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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:semicarbazide
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Accession:CHEBI:28306 term browser browse the term
Definition:A monocarboxylic acid amide that is urea where one of the amino groups has been replaced with hydrazine.
Synonyms:related_synonym: Aminoharnstoff;   Aminourea;   Carbamidsaeurehydrazid;   Carbamoylhydrazine;   Formula=CH5N3O;   Hydrazinecarboxamide;   InChI=1S/CH5N3O/c2-1(5)4-3/h3H2,(H3,2,4,5);   InChIKey=DUIOPKIIICUYRZ-UHFFFAOYSA-N;   SMILES=NNC(N)=O;   Semikarbazid;   carbamylhydrazine;   carbazamide
 alt_id: CHEBI:26644;   CHEBI:9102
 xref: Beilstein:506319;   CAS:57-56-7;   Gmelin:100758;   KEGG:C02077
 xref_mesh: MESH:C010059
 xref: MetaCyc:SEMICARBAZIDE;   PMID:11958526;   PMID:17499072;   PMID:23194563;   PMID:23683401;   Reaxys:506319;   Wikipedia:Semicarbazide


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semicarbazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aoc3 amine oxidase, copper containing 3 decreases activity ISO
EXP
carbamylhydrazine results in decreased activity of AOC3 protein CTD PMID:10406932, PMID:11543647 NCBI chr10:89,251,370...89,259,313
Ensembl chr10:89,251,370...89,259,313
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
multiple interactions
EXP carbamylhydrazine results in increased activity of CYP19A1 protein
[carbamylhydrazine results in increased activity of CYP19A1 protein] which results in increased abundance of Testosterone metabolite
CTD PMID:19788891 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions
increases activity
EXP [carbamylhydrazine results in decreased activity of CYP2A1 protein] which results in decreased abundance of Testosterone metabolite; [carbamylhydrazine results in increased activity of CYP2A1 protein] which results in increased abundance of Testosterone metabolite CTD PMID:19788891 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
multiple interactions
EXP carbamylhydrazine results in increased activity of CYP3A2 protein
[carbamylhydrazine results in increased activity of CYP3A2 protein] which results in increased abundance of Testosterone metabolite
CTD PMID:19788891 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO carbamylhydrazine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:19788891 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases activity ISO carbamylhydrazine results in decreased activity of GRIN1 protein CTD PMID:19788891 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Lox lysyl oxidase decreases activity EXP carbamylhydrazine results in decreased activity of LOX protein CTD PMID:19524603 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
nitrofurantoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Nitrofurantoin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Nitrofurantoin results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Nitrofurantoin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
increases export
affects abundance
multiple interactions
increases transport
affects response to substance
increases secretion
ISO
EXP
ABCG2 protein affects the transport of Nitrofurantoin
ABCG2 protein results in increased export of Nitrofurantoin
ABCG2 protein affects the abundance of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]
ABCG2 affects the susceptibility to Nitrofurantoin
ABCG2 results in increased secretion of Nitrofurantoin
ABCG2 protein results in increased secretion of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]; Elacridar inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]
CTD PMID:15709111, PMID:15722455, PMID:17093006, PMID:17785426, PMID:18799806, PMID:19105722, PMID:19732493, PMID:26907376 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Agt angiotensinogen decreases activity EXP Nitrofurantoin results in decreased activity of AGT protein CTD PMID:1313237 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Nitrofurantoin results in increased expression of ALDOA mRNA; Nitrofurantoin results in increased expression of ALDOA protein CTD PMID:11841787 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Cat catalase decreases activity ISO
EXP
Nitrofurantoin results in decreased activity of CAT protein CTD PMID:1313237, PMID:9000262 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]] CTD PMID:15748169 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
EXP
ISO
Nitrofurantoin results in decreased activity of GSR protein
[Nitrofurantoin co-treated with GSR protein] affects the metabolism of Glucose
CTD PMID:1313237, PMID:1901343, PMID:9000262 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity EXP Nitrofurantoin results in increased activity of HIF1A protein CTD PMID:11841787 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Nitrofurantoin results in increased expression of HMOX1 mRNA CTD PMID:7626009, PMID:11841787 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Nitrofurantoin results in increased expression of HSPA8 mRNA CTD PMID:7626009 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Nitrofurantoin results in increased expression of JUN mRNA CTD PMID:7626009, PMID:11841787 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Nitrofurantoin results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases response to substance
affects reduction
ISO NQO1 protein results in increased susceptibility to Nitrofurantoin
NQO1 protein affects the reduction of Nitrofurantoin
