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 decreases expression EXP trovafloxacin results in decreased expression of AKR7A3 mRNA CTD PMID:24136188 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO trovafloxacin results in increased phosphorylation of AKT1 protein
TNF protein promotes the reaction [trovafloxacin results in increased phosphorylation of AKT1 protein]
CTD PMID:33609687 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression EXP trovafloxacin results in decreased expression of ALDH1A1 mRNA CTD PMID:24136188 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP trovafloxacin results in decreased expression of ALDH1B1 mRNA CTD PMID:24136188 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 decreases expression EXP trovafloxacin results in decreased expression of AMD1 mRNA CTD PMID:24136188 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G Ammecr1l AMMECR1 like increases expression EXP trovafloxacin results in increased expression of AMMECR1L mRNA CTD PMID:24136188 NCBI chr18:23,386,114...23,411,177
Ensembl chr18:23,386,903...23,410,920
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ANGPTL4 mRNA CTD PMID:18930950 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression EXP trovafloxacin results in decreased expression of AP1S1 mRNA CTD PMID:24136188 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APEX1 mRNA CTD PMID:18930950 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apoa5 apolipoprotein A5 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of APOA5 mRNA CTD PMID:18930950 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 decreases expression EXP trovafloxacin results in decreased expression of ARHGAP24 mRNA CTD PMID:24136188 NCBI chr14:6,800,631...7,184,001
Ensembl chr14:6,800,631...7,183,823
JBrowse link
G Arid5b AT-rich interaction domain 5B multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ARID5B mRNA CTD PMID:18930950 NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433
JBrowse link
G Armt1 acidic residue methyltransferase 1 decreases expression EXP trovafloxacin results in decreased expression of ARMT1 mRNA CTD PMID:24136188 NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions
increases phosphorylation
ISO pyrazolanthrone inhibits the reaction [trovafloxacin results in increased phosphorylation of ATF2 protein] CTD PMID:24525298 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atg10 autophagy related 10 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased expression of ATG10 mRNA CTD PMID:33609687 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
JBrowse link
G Atg101 autophagy related 101 increases expression ISO trovafloxacin results in increased expression of ATG101 mRNA CTD PMID:33609687 NCBI chr 7:132,398,477...132,407,643
Ensembl chr 7:132,398,483...132,407,633
JBrowse link
G Atg12 autophagy related 12 increases expression ISO trovafloxacin results in increased expression of ATG12 mRNA CTD PMID:33609687 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg14 autophagy related 14 increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG14 mRNA
TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG14 mRNA]
CTD PMID:33609687 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113
JBrowse link
G Atg16l1 autophagy related 16-like 1 increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG16L1 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ATG16L1 mRNA
CTD PMID:33609687 NCBI chr 9:88,420,737...88,457,530
Ensembl chr 9:88,422,038...88,457,529
JBrowse link
G Atg16l2 autophagy related 16-like 2 decreases expression ISO trovafloxacin results in decreased expression of ATG16L2 mRNA CTD PMID:33609687 NCBI chr 1:155,687,386...155,703,419
Ensembl chr 1:155,684,564...155,703,420
JBrowse link
G Atg2a autophagy related 2A multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased expression of ATG2A mRNA CTD PMID:33609687 NCBI chr 1:203,542,559...203,562,242
Ensembl chr 1:203,542,559...203,562,242
JBrowse link
G Atg2b autophagy related 2B increases expression ISO trovafloxacin results in increased expression of ATG2B mRNA CTD PMID:33609687 NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015
JBrowse link
G Atg3 autophagy related 3 increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG3 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ATG3 mRNA
CTD PMID:33609687 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Atg4a autophagy related 4A, cysteine peptidase increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG4A mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ATG4A mRNA
CTD PMID:33609687 NCBI chr  X:104,665,345...104,765,271 JBrowse link
G Atg4c autophagy related 4C, cysteine peptidase multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in decreased expression of ATG4C mRNA CTD PMID:33609687 NCBI chr 5:113,867,218...113,935,534
Ensembl chr 5:113,867,092...113,934,830
JBrowse link
G Atg5 autophagy related 5 affects response to substance
increases expression
multiple interactions
ISO ATG5 protein affects the susceptibility to trovafloxacin
trovafloxacin results in increased expression of ATG5 mRNA
ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK1 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK3 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK8 protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG5 mRNA]
CTD PMID:33609687 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg9b autophagy related 9B increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG9B mRNA
TNF protein promotes the reaction [trovafloxacin results in increased expression of ATG9B mRNA]; trovafloxacin promotes the reaction [TNF protein results in increased expression of ATG9B mRNA]
CTD PMID:33609687 NCBI chr 4:10,784,934...10,793,832
Ensembl chr 4:10,786,114...10,793,651
JBrowse link
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 decreases expression EXP trovafloxacin results in decreased expression of ATP6V0E2 mRNA CTD PMID:24136188 NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of ATR protein]; 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin results in increased phosphorylation of ATR protein]; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of and results in increased activity of ATR protein; trovafloxacin results in increased phosphorylation of and results in increased activity of ATR protein; U 0126 inhibits the reaction [trovafloxacin results in increased activity of ATR protein] CTD PMID:25748550 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Atrn attractin increases expression EXP trovafloxacin results in increased expression of ATRN mRNA CTD PMID:24136188 NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322
JBrowse link
G B2m beta-2 microglobulin multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of B2M mRNA CTD PMID:18930950 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BHLHE40 mRNA CTD PMID:18930950 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression
ISO trovafloxacin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]
trovafloxacin results in decreased expression of BIRC2 protein
[trovafloxacin co-treated with TNF protein] results in decreased expression of BIRC2 mRNA
trovafloxacin results in decreased expression of BIRC2 mRNA
CTD PMID:32035082 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
decreases expression
ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BIRC3 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of BIRC3 mRNA
trovafloxacin results in decreased expression of BIRC3 mRNA
CTD PMID:18930950 PMID:32035082 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 decreases expression EXP trovafloxacin results in decreased expression of BPNT1 mRNA CTD PMID:24136188 NCBI chr13:96,865,634...96,893,506
Ensembl chr13:96,868,580...96,893,503
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression EXP trovafloxacin results in decreased expression of BST2 mRNA CTD PMID:24136188 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Caprin1 cell cycle associated protein 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CAPRIN1 mRNA CTD PMID:18930950 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
JBrowse link
G Casd1 CAS1 domain containing 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASD1 mRNA CTD PMID:18930950 NCBI chr 4:32,658,888...32,739,224
Ensembl chr 4:32,658,748...32,739,202
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL1B protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL6 protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with TNF protein] results in increased activity of CASP3 protein; ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein]
[TNF protein co-treated with trovafloxacin] results in increased cleavage of CASP3 protein
CTD PMID:19638433 PMID:24097668 PMID:25748550 PMID:30876886 PMID:33609687 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 increases expression EXP trovafloxacin results in increased expression of CASP6 mRNA CTD PMID:24136188 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 decreases expression EXP trovafloxacin results in decreased expression of CASP7 mRNA CTD PMID:24136188 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased activity of CASP8 protein CTD PMID:24097668 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased activity of CASP9 protein CTD PMID:24097668 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccdc6 coiled-coil domain containing 6 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CCDC6 mRNA CTD PMID:18930950 NCBI chr20:18,432,177...18,528,186
Ensembl chr20:18,433,695...18,528,658
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO trovafloxacin promotes the reaction [TNF protein results in increased expression of CCL2 protein] CTD PMID:19638433 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnb2 cyclin B2 decreases expression EXP trovafloxacin results in decreased expression of CCNB2 mRNA CTD PMID:24136188 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP trovafloxacin results in decreased expression of CCND1 mRNA CTD PMID:24136188 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd36 CD36 molecule decreases expression EXP trovafloxacin results in decreased expression of CD36 mRNA CTD PMID:24136188 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd8b CD8b molecule multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CD8B mRNA CTD PMID:18930950 NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553
JBrowse link
G Cdc20 cell division cycle 20 decreases expression EXP trovafloxacin results in decreased expression of CDC20 mRNA CTD PMID:24136188 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc42ep4 CDC42 effector protein 4 increases expression EXP trovafloxacin results in increased expression of CDC42EP4 mRNA CTD PMID:24136188 NCBI chr10:98,772,613...98,797,924
Ensembl chr10:98,772,495...98,797,695
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP trovafloxacin results in decreased expression of CDK1 mRNA CTD PMID:24136188 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk16 cyclin-dependent kinase 16 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CDK16 mRNA CTD PMID:18930950 NCBI chr  X:1,492,814...1,504,309
Ensembl chr  X:1,492,814...1,504,148
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CDKN1A mRNA
trovafloxacin results in increased expression of CDKN1A mRNA
CTD PMID:18930950 PMID:25748550 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP trovafloxacin results in decreased expression of CDKN3 mRNA CTD PMID:24136188 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CEBPA mRNA CTD PMID:18930950 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chfr checkpoint with forkhead and ring finger domains multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CHFR mRNA CTD PMID:18930950 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014
JBrowse link
G Chka choline kinase alpha multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CHKA mRNA CTD PMID:18930950 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP trovafloxacin results in decreased expression of CKS2 mRNA CTD PMID:24136188 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cldn14 claudin 14 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLDN14 mRNA CTD PMID:18930950 NCBI chr11:33,232,281...33,329,440
Ensembl chr11:33,232,220...33,329,171
JBrowse link
G Clint1 clathrin interactor 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CLINT1 mRNA CTD PMID:18930950 NCBI chr10:30,298,618...30,353,185
Ensembl chr10:30,298,704...30,353,063
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of COMT mRNA CTD PMID:18930950 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Copg1 COPI coat complex subunit gamma 1 decreases expression EXP trovafloxacin results in decreased expression of COPG1 mRNA CTD PMID:24136188 NCBI chr 4:120,366,540...120,392,502 JBrowse link
G Cpox coproporphyrinogen oxidase decreases expression EXP trovafloxacin results in decreased expression of CPOX mRNA CTD PMID:24136188 NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP trovafloxacin results in increased expression of CPT1A mRNA CTD PMID:24136188 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CRK mRNA CTD PMID:18930950 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Cs citrate synthase decreases expression EXP trovafloxacin results in decreased expression of CS mRNA CTD PMID:24136188 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CXCL2 mRNA; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL2 protein] CTD PMID:18930950 PMID:19638433 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CXCL3 mRNA; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:18930950 PMID:19638433 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO trovafloxacin results in decreased activity of CYP19A1 protein CTD PMID:26141389 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 decreases expression EXP trovafloxacin results in decreased expression of CYP2B12 mRNA CTD PMID:24136188 NCBI chr 1:82,007,609...82,019,409
Ensembl chr 1:82,007,609...82,080,480
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CYP7A1 mRNA CTD PMID:18930950 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression EXP trovafloxacin results in increased expression of CYP8B1 mRNA CTD PMID:24136188 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression EXP trovafloxacin results in decreased expression of DAPK1 mRNA CTD PMID:24136188 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression ISO trovafloxacin results in decreased expression of DDIT3 mRNA CTD PMID:24136188 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddx1 DEAD-box helicase 1 decreases expression EXP trovafloxacin results in decreased expression of DDX1 mRNA CTD PMID:24136188 NCBI chr 6:35,996,469...36,027,340
