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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lapachol
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Accession:CHEBI:6377 term browser browse the term
Definition:A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae.
Synonyms:exact_synonym: 2-hydroxy-3-(3-methylbut-2-en-1-yl)naphthalene-1,4-dione
 related_synonym: 2-hydroxy-3-(3-methyl-2-buten-1-yl)-1,4-naphthalenedione;   2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione;   2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone;   2-hydroxy-3-(3-methylbut-2-en-1-yl)-1,4-dihydronaphthalene-1,4-dione;   Bethabarra wood;   C.I. 75490;   C.I. natural yellow 16;   Formula=C15H14O3;   InChI=1S/C15H14O3/c1-9(2)7-8-12-13(16)10-5-3-4-6-11(10)14(17)15(12)18/h3-7,18H,8H2,1-2H3;   InChIKey=CIEYTVIYYGTCCI-UHFFFAOYSA-N;   Ipe-tobacco wood;   SMILES=CC(C)=CCC1=C(O)C(=O)C2=C(C=CC=C2)C1=O;   Surinam greenheart wood;   Taigu wood;   greenhartin;   lapachol wood;   taiguic acid;   tecomin
 xref: CAS:84-79-7;   Chemspider:10770962;   HMDB:HMDB0253978;   KEGG:C10366;   KNApSAcK:C00002835
 xref_mesh: MESH:C008252
 xref: PMID:11180522;   PMID:30797783;   PMID:30896339;   PMID:31183610;   PMID:31935485;   PMID:32318101;   PMID:32712193;   PMID:33019942;   PMID:33254016;   PMID:33275860;   Wikipedia:Lapachol


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lapachol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP		 lapachol results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO lapachol affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        anti-inflammatory agent 16580
          lapachol 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      cyclic ketone 15685
                                        quinone 8644
                                          naphthoquinone 1475
                                            1,4-naphthoquinones 1463
                                              hydroxy-1,4-naphthoquinone 157
                                                lapachol 2
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