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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
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Accession:CHEBI:76726 term browser browse the term
Definition:An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-OH group of donors (EC 1.1.*.*).
Synonyms:related_synonym: EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitors;   EC 1.1.* inhibitor;   EC 1.1.* inhibitors;   inhibitor of oxidoreductase acting on CH-OH group of donor;   inhibitor of oxidoreductase acting on CH-OH group of donors;   inhibitors of oxidoreductase acting on CH-OH group of donor;   inhibitors of oxidoreductase acting on CH-OH group of donors;   oxidoreductase acting on donor CH-OH group inhibitor;   oxidoreductase acting on donor CH-OH group inhibitors


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1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions		 EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Aspirin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
dihexadecanoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 multiple interactions
increases activity		 EXP dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
fomepizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
pitavastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NCF1 neutrophil cytosolic factor 1 decreases expression EXP pitavastatin results in decreased expression of NCF1 mRNA CTD PMID:15502390 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458 		JBrowse link
G NOS3 nitric oxide synthase 3 increases activity
increases expression		 EXP pitavastatin results in increased activity of NOS3 protein
pitavastatin results in increased expression of NOS3 mRNA		 CTD PMID:15502390 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
G NOX4 NADPH oxidase 4 decreases expression EXP pitavastatin results in decreased expression of NOX4 mRNA CTD PMID:15502390 NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277 		JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 increases expression
decreases expression		 EXP Simvastatin results in increased expression of NOS3 protein
Simvastatin results in decreased expression of NOS3 mRNA		 CTD PMID:11087217 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
vorinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASQ1 calsequestrin 1 decreases expression EXP Vorinostat results in decreased expression of CASQ1 mRNA CTD PMID:27255383 NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383 		JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Vorinostat results in decreased expression of HSP70 mRNA CTD PMID:27255383 NCBI chr12:1,285,282...1,287,670 JBrowse link
G TNNI3K TNNI3 interacting kinase decreases expression EXP Vorinostat results in decreased expression of TNNI3K mRNA CTD PMID:27255383 NCBI chr 6:71,825,853...72,107,832
Ensembl chr 6:71,815,734...72,119,476 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 501
    role 501
      biological role 501
        biochemical role 459
          enzyme inhibitor 370
            EC 1.* (oxidoreductase) inhibitor 34
              EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor 9
                EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor + 6
                EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor + 3
                EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or similar compound as acceptor) inhibitor + 0
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