Ensembl chr 6:35,996,469...36,027,365
JBrowse link
G Ddx17 DEAD-box helicase 17 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of DDX17 mRNA CTD PMID:18930950 NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
JBrowse link
G Derl2 derlin 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of DERL2 mRNA CTD PMID:18930950 NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression EXP trovafloxacin results in decreased expression of DGAT2 mRNA CTD PMID:24136188 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression EXP trovafloxacin results in decreased expression of DLST mRNA CTD PMID:24136188 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of DNAJB2 mRNA CTD PMID:18930950 NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression EXP trovafloxacin results in decreased expression of DNPH1 mRNA CTD PMID:24136188 NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression EXP trovafloxacin results in decreased expression of DTYMK mRNA CTD PMID:24136188 NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
JBrowse link
G Dusp16 dual specificity phosphatase 16 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of DUSP16 mRNA CTD PMID:18930950 NCBI chr 4:167,546,780...167,629,949
Ensembl chr 4:167,548,155...167,629,980
JBrowse link
G Dusp8 dual specificity phosphatase 8 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of DUSP8 mRNA CTD PMID:18930950 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
JBrowse link
G Dut deoxyuridine triphosphatase decreases expression EXP trovafloxacin results in decreased expression of DUT mRNA CTD PMID:24136188 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of EGFR mRNA CTD PMID:18930950 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases expression EXP trovafloxacin results in decreased expression of EIF2S1 mRNA CTD PMID:24136188 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of EIF2S2 mRNA CTD PMID:18930950 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of EIF3A mRNA CTD PMID:18930950 NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C decreases expression EXP trovafloxacin results in decreased expression of EIF3C mRNA CTD PMID:24136188 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
JBrowse link
G Eif3l eukaryotic translation initiation factor 3, subunit L decreases expression EXP trovafloxacin results in decreased expression of EIF3L mRNA CTD PMID:24136188 NCBI chr 7:110,652,565...110,663,614
Ensembl chr 7:110,627,107...110,663,614
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 increases expression EXP trovafloxacin results in increased expression of EIF4A2 mRNA CTD PMID:24136188 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein; Sirolimus inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:33609687 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif6 eukaryotic translation initiation factor 6 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of EIF6 mRNA CTD PMID:18930950 NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression EXP trovafloxacin results in decreased expression of ELOVL6 mRNA CTD PMID:24136188 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Emc1 ER membrane protein complex subunit 1 decreases expression EXP trovafloxacin results in decreased expression of EMC1 mRNA CTD PMID:24136188 NCBI chr 5:151,608,557...151,633,888
Ensembl chr 5:151,608,568...151,633,888
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP trovafloxacin results in decreased expression of EPHX1 mRNA CTD PMID:24136188 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 decreases expression EXP trovafloxacin results in decreased expression of ERGIC1 mRNA CTD PMID:24136188 NCBI chr10:16,531,192...16,627,183
Ensembl chr10:16,531,194...16,626,957
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression EXP trovafloxacin results in decreased expression of ERP29 mRNA CTD PMID:24136188 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ERRFI1 mRNA CTD PMID:18930950 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ETS2 mRNA CTD PMID:18930950 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
JBrowse link
G F2 coagulation factor II multiple interactions ISO [Lipopolysaccharides co-treated with trovafloxacin] results in increased activity of F2 protein CTD PMID:19367693 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fam98a family with sequence similarity 98, member A decreases expression EXP trovafloxacin results in decreased expression of FAM98A mRNA CTD PMID:24136188 NCBI chr 6:19,874,082...19,888,744
Ensembl chr 6:19,874,071...19,888,742
JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression
ISO
EXP
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of FASN mRNA
trovafloxacin results in decreased expression of FASN mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbxo9 f-box protein 9 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of FBXO9 mRNA CTD PMID:18930950 NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of FGA protein CTD PMID:19367693 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 decreases expression EXP trovafloxacin results in decreased expression of FKBP4 mRNA CTD PMID:24136188 NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases expression EXP trovafloxacin results in increased expression of FMO3 mRNA CTD PMID:24136188 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FOS mRNA CTD PMID:18930950 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fzd7 frizzled class receptor 7 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of FZD7 mRNA CTD PMID:18930950 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of G6PC mRNA CTD PMID:18930950 NCBI chr10:86,307,400...86,318,766 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression EXP trovafloxacin results in decreased expression of G6PD mRNA CTD PMID:24136188 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 multiple interactions
increases expression
ISO [trovafloxacin co-treated with TNF protein] results in increased expression of GABARAPL1 mRNA
trovafloxacin results in increased expression of GABARAPL1 mRNA
CTD PMID:33609687 NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 multiple interactions
increases expression
ISO TNF protein inhibits the reaction [trovafloxacin results in increased expression of GABARAPL2 mRNA] CTD PMID:33609687 NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma decreases expression EXP trovafloxacin results in decreased expression of GADD45G mRNA CTD PMID:24136188 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP trovafloxacin results in decreased expression of GAPDH mRNA CTD PMID:24136188 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gcgr glucagon receptor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GCGR mRNA CTD PMID:18930950 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
multiple interactions
EXP
ISO
trovafloxacin results in decreased expression of GCLC mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GCLC mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 decreases expression EXP trovafloxacin results in decreased expression of GFM1 mRNA CTD PMID:24136188 NCBI chr 2:151,700,573...151,745,477
Ensembl chr 2:151,700,564...151,745,471
JBrowse link
