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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:triapine
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Accession:CHEBI:231347 term browser browse the term
Definition:Triapine is a synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro.
Synonyms:related_synonym: 3-AP;   Formula=C7H9N5S;   InChI=1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+;   InChIKey=XMYKNCNAZKMVQN-NYYWCZLTSA-N;   OCX 191;   SMILES=C1=CC(=C(N=C1)/C=N/NC(=S)N)N
 xref: CAS:143621-35-6
 xref_mesh: MESH:C078157


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triapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases expression ISO 3-aminopyridine-2-carboxaldehyde thiosemicarbazone results in increased expression of H2AX protein CTD PMID:25130544 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Prdx3 peroxiredoxin 3 increases oxidation ISO 3-aminopyridine-2-carboxaldehyde thiosemicarbazone results in increased oxidation of PRDX3 protein CTD PMID:21195754 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B multiple interactions ISO [Cisplatin co-treated with 3-aminopyridine-2-carboxaldehyde thiosemicarbazone] results in increased expression of RRM2B protein CTD PMID:20954859 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Txn2 thioredoxin 2 increases oxidation
multiple interactions		 ISO 3-aminopyridine-2-carboxaldehyde thiosemicarbazone results in increased oxidation of TXN2 protein
[3-aminopyridine-2-carboxaldehyde thiosemicarbazone binds to Iron] which results in increased oxidation of TXN2 protein		 CTD PMID:21195754 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    chemical entity 19838
      atom 19838
        nonmetal atom 19776
          carbon atom 19730
            organic molecular entity 19730
              triapine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19788
                    p-block element atom 19788
                      carbon group element atom 19734
                        carbon atom 19730
                          organic molecular entity 19730
                            triapine 4
paths to the root