naphthoquinone - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	naphthoquinone	go back to main search page
Accession:	CHEBI:25481	browse the term
Definition:	A polycyclic aromatic ketone metabolite of naphthalene.
Synonyms:	related_synonym:	naphthoquinones

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Genes (1475)

1,2-naphthoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions
affects localization

1,2-naphthoquinone promotes the reaction [AHR protein binds to ARNT protein]; 1,2-naphthoquinone promotes the reaction [AHR protein binds to CYP1A1 enhancer]; AHR protein affects the reaction [1,2-naphthoquinone results in increased expression of CYP1A1 mRNA]
1,2-naphthoquinone results in increased expression of and affects the localization of AHR protein
1,2-naphthoquinone affects the localization of AHR protein

PMID:26558468 PMID:27853106

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member A1

increases reduction

AKR1A1 protein results in increased reduction of 1,2-naphthoquinone

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 1 member B1

increases reduction

AKR1B1 protein results in increased reduction of 1,2-naphthoquinone

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 7, member A2

increases reduction

AKR7A2 protein results in increased reduction of 1,2-naphthoquinone

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

albumin

affects binding

1,2-naphthoquinone binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 3 family, member A1

increases expression

1,2-naphthoquinone results in increased expression of ALDH3A1 mRNA

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

1,2-naphthoquinone promotes the reaction [AHR protein binds to ARNT protein]

PMID:26558468 PMID:27853106

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

catalase

multiple interactions

CAT protein inhibits the reaction [1,2-naphthoquinone results in increased expression of CXCL8 mRNA]; CAT protein inhibits the reaction [1,2-naphthoquinone results in increased expression of PTGS2 mRNA]; CAT protein promotes the reaction [1,2-naphthoquinone results in increased expression of HMOX1 mRNA]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

multiple interactions

[S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1,2-naphthoquinone]

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

cAMP responsive element binding protein 1

multiple interactions

1,2-naphthoquinone binds to and results in decreased activity of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

1,2-naphthoquinone promotes the reaction [AHR protein binds to CYP1A1 enhancer]; 1,2-naphthoquinone promotes the reaction [POLR2A protein binds to CYP1A1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1,2-naphthoquinone results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [1,2-naphthoquinone results in increased expression of CYP1A1 mRNA]

PMID:26558468 PMID:26656082 PMID:27853106

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

dicarbonyl and L-xylulose reductase

increases metabolic processing
multiple interactions

DCXR protein results in increased metabolism of 1,2-naphthoquinone
1,2-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]

NCBI chr10:106,006,404...106,008,293

G

dehydrogenase/reductase 7

increases reduction

DHRS7 protein results in increased reduction of 1,2-naphthoquinone

NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation

1,2-naphthoquinone results in increased phosphorylation of and results in increased activity of EGFR protein; 1,4-naphthoquinone promotes the reaction [1,2-naphthoquinone results in increased phosphorylation of EGFR protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [1,4-naphthoquinone promotes the reaction [1,2-naphthoquinone results in increased phosphorylation of EGFR protein]]

PMID:24067727 PMID:33814511

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases stability

1,2-naphthoquinone results in increased stability of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glyceraldehyde-3-phosphate dehydrogenase

decreases activity
affects binding
multiple interactions

1,2-naphthoquinone results in decreased activity of GAPDH protein
1,2-naphthoquinone binds to GAPDH protein
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

heme oxygenase 1

multiple interactions
increases expression

CAT protein promotes the reaction [1,2-naphthoquinone results in increased expression of HMOX1 mRNA]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

Kelch-like ECH-associated protein 1

affects response to substance
increases metabolic processing

KEAP1 protein affects the susceptibility to 1,2-naphthoquinone
1,2-naphthoquinone results in increased metabolism of KEAP1 protein

PMID:21384861 PMID:25807370

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK1 protein]; [1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK1 protein

PMID:24067727 PMID:33814511

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

1,2-naphthoquinone results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK3 protein]; [1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK3 protein

PMID:24067727 PMID:33814511

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression
increases activity
affects response to substance

NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to 1,2-naphthoquinone]
1,2-naphthoquinone results in increased expression of NFE2L2 mRNA
1,2-naphthoquinone results in increased activity of NFE2L2 protein
[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to 1,2-naphthoquinone; NFE2L2 protein affects the susceptibility to 1,2-naphthoquinone

PMID:19303893 PMID:20932822 PMID:21384861 PMID:21651925 PMID:25807370 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

1,2-naphthoquinone inhibits the reaction [[lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

increases reduction
increases expression

NQO1 protein results in increased reduction of 1,2-naphthoquinone
1,2-naphthoquinone results in increased expression of NQO1 mRNA

PMID:21384861 PMID:26558468

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

RNA polymerase II subunit A

multiple interactions

1,2-naphthoquinone promotes the reaction [POLR2A protein binds to CYP1A1 protein]

NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455

G

peroxiredoxin 6

multiple interactions

1,2-naphthoquinone binds to and results in decreased activity of PRDX6 protein

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

1,2-naphthoquinone results in increased expression of PTGS2 mRNA
CAT protein inhibits the reaction [1,2-naphthoquinone results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 1

decreases activity
multiple interactions

1,2-naphthoquinone results in decreased activity of PTPN1 protein
1,2-naphthoquinone promotes the reaction [1,4-naphthoquinone results in increased metabolism of and results in decreased activity of PTPN1 protein]

PMID:24067727 PMID:33814511

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased localization of and results in increased activity of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

tachykinin receptor 1

multiple interactions

[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA]

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

tachykinin receptor 2

multiple interactions

[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR2 mRNA; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR2 mRNA]

NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446

G

DNA topoisomerase II alpha

multiple interactions
affects activity

1,2-naphthoquinone binds to and results in decreased activity of TOP2A protein
1,2-naphthoquinone affects the activity of TOP2A protein

PMID:22218491 PMID:33760604

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

DNA topoisomerase II beta

affects activity

1,2-naphthoquinone affects the activity of TOP2B protein

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

G

transient receptor potential cation channel, subfamily A, member 1

increases activity

1,2-naphthoquinone results in increased activity of TRPA1 protein

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TRPV1 mRNA; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TRPV1 mRNA]

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

transient receptor potential cation channel, subfamily V, member 3

increases activity

1,2-naphthoquinone results in increased activity of TRPV3 protein

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

G

ubiquitin C-terminal hydrolase L1

multiple interactions

1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein; Glutathione inhibits the reaction [1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein]

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

1,4-naphthoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions
affects localization

[2-benzoquinone co-treated with 1,4-naphthoquinone] affects the localization of AHR protein; AHR protein affects the reaction [1,4-naphthoquinone results in increased expression of CYP1A1 mRNA]
1,4-naphthoquinone affects the localization of AHR protein

PMID:26558468 PMID:27853106

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein
Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]; GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

affects binding

1,4-naphthoquinone binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

BCL2 associated X, apoptosis regulator

increases expression

1,4-naphthoquinone analog results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

FR 180204 promotes the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein]; GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein]; SB 203580 inhibits the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

decreases activity
multiple interactions
increases cleavage

1,4-naphthoquinone results in decreased activity of CASP3 protein
Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; FR 180204 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]

PMID:16699520 PMID:30871965

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

1,4-naphthoquinone results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

carbonyl reductase 1

multiple interactions

[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 1,4-naphthoquinone]

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

C-C motif chemokine ligand 2

increases expression

1,4-naphthoquinone results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases abundance
increases expression
multiple interactions

CYP1A1 protein results in increased abundance of 1,4-naphthoquinone
1,4-naphthoquinone results in increased expression of CYP1A1 mRNA
AHR protein affects the reaction [1,4-naphthoquinone results in increased expression of CYP1A1 mRNA]

PMID:16243959 PMID:26558468 PMID:27853106

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases abundance
increases expression

CYP1A2 protein results in increased abundance of 1,4-naphthoquinone
1,4-naphthoquinone results in increased expression of CYP1A2 mRNA

PMID:16243959 PMID:18602459

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases abundance

CYP1B1 protein results in increased abundance of 1,4-naphthoquinone

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases abundance

CYP2B6 protein results in increased abundance of 1,4-naphthoquinone

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

increases abundance

CYP2C18 protein results in increased abundance of 1,4-naphthoquinone

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases abundance

CYP2C19 protein results in increased abundance of 1,4-naphthoquinone

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases abundance

CYP2C8 protein results in increased abundance of 1,4-naphthoquinone

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases abundance

CYP2D6 protein results in increased abundance of 1,4-naphthoquinone

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases abundance

CYP2E1 protein results in increased abundance of 1,4-naphthoquinone

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
increases abundance

1,4-naphthoquinone results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased abundance of 1,4-naphthoquinone

PMID:16243959 PMID:18602459

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases abundance

CYP3A5 protein results in increased abundance of 1,4-naphthoquinone

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

dicarbonyl and L-xylulose reductase

increases metabolic processing
multiple interactions

DCXR protein results in increased metabolism of 1,4-naphthoquinone
1,4-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]

NCBI chr10:106,006,404...106,008,293

G

dihydroorotate dehydrogenase (quinone)

decreases activity

1,4-naphthoquinone results in decreased activity of DHODH protein

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation

1,4-naphthoquinone promotes the reaction [1,2-naphthoquinone results in increased phosphorylation of EGFR protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [1,4-naphthoquinone promotes the reaction [1,2-naphthoquinone results in increased phosphorylation of EGFR protein]]; quinone promotes the reaction [1,4-naphthoquinone results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

interleukin 13

multiple interactions

[1,4-naphthoquinone co-treated with OVAL protein] results in increased expression of IL13 protein

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
decreases phosphorylation

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK1 protein]; [1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of MAPK1 protein]; FR 180204 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of MAPK1 protein]
1,4-naphthoquinone results in increased phosphorylation of MAPK1 protein

PMID:30871965 PMID:33814511

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
increases phosphorylation
multiple interactions

1,4-naphthoquinone analog results in decreased phosphorylation of MAPK3 protein
1,4-naphthoquinone results in increased phosphorylation of MAPK3 protein
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK3 protein]; [1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of MAPK3 protein]; FR 180204 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of MAPK3 protein]

PMID:30871965 PMID:33814511

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

[1,4-naphthoquinone co-treated with OVAL protein] results in increased expression of MUC5AC mRNA

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

NFE2 like bZIP transcription factor 2

affects response to substance
increases expression

NFE2L2 protein affects the susceptibility to 1,4-naphthoquinone
1,4-naphthoquinone results in increased expression of NFE2L2 mRNA

PMID:26862668 PMID:31166132

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; FR 180204 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions

1,2-naphthoquinone promotes the reaction [1,4-naphthoquinone results in increased metabolism of and results in decreased activity of PTPN1 protein]; 1,4-naphthoquinone results in increased metabolism of and results in decreased activity of PTPN1 protein

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; FR 180204 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; SB 203580 inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tumor necrosis factor

multiple interactions
increases expression

1,4-naphthoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
1,4-naphthoquinone results in increased expression of TNF mRNA