G Ggcx gamma-glutamyl carboxylase decreases expression EXP trovafloxacin results in decreased expression of GGCX mRNA CTD PMID:24136188 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GJA1 mRNA CTD PMID:18930950 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Glrx3 glutaredoxin 3 decreases expression EXP trovafloxacin results in decreased expression of GLRX3 mRNA CTD PMID:24136188 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
JBrowse link
G Glyat glycine-N-acyltransferase increases expression EXP trovafloxacin results in increased expression of GLYAT mRNA CTD PMID:24136188 NCBI chr 1:209,704,178...209,724,949
Ensembl chr 1:209,704,268...209,724,942
JBrowse link
G Gnl3 G protein nucleolar 3 increases expression EXP trovafloxacin results in increased expression of GNL3 mRNA CTD PMID:24136188 NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392
JBrowse link
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GNPNAT1 mRNA CTD PMID:18930950 NCBI chr15:18,596,180...18,608,854
Ensembl chr15:18,596,442...18,608,739
JBrowse link
G Golga2 golgin A2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GOLGA2 mRNA CTD PMID:18930950 NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
JBrowse link
G Golga4 golgin A4 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GOLGA4 mRNA CTD PMID:18930950 NCBI chr 8:118,208,200...118,285,003 JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP trovafloxacin results in decreased expression of GPAM mRNA CTD PMID:24136188 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 increases expression EXP trovafloxacin results in increased expression of GPLD1 mRNA CTD PMID:24136188 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression EXP trovafloxacin results in decreased expression of GSR mRNA CTD PMID:24136188 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase decreases expression EXP trovafloxacin results in decreased expression of GSS mRNA CTD PMID:24136188 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP trovafloxacin results in decreased expression of GSTA3 mRNA CTD PMID:24136188 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
increases expression
ISO [TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [trovafloxacin results in increased expression of H2AX protein modified form]; TNF protein promotes the reaction [trovafloxacin results in increased expression of H2AX protein modified form]
trovafloxacin results in increased phosphorylation of H2AX protein
CTD PMID:24817034 PMID:25748550 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression EXP trovafloxacin results in decreased expression of HACD3 mRNA CTD PMID:24136188 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 increases expression EXP trovafloxacin results in increased expression of HACL1 mRNA CTD PMID:24136188 NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027
JBrowse link
G Hao2 hydroxyacid oxidase 2 increases expression EXP trovafloxacin results in increased expression of HAO2 mRNA CTD PMID:24136188 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
JBrowse link
G Hmgn3 high mobility group nucleosomal binding domain 3 decreases expression EXP trovafloxacin results in decreased expression of HMGN3 mRNA CTD PMID:24136188 NCBI chr 8:84,022,493...84,059,329
Ensembl chr 8:84,022,495...84,062,976
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HMOX1 mRNA CTD PMID:18930950 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of HNRNPF mRNA CTD PMID:18930950 NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression EXP trovafloxacin results in decreased expression of HSPH1 mRNA CTD PMID:24136188 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression EXP trovafloxacin results in decreased expression of HTATIP2 mRNA CTD PMID:24136188 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ICAM1 mRNA; trovafloxacin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
[trovafloxacin co-treated with TNF protein] results in increased expression of ICAM1 mRNA
trovafloxacin results in decreased expression of ICAM1 mRNA
CTD PMID:18930950 PMID:32035082 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of ID2 mRNA CTD PMID:18930950 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Ide insulin degrading enzyme decreases expression EXP trovafloxacin results in decreased expression of IDE mRNA CTD PMID:24136188 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression EXP trovafloxacin results in decreased expression of IDH2 mRNA CTD PMID:24136188 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
IFNG protein promotes the reaction [[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF protein]; IFNG protein results in increased susceptibility to [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5]; trovafloxacin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IFNG protein]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin
CTD PMID:18930950 PMID:19362101 PMID:19638433 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression
multiple interactions
EXP
ISO
trovafloxacin results in increased expression of IFRD1 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IFRD1 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IGFBP1 mRNA CTD PMID:18930950 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il17ra interleukin 17 receptor A multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL17RA mRNA CTD PMID:18930950 NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174
JBrowse link
G Il18 interleukin 18 multiple interactions ISO IL18 protein results in increased susceptibility to [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5]; trovafloxacin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IL18 protein] CTD PMID:18930950 PMID:19638433 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO
EXP
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL1B protein] affects the localization of SELE protein; [trovafloxacin co-treated with IL1B protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL1B protein] results in increased expression of SELE mRNA; trovafloxacin promotes the reaction [IL1B protein results in increased secretion of SELE protein]
trovafloxacin promotes the reaction [TNF protein results in increased expression of IL1B protein]
CTD PMID:10822086 PMID:19638433 PMID:30876886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL6 protein] results in increased activity of CASP3 protein
trovafloxacin promotes the reaction [TNF protein results in increased expression of IL6 protein]
CTD PMID:19362101 PMID:19638433 PMID:30876886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 increases expression EXP trovafloxacin results in increased expression of IP6K2 mRNA CTD PMID:24136188 NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions
decreases expression
ISO
EXP
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IRF1 mRNA
trovafloxacin results in decreased expression of IRF1 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ISG20 mRNA CTD PMID:18930950 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Ist1 IST1 factor associated with ESCRT-III increases expression EXP trovafloxacin results in increased expression of IST1 mRNA CTD PMID:24136188 NCBI chr19:37,648,840...37,671,019
Ensembl chr19:37,648,095...37,670,956
JBrowse link
G Ivns1abp influenza virus NS1A binding protein multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IVNS1ABP mRNA CTD PMID:18930950 NCBI chr13:63,427,040...63,446,701
