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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-hydroxyisovaleric acid
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Accession:CHEBI:37084 term browser browse the term
Definition:A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.
Synonyms:exact_synonym: 3-hydroxy-3-methylbutanoic acid
 related_synonym: 3-OH-isovaleric acid;   3-hydroxy-3-methylbutyric acid;   3-hydroxy-isovaleric acid;   3-methyl-3-hydroxybutyric acid;   Formula=C5H10O3;   HMB;   Hmb-d6;   InChI=1S/C5H10O3/c1-5(2,8)3-4(6)7/h8H,3H2,1-2H3,(H,6,7);   InChIKey=AXFYFNCPONWUHW-UHFFFAOYSA-N;   SMILES=CC(C)(O)CC(O)=O;   beta-Hydroxyisovaleric acid;   beta-hydroxy-beta-methylbutyric acid
 xref: Beilstein:1743952;   CAS:625-08-1;   HMDB:HMDB0000754;   LIPID_MAPS_instance:LMFA01050396
 xref_mesh: MESH:C004961
 xref: PMID:12399279;   PMID:22770225;   PMID:9523856;   Reaxys:1743952;   Wikipedia:Beta-Hydroxy_beta-methylbutyric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:82957


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3-hydroxyisovaleric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO [Dexamethasone co-treated with beta-hydroxyisovaleric acid] results in increased phosphorylation of AKT1 protein CTD PMID:24124592 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G FBXO32 F-box protein 32 increases expression
multiple interactions		 ISO beta-hydroxyisovaleric acid results in increased expression of FBXO32 mRNA
beta-hydroxyisovaleric acid inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]		 CTD PMID:24124592 NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206 		JBrowse link
G USP16 ubiquitin specific peptidase 16 increases expression ISO beta-hydroxyisovaleric acid results in increased expression of USP16 mRNA CTD PMID:24124592 NCBI chr21:29,024,668...29,054,488
Ensembl chr21:29,024,629...29,054,488 		JBrowse link
G USP2 ubiquitin specific peptidase 2 increases expression ISO beta-hydroxyisovaleric acid results in increased expression of USP2 mRNA CTD PMID:24124592 NCBI chr11:119,355,215...119,381,690
Ensembl chr11:119,355,215...119,381,711 		JBrowse link
G USP28 ubiquitin specific peptidase 28 increases expression ISO beta-hydroxyisovaleric acid results in increased expression of USP28 mRNA CTD PMID:24124592 NCBI chr11:113,797,875...113,875,572
Ensembl chr11:113,797,874...113,875,572 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        biochemical role 25168
          metabolite 25098
            eukaryotic metabolite 24518
              plant metabolite 20909
                isovaleric acid 1683
                  3-hydroxyisovaleric acid 5
                    3-hydroxyisovaleryl-CoA 0
                    3-hydroxyisovalerylcarnitine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            heteroorganic entity 24770
                              organochalcogen compound 24383
                                organooxygen compound 24060
                                  carbon oxoacid 22761
                                    carboxylic acid 22741
                                      monocarboxylic acid 21745
                                        fatty acid 19090
                                          short-chain fatty acid 17994
                                            fatty acid 4:0 8284
                                              butyric acid 6785
                                                methylbutyric acid 2453
                                                  isovaleric acid 1683
                                                    3-hydroxyisovaleric acid 5
                                                      3-hydroxyisovaleryl-CoA 0
                                                      3-hydroxyisovalerylcarnitine 0
paths to the root