PMID:21235518 PMID:23333790

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

DNA topoisomerase II alpha

multiple interactions

1,4-naphthoquinone binds to and results in decreased activity of TOP2A protein

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

DNA topoisomerase II beta

affects activity

1,4-naphthoquinone affects the activity of TOP2B protein

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

G

transient receptor potential cation channel, subfamily V, member 3

increases activity

1,4-naphthoquinone results in increased activity of TRPV3 protein

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

2,3-dimethoxynaphthalene-1,4-dione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA thioesterase 2

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acid phosphatase 2, lysosomal

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ACP2 mRNA

NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680

G

acyl-CoA synthetase long-chain family member 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

actin, beta

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

alcohol dehydrogenase 6 (class V)

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ADH6 mRNA

NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534

G

adrenomedullin

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

A-kinase anchoring protein 12

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of AKAP12 mRNA

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

aldo-keto reductase family 1 member B1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1, member C1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldehyde dehydrogenase 6 family, member A1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

annexin A1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ANXA2 mRNA; 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ANXA2 protein

PMID:17547211 PMID:37788135

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

arylsulfatase L

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ARSL mRNA

NCBI chr 2:119,038,803...119,047,579
Ensembl chr 2:119,038,921...119,046,846

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 4

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATPase plasma membrane Ca2+ transporting 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ATP2B1 mRNA

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

aurora kinase A

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

alpha-2-glycoprotein 1, zinc-binding

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of AZGP1 mRNA

NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091

G

branched chain amino acid transaminase 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of BCAT1 mRNA

NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597

G

basic helix-loop-helix family, member e40

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 5

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BUB1 mitotic checkpoint serine/threonine kinase B

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

calreticulin

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 3

increases activity

2,3-dimethoxy-1,4-naphthoquinone results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin A2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CCNB2 mRNA

PMID:17547211 PMID:19031421

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cell division cycle 20

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25B

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cadherin 2

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase inhibitor 3

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

centrin 2

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CETN2 mRNA

NCBI chr X:150,769,944...150,774,833
Ensembl chr X:150,769,953...150,774,919

G

complement factor B

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

choline phosphotransferase 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CHPT1 mRNA

NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103

G

cell death-inducing DFFA-like effector b

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CIDEB mRNA

NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605

G

CDC28 protein kinase regulatory subunit 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CKS2 mRNA

PMID:17547211 PMID:19031421

NCBI chr17:13,570,611...13,575,770

G

calmegin

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CLGN mRNA

NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758

G

CLPTM1 regulator of GABA type A receptor forward trafficking

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CLPTM1 mRNA

NCBI chr 1:79,289,478...79,321,079
Ensembl chr 1:79,289,477...79,321,092

G

clusterin

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

crystallin, alpha A

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CRYAA mRNA

NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349

G

C-X3-C motif chemokine ligand 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DNA-damage inducible transcript 3

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of DDIT3 mRNA; 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

desmoplakin

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of DSP protein

NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800

G

dual specificity phosphatase 13B

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of DUSP13B mRNA

NCBI chr15:2,567,432...2,575,105
Ensembl chr15:2,533,547...2,575,539

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

2,3-dimethoxy-1,4-naphthoquinone results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

2,3-dimethoxy-1,4-naphthoquinone results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

epoxide hydrolase 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

coagulation factor X

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor V

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of F5 mRNA

NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317

G

fibronectin 1

multiple interactions

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of and results in decreased secretion of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

FOS like 1, AP-1 transcription factor subunit

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

furin (paired basic amino acid cleaving enzyme)

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of FURIN mRNA

NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glutamate cysteine ligase, modifier subunit

decreases response to substance

[GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

gamma-glutamyl carboxylase

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of GGCX mRNA

NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063

G

growth hormone inducible transmembrane protein

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of GHITM mRNA

NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879

G

galactosidase, alpha

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GLA mRNA

NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664

G

G protein-coupled estrogen receptor 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of GPER1 mRNA

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

growth factor receptor bound protein 10

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GRB10 mRNA

NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806

G

gelsolin

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

GTP binding protein 6 (putative)

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GTPBP6 mRNA

NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873

G

H2A.X variant histone

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of H2AX mRNA

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

high mobility group AT-hook 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of HMGA1 mRNA

NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752

G

high mobility group nucleosomal binding domain 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of HMGN2 mRNA

NCBI chr 5:146,192,126...146,195,580
Ensembl chr 5:146,192,126...146,195,521
Ensembl chr16:146,192,126...146,195,521

G

heme oxygenase 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein A2/B1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of HNRNPA2B1 protein

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

heat shock protein family B (small) member 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of HSPB1 protein

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

immediate early response 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of IER2 mRNA

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211

G

interferon-related developmental regulator 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

immunoglobulin superfamily, member 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of IGSF1 mRNA

NCBI chr X:129,069,891...129,085,331
Ensembl chr X:129,069,896...129,085,139

G

interleukin 17 receptor B

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of IL17RB mRNA

NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125

G

integrin subunit beta 3 binding protein

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ITGB3BP mRNA

NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704

G

inter-alpha trypsin inhibitor, heavy chain 3

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ITIH3 mRNA

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

involucrin

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of IVL protein

NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100

G

junction plakoglobin

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of JUP protein

NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057

G

kinesin family member 20B

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of KIF20B mRNA

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787

G

kinesin family member 22

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of KIF22 mRNA

NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401

G

kinesin family member 23

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

kinesin family member 2C

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of KIF2C mRNA

NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637

G

keratin 19

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

galectin 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of LGALS1 mRNA

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

mitotic arrest deficient 2 like 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

MAF bZIP transcription factor F

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

microtubule-associated protein, RP/EB family, member 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of MAPRE2 mRNA

NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044

G

minichromosome maintenance complex component 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of MCM2 mRNA

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of MGAT2 mRNA

NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177

G

matrix remodeling associated 7

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of MXRA7 mRNA

NCBI chr10:102,003,034...102,031,428
Ensembl chr10:102,003,319...102,031,409

G

non-SMC condensin I complex, subunit G

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of NCAPG mRNA

NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902

G

neural precursor cell expressed, developmentally down-regulated 9

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of NEDD9 mRNA

NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019

G

NIMA-related kinase 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of NEK2 mRNA

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

G

NIMA-related kinase 4

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of NEK4 mRNA

NCBI chr16:6,144,900...6,185,376
Ensembl chr16:6,144,959...6,188,932

G

NFE2 like bZIP transcription factor 2

decreases response to substance

NFE2L2 protein results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nucleolar and coiled-body phosphoprotein 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of NOLC1 mRNA

NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088

G

nucleobindin 2

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of NUCB2 mRNA

NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353

G

nucleoporin 107

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of NUP107 mRNA

NCBI chr 7:53,353,740...53,398,345
Ensembl chr 7:53,353,743...53,398,370

G

nucleolar and spindle associated protein 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

G

OS9, endoplasmic reticulum lectin

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of OS9 mRNA

NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745

G

p21 (RAC1) activated kinase 3

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PAK3 mRNA

NCBI chr X:107,116,308...107,374,342
Ensembl chr X:107,260,898...107,368,314

G

PDZ binding kinase

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

G

progastricsin

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of PGC mRNA

NCBI chr 9:13,257,462...13,265,682
Ensembl chr 9:13,257,462...13,265,682

G

placental growth factor

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of PGF mRNA

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

plakophilin 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PKP1 protein

NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465

G

polo-like kinase 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

DNA polymerase epsilon 2, accessory subunit

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of POLE2 mRNA

NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305

G

paraoxonase 2

decreases response to substance

PON2 protein results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

G

peptidylprolyl isomerase H

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PPIH mRNA

NCBI chr 5:132,906,324...132,924,341
Ensembl chr 5:132,906,328...132,924,267

G

periplakin

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PPL protein

NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575

G

phosphoserine phosphatase

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of PSPH mRNA

NCBI chr12:26,882,524...26,905,084
Ensembl chr12:26,883,133...26,905,074

G

PTTG1 regulator of sister chromatid separation, securin

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

Rac GTPase-activating protein 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

RAD23 homolog B, nucleotide excision repair protein

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of RAD23B mRNA

NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319

G

RAD51 paralog C

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of RAD51C mRNA

NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248

G

RB binding protein 8, endonuclease

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of RBBP8 mRNA

NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846

G

RNA binding protein, mRNA processing factor

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of RBPMS mRNA

NCBI chr16:58,239,370...58,395,424
Ensembl chr16:58,239,474...58,395,426

G

RecQ like helicase

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of RECQL mRNA

NCBI chr 4:175,308,337...175,332,965
Ensembl chr 4:175,304,117...175,332,945

G

replication factor C subunit 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of RFC2 mRNA

NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557

G

replication factor C subunit 4

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of RFC4 mRNA

NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122

G

ribonuclease H2, subunit A

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of RNASEH2A mRNA

NCBI chr19:23,186,325...23,196,045
Ensembl chr19:23,186,383...23,196,041

G

RuvB-like AAA ATPase 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of RUVBL2 mRNA

NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342

G

S100 calcium binding protein A10

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of S100A10 protein

NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661

G

S100 calcium binding protein A11

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of S100A11 protein

NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044

G

S100 calcium binding protein A16

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of S100A16 protein

NCBI chr 2:176,016,405...176,022,117
Ensembl chr 2:176,016,268...176,022,117

G

stearoyl-CoA desaturase

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

serpin family A member 5

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SERPINA5 mRNA

NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407

G

serpin family A member 6

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SERPINA6 mRNA

NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349

G

serpin family B member 1A

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SERPINB1 mRNA

NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102

G

serpin family B member 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SERPINB2 protein

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

serpin family C member 1

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SERPINC1 mRNA

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

stratifin

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SFN mRNA

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

SHC adaptor protein 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SHC1 mRNA

NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536

G

solute carrier family 1 member 2

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SLC1A2 mRNA

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

structural maintenance of chromosomes 4

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SMC4 mRNA

PMID:17547211 PMID:19031421

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

G

small nuclear ribonucleoprotein polypeptide A

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SNRPA mRNA

NCBI chr 1:82,481,770...82,490,540
Ensembl chr 1:82,481,770...82,490,538

G

sperm associated antigen 5

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SPAG5 mRNA

NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745

G

secreted phosphoprotein 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

small proline-rich protein 1A

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SPRR1A protein

NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063

G

small proline-rich protein 1B

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SPRR1B protein

NCBI chr 2:178,008,844...178,010,742
Ensembl chr 2:178,009,130...178,009,567

G

small proline-rich protein 2D

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SPRR2D protein

NCBI chr 2:177,870,082...177,870,679
Ensembl chr 2:177,870,434...177,870,679

G

sulfide quinone oxidoreductase

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SQOR mRNA

NCBI chr 3:109,841,225...109,886,724
Ensembl chr 3:109,841,250...109,960,778

G

serine and arginine rich splicing factor 2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SRSF2 mRNA