Ensembl chr13:63,427,041...63,446,701
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of JUNB mRNA CTD PMID:18930950 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Klf9 Kruppel-like factor 9 increases expression EXP trovafloxacin results in increased expression of KLF9 mRNA CTD PMID:24136188 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037
JBrowse link
G Klhl24 kelch-like family member 24 increases expression EXP trovafloxacin results in increased expression of KLHL24 mRNA CTD PMID:24136188 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression EXP trovafloxacin results in decreased expression of KPNA2 mRNA CTD PMID:24136188 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Kpnb1 karyopherin subunit beta 1 decreases expression EXP trovafloxacin results in decreased expression of KPNB1 mRNA CTD PMID:24136188 NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605
JBrowse link
G Krt18 keratin 18 decreases expression EXP trovafloxacin results in decreased expression of KRT18 mRNA CTD PMID:24136188 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta decreases expression EXP trovafloxacin results in decreased expression of LAPTM4B mRNA CTD PMID:24136188 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of LDLR mRNA CTD PMID:18930950 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Letm1 leucine zipper and EF-hand containing transmembrane protein 1 decreases expression EXP trovafloxacin results in decreased expression of LETM1 mRNA CTD PMID:24136188 NCBI chr14:76,942,647...76,982,220
Ensembl chr14:76,942,729...76,984,904
JBrowse link
G Lgalsl galectin-like decreases expression EXP trovafloxacin results in decreased expression of LGALSL mRNA CTD PMID:24136188 NCBI chr14:94,996,991...95,004,499
Ensembl chr14:94,996,990...95,004,980
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of LITAF mRNA CTD PMID:18930950 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Lmna lamin A/C decreases expression EXP trovafloxacin results in decreased expression of LMNA mRNA CTD PMID:24136188 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lpin1 lipin 1 increases expression EXP trovafloxacin results in increased expression of LPIN1 mRNA CTD PMID:24136188 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Lrp6 LDL receptor related protein 6 increases expression EXP trovafloxacin results in increased expression of LRP6 mRNA CTD PMID:24136188 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
G Lsm4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression EXP trovafloxacin results in decreased expression of LSM4 mRNA CTD PMID:24136188 NCBI chr16:18,755,481...18,761,106
Ensembl chr16:18,755,484...18,760,926
JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression EXP trovafloxacin results in decreased expression of LTA4H mRNA CTD PMID:24136188 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Lyz2 lysozyme 2 decreases expression EXP trovafloxacin results in decreased expression of LYZ2 mRNA CTD PMID:24136188 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Mal2 mal, T-cell differentiation protein 2 decreases expression EXP trovafloxacin results in decreased expression of MAL2 mRNA CTD PMID:24136188 NCBI chr 7:85,900,453...85,933,433
Ensembl chr 7:85,900,453...85,933,429
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MANF mRNA CTD PMID:18930950 NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions
increases expression
ISO TNF protein inhibits the reaction [trovafloxacin results in increased expression of MAP1LC3A mRNA] CTD PMID:33609687 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO [trovafloxacin co-treated with TNF protein] results in increased expression of MAP1LC3B mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein
trovafloxacin results in increased expression of MAP1LC3B mRNA
CTD PMID:33609687 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MAP2K7 mRNA CTD PMID:18930950 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MAP3K8 mRNA CTD PMID:18930950 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
increases phosphorylation
multiple interactions
ISO trovafloxacin results in increased activity of MAPK1 protein
trovafloxacin results in increased phosphorylation of MAPK1 protein
[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK1 protein; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK1 protein]
U 0126 inhibits the reaction [trovafloxacin results in increased activity of MAPK1 protein]
CTD PMID:24525298 PMID:32035082 PMID:33609687 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
increases phosphorylation
multiple interactions
ISO trovafloxacin results in increased activity of MAPK3 protein
trovafloxacin results in increased phosphorylation of MAPK3 protein
[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK3 protein; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK3 protein]
U 0126 inhibits the reaction [trovafloxacin results in increased activity of MAPK3 protein]
CTD PMID:24525298 PMID:32035082 PMID:33609687 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO trovafloxacin results in increased phosphorylation of MAPK8 protein
ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK8 protein]
CTD PMID:33609687 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions
increases phosphorylation
ISO SB 203580 inhibits the reaction [trovafloxacin results in increased phosphorylation of MAPKAPK2 protein] CTD PMID:24525298 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mavs mitochondrial antiviral signaling protein multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MAVS mRNA CTD PMID:18930950 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression EXP trovafloxacin results in decreased expression of MDH2 mRNA CTD PMID:24136188 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MDM2 mRNA CTD PMID:18930950 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Me1 malic enzyme 1 decreases expression EXP trovafloxacin results in decreased expression of ME1 mRNA CTD PMID:24136188 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Med20 mediator complex subunit 20 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MED20 mRNA CTD PMID:18930950 NCBI chr 9:13,370,146...13,382,756
Ensembl chr 9:13,370,146...13,382,476
JBrowse link
G Memo1 mediator of cell motility 1 decreases expression EXP trovafloxacin results in decreased expression of MEMO1 mRNA CTD PMID:24136188 NCBI chr 6:21,144,525...21,234,363
Ensembl chr 6:21,125,639...21,234,561
JBrowse link
G Mgll monoglyceride lipase decreases expression EXP trovafloxacin results in decreased expression of MGLL mRNA CTD PMID:24136188 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Mir877 microRNA 877 increases expression ISO trovafloxacin results in increased expression of MIR877 mRNA CTD PMID:27713024 NCBI chr20:2,811,476...2,811,560
Ensembl chr20:2,811,476...2,811,560
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MLXIPL mRNA CTD PMID:18930950 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MMP13 mRNA CTD PMID:18930950 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mogs mannosyl-oligosaccharide glucosidase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MOGS mRNA CTD PMID:18930950 NCBI chr 4:115,621,623...115,625,026
Ensembl chr 4:115,621,623...115,625,032
JBrowse link
