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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vincristine
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Accession:CHEBI:28445 term browser browse the term
Definition:A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Synonyms:related_synonym: 22-Oxovincaleukoblastine;   22-oxo-vincaleukoblastine;   Formula=C46H56N4O10;   InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1;   InChIKey=OGWKCGZFUXNPDA-XQKSVPLYSA-N;   SMILES=[H][C@@]12N3CC[C@@]11c4cc(c(OC)cc4N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@@H]2C[N@](CCc3c1[nH]c1ccccc31)C[C@](O)(CC)C2)C(=O)OC;   leucristine;   leurocristine;   oncovin;   vincristin;   vinkristin
 alt_id: CHEBI:27289;   CHEBI:9987
 xref: Beilstein:4779289;   CAS:57-22-7;   DrugBank:DB00541;   Drug_Central:2825;   HMDB:HMDB0014681;   KEGG:C07204;   KEGG:D08679;   KNApSAcK:C00001783
 xref_mesh: MESH:D014750
 xref: MetaCyc:CPD-19894;   PMID:18520608;   PMID:30277559;   PMID:30429697;   PMID:30599272;   PMID:30604513;   PMID:30657998;   PMID:31048222;   PMID:31161774;   PMID:31214762;   PMID:31296986;   Wikipedia:Vincristine
 cyclic_relationship: is_conjugate_base_of CHEBI:143658


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vincristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases export
affects response to substance
multiple interactions		 EXP ABCB1 protein results in increased export of Vincristine
ABCB1 protein affects the susceptibility to Vincristine
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]		 CTD PMID:24975508 PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Vincristine CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 495
    role 495
      application 453
        pharmaceutical 447
          drug 447
            vincristine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 495
    subatomic particle 495
      composite particle 495
        hadron 495
          baryon 495
            nucleon 495
              atomic nucleus 495
                atom 495
                  main group element atom 488
                    p-block element atom 488
                      carbon group element atom 477
                        carbon atom 476
                          organic molecular entity 476
                            heteroorganic entity 472
                              organochalcogen compound 426
                                organooxygen compound 424
                                  carbon oxoacid 365
                                    carboxylic acid 365
                                      carboacyl group 306
                                        univalent carboacyl group 306
                                          carbamoyl group 304
                                            carboxamide 304
                                              formamides 2
                                                vincristine 2
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