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

serine and arginine rich splicing factor 7

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SRSF7 mRNA

NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965

G

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ST6GALNAC4 mRNA

NCBI chr 3:15,872,230...15,885,250
Ensembl chr 3:15,872,532...15,885,243

G

titin-cap

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TCAP mRNA

NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887

G

TIMP metallopeptidase inhibitor 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

transmembrane p24 trafficking protein 2

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of TMED2 mRNA

NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903

G

TNF alpha induced protein 3

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TNFAIP3 mRNA

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF alpha induced protein 8

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TNFAIP8 mRNA

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF superfamily member 10

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TPX2, microtubule nucleation factor

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TPX2 mRNA

NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468

G

thyroid hormone receptor interactor 13

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TRIP13 mRNA

NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074

G

tetraspanin 7

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of TSPAN7 mRNA

NCBI chr X:12,208,783...12,306,092
Ensembl chr X:12,208,783...12,306,131

G

thiosulfate sulfurtransferase

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of TST mRNA

NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216

G

tubulin, alpha 1A

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

thioredoxin reductase 1

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thymidylate synthetase

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TYMS mRNA

PMID:17547211 PMID:19031421

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitin-conjugating enzyme E2C

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin conjugating enzyme E2 V2

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of UBE2V2 mRNA

NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369

G

vitronectin

decreases expression

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of VTN mRNA

NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810

G

zw10 kinetochore protein

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ZW10 mRNA

NCBI chr 8:49,396,541...49,424,743
Ensembl chr 8:49,396,545...49,421,805

G

ZW10 interacting kinetochore protein

increases expression

2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ZWINT mRNA

PMID:17547211 PMID:19031421

NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957

2,3-epoxyphylloquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

coagulation factor IX

multiple interactions

[VKORC1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein; [VKORC1L1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein

NCBI chr X:138,352,334...138,396,835
Ensembl chr X:138,352,298...138,396,835

G

vitamin K epoxide reductase complex, subunit 1

multiple interactions
affects reduction
increases reduction

[VKORC1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein; coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]; fluindione inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
VKORC1 protein affects the reduction of vitamin K1 oxide
Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide]

PMID:23928358 PMID:29581108

NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008

G

vitamin K epoxide reductase complex, subunit 1-like 1

multiple interactions
increases reduction
increases metabolic processing

[VKORC1L1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein; coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; fluindione inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin affects the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased metabolism of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]

PMID:23710884 PMID:23928358 PMID:29581108

NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225

2-methoxy-1,4-naphthoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

matrix metallopeptidase 9

decreases activity

2-methoxy-1,4-naphthoquinone results in decreased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

NAD(P)H quinone dehydrogenase 1

increases activity

2-methoxy-1,4-naphthoquinone results in increased activity of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

Alkannin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 1 beta

multiple interactions

alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

myeloperoxidase

multiple interactions

alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFKB inhibitor alpha

multiple interactions

alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

rhodopsin

multiple interactions

alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein]

NCBI chr 4:148,975,597...148,988,693
Ensembl chr 4:148,980,611...148,985,773

G

Rho-associated coiled-coil containing protein kinase 1

multiple interactions

alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein]

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

Rho-associated coiled-coil containing protein kinase 2

multiple interactions

alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 mRNA]; alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 protein]

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

tumor necrosis factor

multiple interactions

alkannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

atovaquone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity

Atovaquone results in increased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

dihydroorotate dehydrogenase (quinone)

decreases activity
affects binding

Atovaquone results in decreased activity of DHODH protein
Atovaquone binds to Dhodh protein

CTD
RGD

PMID:10658902 PMID:15044733

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

glutathione S-transferase pi 1

multiple interactions

Atovaquone inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

C.I. Natural Red 20

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

decreases expression

shikonin results in decreased expression of ACTA2 mRNA

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

shikonin results in decreased phosphorylation of AKT1 protein
shikonin promotes the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]

PMID:24463199 PMID:28684144

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

amphiregulin

decreases expression

shikonin results in decreased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

activating transcription factor 3

multiple interactions
increases expression

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ATF3 mRNA]
[shikonin results in increased acetylation of HDAC1 protein] which results in increased expression of ATF3 protein; ATF3 protein promotes the reaction [shikonin results in decreased expression of GPX4 protein]; ATF3 protein promotes the reaction [shikonin results in decreased expression of SLC7A11 protein]; MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 mRNA]; MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 protein]; shikonin promotes the reaction [HDAC1 protein binds to ATF3 promoter]
shikonin results in increased expression of ATF3 mRNA; shikonin results in increased expression of ATF3 protein

PMID:25451590 PMID:37268198

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 6

multiple interactions

shikonin inhibits the reaction [Glutamic Acid results in increased expression of ATF6 protein]

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of BAX protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of and affects the localization of BAX protein]; shikonin inhibits the reaction [Thapsigargin results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

shikonin results in decreased expression of BCL2 protein
1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]; MKC8866 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]; shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; shikonin inhibits the reaction [Thapsigargin results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]

PMID:25591861 PMID:35028790

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 12

multiple interactions

[Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased cleavage of CASP12 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of and results in increased cleavage of CASP12 protein]

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

increases cleavage
multiple interactions

shikonin results in increased cleavage of CASP3 protein
shikonin inhibits the reaction [Benzene results in increased expression of CASP3 mRNA]
shikonin inhibits the reaction [Glutamic Acid results in increased expression of CASP3 protein modified form]

PMID:25591861 PMID:35028790 PMID:36306860 PMID:37268198

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

shikonin inhibits the reaction [Benzene results in increased expression of CASP7 mRNA]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

multiple interactions

shikonin inhibits the reaction [Benzene results in increased cleavage of CASP9 protein]; shikonin inhibits the reaction [Benzene results in increased expression of CASP9 mRNA]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

C-C motif chemokine ligand 1

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL1 mRNA]

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 4

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL4 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of CCL4 mRNA]

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 7

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL7 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of CCL7 mRNA]

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cyclin D1

decreases expression

shikonin results in decreased expression of CCND1 protein

PMID:16061028 PMID:28684144

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

decreases expression

shikonin results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cadherin 1

multiple interactions
increases expression

shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in decreased expression of CDH1 protein]
shikonin results in increased expression of CDH1 protein

PMID:35787437 PMID:37268198

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

multiple interactions
decreases expression

shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of CDH2 protein]
shikonin results in decreased expression of CDH2 protein

PMID:35787437 PMID:37268198

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase inhibitor 1A

increases expression

shikonin results in increased expression of CDKN1A protein

PMID:16061028 PMID:28684144

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

collagen type I alpha 1 chain

decreases expression

shikonin results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

decreases expression

shikonin results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

colony stimulating factor 1

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CSF1 mRNA]

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

cysteine and serine rich nuclear protein 1

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of AXUD1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of AXUD1 mRNA]

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

C-X-C motif chemokine ligand 3

multiple interactions

shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of CXCL1 protein]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

shikonin results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

decreases activity

shikonin results in decreased activity of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity

shikonin results in decreased activity of CYP2B6 protein

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

decreases activity

shikonin results in decreased activity of CYP2C11 protein

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily d, polypeptide 1

decreases activity

shikonin results in decreased activity of CYP2D1 protein

NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

shikonin results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

shikonin results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
multiple interactions

shikonin results in decreased activity of CYP3A2 protein
shikonin results in decreased activity of CYP3A4 protein
shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DNA-damage inducible transcript 3

multiple interactions

[Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dual specificity phosphatase 1

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of DUSP1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP1 mRNA]

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

multiple interactions

shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP6 mRNA]

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

early growth response 2

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of EGR2 mRNA]

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

early growth response 3

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR3 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of EGR3 mRNA]

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

[Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased cleavage of CASP12 protein]]; [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of BAX protein]]; [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein]]; GSK2656157 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

GSK2656157 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

shikonin affects the reaction [Oxygen deficiency affects the phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOS mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOSB mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of FOSB mRNA]

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

glutathione peroxidase 4

multiple interactions
decreases expression

ATF3 protein promotes the reaction [shikonin results in decreased expression of GPX4 protein]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

histone deacetylase 1

multiple interactions

[shikonin results in increased acetylation of HDAC1 protein] which results in increased expression of ATF3 protein; shikonin promotes the reaction [HDAC1 protein binds to ATF3 promoter]

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression

shikonin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
shikonin results in decreased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heat shock transcription factor 1

increases activity

shikonin results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

interleukin 13

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of IL13 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA]

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 beta

multiple interactions

shikonin inhibits the reaction [Benzene results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

integrin subunit beta 1

decreases expression

shikonin results in decreased expression of ITGB1 mRNA; shikonin results in decreased expression of ITGB1 protein

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

shikonin inhibits the reaction [Calcimycin results in increased expression of JUN mRNA]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

mitogen-activated protein kinase kinase kinase 8

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of MAP3K8 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of MAP3K8 mRNA]

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK1 protein]
shikonin results in increased phosphorylation of MAPK1 protein

PMID:23562787 PMID:24463199 PMID:25591861

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions
increases phosphorylation

shikonin results in decreased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK3 protein]
shikonin results in increased phosphorylation of MAPK3 protein

PMID:23562787 PMID:24463199 PMID:25591861

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

matrix metallopeptidase 2

decreases expression

shikonin results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

decreases expression

shikonin results in decreased expression of MMP3 protein

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 7

decreases expression

shikonin results in decreased expression of MMP7 protein

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

decreases expression

shikonin results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

metallothionein 2A

multiple interactions

shikonin inhibits the reaction [Calcimycin results in increased expression of MT2 mRNA]

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mechanistic target of rapamycin kinase

multiple interactions

shikonin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 mRNA]; MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 protein]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NFE2 like bZIP transcription factor 2

multiple interactions

shikonin inhibits the reaction [Benzene results in increased expression of and affects the localization of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor delta

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NFKBID mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NFKBID mRNA]

NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447

G

NFKB inhibitor zeta

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NFKBIZ mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NFKBIZ mRNA]

NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723

G

NKD inhibitor of WNT signaling pathway 2

decreases expression

shikonin results in decreased expression of NKD2 mRNA

NCBI chr 1:29,442,898...29,470,839
Ensembl chr 1:29,441,328...29,470,821

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A1 mRNA]

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 2

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A2 mRNA]

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A3 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A3 mRNA]

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

oxidized low density lipoprotein receptor 1

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of OLR1 mRNA]

NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Acetylcysteine inhibits the reaction [shikonin results in increased cleavage of PARP1 protein]

PMID:24463199 PMID:37268198

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

decreases expression

shikonin results in decreased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

pyruvate kinase M1/2

multiple interactions

shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of PKM protein]

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

polo-like kinase 3

multiple interactions

shikonin inhibits the reaction [Calcimycin results in increased expression of PLK3 mRNA]

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

G

protein phosphatase 1, regulatory subunit 15A

multiple interactions

shikonin inhibits the reaction [Calcimycin results in increased expression of PPP1R15A mRNA]

