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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxy-1,4-naphthoquinone
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Accession:CHEBI:132157 term browser browse the term
Definition:Any member of the class of 1,4-naphthoquinones in which the naphthoquinone moiety is substituted by at least one hydroxy group.
Synonyms:related_synonym: hydroxy-1,4-naphthoquinones


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Alkannin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] CTD PMID:30924981 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:30924981 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of MPO protein] CTD PMID:30924981 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein] CTD PMID:30924981 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein] CTD PMID:30924981 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rho rhodopsin multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein] CTD PMID:30924981 NCBI chr 4:147,832,136...147,837,298
Ensembl chr 4:147,832,136...147,837,298
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein] CTD PMID:30924981 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 mRNA]; alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 protein] CTD PMID:30924981 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:30924981 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
atovaquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO Atovaquone results in increased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
Atovaquone results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Atovaquone inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
juglone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO juglone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
ISO [Indomethacin co-treated with juglone] results in increased expression of BAD mRNA; [Indomethacin co-treated with juglone] results in increased expression of BAD protein; [juglone co-treated with Ascorbic Acid] results in increased expression of BAD protein
juglone results in increased expression of BAD mRNA; juglone results in increased expression of BAD protein
CTD PMID:29992683 PMID:31916655 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [Indomethacin co-treated with juglone] results in increased expression of BAX mRNA; [Indomethacin co-treated with juglone] results in increased expression of BAX protein; [juglone co-treated with Ascorbic Acid] results in increased expression of BAX protein
juglone results in increased expression of BAX mRNA; juglone results in increased expression of BAX protein
CTD PMID:29992683 PMID:31916655 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions
ISO juglone results in increased expression of BBC3 protein
[Indomethacin co-treated with juglone] results in increased expression of BBC3 protein
CTD PMID:31916655 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of BCL2 mRNA
juglone results in decreased expression of BCL2 mRNA
CTD PMID:31916655 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [juglone co-treated with Ascorbic Acid] affects the expression of BID protein CTD PMID:29992683 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO [Indomethacin co-treated with juglone] results in increased expression of CASP3 mRNA; [juglone co-treated with Ascorbic Acid] results in decreased expression of CASP3 protein
juglone results in increased expression of CASP3 mRNA
CTD PMID:29992683 PMID:31916655 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO juglone results in increased activity of CASP8 protein CTD PMID:20138029 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased activity of CAT protein CTD PMID:29992683 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO juglone results in decreased expression of CCND1 mRNA; juglone results in decreased expression of CCND1 protein
[Indomethacin co-treated with juglone] results in decreased expression of CCND1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of CCND1 protein
CTD PMID:31916655 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression
multiple interactions
ISO juglone results in decreased expression of CCND3 protein
Ascorbic Acid promotes the reaction [juglone results in decreased expression of CCND3 protein]
CTD PMID:29992683 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased expression of CDK4 protein CTD PMID:29992683 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of CTNNB1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of CTNNB1 protein
juglone results in decreased expression of CTNNB1 mRNA; juglone results in decreased expression of CTNNB1 protein
CTD PMID:31916655 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO juglone results in increased expression of CYP1A1 mRNA CTD PMID:26558468 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
juglone results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein] CTD PMID:20479004 NCBI chr19:37,252,828...37,260,239
Ensembl chr19:37,252,843...37,260,239
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGR1 protein] CTD PMID:20479004 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased activity of GSR protein CTD PMID:29992683 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of HES1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of HES1 protein
juglone results in decreased expression of HES1 mRNA; juglone results in decreased expression of HES1 protein
CTD PMID:31916655 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] CTD PMID:20479004 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased phosphorylation of MAPK1 protein CTD PMID:29992683 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased phosphorylation of MAPK3 protein CTD PMID:29992683 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [juglone co-treated with Ascorbic Acid] affects the expression of MMP2 mRNA CTD PMID:29992683 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased expression of MMP9 mRNA CTD PMID:29992683 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in increased degradation of PARP1 protein CTD PMID:29992683 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
ISO juglone results in decreased expression of PCNA protein
[Indomethacin co-treated with juglone] results in decreased expression of PCNA protein
CTD PMID:31916655 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 multiple interactions ISO juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA]; juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 protein]; juglone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein] CTD PMID:23754278 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO [Indomethacin co-treated with juglone] results in increased expression of PPARG mRNA; [Indomethacin co-treated with juglone] results in increased expression of PPARG protein
juglone results in increased expression of PPARG mRNA; juglone results in increased expression of PPARG protein
CTD PMID:31916655 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of PTGS2 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of PTGS2 protein; [juglone co-treated with Ascorbic Acid] results in decreased expression of PTGS2 mRNA
juglone results in decreased expression of PTGS2 mRNA; juglone results in decreased expression of PTGS2 protein