G Mphosph8 M-phase phosphoprotein 8 increases expression EXP trovafloxacin results in increased expression of MPHOSPH8 mRNA CTD PMID:24136188 NCBI chr15:30,800,546...30,828,415 JBrowse link
G Mrpl12 mitochondrial ribosomal protein L12 decreases expression EXP trovafloxacin results in decreased expression of MRPL12 mRNA CTD PMID:24136188 NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B decreases expression EXP trovafloxacin results in decreased expression of MRPS18B mRNA CTD PMID:24136188 NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260
JBrowse link
G Mt1 metallothionein 1 increases expression EXP trovafloxacin results in increased expression of MT1A mRNA CTD PMID:24136188 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MT1E mRNA CTD PMID:18930950 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression EXP trovafloxacin results in decreased expression of MTTP mRNA CTD PMID:24136188 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MYD88 mRNA CTD PMID:18930950 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit decreases expression EXP trovafloxacin results in decreased expression of NAA15 mRNA CTD PMID:24136188 NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756
JBrowse link
G Ndufaf4 NADH:ubiquinone oxidoreductase complex assembly factor 4 decreases expression EXP trovafloxacin results in decreased expression of NDUFAF4 mRNA CTD PMID:24136188 NCBI chr 5:38,605,169...38,610,341
Ensembl chr 5:38,605,153...38,610,336
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NEDD4L mRNA CTD PMID:18930950 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NEDD9 mRNA CTD PMID:18930950 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
ISO [Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of NFKBIA mRNA; [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NFKBIA mRNA; [trovafloxacin co-treated with TNF protein] results in decreased expression of NFKBIA protein; trovafloxacin promotes the reaction [TNF protein results in increased expression of NFKBIA mRNA]
[trovafloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA
trovafloxacin results in increased expression of NFKBIA mRNA; trovafloxacin results in increased expression of NFKBIA protein
CTD PMID:18930950 PMID:32035082 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbiz NFKB inhibitor zeta multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NFKBIZ mRNA CTD PMID:18930950 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 decreases expression EXP trovafloxacin results in decreased expression of NME1 mRNA CTD PMID:24136188 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 decreases expression EXP trovafloxacin results in decreased expression of NME2 mRNA CTD PMID:24136188 NCBI chr10:78,898,097...78,903,600
Ensembl chr10:78,897,770...78,903,538
JBrowse link
G Noct nocturnin multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NOCT mRNA CTD PMID:18930950 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Notch2 notch receptor 2 decreases expression EXP trovafloxacin results in decreased expression of NOTCH2 mRNA CTD PMID:24136188 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of NR2F6 mRNA CTD PMID:18930950 NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP trovafloxacin results in increased expression of NR3C1 mRNA CTD PMID:24136188 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nudt7 nudix hydrolase 7 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of NUDT7 mRNA CTD PMID:18930950 NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081
JBrowse link
G Nup98 nucleoporin 98 and 96 precursor increases expression EXP trovafloxacin results in increased expression of NUP98 mRNA CTD PMID:24136188 NCBI chr 1:156,494,423...156,591,415
Ensembl chr 1:156,494,423...156,591,415
JBrowse link
G Obp3 alpha-2u globulin PGCL4 increases expression EXP trovafloxacin results in increased expression of OBP3 mRNA CTD PMID:24136188 NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757
JBrowse link
G P2ry2 purinergic receptor P2Y2 decreases expression EXP trovafloxacin results in decreased expression of P2RY2 mRNA CTD PMID:24136188 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
JBrowse link
G Pacsin2 protein kinase C and casein kinase substrate in neurons 2 decreases expression EXP trovafloxacin results in decreased expression of PACSIN2 mRNA CTD PMID:24136188 NCBI chr 7:114,505,525...114,599,087
Ensembl chr 7:114,505,152...114,598,546
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO trovafloxacin results in increased cleavage of PARP1 protein
ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of PARP1 protein]
CTD PMID:33609687 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 increases expression EXP trovafloxacin results in increased expression of PBLD1 mRNA CTD PMID:24136188 NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 decreases expression EXP trovafloxacin results in decreased expression of PCSK6 mRNA CTD PMID:24136188 NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596
JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression EXP trovafloxacin results in decreased expression of PCTP mRNA CTD PMID:24136188 NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
multiple interactions
EXP
ISO
trovafloxacin results in decreased expression of PDE4B mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PDE4B mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X decreases expression EXP trovafloxacin results in decreased expression of PDHX mRNA CTD PMID:24136188 NCBI chr 3:89,372,472...89,396,759
Ensembl chr 3:89,371,497...89,431,773
JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression EXP trovafloxacin results in decreased expression of PDLIM1 mRNA CTD PMID:24136188 NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
JBrowse link
G Perp p53 apoptosis effector related to PMP22 decreases expression EXP trovafloxacin results in decreased expression of PERP mRNA CTD PMID:24136188 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Pex2 peroxisomal biogenesis factor 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PEX2 mRNA CTD PMID:18930950 NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404
JBrowse link
G Pgk1 phosphoglycerate kinase 1 decreases expression EXP trovafloxacin results in decreased expression of PGK1 mRNA CTD PMID:24136188 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Pgm1 phosphoglucomutase 1 decreases expression EXP trovafloxacin results in decreased expression of PGM1 mRNA CTD PMID:24136188 NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PHLDA1 mRNA CTD PMID:18930950 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Pink1 PTEN induced kinase 1 increases expression EXP trovafloxacin results in increased expression of PINK1 mRNA CTD PMID:24136188 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PIP5K1A mRNA CTD PMID:18930950 NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598
JBrowse link
G Pisd phosphatidylserine decarboxylase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PISD mRNA CTD PMID:18930950 NCBI chr14:77,941,927...77,991,021
Ensembl chr14:77,941,948...77,991,003
JBrowse link
G Plbd1 phospholipase B domain containing 1 decreases expression EXP trovafloxacin results in decreased expression of PLBD1 mRNA CTD PMID:24136188 NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277
JBrowse link
