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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nadolol
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Accession:CHEBI:7444 term browser browse the term
Definition:Nadolol is a diastereoisomeric mixture consisting of equimolar amounts of the four possible 2,3-cis-isomers of 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol.
Synonyms:exact_synonym: rac-(2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol
 related_synonym: 1-(tert-butylamino)-3-[(5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy]-2-propanol;   2,3-cis-1,2,3,4-tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol;   Corgard;   Solgol
 xref: Beilstein:2508986;   CAS:42200-33-9;   DrugBank:DB01203;   KEGG:D00432;   LINCS:LSM-1879
 xref_mesh: MESH:D009248
 xref: Patent:DE2258995;   Patent:DE2421549;   Patent:US3935267


show annotations for term's descendants           Sort by:
nadolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions EXP Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:15060759 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Nadolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP CTD PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO [Nadolol co-treated with Mifepristone] promotes the reaction [methyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]] CTD PMID:16321413 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12B interleukin 12B multiple interactions ISO [Nadolol co-treated with Mifepristone] inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:16321413 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Nadolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26504
    chemical entity 26484
      chemical substance 15522
        mixture 14694
          diastereoisomeric mixture 729
            nadolol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 26504
    subatomic particle 26480
      composite particle 26480
        hadron 26480
          baryon 26480
            nucleon 26480
              atomic nucleus 26480
                atom 26480
                  main group element atom 26218
                    main group molecular entity 26218
                      s-block molecular entity 25456
                        hydrogen molecular entity 24863
                          hydrides 23081
                            inorganic hydride 20555
                              pnictogen hydride 20497
                                nitrogen hydride 20283
                                  azane 20009
                                    ammonia 20008
                                      organic amino compound 20008
                                        secondary amino compound 7092
                                          (2R,3S,2'R)-nadolol 5
                                            nadolol 5
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