CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (+)-Nornicotine
Accession: CHEBI:37
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Definition: A pyrrolidine that has formula C9H12N2.
Synonyms: related_synonym: (+-)-1'-Demethylnicotine; (+-)-1'-demethyl-Nicotine; (R)-3-(Pyrrolidin-2-yl)pyridine; (R,S)-Nornicotine; (S)-2-(3-Pyridyl)pyrrolidine; 2-(3-Pyridyl)pyrrolidine; 3-(2-Pyrrolidinyl)pyridine; 3-(pyrrolidin-2-yl)pyridine; Dl-Norcitine; Formula=C9H12N2; InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2/t9-/m1/s1; InChIKey=MYKUKUCHPMASKF-SECBINFHSA-N; L-Nor-nicotine; Nornicotin; S-(-)-Nornicotine; SMILES=C1CN[C@H](C1)c1cccnc1
xref: CAS:494-97-3; CAS:7076-23-5; HMDB:HMDB0001126; KEGG:C11360; KNApSAcK:C00002061; LINCS:LSM-5009
xref_mesh: MESH:C005311
xref: MetaCyc:CPD-2748; PMID:12194923; PMID:127438; PMID:15472033; PMID:7855117; PMID:8245163
cyclic_relationship: is_enantiomer_of CHEBI:28313
G
Ager
advanced glycosylation end product-specific receptor
increases expression
ISO
nornicotine results in increased expression of AGER mRNA; nornicotine results in increased expression of AGER protein
CTD
PMID:17397323
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
G
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
increases activity
EXP
nornicotine results in increased activity of CHRNA7 protein
CTD
PMID:17241116
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases chemical synthesis
ISO
CYP2B6 protein results in increased chemical synthesis of nornicotine
CTD
PMID:30906561
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Serpinf1
serpin family F member 1
decreases expression
ISO
nornicotine results in decreased expression of SERPINF1 mRNA; nornicotine results in decreased expression of SERPINF1 protein
CTD
PMID:26536586
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
G
Vegfa
vascular endothelial growth factor A
increases expression
ISO
nornicotine results in increased expression of VEGFA mRNA; nornicotine results in increased expression of VEGFA protein
CTD
PMID:26536586
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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