G Plin2 perilipin 2 decreases expression EXP trovafloxacin results in decreased expression of PLIN2 mRNA CTD PMID:24136188 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Plin3 perilipin 3 decreases expression EXP trovafloxacin results in decreased expression of PLIN3 mRNA CTD PMID:24136188 NCBI chr 9:1,111,178...1,123,117 JBrowse link
G Plk3 polo-like kinase 3 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PLK3 mRNA CTD PMID:18930950 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Plpp3 phospholipid phosphatase 3 increases expression EXP trovafloxacin results in increased expression of PLPP3 mRNA CTD PMID:24136188 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
JBrowse link
G Pnp purine nucleoside phosphorylase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PNP2 mRNA CTD PMID:18930950 NCBI chr15:24,170,456...24,178,274
Ensembl chr15:24,170,602...24,203,986
JBrowse link
G Polrmt RNA polymerase mitochondrial multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of POLRMT mRNA CTD PMID:18930950 NCBI chr 7:9,959,532...9,969,791
Ensembl chr 7:9,959,576...9,969,791
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 decreases expression EXP trovafloxacin results in decreased expression of PPA1 mRNA CTD PMID:24136188 NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO trovafloxacin results in decreased expression of PPARA mRNA CTD PMID:25689681 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppox protoporphyrinogen oxidase decreases expression EXP trovafloxacin results in decreased expression of PPOX mRNA CTD PMID:24136188 NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A decreases expression EXP trovafloxacin results in decreased expression of PPP1R14A mRNA CTD PMID:24136188 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Ppp1r14b protein phosphatase 1, regulatory (inhibitor) subunit 14B decreases expression EXP trovafloxacin results in decreased expression of PPP1R14B mRNA CTD PMID:24136188 NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PPP1R15A mRNA CTD PMID:18930950 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Preb prolactin regulatory element binding multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PREB mRNA CTD PMID:18930950 NCBI chr 6:25,418,805...25,422,594
Ensembl chr 6:25,418,776...25,422,590
JBrowse link
G Proser2 proline and serine rich 2 increases expression EXP trovafloxacin results in increased expression of PROSER2 mRNA CTD PMID:24136188 NCBI chr17:72,151,961...72,187,524
Ensembl chr17:72,151,872...72,185,825
JBrowse link
G Prss23 serine protease 23 decreases expression EXP trovafloxacin results in decreased expression of PRSS23 mRNA CTD PMID:24136188 NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PSMA5 mRNA CTD PMID:18930950 NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 decreases expression EXP trovafloxacin results in decreased expression of PSMB10 mRNA CTD PMID:24136188 NCBI chr19:33,830,958...33,833,442 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTEN mRNA CTD PMID:18930950 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgr2 prostaglandin reductase 2 decreases expression EXP trovafloxacin results in decreased expression of PTGR2 mRNA CTD PMID:24136188 NCBI chr 6:103,931,367...103,963,113
Ensembl chr 6:103,931,409...103,963,111
JBrowse link
G Ptma prothymosin alpha decreases expression EXP trovafloxacin results in decreased expression of PTMA mRNA CTD PMID:24136188 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression
multiple interactions
EXP
ISO
trovafloxacin results in increased expression of PTP4A1 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTP4A1 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTPN2 mRNA CTD PMID:18930950 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Ptpn21 protein tyrosine phosphatase, non-receptor type 21 decreases expression EXP trovafloxacin results in decreased expression of PTPN21 mRNA CTD PMID:24136188 NCBI chr 6:117,933,066...117,998,095
Ensembl chr 6:117,933,066...117,998,095
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression EXP trovafloxacin results in decreased expression of PTTG1 mRNA CTD PMID:24136188 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Ran RAN, member RAS oncogene family decreases expression EXP trovafloxacin results in decreased expression of RAN mRNA CTD PMID:24136188 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rangap1 RAN GTPase activating protein 1 decreases expression EXP trovafloxacin results in decreased expression of RANGAP1 mRNA CTD PMID:24136188 NCBI chr 7:113,224,695...113,250,441
Ensembl chr 7:113,224,703...113,250,438
JBrowse link
G Rarb retinoic acid receptor, beta decreases expression EXP trovafloxacin results in decreased expression of RARB mRNA CTD PMID:24136188 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP trovafloxacin results in decreased expression of RB1 mRNA CTD PMID:24136188 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 multiple interactions
increases expression
ISO TNF protein inhibits the reaction [trovafloxacin results in increased expression of RB1CC1 mRNA] CTD PMID:33609687 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560
JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of RCAN1 mRNA CTD PMID:18930950 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Rdx radixin multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RDX mRNA CTD PMID:18930950 NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678
JBrowse link
G Reep6 receptor accessory protein 6 decreases expression EXP trovafloxacin results in decreased expression of REEP6 mRNA CTD PMID:24136188 NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of REL mRNA CTD PMID:18930950 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO trovafloxacin affects the reaction [TNF protein affects the localization of RELA protein modified form]; trovafloxacin affects the reaction [TNF protein results in increased phosphorylation of RELA protein]
trovafloxacin affects the localization of RELA protein
trovafloxacin affects the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD PMID:32035082 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RGD1308742 similar to Complement C5 precursor increases expression EXP trovafloxacin results in increased expression of RGD1308742 mRNA CTD PMID:24136188 NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054
JBrowse link
G RGD1309534 similar to RIKEN cDNA 4931406C07 decreases expression EXP trovafloxacin results in decreased expression of RGD1309534 mRNA CTD PMID:24136188 NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473
JBrowse link
G RGD1564804 similar to chromosome 1 open reading frame 50 increases expression EXP trovafloxacin results in increased expression of RGD1564804 mRNA CTD PMID:24136188 NCBI chr 5:132,837,135...132,841,744
Ensembl chr 5:132,836,506...132,841,762
JBrowse link
G Rmdn2 regulator of microtubule dynamics 2 decreases expression EXP trovafloxacin results in decreased expression of RMDN2 mRNA CTD PMID:24136188 NCBI chr 6:15,372,569...15,443,000
Ensembl chr 6:15,375,496...15,441,480
JBrowse link
G Rnd3 Rho family GTPase 3 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of RND3 mRNA CTD PMID:18930950 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Rnf26 ring finger protein 26 decreases expression EXP trovafloxacin results in decreased expression of RNF26 mRNA CTD PMID:24136188 NCBI chr 8:44,454,551...44,456,745
