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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrahydrofolic acid
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Accession:CHEBI:26907 term browser browse the term
Definition:A group of heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more L-glutamic acid units.
Synonyms:related_synonym: tetrahydrofolate;   tetrahydrofolates;   tetrahydrofolic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:67016

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10-formyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases metabolic processing ISO ALDH1L2 protein results in increased metabolism of 10-formyltetrahydropteroylglutamic acid CTD PMID:21238436 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108 		JBrowse link
5,10-methylenetetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfr methylenetetrahydrofolate reductase increases metabolic processing
increases reduction		 ISO MTHFR protein results in increased metabolism of 5,10-methylenetetrahydrofolic acid
MTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolic acid		 CTD PMID:7647779 PMID:16187112 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910 		JBrowse link
5,6,7,8-tetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases chemical synthesis ISO ALDH1L2 protein results in increased chemical synthesis of 5,6,7,8-tetrahydrofolic acid CTD PMID:21238436 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO 5,6,7,8-tetrahydrofolic acid results in decreased expression of IGF1R mRNA CTD PMID:16728583 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in decreased expression of MTR protein]; [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein] CTD PMID:16598758 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity		 EXP 5,6,7,8-tetrahydrofolic acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
5,6,7,8-tetrahydrofolic acid results in decreased activity of SLC19A1 protein		 CTD PMID:14612385 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377 		JBrowse link
G Tyms thymidylate synthetase increases activity EXP 5,6,7,8-tetrahydrofolic acid results in increased activity of TYMS protein CTD PMID:187325 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
5-formyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP Leucovorin inhibits the reaction [Methotrexate results in decreased expression of ABCC2 protein] CTD PMID:16925582 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Alb albumin multiple interactions ISO [Leucovorin co-treated with Cisplatin co-treated with Fluorouracil] results in decreased expression of ALB protein CTD PMID:20180123 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Angptl2 angiopoietin-like 2 multiple interactions ISO ANGPTL2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 3:12,262,822...12,292,665
Ensembl chr 3:12,262,822...12,292,663 		JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 multiple interactions ISO ARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]; ARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:22452940 NCBI chr 4:129,574,363...129,598,240
Ensembl chr 4:129,574,264...129,598,915 		JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP multiple interactions ISO ATP5PO mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr11:32,081,606...32,087,918
Ensembl chr11:32,081,574...32,088,002 		JBrowse link
G Axin2 axin 2 multiple interactions EXP [Methotrexate co-treated with Leucovorin] results in increased expression of AXIN2 mRNA CTD PMID:25187349 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP [Methotrexate co-treated with Leucovorin] results in increased expression of BGLAP mRNA CTD PMID:25187349 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Boll boule homolog, RNA binding protein multiple interactions ISO BOLL mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 9:61,836,517...61,975,640
Ensembl chr 9:64,480,031...64,573,660
Ensembl chr 9:64,480,031...64,573,660 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [10-hydroxycamptothecin co-treated with Fluorouracil co-treated with Leucovorin] results in increased activity of CASP3 protein CTD PMID:12934351 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP [Methotrexate co-treated with Leucovorin] results in increased expression of CCND1 mRNA CTD PMID:25187349 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [Leucovorin co-treated with Fluorouracil] results in increased expression of CCNE1 mRNA CTD PMID:15342418 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cdc45 cell division cycle 45 multiple interactions ISO [Leucovorin co-treated with Fluorouracil] results in increased expression of CDC45 mRNA CTD PMID:15342418 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453 		JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO [Leucovorin co-treated with Fluorouracil] results in increased expression of CDC6 mRNA CTD PMID:15342418 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [Leucovorin co-treated with Fluorouracil] results in increased expression of CDK1 mRNA CTD PMID:15342418 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [Leucovorin co-treated with Fluorouracil] results in increased expression of CDK2 mRNA CTD PMID:15342418 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Leucovorin co-treated with Fluorouracil] results in increased expression of CDKN1A mRNA CTD PMID:15342418 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Methotrexate co-treated with Leucovorin] results in increased expression of CTNNB1 protein CTD PMID:25187349 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP Leucovorin affects the reaction [Methotrexate results in decreased expression of CYP11A1 mRNA]; Leucovorin affects the reaction [Methotrexate results in decreased expression of CYP11A1 protein] CTD PMID:21213337 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
