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5-oxo-L-proline - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-oxo-L-proline
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Accession:CHEBI:18183 term browser browse the term
Definition:An optically active form of 5-oxoproline having L-configuration.
Synonyms:exact_synonym: (2S)-5-oxopyrrolidine-2-carboxylic acid
 related_synonym: (S)-(-)-2-pyrrolidone-5-carboxylic acid;   (S)-pyroglutamic acid;   5-Pyrrolidone-2-carboxylic acid;   Formula=C5H7NO3;   InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1;   InChIKey=ODHCTXKNWHHXJC-VKHMYHEASA-N;   L-5-Pyrrolidone-2-carboxylic acid;   L-Pyroglutamic acid;   PYROGLUTAMIC ACID;   Pyroglutamate;   SMILES=OC(=O)[C@@H]1CCC(=O)N1;   pidolic acid
 alt_id: CHEBI:12153;   CHEBI:20619;   CHEBI:2113;   CHEBI:44704
 xref: Beilstein:5251861;   CAS:98-79-3;   DrugBank:DB03088;   Gmelin:1125330;   HMDB:HMDB0000267;   KEGG:C01879;   KNApSAcK:C00007403
 xref_mesh: MESH:D011761
 xref: MetaCyc:5-OXOPROLINE;   PDBeChem:PCA;   PMID:17439666;   PMID:22560249;   PMID:22619187;   Reaxys:82132;   Wikipedia:Pyroglutamic_acid;   YMDB:YMDB00107
 cyclic_relationship: is_conjugate_acid_of CHEBI:58402;   is_enantiomer_of CHEBI:16924

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5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [NR1I2 protein affects the susceptibility to Pregnenolone Carbonitrile] which affects the abundance of Pyrrolidonecarboxylic Acid CTD PMID:38971454 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        osmolyte 3482
          compatible osmolytes 383
            L-proline 301
              L-proline derivative 276
                5-oxo-L-proline 3
                  5-oxo-L-proline residue 0
                  N-terminal 5-oxo-L-proline residue 0
                  pyroglutamylglycine 0
                  pyroglutamylvaline 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          carbamoyl group 17918
                                            carboxamide 17918
                                              lactam 8434
                                                gamma-lactam 6677
                                                  pyrrolidin-2-ones 171
                                                    5-oxoproline 3
                                                      5-oxo-L-proline 3
                                                        5-oxo-L-proline residue 0
                                                        N-terminal 5-oxo-L-proline residue 0
                                                        pyroglutamylglycine 0
                                                        pyroglutamylvaline 0
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