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

prostaglandin-endoperoxide synthase 2

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of PTGS2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

shikonin inhibits the reaction [Benzene results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

receptor interacting serine/threonine kinase 1

multiple interactions

shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein]

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

receptor-interacting serine-threonine kinase 3

multiple interactions

shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein]

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

G

ribosomal protein S6 kinase B1

multiple interactions

shikonin promotes the reaction [Oxygen deficiency results in decreased phosphorylation of RPS6KB1 protein]

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

serpin family E member 1

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 7 member 11

decreases expression
multiple interactions

shikonin results in decreased expression of SLC7A11 protein
ATF3 protein promotes the reaction [shikonin results in decreased expression of SLC7A11 protein]

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

snail family transcriptional repressor 1

decreases expression

shikonin results in decreased expression of SNAI1 protein

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

decreases expression

shikonin results in decreased expression of SNAI2 protein

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

T-cell activation RhoGTPase activating protein

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of TAGAP mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of TAGAP mRNA]

NCBI chr 1:47,170,725...47,179,705
Ensembl chr 1:47,170,725...47,179,792

G

TIMP metallopeptidase inhibitor 2

increases expression

shikonin results in increased expression of TIMP2 protein

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

tumor necrosis factor

multiple interactions

shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of TNF protein]; shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of TNF mRNA]; shikonin inhibits the reaction [Benzene results in increased expression of TNF mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of TNF mRNA]

PMID:25451590 PMID:35787437 PMID:36306860

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

shikonin results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

shikonin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

multiple interactions

shikonin inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Chenodeoxycholic Acid]

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

multiple interactions

shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B7

multiple interactions

shikonin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

X-box binding protein 1

multiple interactions

MKC8866 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of XBP1 protein alternative form]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of XBP1 protein alternative form]

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

zinc finger protein 36

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of ZFP36 mRNA]

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 36, C3H type-like 1

multiple interactions

shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36L1 mRNA]

NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748

Chimaphylin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

insulin-like growth factor 1 receptor

decreases expression

chimaphilin results in decreased expression of IGF1R protein; chimaphilin results in decreased expression of IGF1R protein modified form

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

juglone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

juglone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

BCL2-associated agonist of cell death

multiple interactions
increases expression

[Indomethacin co-treated with juglone] results in increased expression of BAD mRNA; [Indomethacin co-treated with juglone] results in increased expression of BAD protein; [juglone co-treated with Ascorbic Acid] results in increased expression of BAD protein
juglone results in increased expression of BAD mRNA; juglone results in increased expression of BAD protein

PMID:29992683 PMID:31916655

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Indomethacin co-treated with juglone] results in increased expression of BAX mRNA; [Indomethacin co-treated with juglone] results in increased expression of BAX protein; [juglone co-treated with Ascorbic Acid] results in increased expression of BAX protein
juglone results in increased expression of BAX mRNA; juglone results in increased expression of BAX protein

PMID:29992683 PMID:31916655

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression
multiple interactions

juglone results in increased expression of BBC3 protein
[Indomethacin co-treated with juglone] results in increased expression of BBC3 protein

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Indomethacin co-treated with juglone] results in decreased expression of BCL2 mRNA
juglone results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BH3 interacting domain death agonist

multiple interactions

[juglone co-treated with Ascorbic Acid] affects the expression of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

caspase 3

multiple interactions
increases expression

[Indomethacin co-treated with juglone] results in increased expression of CASP3 mRNA; [juglone co-treated with Ascorbic Acid] results in decreased expression of CASP3 protein
juglone results in increased expression of CASP3 mRNA

PMID:29992683 PMID:31916655

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

juglone results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

[juglone co-treated with Ascorbic Acid] results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

decreases expression
multiple interactions

juglone results in decreased expression of CCND1 mRNA; juglone results in decreased expression of CCND1 protein
[Indomethacin co-treated with juglone] results in decreased expression of CCND1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

decreases expression
multiple interactions

juglone results in decreased expression of CCND3 protein
Ascorbic Acid promotes the reaction [juglone results in decreased expression of CCND3 protein]

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin-dependent kinase 4

multiple interactions

[juglone co-treated with Ascorbic Acid] results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

catenin beta 1

multiple interactions
decreases expression

[Indomethacin co-treated with juglone] results in decreased expression of CTNNB1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of CTNNB1 protein
juglone results in decreased expression of CTNNB1 mRNA; juglone results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

juglone results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DAB adaptor protein 2

affects phosphorylation

juglone affects the phosphorylation of DAB2 protein

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

dihydroorotate dehydrogenase (quinone)

decreases activity

juglone results in decreased activity of DHODH protein

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

E2F transcription factor 4

multiple interactions

juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein]

NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806

G

early growth response 1

multiple interactions

juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGR1 protein]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

glutathione-disulfide reductase

multiple interactions

[juglone co-treated with Ascorbic Acid] results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hes family bHLH transcription factor 1

multiple interactions
decreases expression

[Indomethacin co-treated with juglone] results in decreased expression of HES1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of HES1 protein
juglone results in decreased expression of HES1 mRNA; juglone results in decreased expression of HES1 protein

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase 1

multiple interactions

[juglone co-treated with Ascorbic Acid] results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[juglone co-treated with Ascorbic Acid] results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 2

multiple interactions

[juglone co-treated with Ascorbic Acid] affects the expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

[juglone co-treated with Ascorbic Acid] results in decreased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

poly (ADP-ribose) polymerase 1

multiple interactions

[juglone co-treated with Ascorbic Acid] results in increased degradation of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

decreases expression
multiple interactions

juglone results in decreased expression of PCNA protein
[Indomethacin co-treated with juglone] results in decreased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

multiple interactions

juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA]; juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 protein]; juglone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein]

NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

[Indomethacin co-treated with juglone] results in increased expression of PPARG mRNA; [Indomethacin co-treated with juglone] results in increased expression of PPARG protein
juglone results in increased expression of PPARG mRNA; juglone results in increased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

[Indomethacin co-treated with juglone] results in decreased expression of PTGS2 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of PTGS2 protein; [juglone co-treated with Ascorbic Acid] results in decreased expression of PTGS2 mRNA
juglone results in decreased expression of PTGS2 mRNA; juglone results in decreased expression of PTGS2 protein

PMID:29992683 PMID:31916655

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

tyrosine hydroxylase

multiple interactions

juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

TIMP metallopeptidase inhibitor 1

multiple interactions

[juglone co-treated with Ascorbic Acid] affects the expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

increases expression

juglone results in increased expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

tumor necrosis factor

multiple interactions
decreases expression

[Indomethacin co-treated with juglone] results in decreased expression of TNF mRNA; [Indomethacin co-treated with juglone] results in decreased expression of TNF protein
juglone results in decreased expression of TNF mRNA; juglone results in decreased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

[juglone co-treated with Ascorbic Acid] results in increased phosphorylation of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thioredoxin reductase 1

increases reduction

TXNRD1 protein results in increased reduction of juglone

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

increases reduction

TXNRD2 protein results in increased reduction of juglone

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

G

vascular endothelial growth factor A

multiple interactions

[juglone co-treated with Ascorbic Acid] results in decreased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

lapachol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dihydroorotate dehydrogenase (quinone)

decreases activity

lapachol results in decreased activity of DHODH protein

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

tumor protein p53

affects activity

lapachol affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

lawsone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

lawsone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

dihydroorotate dehydrogenase (quinone)

decreases activity

lawsone results in decreased activity of DHODH protein

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

melanocyte inducing transcription factor

decreases expression

lawsone results in decreased expression of MITF protein

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

NFE2 like bZIP transcription factor 2

decreases expression

lawsone results in decreased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

increases activity

lawsone results in increased activity of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

tyrosinase

multiple interactions

lawsone results in decreased expression of and results in decreased activity of TYR protein

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

menadione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

affects expression

Vitamin K 3 affects the expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 11

decreases expression

Vitamin K 3 results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 7

affects expression

Vitamin K 3 affects the expression of ABCB7 mRNA

NCBI chr X:69,295,598...69,436,775
Ensembl chr X:69,295,552...69,436,858

G

ATP binding cassette subfamily C member 3

affects expression

Vitamin K 3 affects the expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily D member 4

decreases expression

Vitamin K 3 results in decreased expression of ABCD4 mRNA

NCBI chr 6:104,246,459...104,260,965
Ensembl chr 6:104,246,468...104,280,276

G

ATP binding cassette subfamily G member 2

affects expression

Vitamin K 3 affects the expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

abhydrolase domain containing 14b

affects expression

Vitamin K 3 affects the expression of ABHD14B mRNA

NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119

G

abhydrolase domain containing 4, N-acyl phospholipase B

increases expression

Vitamin K 3 results in increased expression of ABHD4 mRNA

NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966

G

abhydrolase domain containing 5, lysophosphatidic acid acyltransferase

affects expression

Vitamin K 3 affects the expression of ABHD5 mRNA

NCBI chr 8:122,000,241...122,026,447
Ensembl chr 8:122,000,389...122,026,447

G

ABR activator of RhoGEF and GTPase

affects expression

Vitamin K 3 affects the expression of ABR mRNA

NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505

G

acetyl-CoA acetyltransferase 2

affects expression

Vitamin K 3 affects the expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

aconitase 1

affects activity

Vitamin K 3 affects the activity of ACO1 protein

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

affects expression

Vitamin K 3 affects the expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA thioesterase 13

affects expression

Vitamin K 3 affects the expression of ACOT13 mRNA

NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851

G

acyl-CoA synthetase long-chain family member 1

affects expression

Vitamin K 3 affects the expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase short-chain family member 1

affects expression

Vitamin K 3 affects the expression of ACSS1 mRNA

NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325

G

actin related protein 3B

affects expression

Vitamin K 3 affects the expression of ACTR3B mRNA

NCBI chr 4:9,261,631...9,355,496
Ensembl chr 4:9,262,233...9,355,441

G

ADAM metallopeptidase domain 19

decreases expression

Vitamin K 3 results in decreased expression of ADAM19 mRNA

NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105

G

ADAM metallopeptidase domain 9

affects expression

Vitamin K 3 affects the expression of ADAM9 mRNA

NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917

G

adenylate cyclase 3

affects expression
decreases expression

Vitamin K 3 affects the expression of ADCY3 mRNA
Vitamin K 3 results in decreased expression of ADCY3 mRNA

