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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
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Accession:CHEBI:43561 term browser browse the term
Definition:An isoquinoline that has formula C12H15N3O2S.
Synonyms:related_synonym: Formula=C12H15N3O2S;   InChI=1S/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3;   InChIKey=PJWUXKNZVMEPPH-UHFFFAOYSA-N;   N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide;   SMILES=CNCCNS(=O)(=O)c1cccc2cnccc12
 xref: Beilstein:6337250;   CAS:84478-11-5;   DrugBank:DB07997;   LINCS:LSM-2410
 xref_mesh: MESH:C053177
 xref: PDBeChem:IQS


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N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Polr2a RNA polymerase II subunit A multiple interactions
decreases phosphorylation		 ISO sodium arsenite inhibits the reaction [N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of POLR2A protein] CTD PMID:8126066 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein] CTD PMID:19822634 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          sulfur atom 17688
            sulfur molecular entity 17688
              organosulfur compound 17335
                sulfonamide 5287
                  N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              oxoacid 18736
                                chalcogen oxoacid 13754
                                  sulfur oxoacid 13542
                                    sulfonic acid 11577
                                      sulfonic acid derivative 11577
                                        sulfonamide 5287
                                          N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide 2
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