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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyriproxyfen
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Accession:CHEBI:39260 term browser browse the term
Definition:An aromatic ether that consists of propylene glycol having a 2-pyridyl group at the O-1 position and a 4-phenoxyphenyl group at the O-3 position.
Synonyms:exact_synonym: 2-[1-methyl-2-(4-phenoxyphenoxy)ethoxy]pyridine
 related_synonym: 4-phenoxyphenyl (RS)-2-(2-pyridyloxy)propyl ether;   Formula=C20H19NO3;   InChI=1S/C20H19NO3/c1-16(23-20-9-5-6-14-21-20)15-22-17-10-12-19(13-11-17)24-18-7-3-2-4-8-18/h2-14,16H,15H2,1H3;   InChIKey=NHDHVHZZCFYRSB-UHFFFAOYSA-N;   SMILES=CC(COc1ccc(Oc2ccccc2)cc1)Oc1ccccn1
 xref: CAS:95737-68-1;   KEGG:C18605;   KEGG:D08455
 xref_mesh: MESH:C055613
 xref: PMID:11466738;   PMID:11754538;   PMID:15756702;   PMID:15969518;   PMID:17437255;   PMID:17569108;   PMID:17582630;   PMID:18485359;   PMID:21036621;   PPDB:574;   Patent:GB2140010;   Patent:US4751225;   Reaxys:6932868;   VSDB:574;   Wikipedia:Pyriproxyfen


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pyriproxyfen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression ISO pyriproxyfen metabolite results in increased expression of CASP3 protein CTD PMID:34289950 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Dlx2 distal-less homeobox 2 increases expression
multiple interactions		 ISO pyriproxyfen metabolite results in increased expression of DLX2 mRNA
[pyriproxyfen metabolite co-treated with Triiodothyronine] results in increased expression of DLX2 mRNA		 CTD PMID:34289950 NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597 		JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions		 ISO pyriproxyfen metabolite results in increased expression of FASN mRNA
[pyriproxyfen metabolite co-treated with Triiodothyronine] results in increased expression of FASN mRNA		 CTD PMID:34289950 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Msi1 musashi RNA-binding protein 1 multiple interactions
increases expression		 ISO [pyriproxyfen metabolite co-treated with Triiodothyronine] results in increased expression of MSI1 mRNA
pyriproxyfen metabolite results in increased expression of MSI1 mRNA; pyriproxyfen metabolite results in increased expression of MSI1 protein		 CTD PMID:34289950 NCBI chr12:41,158,301...41,251,134
Ensembl chr12:41,158,599...41,191,076 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO pyriproxyfen results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Sox10 SRY-box transcription factor 10 decreases expression
multiple interactions		 ISO pyriproxyfen metabolite results in decreased expression of SOX10 mRNA
[pyriproxyfen metabolite co-treated with Triiodothyronine] results in decreased expression of SOX10 mRNA		 CTD PMID:34289950 NCBI chr 7:110,725,274...110,734,651
Ensembl chr 7:110,725,274...110,735,544 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        growth regulator 9016
          insect growth regulator 101
            juvenile hormone mimic 15
              pyriproxyfen 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  ether 17326
                                    aromatic ether 16608
                                      diphenyl ether 4169
                                        phenoxyphenol 13
                                          4-phenoxyphenol 13
                                            pyriproxyfen 6
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