CTD PMID:9310146 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Nitrofurantoin results in increased expression of ORM1 mRNA; Nitrofurantoin results in increased expression of ORM1 protein CTD PMID:11841787 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Por cytochrome p450 oxidoreductase increases metabolic processing
multiple interactions
affects metabolic processing
ISO
EXP
POR protein results in increased metabolism of Nitrofurantoin
diphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]; NADP affects the reaction [POR protein affects the metabolism of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]
CTD PMID:6802140, PMID:18206659 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]] CTD PMID:15748169 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases activity
increases expression
ISO
EXP
Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]
Nitrofurantoin results in increased activity of STAT3 protein
Nitrofurantoin results in increased expression of STAT3 mRNA
CTD PMID:11841787, PMID:15748169 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Nitrofurantoin results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
nitrofurazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccne1 cyclin E1 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA] CTD PMID:15945272 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects binding EXP Nitrofurazone binds to GSK3B protein CTD PMID:18222664 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA] CTD PMID:15945272 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Nitrofurazone results in increased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of JUN mRNA] CTD PMID:15945272 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Nitrofurazone results in decreased expression of LHB protein CTD PMID:11548123 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mir128-1 microRNA 128-1 increases expression EXP Nitrofurazone results in increased expression of MIR128-1 mRNA CTD PMID:32418910 NCBI chr13:44,916,534...44,916,615
Ensembl chr13:44,916,534...44,916,615
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
EXP Nitrofurazone results in increased expression of MYC mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of MYC mRNA]
CTD PMID:15945272 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; Nitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole] CTD PMID:6802140, PMID:15488632 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prl prolactin decreases expression EXP Nitrofurazone results in decreased expression of PRL protein CTD PMID:11548123 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Tgfa transforming growth factor alpha increases expression
multiple interactions
EXP Nitrofurazone results in increased expression of TGFA mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TGFA mRNA]
CTD PMID:15945272 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TNF mRNA] CTD PMID:15945272 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases mutagenesis ISO Nitrofurazone results in increased mutagenesis of TP53 gene CTD PMID:15488632 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        agrochemical 14503
          fertilizer 11807
            urea 4990
              ureas 4987
                semicarbazide 41
                  1-(3-(2,4-dimethylthiazol-5-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl)-3-(4-methylpiperazin-1-yl)urea 0
                  2-(2-hydroxybenzoyl)hydrazinecarboxamide 0
                  2-(aminomethylidene)hydrazinyl group 0
                  4-(\{[(4-methylpiperazin-1-yl)amino]carbothioyl\}amino)benzenesulfonamide 0
                  C-aminocarbonohydrazonoyl group 0
                  N-[(5-acetyl-3-thienyl)methyl]-2-chloroacetamide semicarbazone 0
                  N-\{[2-(3-chloro-4-fluorophenyl)hydrazino]carbonyl\}-3,5-bis(methylthio)isothiazole-4-carboxamide 0
                  carbazochrome + 0
                  furagin 0
                  nifurtoinol 0
                  nitrofurantoin 21
                  semicarbazido group 0
                  semicarbazone + 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  urea 4990
                                                    ureas 4987
                                                      semicarbazide 41
                                                        1-(3-(2,4-dimethylthiazol-5-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl)-3-(4-methylpiperazin-1-yl)urea 0
                                                        2-(2-hydroxybenzoyl)hydrazinecarboxamide 0
                                                        2-(aminomethylidene)hydrazinyl group 0
                                                        4-(\{[(4-methylpiperazin-1-yl)amino]carbothioyl\}amino)benzenesulfonamide 0
                                                        C-aminocarbonohydrazonoyl group 0
                                                        N-[(5-acetyl-3-thienyl)methyl]-2-chloroacetamide semicarbazone 0
                                                        N-\{[2-(3-chloro-4-fluorophenyl)hydrazino]carbonyl\}-3,5-bis(methylthio)isothiazole-4-carboxamide 0
                                                        carbazochrome + 0
                                                        furagin 0
                                                        nifurtoinol 0
                                                        nitrofurantoin 21
                                                        semicarbazido group 0
                                                        semicarbazone + 15
paths to the root

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