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atorvastatin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:atorvastatin
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Accession:CHEBI:39548 term browser browse the term
Definition:A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases.
Synonyms:exact_synonym: (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-4-phenyl-2-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
 related_synonym: (R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid;   7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID;   Atorlip;   Formula=C33H35FN2O5;   InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1;   InChIKey=XUKUURHRXDUEBC-KAYWLYCHSA-N;   SMILES=CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC(O)=O)C1=CC=C(F)C=C1)C1=CC=CC=C1;   atorvastatina;   atorvastatine;   atorvastatinum
 alt_id: CHEBI:2910;   CHEBI:39538;   CHEBI:94450
 xref: Beilstein:8373630;   CAS:134523-00-5;   DrugBank:DB01076;   Drug_Central:257;   HMDB:HMDB0005006;   KEGG:C06834;   KEGG:D07474;   LINCS:LSM-5771;   PDBeChem:117;   PMID:11693468;   PMID:15012735;   PMID:18720283;   Patent:EP409281;   Patent:US5273995;   Reaxys:8373630;   Wikipedia:Atorvastatin
 cyclic_relationship: is_conjugate_acid_of CHEBI:50690

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atorvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 increases expression ISO atorvastatin co-treated with N-nitrosodiethylamine increases expression of Cdh1 mRNA in liver RGD PMID:25319454 RGD:152995431 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO atorvastatin inhibits the reaction [alcohol increases expression of HSPA5 protein in cardiomyocytes] RGD PMID:30160187 RGD:401827866 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression
decreases expression 		ISO Atorvastatin increases expression of NR1H3 mRNA in mononuclear cells
Atorvastatin decreases expression of NR1H3 protein in macrophages		 RGD PMID:16252156 PMID:17644777 RGD:401827902, RGD:401827903 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression ISO atorvastatin co-treated with N-nitrosodiethylamine decreases expression of Slco1b2 mRNA in liver RGD PMID:25319454 RGD:152995431 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO atorvastatin decreases expression of SREBF1 protein in cardiomyocytes RGD PMID:30160187 RGD:401827866 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        xenobiotic 18730
          atorvastatin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      monocarboxylic acid 18012
                                        fatty acid 16849
                                          saturated fatty acid 16565
                                            straight-chain saturated fatty acid 16099
                                              heptanoic acid 639
                                                atorvastatin 5
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