Ensembl chr 8:44,454,292...44,457,331
JBrowse link
G Rnf39 ring finger protein 39 increases expression EXP trovafloxacin results in increased expression of RNF39 mRNA CTD PMID:24136188 NCBI chr20:1,604,794...1,610,283
Ensembl chr20:1,604,794...1,610,283
JBrowse link
G Rnf6 ring finger protein 6 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RNF6 mRNA CTD PMID:18930950 NCBI chr12:8,816,777...8,826,870
Ensembl chr12:8,816,833...8,826,847
JBrowse link
G Rpa1 replication protein A1 decreases expression EXP trovafloxacin results in decreased expression of RPA1 mRNA CTD PMID:24136188 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rpl7l1 ribosomal protein L7-like 1 decreases expression EXP trovafloxacin results in decreased expression of RPL7L1 mRNA CTD PMID:24136188 NCBI chr 9:14,198,101...14,206,119
Ensembl chr 9:14,198,092...14,206,110
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of RPS6KB1 protein CTD PMID:33609687 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression EXP trovafloxacin results in decreased expression of RRM2 mRNA CTD PMID:24136188 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rsrp1 arginine and serine rich protein 1 increases expression EXP trovafloxacin results in increased expression of RSRP1 mRNA CTD PMID:24136188 NCBI chr 5:147,147,774...147,151,523
Ensembl chr 5:147,147,784...147,151,523
JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of S100A11 mRNA CTD PMID:18930950 NCBI chr 2:179,191,504...179,197,098
Ensembl chr 2:179,191,715...179,197,044
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression EXP trovafloxacin results in decreased expression of SAE1 mRNA CTD PMID:24136188 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
JBrowse link
G Sarnp SAP domain containing ribonucleoprotein decreases expression EXP trovafloxacin results in decreased expression of SARNP mRNA CTD PMID:24136188 NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression EXP trovafloxacin results in increased expression of SAT1 mRNA CTD PMID:24136188 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP trovafloxacin results in decreased expression of SCD1 mRNA CTD PMID:24136188 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sds serine dehydratase increases expression EXP trovafloxacin results in increased expression of SDS mRNA CTD PMID:24136188 NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component decreases expression EXP trovafloxacin results in decreased expression of SEC24D mRNA CTD PMID:24136188 NCBI chr 2:211,418,557...211,526,588
Ensembl chr 2:211,418,623...211,526,587
JBrowse link
G Sele selectin E multiple interactions ISO [trovafloxacin co-treated with IL1B protein] affects the localization of SELE protein; [trovafloxacin co-treated with IL1B protein] results in increased expression of SELE mRNA; trovafloxacin promotes the reaction [IL1B protein results in increased secretion of SELE protein]
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SELE mRNA
CTD PMID:10822086 PMID:18930950 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Senp2 SUMO specific peptidase 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SENP2 mRNA CTD PMID:18930950 NCBI chr11:78,981,429...79,018,274
Ensembl chr11:78,981,432...79,018,238
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINE1 mRNA; SERPINE1 protein results in increased susceptibility to [trovafloxacin co-treated with Lipopolysaccharides]; trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein] CTD PMID:18930950 PMID:19367693 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sf3a3 splicing factor 3a, subunit 3 decreases expression EXP trovafloxacin results in decreased expression of SF3A3 mRNA CTD PMID:24136188 NCBI chr 5:136,967,713...136,987,345
Ensembl chr 5:136,967,691...136,987,361
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression EXP trovafloxacin results in decreased expression of SFPQ mRNA CTD PMID:24136188 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 increases expression EXP trovafloxacin results in increased expression of SH3BP5 mRNA CTD PMID:24136188 NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
JBrowse link
G Skil SKI-like proto-oncogene multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SKIL mRNA CTD PMID:18930950 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC11A2 mRNA CTD PMID:18930950 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc17a2 solute carrier family 17, member 2 increases expression EXP trovafloxacin results in increased expression of SLC17A2 mRNA CTD PMID:24136188 NCBI chr17:41,318,312...41,339,012
Ensembl chr17:41,319,701...41,336,325
JBrowse link
G Slc17a3 solute carrier family 17 member 3 decreases expression
multiple interactions
EXP
ISO
trovafloxacin results in decreased expression of SLC17A3 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SLC17A3 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression EXP trovafloxacin results in decreased expression of SLC22A1 mRNA CTD PMID:24136188 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression EXP trovafloxacin results in decreased expression of SLC34A2 mRNA CTD PMID:24136188 NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
JBrowse link
G Slc35e3 solute carrier family 35, member E3 decreases expression EXP trovafloxacin results in decreased expression of SLC35E3 mRNA CTD PMID:24136188 NCBI chr 7:53,337,091...53,350,152
Ensembl chr 7:53,337,095...53,350,165
JBrowse link
G Slc39a14 solute carrier family 39 member 14 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC39A14 mRNA CTD PMID:18930950 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
JBrowse link
G Slc41a2 solute carrier family 41 member 2 decreases expression EXP trovafloxacin results in decreased expression of SLC41A2 mRNA CTD PMID:24136188 NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166
JBrowse link
G Slc46a1 solute carrier family 46 member 1 increases expression EXP trovafloxacin results in increased expression of SLC46A1 mRNA CTD PMID:24136188 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Slc7a2 solute carrier family 7 member 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC7A2 mRNA CTD PMID:18930950 NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC9A3R1 mRNA CTD PMID:18930950 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP trovafloxacin results in increased expression of SLCO1A2 mRNA CTD PMID:24136188 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SLCO1B3 mRNA CTD PMID:18930950 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Smarcd2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SMARCD2 mRNA CTD PMID:18930950 NCBI chr10:91,193,752...91,202,817
Ensembl chr10:91,193,752...91,204,341
JBrowse link
G Smndc1 survival motor neuron domain containing 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SMNDC1 mRNA CTD PMID:18930950 NCBI chr 1:252,389,675...252,400,749
Ensembl chr 1:252,389,673...252,401,616
JBrowse link
G Snd1 staphylococcal nuclease and tudor domain containing 1 decreases expression EXP trovafloxacin results in decreased expression of SND1 mRNA CTD PMID:24136188 NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843
JBrowse link
G Snx4 sorting nexin 4 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in decreased expression of SNX4 mRNA CTD PMID:33609687 NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression
multiple interactions