CTD PMID:29992683 PMID:31916655 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:23754278 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [juglone co-treated with Ascorbic Acid] affects the expression of TIMP1 mRNA CTD PMID:29992683 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO juglone results in increased expression of TIMP2 mRNA CTD PMID:29992683 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO [Indomethacin co-treated with juglone] results in decreased expression of TNF mRNA; [Indomethacin co-treated with juglone] results in decreased expression of TNF protein
juglone results in decreased expression of TNF mRNA; juglone results in decreased expression of TNF protein
CTD PMID:31916655 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in increased phosphorylation of TP53 protein CTD PMID:29992683 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction ISO TXNRD1 protein results in increased reduction of juglone CTD PMID:21172426 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases reduction ISO TXNRD2 protein results in increased reduction of juglone CTD PMID:21172426 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased expression of VEGFA mRNA CTD PMID:29992683 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
Lapachol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
lapachol results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
lawsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO lawsone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
lawsone results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO lawsone results in decreased expression of MITF protein CTD PMID:25584612 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP lawsone results in increased activity of NQO1 protein CTD PMID:17265417 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tyr tyrosinase multiple interactions ISO lawsone results in decreased expression of and results in decreased activity of TYR protein CTD PMID:25584612 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
naphthazarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO naphthazarin results in increased expression of CYP1A1 mRNA CTD PMID:26558468 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity EXP
ISO
naphthazarin results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
plumbagin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
plumbagin results in increased phosphorylation of AKT1 protein
plumbagin inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]
CTD PMID:20028456 PMID:32691977 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of BAD protein] CTD PMID:32691977 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
plumbagin results in increased activity of CASP3 protein
NFE2L2 protein mutant form affects the reaction [plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]; plumbagin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
CTD PMID:20028456 PMID:20576514 PMID:32691977 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO plumbagin results in increased activity of CASP8 protein
Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein]
CTD PMID:20576514 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP9 protein] CTD PMID:20576514 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:32691977 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of CCL2 protein] CTD PMID:32691977 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ctrl chymotrypsin-like multiple interactions
decreases activity
ISO Acetylcysteine inhibits the reaction [plumbagin results in decreased activity of CTRL protein] CTD PMID:31276663 NCBI chr19:37,905,864...37,907,714
Ensembl chr19:37,905,864...37,907,714
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO plumbagin results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]; Cycloheximide inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]
CTD PMID:31276663 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
plumbagin results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein] CTD PMID:32691977 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO plumbagin results in increased expression of FAS mRNA; plumbagin results in increased expression of FAS protein CTD PMID:20576514 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP plumbagin inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] CTD PMID:22960630 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO plumbagin results in increased expression of GCLM mRNA CTD PMID:20028456 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO plumbagin results in increased expression of GSTP1 mRNA CTD PMID:20028456 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hk1 hexokinase 1 multiple interactions EXP plumbagin inhibits the reaction [Streptozocin results in decreased activity of HK1 protein] CTD PMID:22960630 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]; NFE2L2 mRNA affects the reaction [plumbagin results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]
plumbagin promotes the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]
plumbagin results in increased expression of HMOX1 mRNA; plumbagin results in increased expression of HMOX1 protein
CTD PMID:20028456 PMID:32691977 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO plumbagin results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]; Cycloheximide inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]
CTD PMID:31276663 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
plumbagin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
plumbagin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]
CTD PMID:23942037 PMID:32691977 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO plumbagin results in increased phosphorylation of MAPK1 protein CTD PMID:20028456 PMID:20576514 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO plumbagin results in increased phosphorylation of MAPK3 protein CTD PMID:20028456 PMID:20576514 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
affects response to substance
ISO
EXP
NFE2L2 mRNA affects the reaction [plumbagin results in decreased susceptibility to tert-Butylhydroperoxide]; NFE2L2 mRNA affects the reaction [plumbagin results in increased expression of HMOX1 mRNA]
plumbagin affects the localization of NFE2L2 protein
NFE2L2 protein mutant form affects the reaction [plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]
NFE2L2 mRNA affects the susceptibility to plumbagin
CTD PMID:20028456 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:32691977 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO plumbagin results in increased expression of NQO1 mRNA; plumbagin results in increased expression of NQO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [plumbagin results in increased expression of NQO1 protein]; wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein]
CTD PMID:20028456 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Per2 period circadian regulator 2 decreases response to substance ISO PER2 protein mutant form results in decreased susceptibility to plumbagin CTD PMID:25628599 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in decreased phosphorylation of PTEN protein] CTD PMID:32691977 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions ISO plumbagin binds to and results in decreased activity of PTPN2 protein CTD PMID:31248982 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Pygb glycogen phosphorylase B multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of PYGB protein] CTD PMID:32691977 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP plumbagin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; plumbagin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:22960630 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO plumbagin results in increased expression of SQSTM1 protein CTD PMID:31276663 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:32691977 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:32691977 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO plumbagin results in increased expression of TXNRD1 mRNA CTD PMID:20028456 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of plumbagin CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of plumbagin CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of plumbagin CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
Shikonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO shikonin results in decreased expression of ACTA2 mRNA CTD PMID:25591861 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO shikonin results in decreased phosphorylation of AKT1 protein
shikonin promotes the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]
CTD PMID:24463199 PMID:28684144 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ATF3 mRNA] CTD PMID:25451590 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO shikonin results in decreased expression of BCL2 protein CTD PMID:25591861 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases cleavage ISO shikonin results in increased cleavage of CASP3 protein CTD PMID:25591861 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL1 mRNA] CTD PMID:25451590 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL4 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of CCL4 mRNA] CTD PMID:25451590 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL7 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of CCL7 mRNA] CTD PMID:25451590 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO
shikonin results in decreased expression of CCND1 protein CTD PMID:16061028 PMID:28684144 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression EXP shikonin results in decreased expression of CCNE1 protein CTD PMID:16061028 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP
ISO
shikonin results in increased expression of CDKN1A protein CTD PMID:16061028 PMID:28684144 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO shikonin results in decreased expression of COL1A1 mRNA CTD PMID:25591861 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO shikonin results in decreased expression of COL3A1 mRNA CTD PMID:25591861 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CSF1 mRNA] CTD PMID:25451590 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of AXUD1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of AXUD1 mRNA] CTD PMID:25451590 NCBI chr 8:128,659,883...128,673,339
Ensembl chr 8:128,659,868...128,672,284
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP
ISO
shikonin results in decreased activity of CYP1A2 protein CTD PMID:28941798 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP shikonin results in decreased activity of CYP2B1 protein CTD PMID:28941798 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO shikonin results in decreased activity of CYP2B6 protein CTD PMID:28941798 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP shikonin results in decreased activity of CYP2C11 protein CTD PMID:28941798 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 decreases activity EXP shikonin results in decreased activity of CYP2D1 protein CTD PMID:28941798 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO shikonin results in decreased activity of CYP2D6 protein CTD PMID:28941798 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP
ISO
shikonin results in decreased activity of CYP2E1 protein CTD PMID:28941798 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
EXP shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam]
shikonin results in decreased activity of CYP3A2 protein
CTD PMID:28941798 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO shikonin results in decreased activity of CYP3A4 protein CTD PMID:28941798 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of DUSP1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP1 mRNA] CTD PMID:25451590 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP6 mRNA] CTD PMID:25451590 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Egr2 early growth response 2 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of EGR2 mRNA] CTD PMID:25451590 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Egr3 early growth response 3 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR3 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of EGR3 mRNA] CTD PMID:25451590 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO shikonin affects the reaction [Oxygen deficiency affects the phosphorylation of EIF4EBP1 protein] CTD PMID:28684144 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOS mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of FOS mRNA] CTD PMID:25451590 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOSB mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of FOSB mRNA] CTD PMID:25451590 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO shikonin results in decreased expression of HIF1A protein
shikonin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:28684144 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Il13 interleukin 13 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of IL13 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:25451590 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO shikonin results in decreased expression of ITGB1 mRNA; shikonin results in decreased expression of ITGB1 protein CTD PMID:23562787 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of JUN mRNA] CTD PMID:25451590 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of MAP3K8 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of MAP3K8 mRNA] CTD PMID:25451590 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK1 protein]
shikonin results in increased phosphorylation of MAPK1 protein
CTD PMID:23562787 PMID:24463199 PMID:25591861 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO shikonin results in decreased phosphorylation of MAPK3 protein
shikonin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK3 protein]
CTD PMID:23562787 PMID:24463199 PMID:25591861 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of MT2 mRNA] CTD PMID:25451590 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO shikonin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein] CTD PMID:28684144 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfkbid NFKB inhibitor delta multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NFKBID mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NFKBID mRNA] CTD PMID:25451590 NCBI chr 1:88,883,816...88,892,543
Ensembl chr 1:88,885,937...88,892,615
JBrowse link