PMID:12414654 PMID:20044591

NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686

G

adducin 3

affects expression

Vitamin K 3 affects the expression of ADD3 mRNA

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

G

adhesion G protein-coupled receptor A3

affects expression

Vitamin K 3 affects the expression of ADGRA3 mRNA

NCBI chr14:60,874,719...60,976,341
Ensembl chr14:60,874,715...60,976,332

G

adhesion G protein-coupled receptor V1

affects expression

Vitamin K 3 affects the expression of ADGRV1 mRNA

NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688

G

adenosine kinase

affects expression

Vitamin K 3 affects the expression of ADK mRNA

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

argonaute RISC component 1

affects expression

Vitamin K 3 affects the expression of AGO1 mRNA

NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546

G

1-acylglycerol-3-phosphate O-acyltransferase 3

affects expression

Vitamin K 3 affects the expression of AGPAT3 mRNA

NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358

G

anterior gradient 2, protein disulphide isomerase family member

affects expression

Vitamin K 3 affects the expression of AGR2 mRNA

NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371

G

aryl hydrocarbon receptor

affects expression

Vitamin K 3 affects the expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

autoimmune regulator

decreases expression

Vitamin K 3 results in decreased expression of AIRE mRNA

NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060

G

A-kinase anchoring protein 12

affects expression

Vitamin K 3 affects the expression of AKAP12 mRNA

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

A-kinase anchoring protein 9

affects expression

Vitamin K 3 affects the expression of AKAP9 mRNA

NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606

G

A-kinase interacting protein 1

affects expression

Vitamin K 3 affects the expression of AKIP1 mRNA

NCBI chr 1:163,734,730...163,743,648
Ensembl chr 1:163,734,798...163,743,648

G

aldo-keto reductase family 1 member B10

increases expression

Vitamin K 3 results in increased expression of AKR1B10 mRNA

PMID:23410634 PMID:34767876

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C1

affects expression

Vitamin K 3 affects the expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C2

increases expression

Vitamin K 3 results in increased expression of AKR1C2 mRNA

PMID:12414654 PMID:23410634

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 7, member A2

multiple interactions
increases metabolic processing
decreases response to substance

AKR7A2 protein inhibits the reaction [Vitamin K 3 results in decreased abundance of Glutathione]; AKR7A2 protein inhibits the reaction [Vitamin K 3 results in increased abundance of Reactive Oxygen Species]
AKR7A5 protein results in increased metabolism of Vitamin K 3
AKR7A2 protein results in decreased susceptibility to Vitamin K 3

PMID:22001351 PMID:24590062

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

albumin

affects expression

Vitamin K 3 affects the expression of ALB mRNA

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 18 family, member A1

affects expression

Vitamin K 3 affects the expression of ALDH18A1 mRNA

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member A1

affects expression

Vitamin K 3 affects the expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A3

affects expression

Vitamin K 3 affects the expression of ALDH1A3 mRNA

NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436

G

aldehyde dehydrogenase 2 family member

affects expression

Vitamin K 3 affects the expression of ALDH2 mRNA

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member B1

decreases response to substance

ALDH3B1 protein results in decreased susceptibility to Vitamin K 3

NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921

G

aldehyde dehydrogenase 6 family, member A1

affects expression

Vitamin K 3 affects the expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

alkaline phosphatase, biomineralization associated

decreases secretion

Vitamin K 3 results in decreased secretion of ALPL protein

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

Aly/REF export factor

affects expression

Vitamin K 3 affects the expression of ALYREF mRNA

NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069

G

angiomotin like 2

affects expression

Vitamin K 3 affects the expression of AMOTL2 mRNA

NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910

G

anaphase promoting complex subunit 1

affects expression

Vitamin K 3 affects the expression of ANAPC1 mRNA

NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273

G

angiogenin

affects expression

Vitamin K 3 affects the expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

ankyrin 3

affects expression

Vitamin K 3 affects the expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

ankyrin repeat family A member 2

affects expression

Vitamin K 3 affects the expression of ANKRA2 mRNA

NCBI chr 2:29,612,867...29,623,748
Ensembl chr 2:29,612,925...29,623,730

G

ankyrin repeat domain containing 11

affects expression

Vitamin K 3 affects the expression of ANKRD11 mRNA

NCBI chr19:50,940,284...51,098,962
Ensembl chr19:50,940,299...51,098,962

G

ankyrin repeat domain 37

decreases expression

Vitamin K 3 results in decreased expression of ANKRD37 mRNA

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

ankyrin repeat and sterile alpha motif domain containing 1A

affects expression

Vitamin K 3 affects the expression of ANKS1 mRNA

NCBI chr20:5,963,658...6,117,139
Ensembl chr20:5,963,678...6,117,148

G

ankyrin repeat and sterile alpha motif domain containing 6

affects expression

Vitamin K 3 affects the expression of ANKS6 mRNA

NCBI chr 5:61,309,183...61,350,596
Ensembl chr 5:61,309,183...61,350,596

G

acidic nuclear phosphoprotein 32 family member B

affects expression

Vitamin K 3 affects the expression of ANP32B mRNA

NCBI chr 5:60,743,077...60,765,726
Ensembl chr 5:60,743,443...60,765,717

G

adenine nucleotide translocase lysine methyltransferase

affects expression

Vitamin K 3 affects the expression of ANTKMT mRNA

NCBI chr10:14,812,274...14,814,798
Ensembl chr10:14,812,269...14,814,193

G

annexin A13

affects expression

Vitamin K 3 affects the expression of ANXA13 mRNA

NCBI chr 7:89,884,356...89,936,907
Ensembl chr 7:89,884,356...89,936,907

G

aldehyde oxidase 1

multiple interactions
decreases activity

Vitamin K 3 inhibits the reaction [AOX1 protein results in increased metabolism of zoniporide]
Vitamin K 3 results in decreased activity of AOX1 protein

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

amyloid beta precursor protein binding family B member 2

affects expression

Vitamin K 3 affects the expression of APBB2 mRNA

NCBI chr14:41,557,918...41,878,622
Ensembl chr14:41,557,972...41,877,495

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases response to substance

APEX1 gene mutant form results in increased susceptibility to Vitamin K 3

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

amyloid beta precursor like protein 2

affects expression

Vitamin K 3 affects the expression of APLP2 mRNA

NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855

G

apolipoprotein A1

affects expression

Vitamin K 3 affects the expression of APOA1 mRNA

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A5

affects expression

Vitamin K 3 affects the expression of APOA5 mRNA

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

G

apolipoprotein C3

affects expression

Vitamin K 3 affects the expression of APOC3 mRNA

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

apolipoprotein E

affects response to substance

APOE protein affects the susceptibility to Vitamin K 3

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein H

affects expression

Vitamin K 3 affects the expression of APOH mRNA

NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329

G

aquaporin 11

affects expression

Vitamin K 3 affects the expression of AQP11 mRNA

NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725

G

amphiregulin

increases expression

Vitamin K 3 results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

arginase 2

affects expression

Vitamin K 3 affects the expression of ARG2 mRNA

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

Rho guanine nucleotide exchange factor 7

affects expression

Vitamin K 3 affects the expression of ARHGEF7 mRNA

NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697

G

AT-rich interaction domain 3A

affects expression

Vitamin K 3 affects the expression of ARID3A mRNA

PMID:20044591 PMID:23410634

NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599

G

AT-rich interaction domain 5A

affects expression

Vitamin K 3 affects the expression of ARID5A mRNA

NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597

G

armadillo repeat containing, X-linked 1

decreases expression

Vitamin K 3 results in decreased expression of ARMCX1 mRNA

NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299

G

arrestin domain containing 2

affects expression

Vitamin K 3 affects the expression of ARRDC2 mRNA

NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029

G

anti-silencing function 1A histone chaperone

increases expression

Vitamin K 3 results in increased expression of ASF1A mRNA

NCBI chr20:32,893,962...32,908,808
Ensembl chr20:32,893,573...32,908,808

G

acid sensing ion channel subunit 1

decreases expression

Vitamin K 3 results in decreased expression of ASIC1 mRNA

NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541

G

activating transcription factor 3

affects expression
increases expression

Vitamin K 3 affects the expression of ATF3 mRNA
Vitamin K 3 results in increased expression of ATF3 mRNA

PMID:12414654 PMID:20044591

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 6

multiple interactions
increases expression

Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein]; S 3483 promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein]

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

autophagy related 5

affects response to substance

ATG5 mRNA affects the susceptibility to Vitamin K 3
ATG5 protein affects the susceptibility to Vitamin K 3

PMID:18073215 PMID:18319638 PMID:20578144

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

affects expression

Vitamin K 3 affects the expression of ATIC mRNA

NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889

G

antioxidant 1 copper chaperone

affects expression

Vitamin K 3 affects the expression of ATOX1 mRNA

NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950

G

ATP synthase inhibitory factor subunit 1

affects expression

Vitamin K 3 affects the expression of ATP5IF1 mRNA

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

G

ATP synthase peripheral stalk subunit OSCP

affects expression

Vitamin K 3 affects the expression of ATP5PO mRNA

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATPase copper transporting beta

affects expression

Vitamin K 3 affects the expression of ATP7B mRNA

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

attractin

affects expression

Vitamin K 3 affects the expression of ATRN mRNA

NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322

G

ATRX, chromatin remodeler

affects expression

Vitamin K 3 affects the expression of ATRX mRNA

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

ataxin 2-like

affects expression

Vitamin K 3 affects the expression of ATXN2L mRNA

NCBI chr 1:181,078,293...181,090,079
Ensembl chr 1:181,078,288...181,089,686

G

AU RNA binding methylglutaconyl-CoA hydratase

affects expression

Vitamin K 3 affects the expression of AUH mRNA

NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896

G

aurora kinase B

decreases expression

Vitamin K 3 results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

activator of transcription and developmental regulator AUTS2

affects expression

Vitamin K 3 affects the expression of AUTS2 mRNA

NCBI chr12:24,104,187...25,194,123
Ensembl chr12:24,104,192...25,194,416

G

Beta-1,3-galactosyltransferase 6

affects expression

Vitamin K 3 affects the expression of B3GALT6 mRNA

NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338

G

bromo adjacent homology domain containing 1

affects expression

Vitamin K 3 affects the expression of BAHD1 mRNA

NCBI chr 3:105,891,207...105,914,414
Ensembl chr 3:105,892,478...105,914,410

G

BCL2-antagonist/killer 1

affects expression

Vitamin K 3 affects the expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BMP and activin membrane-bound inhibitor

affects expression

Vitamin K 3 affects the expression of BAMBI mRNA

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

basic leucine zipper ATF-like transcription factor

increases expression

Vitamin K 3 results in increased expression of BATF mRNA

NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051

G

BCL2 associated X, apoptosis regulator

affects localization
increases expression
multiple interactions

Vitamin K 3 affects the localization of BAX protein
Vitamin K 3 results in increased expression of BAX protein
EUK-134 inhibits the reaction [Vitamin K 3 results in increased expression of BAX protein]

PMID:15961378 PMID:25005833

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

affects expression

Vitamin K 3 affects the expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

Bardet-Biedl syndrome 2

affects expression

Vitamin K 3 affects the expression of BBS2 mRNA

NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993

G

BCAR3 adaptor protein, NSP family member

affects expression

Vitamin K 3 affects the expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

G

brain enriched myelin associated protein 1

affects expression

Vitamin K 3 affects the expression of BCAS1 mRNA

NCBI chr 3:159,136,077...159,219,072
Ensembl chr 3:159,136,083...159,219,106

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[sodium arsenite co-treated with Vitamin K 3] results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in decreased expression of BCL2 protein]; EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of BCL2 protein]
Vitamin K 3 results in decreased expression of BCL2 mRNA; Vitamin K 3 results in decreased expression of BCL2 protein
Acetaminophen inhibits the reaction [Vitamin K 3 results in decreased expression of BCL2 mRNA]; Acetaminophen inhibits the reaction [Vitamin K 3 results in decreased expression of BCL2 protein]

