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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:brompheniramine
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Accession:CHEBI:3183 term browser browse the term
Definition:Pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Synonyms:exact_synonym: 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
 related_synonym: 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane;   2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine;   3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine;   3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine;   Formula=C16H19BrN2;   InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3;   InChIKey=ZDIGNSYAACHWNL-UHFFFAOYSA-N;   SMILES=CN(C)CCC(c1ccc(Br)cc1)c1ccccn1;   [3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl]-dimethyl-amine;   bromfeniramina;   brompheniraminum
 alt_id: CHEBI:154051
 xref: Beilstein:217066;   CAS:86-22-6;   DrugBank:DB00835;   Drug_Central:408;   KEGG:C06857;   KEGG:D07543;   LINCS:LSM-1736
 xref_mesh: MESH:D001977
 xref: PMID:2570152;   PMID:2579237;   PMID:6458703;   PMID:9526560;   Patent:US2567245;   Patent:US2676964;   Wikipedia:Brompheniramine


show annotations for term's descendants           Sort by:
brompheniramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Brompheniramine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Brompheniramine results in decreased activity of KCNH2 protein CTD PMID:17010640 PMID:17516459 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Brompheniramine results in decreased activity of SCN5A protein CTD PMID:17010640 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Brompheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
dexbrompheniramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO dexbrompheniramine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO dexbrompheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      application 19729
        pharmaceutical 19563
          drug 19563
            anti-allergic agent 3941
              brompheniramine 4
                brompheniramine maleate + 0
                dexbrompheniramine + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19794
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                organic heterocyclic compound 18900
                                  organic heteromonocyclic compound 17827
                                    pyridines 11524
                                      brompheniramine 4
                                        brompheniramine maleate + 0
                                        dexbrompheniramine + 2
paths to the root