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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,6,7,8-tetrahydrofolic acid
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Accession:CHEBI:20506 term browser browse the term
Definition:A tetrahydrofolic acid that has formula C19H23N7O6.
Synonyms:exact_synonym: N-[4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl]-L-glutamic acid
 related_synonym: (6S)-THFA;   (6S)-Tetrahydrofolate;   (6S)-Tetrahydrofolic acid;   5,6,7,8-Tetrahydrofolate;   Formula=C19H23N7O6;   InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1;   InChIKey=MSTNYGQPCMXVAQ-KIYNQFGBSA-N;   SMILES=Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Nc2c(=O)[nH]1;   THF;   Tetrahydrofolic acid;   tetrahydrofolate
 xref: Beilstein:101189;   CAS:135-16-0;   DrugBank:DB00116;   KEGG:C00101;   KNApSAcK:C00007249
 xref_mesh: MESH:C030371
 cyclic_relationship: is_conjugate_acid_of CHEBI:68437


show annotations for term's descendants           Sort by:
5,6,7,8-tetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 increases chemical synthesis EXP ALDH1L2 protein results in increased chemical synthesis of 5,6,7,8-tetrahydrofolic acid CTD PMID:21238436 NCBI chr12:105,019,790...105,084,458
Ensembl chr12:105,019,784...105,107,643 		JBrowse link
G ALPI alkaline phosphatase, intestinal multiple interactions EXP 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 2:232,456,153...232,460,753
Ensembl chr 2:232,456,125...232,460,753 		JBrowse link
G IGF1R insulin like growth factor 1 receptor decreases expression EXP 5,6,7,8-tetrahydrofolic acid results in decreased expression of IGF1R mRNA CTD PMID:16728583 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions EXP 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in decreased expression of MTR protein]; [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein] CTD PMID:16598758 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 multiple interactions
decreases activity		 ISO 5,6,7,8-tetrahydrofolic acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
5,6,7,8-tetrahydrofolic acid results in decreased activity of SLC19A1 protein		 CTD PMID:14612385 NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365 		JBrowse link
G TYMS thymidylate synthetase increases activity ISO 5,6,7,8-tetrahydrofolic acid results in increased activity of TYMS protein CTD PMID:187325 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578 		JBrowse link
5-methyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 decreases abundance EXP ALDH1L1 protein results in decreased abundance of 5-methyltetrahydrofolate CTD PMID:16627483 NCBI chr 3:126,103,570...126,197,945
Ensembl chr 3:126,103,562...126,197,994 		JBrowse link
G FOLR1 folate receptor alpha increases uptake EXP FOLR1 protein results in increased uptake of 5-methyltetrahydrofolate CTD PMID:17473184 NCBI chr11:72,189,709...72,196,323
Ensembl chr11:72,189,558...72,196,323 		JBrowse link
G GNMT glycine N-methyltransferase affects binding ISO GNMT protein binds to 5-methyltetrahydrofolate CTD PMID:17158459 NCBI chr 6:42,960,754...42,963,880
Ensembl chr 6:42,960,754...42,963,880 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase increases chemical synthesis EXP MTHFR protein results in increased chemical synthesis of 5-methyltetrahydrofolate CTD PMID:7647779 PMID:9719624 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding EXP 5-methyltetrahydrofolate binds to MTR protein CTD PMID:17477549 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase affects abundance ISO MTRR protein affects the abundance of 5-methyltetrahydrofolate CTD PMID:17369066 NCBI chr 5:7,850,859...7,901,113
Ensembl chr 5:7,851,186...7,906,025 		JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions EXP [Docosahexaenoic Acids co-treated with 5-methyltetrahydrofolate] results in increased expression of PCNA protein CTD PMID:16870008 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 multiple interactions
decreases activity		 EXP
ISO		 [5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid
5-methyltetrahydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]		 CTD PMID:14612385 PMID:17034785 NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 multiple interactions
decreases activity		 EXP 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
5-methyltetrahydrofolate results in decreased activity of SLC46A1 protein		 CTD PMID:17475902 NCBI chr17:28,394,642...28,406,592
Ensembl chr17:28,394,642...28,407,197 		JBrowse link
G STK11 serine/threonine kinase 11 multiple interactions EXP 5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]; dorsomorphin inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]] CTD PMID:26400185 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26504
    role 26326
      biological role 26305
        biochemical role 25518
          metabolite 25454
            eukaryotic metabolite 24920
              fungal metabolite 21449
                Saccharomyces cerevisiae metabolite 20197
                  5,6,7,8-tetrahydrofolic acid 14
                    (6S)-5,6,7,8-tetrahydrofolic acid 0
                    5-methyltetrahydrofolic acid + 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 26504
    subatomic particle 26480
      composite particle 26480
        hadron 26480
          baryon 26480
            nucleon 26480
              atomic nucleus 26480
                atom 26480
                  main group element atom 26217
                    main group molecular entity 26217
                      s-block molecular entity 25454
                        hydrogen molecular entity 24861
                          hydrides 23080
                            inorganic hydride 20556
                              pnictogen hydride 20498
                                nitrogen hydride 20283
                                  azane 20008
                                    ammonia 20007
                                      organic amino compound 20007
                                        amino acid 17304
                                          alpha-amino acid 14772
                                            L-alpha-amino acid 13150
                                              glutamine family amino acid 10616
                                                L-glutamic acid 10551
                                                  L-glutamic acid derivative 9589
                                                    folic acids 9588
                                                      tetrahydrofolic acid 71
                                                        5,6,7,8-tetrahydrofolic acid 14
                                                          (6S)-5,6,7,8-tetrahydrofolic acid 0
                                                          5-methyltetrahydrofolic acid + 10
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