PMID:19082730 PMID:19265712 PMID:25005833

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL6, transcription repressor

affects expression

Vitamin K 3 affects the expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

BCL9 like

decreases expression

Vitamin K 3 results in decreased expression of BCL9L protein

NCBI chr 8:44,811,977...44,840,611
Ensembl chr 8:44,811,977...44,840,611

G

3-hydroxybutyrate dehydrogenase 2

affects expression

Vitamin K 3 affects the expression of BDH2 mRNA

NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072

G

beclin 1

affects expression

Vitamin K 3 affects the expression of BECN1 mRNA

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

Bet1 golgi vesicular membrane trafficking protein-like

affects expression

Vitamin K 3 affects the expression of BET1L mRNA

NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040

G

bone gamma-carboxyglutamate protein

decreases expression
increases secretion
increases expression
multiple interactions

Vitamin K 3 results in decreased expression of BGLAP mRNA
Vitamin K 3 results in increased secretion of BGLAP protein
Vitamin K 3 results in increased expression of BGLAP protein modified form
Vitamin K 3 inhibits the reaction [Estrogens deficiency results in decreased secretion of BGLAP protein]

PMID:19675304 PMID:30453296

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

BCL2-interacting killer

increases expression

Vitamin K 3 results in increased expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

baculoviral IAP repeat-containing 5

affects expression

Vitamin K 3 affects the expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

biliverdin reductase B

increases expression

Vitamin K 3 results in increased expression of BLVRB mRNA

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

BMS1 ribosome biogenesis factor

affects expression

Vitamin K 3 affects the expression of BMS1 mRNA

NCBI chr 4:151,558,163...151,595,187
Ensembl chr 4:151,558,163...151,595,127

G

BCL2 interacting protein 3

decreases expression

Vitamin K 3 results in decreased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

bromodomain containing 8

affects expression

Vitamin K 3 affects the expression of BRD8 mRNA

NCBI chr18:26,204,892...26,229,999
Ensembl chr18:26,181,732...26,229,884

G

BRMS1, transcriptional repressor and anoikis regulator

affects expression

Vitamin K 3 affects the expression of BRMS1 mRNA

NCBI chr 1:202,345,766...202,355,028
Ensembl chr 1:202,345,704...202,355,028

G

BTG anti-proliferation factor 2

increases expression

Vitamin K 3 results in increased expression of BTG2 mRNA

PMID:12414654 PMID:21382384

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BUB1 mitotic checkpoint serine/threonine kinase

affects expression

Vitamin K 3 affects the expression of BUB1 mRNA

PMID:20044591 PMID:23410634

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

BUD13 homolog

affects expression

Vitamin K 3 affects the expression of BUD13 mRNA

NCBI chr 8:46,575,124...46,590,964
Ensembl chr 8:46,575,115...46,590,958

G

similar to human chromosome 17 open reading frame 100

affects expression

Vitamin K 3 affects the expression of C17ORF100 mRNA

NCBI chr10:56,840,451...56,843,674
Ensembl chr10:56,832,412...56,843,871

G

similar to human chromosome 3 open reading frame 52

affects expression

Vitamin K 3 affects the expression of C3ORF52 mRNA

NCBI chr11:55,166,986...55,192,273
Ensembl chr11:55,166,678...55,192,292

G

similar to human chromosome 6 open reading frame 62

affects expression

Vitamin K 3 affects the expression of C6ORF62 mRNA

NCBI chr17:40,256,211...40,267,851
Ensembl chr17:40,256,211...40,276,020

G

C1GALT1-specific chaperone 1

affects expression

Vitamin K 3 affects the expression of C1GALT1C1 mRNA

NCBI chr X:117,378,123...117,382,620
Ensembl chr X:117,375,525...117,382,787

G

complement C1q binding protein

affects expression

Vitamin K 3 affects the expression of C1QBP mRNA

NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649

G

C2 calcium-dependent domain containing 5

affects expression

Vitamin K 3 affects the expression of C2CD5 mRNA

NCBI chr 4:175,969,544...176,055,597
Ensembl chr 4:175,969,545...176,055,558

G

similar to human chromosome 8 open reading frame 76

affects expression

Vitamin K 3 affects the expression of C8ORF76 mRNA

NCBI chr 7:89,558,890...89,569,810
Ensembl chr 7:89,558,909...89,569,810

G

similar to human chromosome 15 open reading frame 39

affects expression

Vitamin K 3 affects the expression of C15ORF39 mRNA

NCBI chr 8:57,646,324...57,655,896
Ensembl chr 8:57,645,756...57,655,941

G

Cdk5 and Abl enzyme substrate 1

affects expression

Vitamin K 3 affects the expression of CABLES1 mRNA

NCBI chr18:3,076,556...3,181,181
Ensembl chr18:3,075,524...3,181,181

G

calcium voltage-gated channel subunit alpha1 G

affects expression

Vitamin K 3 affects the expression of CACNA1G mRNA

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

G

calbindin 1

increases expression

Vitamin K 3 results in increased expression of CALB1 mRNA

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

affects expression

Vitamin K 3 affects the expression of CAMK2N1 mRNA

NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600

G

calnexin

affects expression

Vitamin K 3 affects the expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

calpain 2

affects expression

Vitamin K 3 affects the expression of CAPN2 mRNA

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

carbonic anhydrase 12

affects expression

Vitamin K 3 affects the expression of CA12 mRNA

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

caspase 2

increases expression

Vitamin K 3 results in increased expression of CASP2 protein modified form

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP3 protein]; Vitamin K 3 analog inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Vitamin K 3 analog promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]
Vitamin K 3 results in increased activity of CASP3 protein
Vitamin K 3 results in increased cleavage of CASP3 protein
Buthionine Sulfoximine promotes the reaction [Vitamin K 3 results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Vitamin K 3 results in increased activity of CASP3 protein]
Vitamin K 3 results in increased expression of CASP3 protein modified form

PMID:12965111 PMID:16310883 PMID:19082730 PMID:20829426 PMID:23300732 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

multiple interactions

[Metyrapone co-treated with Vitamin K 3] affects the localization of CASP4 protein; [S 3483 co-treated with Vitamin K 3] affects the localization of CASP4 protein

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 6

multiple interactions
increases cleavage

pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased activity of CASP6 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP6 protein]

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 9

multiple interactions
increases cleavage

[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP9 protein]; EUK-134 inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP9 protein]; Vitamin K 3 analog promotes the reaction [Doxorubicin results in increased activity of CASP9 protein]
pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP9 protein]

PMID:16310883 PMID:19082730 PMID:25005833 PMID:29141199

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

affects expression
decreases activity
decreases response to substance
multiple interactions

Vitamin K 3 affects the expression of CAT mRNA
Vitamin K 3 results in decreased activity of CAT protein
CAT protein results in decreased susceptibility to Vitamin K 3
[CAT protein co-treated with SOD1 protein] results in decreased susceptibility to Vitamin K 3; [CAT protein co-treated with SOD2 protein] results in decreased susceptibility to Vitamin K 3; CAT protein inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; CAT protein inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Hydrogen Peroxide]; CAT results in decreased susceptibility to [Vitamin K 3 co-treated with Ascorbic Acid]

PMID:12633745 PMID:14698046 PMID:15331536 PMID:20044591 PMID:21689642 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolae associated protein 2

affects expression

Vitamin K 3 affects the expression of CAVIN2 mRNA

NCBI chr 9:50,302,079...50,314,096
Ensembl chr 9:50,301,206...50,314,147

G

core-binding factor subunit beta

affects expression

Vitamin K 3 affects the expression of CBFB mRNA

NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751

G

carbonyl reductase 1

multiple interactions
increases metabolic processing

[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Vitamin K 3]; Vitamin K 3 inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

PMID:11306090 PMID:19061875 PMID:23295225

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

carbonyl reductase 3

affects metabolic processing
increases expression

CBR3 protein affects the metabolism of Vitamin K 3
Vitamin K 3 results in increased expression of CBR3 mRNA

PMID:20007405 PMID:21382384 PMID:25270620

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

cell cycle and apoptosis regulator 2

affects expression

Vitamin K 3 affects the expression of CCAR2 mRNA

NCBI chr15:45,212,797...45,228,001
Ensembl chr15:45,212,803...45,227,636

G

coiled-coil domain containing 12

affects expression

Vitamin K 3 affects the expression of CCDC12 mRNA

NCBI chr 8:110,635,276...110,686,417
Ensembl chr 8:110,635,710...110,686,417

G

coiled-coil domain containing 125

affects expression

Vitamin K 3 affects the expression of CCDC125 mRNA

NCBI chr 2:31,809,120...31,835,538
Ensembl chr 2:31,809,228...31,850,152

G

coiled-coil domain containing 136

decreases expression

Vitamin K 3 results in decreased expression of CCDC136 mRNA

NCBI chr 4:57,997,825...58,027,598
Ensembl chr 4:57,997,853...58,027,646

G

coiled-coil domain containing 88B

affects expression

Vitamin K 3 affects the expression of CCDC88B mRNA

NCBI chr 1:204,036,913...204,052,878
Ensembl chr 1:204,036,918...204,052,970

G

coiled-coil domain containing 90B

affects expression

Vitamin K 3 affects the expression of CCDC90B mRNA

NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338

G

C-C motif chemokine ligand 3

multiple interactions
increases secretion
increases expression

Acetaminophen inhibits the reaction [Vitamin K 3 results in increased expression of CCL3 mRNA]; Acetaminophen inhibits the reaction [Vitamin K 3 results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

multiple interactions
increases secretion
increases expression

Acetaminophen inhibits the reaction [Vitamin K 3 results in increased expression of CCL5 mRNA]; Acetaminophen inhibits the reaction [Vitamin K 3 results in increased secretion of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 1

increases expression

Vitamin K 3 results in increased expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 2

affects expression

Vitamin K 3 affects the expression of CCN2 mRNA

PMID:20044591 PMID:23410634

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin A2

decreases expression
affects expression

Vitamin K 3 results in decreased expression of CCNA2 mRNA
Vitamin K 3 affects the expression of CCNA2 mRNA

PMID:12414654 PMID:23410634

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B2

affects expression

Vitamin K 3 affects the expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

affects expression
decreases expression

Vitamin K 3 affects the expression of CCND1 mRNA
Vitamin K 3 results in decreased expression of CCND1 protein