increases expression		 ISO Leucovorin inhibits the reaction [DHFR gene mutant form results in decreased abundance of Folic Acid]
Leucovorin results in increased expression of DHFR protein		 CTD PMID:16712799 PMID:21310277 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO [Leucovorin co-treated with Fluorouracil] results in decreased activity of DPYD protein CTD PMID:7503095 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627 		JBrowse link
G Drd5 dopamine receptor D5 multiple interactions ISO DRD5 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006 		JBrowse link
G Edn1 endothelin 1 increases expression ISO Leucovorin results in increased expression of EDN1 mRNA; Leucovorin results in increased expression of EDN1 protein CTD PMID:16925845 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Eml2 EMAP like 2 multiple interactions ISO EML2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions ISO ERCC1 gene SNP affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:17401013 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit multiple interactions ISO ERCC2 gene SNP affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:17401013 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344 		JBrowse link
G F8 coagulation factor VIII multiple interactions ISO F8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions EXP Leucovorin inhibits the reaction [Methotrexate results in increased expression of FABP4 protein] CTD PMID:25187349 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Folr1 folate receptor alpha multiple interactions ISO FOLR1 protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein] CTD PMID:25841994 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Leucovorin affects the reaction [Methotrexate results in increased expression of FSHB protein] CTD PMID:21213337 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Leucovorin inhibits the reaction [Methotrexate results in decreased activity of G6PD protein] CTD PMID:21213337 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 increases expression ISO Leucovorin results in increased expression of HAND2 mRNA; Leucovorin results in increased expression of HAND2 protein CTD PMID:16925845 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO HSPB1 protein affects the susceptibility to [Cisplatin co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:19088045 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Leucovorin inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA] CTD PMID:24444433 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Leucovorin inhibits the reaction [Methotrexate results in increased expression of IL6 mRNA] CTD PMID:24444433 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer multiple interactions ISO IL6ST protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein] CTD PMID:25841994 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions EXP [Methotrexate co-treated with Leucovorin] results in increased expression of LEF1 mRNA CTD PMID:25187349 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056 		JBrowse link
G Lgals8 galectin 8 multiple interactions ISO LGALS8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr17:66,487,451...66,515,316
Ensembl chr17:66,487,457...66,511,870 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Leucovorin affects the reaction [Methotrexate results in increased expression of LHB protein] CTD PMID:21213337 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G LOC102548162 zinc finger protein 582-like multiple interactions ISO ZNF582 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 1:71,206,073...71,228,209 JBrowse link
G Mat2a methionine adenosyltransferase 2A multiple interactions ISO Leucovorin inhibits the reaction [Methotrexate results in decreased expression of MAT2A mRNA] CTD PMID:22193356 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase multiple interactions ISO MTHFR gene polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin] CTD PMID:18633250 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP [Methotrexate co-treated with Leucovorin] results in increased expression of PPARG mRNA; [Methotrexate co-treated with Leucovorin] results in increased expression of PPARG protein CTD PMID:25187349 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO SERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions EXP Leucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 mRNA]; Leucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 protein] CTD PMID:25187349 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions ISO Leucovorin inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate] CTD PMID:21879757 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases uptake		 EXP
ISO		 Leucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A6 protein]
SLC22A6 protein results in increased uptake of Leucovorin		 CTD PMID:16098483 PMID:16925582 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases uptake		 EXP
ISO		 Leucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A8 protein]
SLC22A8 protein results in increased uptake of Leucovorin		 CTD PMID:16098483 PMID:16925582 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 decreases activity
multiple interactions		 ISO Leucovorin results in decreased activity of SLC46A1 protein
Leucovorin inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]		 CTD PMID:17475902 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828 		JBrowse link