G Nfkbiz NFKB inhibitor zeta multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NFKBIZ mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NFKBIZ mRNA] CTD PMID:25451590 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A1 mRNA] CTD PMID:25451590 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A2 mRNA] CTD PMID:25451590 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A3 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A3 mRNA] CTD PMID:25451590 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of OLR1 mRNA] CTD PMID:25451590 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [shikonin results in increased cleavage of PARP1 protein] CTD PMID:24463199 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP shikonin results in decreased expression of PCNA protein CTD PMID:16061028 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Plk3 polo-like kinase 3 multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of PLK3 mRNA] CTD PMID:25451590 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of PPP1R15A mRNA] CTD PMID:25451590 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of PTGS2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of PTGS2 mRNA] CTD PMID:25451590 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein] CTD PMID:23261677 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein] CTD PMID:23261677 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO shikonin promotes the reaction [Oxygen deficiency results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:28684144 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of SERPINE1 mRNA] CTD PMID:25451590 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tagap T-cell activation RhoGTPase activating protein multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of TAGAP mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of TAGAP mRNA] CTD PMID:25451590 NCBI chr 1:47,493,990...47,503,492
Ensembl chr 1:47,493,994...47,502,952
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of TNF mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of TNF mRNA] CTD PMID:25451590 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO shikonin results in increased expression of TP53 protein CTD PMID:28684144 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO
EXP
shikonin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol] CTD PMID:31128210 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO shikonin inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Chenodeoxycholic Acid] CTD PMID:31128210 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol] CTD PMID:31128210 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO shikonin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine] CTD PMID:31128210 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of ZFP36 mRNA] CTD PMID:25451590 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36L1 mRNA] CTD PMID:25451590 NCBI chr 6:103,308,032...103,313,074
Ensembl chr 6:103,308,045...103,313,074
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      molecular entity 19771
        polyatomic entity 19689
          heteroatomic molecular entity 19619
            hydroxides 19080
              organic hydroxy compound 18659
                hydroxyquinone 183
                  hydroxynaphthoquinone 126
                    hydroxy-1,4-naphthoquinone 126
                      2,6,7-trihydroxy-3-methylnaphthalene-1,4-dione 0
                      2,8-dihydroxy-1,4-naphthoquinone 0
                      2-O,3-dimethylflaviolin 0
                      2-hydroxy-3-(2-hydroxyethyl)naphthalene-1,4-dione 0
                      3-linalylflaviolin 0
                      6-linalyl-2-O,3-dimethylflaviolin 0
                      7-O-geranyl-2-O,3-dimethylflaviolin 0
                      Acetylshikonin 0
                      Alkannin 9
                      Alkannin beta,beta-dimethylacrylate 0
                      Aristolindiquinone 0
                      Deoxyshikonin 0
                      Diospyrin 0
                      Droserone 0
                      Echinone 0
                      Hypoxylone 0
                      Isobutylshikonin 0
                      Lapachol 1
                      Ramentaceone 0
                      Shikonin 64
                      Tricrozarin A 0
                      atovaquone 3
                      aureoquinone 0
                      beta,beta-Dimethylacrylshikonin 0
                      flaviolin + 0
                      hypocrellin D 0
                      impatienol 0
                      juglone 37
                      lawsone 5
                      naphthazarin 2
                      phosphatoquinone B 0
                      plumbagin 36
                      rhinacanthin C 0
                      rhinacanthin D 0
                      rifamycin-undecaketide carboxylic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic group 18603
                              organic divalent group 18594
                                organodiyl group 18594
                                  carbonyl group 18507
                                    carbonyl compound 18507
                                      ketone 16828
                                        cyclic ketone 15239
                                          quinone 8387
                                            naphthoquinone 1439
                                              1,4-naphthoquinones 1415
                                                hydroxy-1,4-naphthoquinone 126
                                                  2,6,7-trihydroxy-3-methylnaphthalene-1,4-dione 0
                                                  2,8-dihydroxy-1,4-naphthoquinone 0
                                                  2-O,3-dimethylflaviolin 0
                                                  2-hydroxy-3-(2-hydroxyethyl)naphthalene-1,4-dione 0
                                                  3-linalylflaviolin 0
                                                  6-linalyl-2-O,3-dimethylflaviolin 0
                                                  7-O-geranyl-2-O,3-dimethylflaviolin 0
                                                  Acetylshikonin 0
                                                  Alkannin 9
                                                  Alkannin beta,beta-dimethylacrylate 0
                                                  Aristolindiquinone 0
                                                  Deoxyshikonin 0
                                                  Diospyrin 0
                                                  Droserone 0
                                                  Echinone 0
                                                  Hypoxylone 0
                                                  Isobutylshikonin 0
                                                  Lapachol 1
                                                  Ramentaceone 0
                                                  Shikonin 64
                                                  Tricrozarin A 0
                                                  atovaquone 3
                                                  aureoquinone 0
                                                  beta,beta-Dimethylacrylshikonin 0
                                                  flaviolin + 0
                                                  hypocrellin D 0
                                                  impatienol 0
                                                  juglone 37
                                                  lawsone 5
                                                  naphthazarin 2
                                                  phosphatoquinone B 0
                                                  plumbagin 36
                                                  rhinacanthin C 0
                                                  rhinacanthin D 0
                                                  rifamycin-undecaketide carboxylic acid + 0
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