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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:colesevelam hydrochloride
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Accession:CHEBI:59599 term browser browse the term
Definition:The hydrochloride of colesevelam. It is used as an orally administered bile acid sequestrant to reduce the amount of cholesterol and certain fatty substances in the blood.
Synonyms:related_synonym: colesevelam HCl
 xref: CAS:182815-44-7;   DrugBank:DB00930;   KEGG:D03582
 xref_mesh: MESH:C107058
 xref: Patent:US5693675;   Patent:WO9534585


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colesevelam hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRP C-reactive protein decreases expression EXP Colesevelam Hydrochloride results in decreased expression of CRP protein CTD PMID:16616026 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression		 ISO Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]
Colesevelam Hydrochloride results in increased expression of HMGCR mRNA		 CTD PMID:22120639 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G LDLR low density lipoprotein receptor increases expression ISO Colesevelam Hydrochloride results in increased expression of LDLR mRNA CTD PMID:22120639 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26504
    role 26326
      application 25592
        pharmaceutical 25010
          drug 25007
            antilipemic drug 9458
              anticholesteremic drug 3963
                colesevelam hydrochloride 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 26504
    subatomic particle 26480
      composite particle 26480
        hadron 26480
          baryon 26480
            nucleon 26480
              atomic nucleus 26480
                atom 26480
                  main group element atom 26217
                    main group molecular entity 26217
                      s-block molecular entity 25456
                        hydrogen molecular entity 24862
                          hydrides 23079
                            inorganic hydride 20549
                              pnictogen hydride 20491
                                nitrogen hydride 20275
                                  ammonium 8210
                                    ammonium ion derivative 8205
                                      ammonium compound 5030
                                        organoammonium salt 721
                                          quaternary ammonium salt 605
                                            colesevelam 3
                                              colesevelam hydrochloride 3
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