G Sp7 Sp7 transcription factor multiple interactions EXP [Methotrexate co-treated with Leucovorin] results in increased expression of SP7 mRNA CTD PMID:25187349 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Leucovorin affects the reaction [Methotrexate results in decreased expression of STAR mRNA]; Leucovorin affects the reaction [Methotrexate results in decreased expression of STAR protein] CTD PMID:21213337 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO FOLR1 protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein]; IL6ST protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein]; Leucovorin results in increased activity of and results in increased phosphorylation of STAT3 protein CTD PMID:25841994 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO TYMP mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:17454858 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587 		JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO [arsenic trioxide co-treated with Fluorouracil co-treated with Leucovorin] results in decreased expression of TYMS mRNA; TYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]; TYMS mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]; TYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin co-treated with docetaxel]; TYMS protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin]
Leucovorin promotes the reaction [Fluorouracil results in decreased expression of TYMS]		 CTD PMID:9050858 PMID:16424979 PMID:17454858 PMID:18676755 PMID:19074750 PMID:20501625 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
G Wnt10b Wnt family member 10B multiple interactions EXP [Methotrexate co-treated with Leucovorin] results in increased expression of WNT10B mRNA CTD PMID:25187349 NCBI chr 7:140,448,284...140,466,159
Ensembl chr 7:140,448,465...140,454,268 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO XRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]; XRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:22452940 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678 		JBrowse link
G Zfp637 zinc finger protein 637 multiple interactions ISO ZNF32 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 4:149,857,127...149,882,828
Ensembl chr 4:149,877,889...149,882,824 		JBrowse link
G Zrsr2 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 multiple interactions ISO ZRSR2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr  X:32,304,707...32,327,419
Ensembl chr  X:32,304,757...32,328,364 		JBrowse link
5-methyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 decreases abundance ISO ALDH1L1 protein results in decreased abundance of 5-methyltetrahydrofolate CTD PMID:16627483 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501 		JBrowse link
G Folr1 folate receptor alpha increases uptake ISO FOLR1 protein results in increased uptake of 5-methyltetrahydrofolate CTD PMID:17473184 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592 		JBrowse link
G Gnmt glycine N-methyltransferase affects binding EXP GNMT protein binds to 5-methyltetrahydrofolate CTD PMID:17158459 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases chemical synthesis ISO MTHFR protein results in increased chemical synthesis of 5-methyltetrahydrofolate CTD PMID:7647779 PMID:9719624 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding ISO 5-methyltetrahydrofolate binds to MTR protein CTD PMID:17477549 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase affects abundance ISO MTRR protein affects the abundance of 5-methyltetrahydrofolate CTD PMID:17369066 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [Docosahexaenoic Acids co-treated with 5-methyltetrahydrofolate] results in increased expression of PCNA protein CTD PMID:16870008 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity		 ISO
EXP		 [5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid
5-methyltetrahydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]		 CTD PMID:14612385 PMID:17034785 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity		 ISO 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
5-methyltetrahydrofolate results in decreased activity of SLC46A1 protein		 CTD PMID:17475902 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO 5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]; dorsomorphin inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]] CTD PMID:26400185 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        molecular messenger 18307
          neurotransmitter 10811
            L-glutamic acid 10207
              L-glutamic acid derivative 9369
                folic acids 9369
                  tetrahydrofolic acid 66
                    5,6,7,8-tetrahydrofolic acid + 6
                    5-methyltetrahydrofolic acid + 10
                    6R-Tetrahydrofolic acid 0
                    Calcium folinate 0
                    formimidoyltetrahydrofolic acid + 0
                    formyltetrahydrofolic acid + 58
                    levomefolic acid 0
                    methylenetetrahydrofolic acid + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        amino acid 14119
                                          alpha-amino acid 11599
                                            L-alpha-amino acid 11436
                                              glutamine family amino acid 10261
                                                L-glutamic acid 10207
                                                  L-glutamic acid derivative 9369
                                                    folic acids 9369
                                                      tetrahydrofolic acid 66
                                                        5,6,7,8-tetrahydrofolic acid + 6
                                                        5-methyltetrahydrofolic acid + 10
                                                        6R-Tetrahydrofolic acid 0
                                                        Calcium folinate 0
                                                        formimidoyltetrahydrofolic acid + 0
                                                        formyltetrahydrofolic acid + 58
                                                        levomefolic acid 0
                                                        methylenetetrahydrofolic acid + 1
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