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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-phenoxyphenol
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Accession:CHEBI:39264 term browser browse the term
Definition:A phenoxyphenol that has formula C12H10O2.
Synonyms:related_synonym: 4-hydroxydiphenyl ether;   Formula=C12H10O2;   InChI=1S/C12H10O2/c13-10-6-8-12(9-7-10)14-11-4-2-1-3-5-11/h1-9,13H;   InChIKey=ZSBDGXGICLIJGD-UHFFFAOYSA-N;   SMILES=Oc1ccc(Oc2ccccc2)cc1;   p-hydroxydiphenyl ether;   p-phenoxyphenol
 xref: Beilstein:2047182;   CAS:831-82-3;   Gmelin:604158
 xref_mesh: MESH:C530483


show annotations for term's descendants           Sort by:
4-phenoxyphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO 4-phenoxyphenol binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
fenoxycarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity		 ISO fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
fenoxycarb results in decreased activity of ABCB1 protein		 CTD PMID:21783720 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ache acetylcholinesterase decreases activity EXP fenoxycarb results in decreased activity of ACHE protein CTD PMID:14644616 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14644616 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO fenoxycarb results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
pyriproxyfen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression ISO pyriproxyfen metabolite results in increased expression of CASP3 protein CTD PMID:34289950 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Dlx2 distal-less homeobox 2 increases expression
multiple interactions		 ISO pyriproxyfen metabolite results in increased expression of DLX2 mRNA
[pyriproxyfen metabolite co-treated with Triiodothyronine] results in increased expression of DLX2 mRNA		 CTD PMID:34289950 NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597 		JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions		 ISO pyriproxyfen metabolite results in increased expression of FASN mRNA
[pyriproxyfen metabolite co-treated with Triiodothyronine] results in increased expression of FASN mRNA		 CTD PMID:34289950 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Msi1 musashi RNA-binding protein 1 multiple interactions
increases expression		 ISO [pyriproxyfen metabolite co-treated with Triiodothyronine] results in increased expression of MSI1 mRNA
pyriproxyfen metabolite results in increased expression of MSI1 mRNA; pyriproxyfen metabolite results in increased expression of MSI1 protein		 CTD PMID:34289950 NCBI chr12:41,158,301...41,251,134
Ensembl chr12:41,158,599...41,191,076 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO pyriproxyfen results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Sox10 SRY-box transcription factor 10 decreases expression
multiple interactions		 ISO pyriproxyfen metabolite results in decreased expression of SOX10 mRNA
[pyriproxyfen metabolite co-treated with Triiodothyronine] results in decreased expression of SOX10 mRNA		 CTD PMID:34289950 NCBI chr 7:110,725,274...110,734,651
Ensembl chr 7:110,725,274...110,735,544 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      molecular entity 19809
        polyatomic entity 19767
          heteroatomic molecular entity 19723
            hydroxides 19300
              organic hydroxy compound 18928
                phenols 18609
                  phenoxyphenol 13
                    4-phenoxyphenol 13
                      1,4-diphenoxybenzene 0
                      fenoxycarb 7
                      pyriproxyfen 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  ether 17284
                                    aromatic ether 16529
                                      diphenyl ether 2803
                                        phenoxyphenol 13
                                          4-phenoxyphenol 13
                                            1,4-diphenoxybenzene 0
                                            fenoxycarb 7
                                            pyriproxyfen 6
paths to the root