PMID:20044591 PMID:31238027

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

affects expression

Vitamin K 3 affects the expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin G1

affects expression

Vitamin K 3 affects the expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin I

affects expression

Vitamin K 3 affects the expression of CCNI mRNA

NCBI chr14:14,879,698...14,902,510
Ensembl chr14:14,879,717...14,902,510

G

cyclin J-like

affects expression

Vitamin K 3 affects the expression of CCNJL mRNA

NCBI chr10:27,995,682...28,053,428
Ensembl chr10:27,995,679...28,053,426

G

cyclin Q

affects expression

Vitamin K 3 affects the expression of CCNQ mRNA

NCBI chr10:63,646,532...63,647,695
Ensembl chr10:63,646,527...63,647,961

G

chaperonin containing TCP1 subunit 2

affects expression

Vitamin K 3 affects the expression of CCT2 mRNA

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

chaperonin containing TCP1 subunit 5

affects expression

Vitamin K 3 affects the expression of CCT5 mRNA

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

CD1d1 molecule

affects expression

Vitamin K 3 affects the expression of CD1D mRNA

NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089

G

CD36 molecule

affects expression

Vitamin K 3 affects the expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD44 molecule

affects expression

Vitamin K 3 affects the expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

Cd48 molecule

affects expression

Vitamin K 3 affects the expression of CD48 mRNA

NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142

G

CD74 molecule

affects expression

Vitamin K 3 affects the expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

CD9 molecule

affects expression

Vitamin K 3 affects the expression of CD9 mRNA

PMID:20044591 PMID:23410634

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

G

cell division cycle 14B

affects expression

Vitamin K 3 affects the expression of CDC14B mRNA

NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235

G

CDC42 effector protein 4

affects expression

Vitamin K 3 affects the expression of CDC42EP4 mRNA

NCBI chr10:98,772,613...98,797,924
Ensembl chr10:98,772,495...98,797,695

G

cell division cycle 45

affects expression

Vitamin K 3 affects the expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle associated 5

affects expression

Vitamin K 3 affects the expression of CDCA5 mRNA

NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023

G

cell division cycle associated 7

affects expression

Vitamin K 3 affects the expression of CDCA7 mRNA

NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353

G

cadherin 1

increases expression

Vitamin K 3 results in increased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 16

affects expression

Vitamin K 3 affects the expression of CDH16 mRNA

NCBI chr19:360,824...371,008
Ensembl chr19:360,824...371,007

G

cadherin 2

decreases expression

Vitamin K 3 results in decreased expression of CDH2 protein

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 4

decreases expression

Vitamin K 3 results in decreased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1A protein; EUK-134 affects the reaction [Vitamin K 3 results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1A protein]
Vitamin K 3 results in increased expression of CDKN1A mRNA; Vitamin K 3 results in increased expression of CDKN1A protein

PMID:12414654 PMID:19082730 PMID:23410634 PMID:25005833

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein]

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 1C

affects expression

Vitamin K 3 affects the expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin-dependent kinase inhibitor 2A

increases expression

Vitamin K 3 results in increased expression of CDKN2A mRNA

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

chromatin licensing and DNA replication factor 1

affects expression

Vitamin K 3 affects the expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

G

caudal type homeo box 1

increases expression

Vitamin K 3 results in increased expression of CDX1 mRNA

NCBI chr18:54,472,587...54,490,913
Ensembl chr18:54,473,444...54,490,814

G

CCAAT/enhancer binding protein alpha

affects expression

Vitamin K 3 affects the expression of CEBPA mRNA

PMID:20044591 PMID:23410634

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

centromere protein A

decreases expression

Vitamin K 3 results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein F

affects expression

Vitamin K 3 affects the expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

centrosomal protein 95

affects expression

Vitamin K 3 affects the expression of CEP95 mRNA

NCBI chr10:91,732,111...91,760,095
Ensembl chr10:91,732,111...91,760,092

G

cilia and flagella associated protein 20

affects expression

Vitamin K 3 affects the expression of CFAP20 mRNA

NCBI chr19:9,608,867...9,622,558
Ensembl chr19:9,608,859...9,622,558

G

cingulin-like 1

affects expression

Vitamin K 3 affects the expression of CGNL1 mRNA

NCBI chr 8:72,273,401...72,424,842
Ensembl chr 8:72,275,645...72,422,917

G

checkpoint kinase 1

decreases expression

Vitamin K 3 results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

choline kinase alpha

affects expression

Vitamin K 3 affects the expression of CHKA mRNA

PMID:20044591 PMID:23410634

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

chondroitin polymerizing factor 2

increases expression

Vitamin K 3 results in increased expression of CHPF2 mRNA

NCBI chr 4:10,578,470...10,585,940
Ensembl chr 4:10,580,462...10,585,916

G

carbohydrate sulfotransferase 15

affects expression

Vitamin K 3 affects the expression of CHST15 mRNA

NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707

G

carbohydrate sulfotransferase 7

affects expression

Vitamin K 3 affects the expression of CHST7 mRNA

NCBI chr X:2,396,260...2,432,828
Ensembl chr X:2,393,874...2,432,840

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

affects expression

Vitamin K 3 affects the expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

cytoskeleton associated protein 5

affects expression

Vitamin K 3 affects the expression of CKAP5 mRNA

NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264

G

creatine kinase B

affects expression

Vitamin K 3 affects the expression of CKB mRNA

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

CDC28 protein kinase regulatory subunit 1B

affects expression

Vitamin K 3 affects the expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

claudin 23

affects expression

Vitamin K 3 affects the expression of CLDN23 mRNA

NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523

G

claudin 3

affects expression

Vitamin K 3 affects the expression of CLDN3 mRNA

NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001

G

CAP-GLY domain containing linker protein 1

affects expression

Vitamin K 3 affects the expression of CLIP1 mRNA

NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884

G

ClpB family mitochondrial disaggregase

affects expression

Vitamin K 3 affects the expression of CLPB mRNA

NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788

G

carboxymethylenebutenolidase homolog

affects expression

Vitamin K 3 affects the expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009

G

c-Maf-inducing protein

affects expression

Vitamin K 3 affects the expression of CMIP mRNA

NCBI chr19:45,304,597...45,510,653
Ensembl chr19:45,304,031...45,508,709

G

CKLF-like MARVEL transmembrane domain containing 3

affects expression

Vitamin K 3 affects the expression of CMTM3 mRNA

NCBI chr19:622,563...630,721
Ensembl chr19:604,458...629,790

G

contactin associated protein 2

affects expression

Vitamin K 3 affects the expression of CNTNAP2 mRNA

NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027

G

cytochrome c oxidase assembly factor 4 homolog

affects expression

Vitamin K 3 affects the expression of COA4 mRNA

NCBI chr 1:154,882,199...154,885,445
Ensembl chr 1:154,882,155...154,888,174

G

cytochrome C oxidase assembly factor 5

affects expression

Vitamin K 3 affects the expression of COA5 mRNA

NCBI chr 9:39,651,459...39,664,870

G

collagen type I alpha 1 chain

decreases expression

Vitamin K 3 results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type V alpha 2 chain

affects expression

Vitamin K 3 affects the expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

coronin 2A

affects expression

Vitamin K 3 affects the expression of CORO2A mRNA

NCBI chr 5:60,825,630...60,881,917
Ensembl chr 5:60,828,247...60,859,035

G

cAMP responsive element binding protein 1

multiple interactions

[sodium arsenite co-treated with Vitamin K 3] results in increased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cysteine rich protein 1

affects expression

Vitamin K 3 affects the expression of CRIP1 mRNA

NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620

G

crystallin, lambda 1

affects expression

Vitamin K 3 affects the expression of CRYL1 mRNA

NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997

G

C-terminal binding protein 2

affects expression

Vitamin K 3 affects the expression of CTBP2 mRNA

NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222

G

cardiotrophin 1

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; 2-methoxyestradiol inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; acetovanillone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; diphenyleneiodonium inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; U 0126 inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]
Vitamin K 3 results in increased expression of CTF1 mRNA; Vitamin K 3 results in increased expression of CTF1 protein

NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335

G

catenin beta 1

decreases expression

Vitamin K 3 results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

catenin delta 1

affects expression

Vitamin K 3 affects the expression of CTNND1 mRNA

NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516

G

CTP synthase 1

affects expression

Vitamin K 3 affects the expression of CTPS1 mRNA

NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180

G

CTR9 homolog, Paf1/RNA polymerase II complex component

affects expression

Vitamin K 3 affects the expression of CTR9 mRNA

NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303

G

cullin 4A

affects expression

Vitamin K 3 affects the expression of CUL4A mRNA

NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330

G

CXXC finger protein 5

affects expression

Vitamin K 3 affects the expression of CXXC5 mRNA

NCBI chr18:27,427,591...27,458,579
Ensembl chr18:27,427,230...27,458,673

G

cytochrome b5 domain containing 2

affects expression

Vitamin K 3 affects the expression of CYB5D2 mRNA

NCBI chr10:57,394,268...57,413,336
Ensembl chr10:57,396,765...57,413,715

G

cytochrome b5 reductase 1

affects expression

Vitamin K 3 affects the expression of CYB5R1 mRNA

NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458

G

cytochrome b-245 alpha chain

increases expression

Vitamin K 3 results in increased expression of CYBA protein

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases activity
increases expression

Vitamin K 3 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Vitamin K 3 results in increased activity of CYP1A1 protein
Vitamin K 3 results in increased expression of CYP1A1 mRNA

PMID:15603920 PMID:18493746

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression
increases activity

Vitamin K 3 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
Vitamin K 3 results in increased expression of CYP1A2 mRNA
Vitamin K 3 results in increased activity of CYP1A2 protein

PMID:15603920 PMID:18493746

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

Vitamin K 3 results in increased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 24, subfamily a, polypeptide 1

affects expression

Vitamin K 3 affects the expression of CYP24A1 mRNA

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression
multiple interactions

Vitamin K 3 results in decreased expression of CYP2E1 mRNA
[CYP2E1 protein co-treated with Vitamin K 3 co-treated with Arachidonic Acid] results in increased expression of KLF6 protein; [CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein; Buthionine Sulfoximine promotes the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; CAT protein inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; Dicumarol inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; S-ethyl glutathione inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; Vitamin E inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; Vitamin K 3 promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA alternative form]; Vitamin K 3 promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]

PMID:22486562 PMID:25270620

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily j, polypeptide 4

affects expression

Vitamin K 3 affects the expression of CYP2J9 mRNA

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 2, subfamily r, polypeptide 1

affects expression

Vitamin K 3 affects the expression of CYP2R1 mRNA

NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759

G

diazepam binding inhibitor

affects expression

Vitamin K 3 affects the expression of DBI mRNA

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

decapping mRNA 1B

affects expression

Vitamin K 3 affects the expression of DCP1B mRNA

NCBI chr 4:152,358,267...152,395,747
Ensembl chr 4:152,358,241...152,397,145

G

dicarbonyl and L-xylulose reductase

multiple interactions
increases metabolic processing
decreases activity

[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Hydrogen Peroxide; [DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides; [Vitamin K 3 co-treated with NADP] binds to DCXR protein; CAT protein inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Hydrogen Peroxide]; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]; Vitamin K 3 inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]
Vitamin K 3 results in decreased activity of DCXR protein

PMID:25526675 PMID:28595002

NCBI chr10:106,006,404...106,008,293

G

dopa decarboxylase

affects expression

Vitamin K 3 affects the expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Vitamin K 3 results in increased expression of DDIT3 mRNA; Vitamin K 3 results in increased expression of DDIT3 protein
Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of DDIT3 protein]; S 3483 promotes the reaction [Vitamin K 3 results in increased expression of DDIT3 protein]

PMID:12414654 PMID:19819344

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

affects expression

Vitamin K 3 affects the expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DNA-damage-inducible transcript 4-like

increases expression

Vitamin K 3 results in increased expression of DDIT4L mRNA

NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375

G

DEAD-box helicase 1

affects expression

Vitamin K 3 affects the expression of DDX1 mRNA

NCBI chr 6:35,996,469...36,027,340
Ensembl chr 6:35,996,469...36,027,365

G

DEAD-box helicase 23

affects expression

Vitamin K 3 affects the expression of DDX23 mRNA

NCBI chr 7:129,797,620...129,814,909
Ensembl chr 7:129,797,614...129,814,949

G

DEAD-box helicase 42

increases expression

Vitamin K 3 results in increased expression of DDX42 mRNA

NCBI chr10:91,148,926...91,180,940
Ensembl chr10:91,148,254...91,180,939

G

DEAD-box helicase 47

affects expression

Vitamin K 3 affects the expression of DDX47 mRNA

NCBI chr 4:167,845,652...167,858,115
Ensembl chr 4:167,845,640...167,859,115

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defensin beta 1

affects expression

Vitamin K 3 affects the expression of DEFB1 mRNA

NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604

G

DEP domain containing 7

affects expression

Vitamin K 3 affects the expression of DEPDC7 mRNA

NCBI chr 3:91,099,111...91,121,152
Ensembl chr 3:91,099,835...91,121,124

G

DEP domain containing MTOR-interacting protein

affects expression

Vitamin K 3 affects the expression of DEPTOR mRNA

NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773

G

desumoylating isopeptidase 2

affects expression

Vitamin K 3 affects the expression of DESI2 mRNA

NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416

G

diacylglycerol O-acyltransferase 1

affects expression

Vitamin K 3 affects the expression of DGAT1 mRNA

NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299

G

diacylglycerol O-acyltransferase 2

affects expression

Vitamin K 3 affects the expression of DGAT2 mRNA

PMID:20044591 PMID:23410634

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

diacylglycerol kinase, delta

affects expression

Vitamin K 3 affects the expression of DGKD mRNA

NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345

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dehydrogenase/reductase 11

increases reduction

DHRS11 protein results in increased reduction of Vitamin K 3

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

G

DEAH-box helicase 35

affects expression

Vitamin K 3 affects the expression of DHX35 mRNA

NCBI chr 3:147,450,178...147,507,473
Ensembl chr 3:147,450,163...147,507,451

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DExH-box helicase 9

affects expression

Vitamin K 3 affects the expression of DHX9 mRNA

NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069

G

divergent protein kinase domain 1B

affects expression

Vitamin K 3 affects the expression of DIPK1B mRNA

NCBI chr 3:9,455,914...9,464,169
Ensembl chr 3:9,456,409...9,464,161

G

dyskerin pseudouridine synthase 1

affects expression

Vitamin K 3 affects the expression of DKC1 mRNA

G

dickkopf WNT signaling pathway inhibitor 1

affects expression
increases expression

Vitamin K 3 affects the expression of DKK1 mRNA
Vitamin K 3 results in increased expression of DKK1 mRNA

PMID:12414654 PMID:20044591

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

DLG associated protein 5

affects expression

Vitamin K 3 affects the expression of DLGAP5 mRNA

PMID:20044591 PMID:23410634

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

dystrophin

increases response to substance

DMD gene mutant form results in increased susceptibility to Vitamin K 3

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

doublesex and mab-3 related transcription factor 1

increases expression

Vitamin K 3 results in increased expression of DMRT1 mRNA

NCBI chr 1:223,142,859...223,241,333
Ensembl chr 1:223,142,859...223,241,333

G

DnaJ heat shock protein family (Hsp40) member B1

affects expression

Vitamin K 3 affects the expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

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DnaJ heat shock protein family (Hsp40) member C14

affects expression

Vitamin K 3 affects the expression of DNAJC14 mRNA

NCBI chr 7:1,233,856...1,247,349
Ensembl chr 7:1,235,162...1,248,645

G

dynamin 1-like

affects expression

Vitamin K 3 affects the expression of DNM1L mRNA

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

DNA methyltransferase 3 beta

affects expression

Vitamin K 3 affects the expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

DNA methyltransferase 3 like

decreases expression

Vitamin K 3 results in decreased expression of DNMT3L mRNA

NCBI chr20:10,614,933...10,629,337
Ensembl chr20:10,614,934...10,629,516

G

diphthamide biosynthesis 1

affects expression

Vitamin K 3 affects the expression of DPH1 mRNA

NCBI chr10:60,028,081...60,039,764
Ensembl chr10:60,026,048...60,039,850

G

diphthamide biosynthesis 3

affects expression

Vitamin K 3 affects the expression of DPH3 mRNA

NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265

G

dolichyl-phosphate mannosyltransferase subunit 3, regulatory

affects expression

Vitamin K 3 affects the expression of DPM3 mRNA

NCBI chr 2:174,676,532...174,677,047
Ensembl chr 2:174,676,363...174,677,668
Ensembl chr15:174,676,363...174,677,668

G

dihydropyrimidine dehydrogenase

affects expression

Vitamin K 3 affects the expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

dual specificity phosphatase 1

affects expression
decreases expression

Vitamin K 3 affects the expression of DUSP1 mRNA
Vitamin K 3 results in decreased expression of DUSP1 mRNA

PMID:23410634 PMID:25270620

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 2

affects expression

Vitamin K 3 affects the expression of DUSP2 mRNA

NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499

G

dual specificity phosphatase 3

affects expression

Vitamin K 3 affects the expression of DUSP3 mRNA

NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962

G

dual specificity phosphatase 6

affects expression

Vitamin K 3 affects the expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dual specificity phosphatase 9

affects expression

Vitamin K 3 affects the expression of DUSP9 mRNA

NCBI chr X:151,351,897...151,355,822
Ensembl chr X:151,351,897...151,355,821

G

dynein cytoplasmic 1 heavy chain 1

affects expression

Vitamin K 3 affects the expression of DYNC1H1 mRNA

NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883

G

dynein, cytoplasmic 1 light intermediate chain 2

affects expression

Vitamin K 3 affects the expression of DYNC1LI2 mRNA

NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670

G

dual specificity tyrosine phosphorylation regulated kinase 2

affects expression

Vitamin K 3 affects the expression of DYRK2 mRNA

NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106

G

E2F transcription factor 1

affects expression

Vitamin K 3 affects the expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

affects expression

Vitamin K 3 affects the expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

EBNA1 binding protein 2

affects expression

Vitamin K 3 affects the expression of EBNA1BP2 mRNA

NCBI chr 5:132,148,164...132,152,730
Ensembl chr 5:132,148,143...132,153,267

G

Ecm29 proteasome adaptor and scaffold

affects expression

Vitamin K 3 affects the expression of ECPAS mRNA

NCBI chr 5:73,601,745...73,714,026
Ensembl chr 5:73,604,533...73,713,860

G

enhancer of mRNA decapping 3

affects expression

Vitamin K 3 affects the expression of EDC3 mRNA

NCBI chr 8:58,106,147...58,151,685
Ensembl chr 8:58,106,175...58,151,671

G

endothelin 1

increases expression
affects expression

Vitamin K 3 results in increased expression of EDN1 mRNA
Vitamin K 3 affects the expression of EDN1 mRNA

PMID:12414654 PMID:20044591 PMID:23410634

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

ephrin B2

decreases expression

Vitamin K 3 results in decreased expression of EFNB2 mRNA

NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391

G

epidermal growth factor receptor

increases phosphorylation

Vitamin K 3 results in increased phosphorylation of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 3

decreases expression

Vitamin K 3 results in decreased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

increases expression
affects expression

Vitamin K 3 results in increased expression of EGR1 mRNA
Vitamin K 3 affects the expression of EGR1 mRNA

PMID:12414654 PMID:20044591 PMID:23410634

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

euchromatic histone lysine methyltransferase 1

affects expression

Vitamin K 3 affects the expression of EHMT1 mRNA

NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007

G

eukaryotic translation initiation factor 3, subunit C

affects expression

Vitamin K 3 affects the expression of EIF3C mRNA

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 3, subunit J

affects expression

Vitamin K 3 affects the expression of EIF3J mRNA

NCBI chr 3:108,985,103...109,007,341
Ensembl chr 3:108,985,118...109,007,953

G

eukaryotic translation initiation factor 4A1

affects expression

Vitamin K 3 affects the expression of EIF4A1 mRNA

NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858

G

eukaryotic translation initiation factor 4B

affects expression

Vitamin K 3 affects the expression of EIF4B mRNA

NCBI chr 7:133,206,637...133,228,436

G

eukaryotic translation initiation factor 4E nuclear import factor 1

affects expression

Vitamin K 3 affects the expression of EIF4ENIF1 mRNA

NCBI chr14:78,056,115...78,099,846
Ensembl chr14:78,056,297...78,098,793

G

eukaryotic translation initiation factor 4, gamma 2

affects expression

Vitamin K 3 affects the expression of EIF4G2 mRNA

NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588

G

ELAV like RNA binding protein 1

multiple interactions
increases phosphorylation

[[Vitamin K 3 results in increased phosphorylation of JAK3 protein] which results in increased phosphorylation of and affects the localization of ELAVL1 protein] inhibits the reaction [ELAVL1 protein binds to and results in decreased degradation of SIRT1 mRNA]; [[Vitamin K 3 results in increased phosphorylation of JAK3 protein] which results in increased phosphorylation of and affects the localization of ELAVL1 protein] inhibits the reaction [ELAVL1 protein binds to and results in decreased degradation of VHL mRNA]; [Vitamin K 3 results in increased phosphorylation of JAK3 protein] which results in increased phosphorylation of and affects the localization of ELAVL1 protein; JAK3 protein promotes the reaction [Vitamin K 3 results in increased phosphorylation of ELAVL1 protein]; Janus Kinase Inhibitors inhibits the reaction [Vitamin K 3 results in increased phosphorylation of ELAVL1 protein]; Vitamin K 3 inhibits the reaction [sodium arsenite promotes the reaction [ELAVL1 protein binds to and results in decreased degradation of SIRT1 mRNA]]; Vitamin K 3 inhibits the reaction [sodium arsenite promotes the reaction [ELAVL1 protein binds to and results in decreased degradation of VHL mRNA]]

NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784

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ELAV like RNA binding protein 2

affects expression

Vitamin K 3 affects the expression of ELAVL2 mRNA

NCBI chr 5:105,960,872...106,086,463
Ensembl chr 5:105,960,875...106,109,097